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Oculoplastic publication trends in general ophthalmology journals

International Journal of Ophthalmology(English edition) 2022年第11期15卷 1852-1856页

作者： Jean-Paul Dray Nur Khatib Eric Souied Peerooz Saeed guy ben simon Juliana Gildener-Leapman Ofira Zloto Department of Ophthalmology Centre Hospitalier Intercommunal de CreteilCreteil 94000France Orbital Center Department of OphthalmologyAmsterdam University Medical CentersAmsterdam 1105the Netherlands Goldschleger Eye Institute Sheba Medical CenterAffiliated to the Sackler Faculty of MedicineTel Aviv UniversityTel Aviv6997801Israel Meir Medical Center Kfar Saba 4428164Israel

AIM: To examine the publication trend of oculoplastic articles throughout the last decade in general ophthalmology ***: A review of all abstracts published between Januar y 2010 to December 2019 in general, clinical ophthalmic journals was conducted. Articles that were categorized as original articles in general and clinical journals were included in the ***: Totally 10 281 abstracts were included. Of them 465(4.5%) were oculoplastic publications. The mean number of annual-publications was 46.5 and the mean annual-rate of oculoplastic publications was 4.51%. A significant decreasing trend in the number of oculoplastic publication in the last decade was found(P<0.01, R^(2)=0.770). However, there was no significant change in the annual-rate of oculoplastic publications during the last decade(P=0.191, R2=0.203). From the 465 oculoplastic articles: 179(38.5%) were articles about eyelid diseases, 160(34.40%) were about orbit diseases, 92(19.80%) were about lacrimal diseases and 34(7.30%) were about thyroid eye disease(TED). A significant decreasing trends in the number of orbital and eyelids publications were found(P<0.01, P<0.01). However, there were no significant changes in the annual-rate of orbital, eyelids, TED and lacrimal-diseases publications throughout the last ***: Oculoplastic subspecialty deals with a wide range of pathologies in different ages. However, less than 5% of the articles in general, clinical, high impact factor ophthalmology journals are about oculoplastic diseases. One of the best way for ophthalmologists from different subspecilties, nowadays, to be updated, is to read highimpact-factor, general ophthalmology journals. Therefore, it is important that those journals will include articles about breakthroughs in oculoplastic.

关键词： oculoplastic publications journals general articles ophthalmology

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Quasi-morphisms via Local Action Data and Quasi-isometries

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Algebra Colloquium 2016年第1期23卷 111-116页

作者： Gabi ben-simon Department of Mathematics ORT Braude College P.O. Box 78 Karmiel 2161002 Israel

In this work we first present a principle which says that quasi-morphisms can be obtained via local data of group action on certain appropriate spaces. In a rough manner the principle says that instead of starting with a given group and trying to build or study its space of quasi-morphisms, we should start with a space with a certain structure, in such a way that groups acting on this space and respecting this structure will automatically carry quasi-morphisms, where these are supposed to be better understood. This principle plays an important role in the second result of this paper, which is a universal embedding of the projective space of the linear space of quasi-morphisms of any given countable group, into the space of quasi-isometries of a certain universal metric space.

关键词： quasi-rnorphisms discrete groups quasi-isometries

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Numerical simulations of water flow and contaminants transport near mining wastes disposed in a fractured rock mass

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International Journal of Mining Science and Technology 2015年第1期25卷 37-45页

作者： ben Abdelghani Farouk Aubertin Michel simon Richard Therrien René Department of Civil Engineering Institut Supérieur de la Construction et de l’Urbanisme Research Institute on Mines and the Environment (RIME) Polytechnique Montreal Department of Geology and Geological Engineering University Laval

A numerical tool, called Hydro-Geosphere, was used to simulate unsaturated water flow and contaminants migration around an open pit filled with mining wastes. Numerical simulations had been carried out to assess the influence of various factors on water flow and solute transport in and around the surface openings including recharge, properties of the waste material and presence of fractures in the surrounding rock mass. The effect of the regional hydraulic gradient was also investigated. The analyses were conducted by simulating various 2D cases using experimentally obtained material properties and controlled boundary conditions. The effects of the hydrogeological properties of the filling material(i.e., water retention curve and hydraulic conductivity function), fracture network characteristics and conductivity of the joints were assessed. The results illustrate that fractures control water flow and contaminants transport around the waste disposal area. A fracture network can desaturate the system and improve the regional gradient effect.

关键词： Hydro-GeosphereNumerical modellingUnsaturated water flowContaminants transportTailingsWaste rocks

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Modulation of the intracellular inhibitory checkpoint SHP-1 enhances the antitumor activity of engineered NK cells

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Cellular & Molecular Immunology 2021年第5期18卷 1314-1316页

作者： Aviad ben-Shmuel guy Biber Batel Sabag Mira Barda-Saad The Mina and Everard Goodman Faculty of Life Sciences Bar-Ilan UniversityRamat-Gan5290002Israel

Natural killer(NK)cells are innate lymphoid cells(ILCs)that eliminate virally infected and cancerous *** cells directly induce target cell death and release cytokines and chemokines that activate the adaptive arm of t... 详细信息

关键词： killer death lymphoid

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最小侵入性眼眶减压术局部麻醉和人造骨

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美国医学会眼科杂志（中文版） 2006年第4期18卷 252-252页

作者： guy J. ben simon Robert M. Schwarcz Ahmad M. Mansury Lillian Wang John D. McCann Robert A. Goldberg 刘亮（译）

目的：探讨用刮匙进行骨性减压和经结膜切口圆锥内脂肪切除的保守的眼眶减压术对甲状腺相关性眼病和轻中度突眼患者的安全性和有效性。

关键词：眼眶减压术最小侵入性局部麻醉人造骨甲状腺相关性眼病经结膜切口脂肪切除有效性

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The microbiology of infected pancreatic necrosis

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 456-460页

作者： Nicholas G.Mowbray Bassam ben-Ismaeil Mohammed Hammoda guy Shingler Bilal Al-Sarireh Swansea University Medical School Singleton Park Campus Abertawe Bro-Morgannwg University Health Board Public Health Wales Microbiology ABM Morriston Hospital Abertawe Bro-Morgannwg University Health Board Department of Surgery Morriston Hospital

Background: Acute pancreatitis(AP) continues to cause significant morbidity and mortality, especially when it leads to infected pancreatic necrosis(IPN). Modern treatment of IPN frequently involves prolonged courses of antibiotics in combination with minimally invasive therapies. This study aimed to update the existing evidence base by identifying the pathogens causing IPN and therefore aid future selection of empirical antibiotics. Methods: Clinical data, including microbiology results, of consecutive patients with IPN undergoing minimally invasive necrosectomy at our institution between January 2009 and July 2016 were retrospectively reviewed. Results: The results of 40 patients(22 males and 18 females, median age 60 years) with IPN were reviewed. The etiology of AP was gallstones, alcohol, dyslipidemia and unknown in 31, 2, 2 and 5 patients, respectively. The most frequently identified microbes in microbiology cultures were Enterococcus faecalis and faecium(22.5% and 20.0%) and Escherichia coli(20.0%). In 19 cases the cultures grew multiple organisms. The antibiotics with the least resistance amongst the microbiota were teicoplanin(5.0%), linezolid(5.6%), ertapenem(6.5%), and meropenem(7.4%). Conclusion: The carbapenem antibiotics, ertapenem and meropenem provide good antimicrobial cover against the common, mainly enteral, microorganisms causing IPN. Culture and sensitivity results of acquired samples should be regularly reviewed to adjust prescribing and monitor for emergence of resistance.

关键词： Acute pancreatitis Pancreatic abscess Pancreatic necrosis Infected pancreatic necrosis Antibiotics Intra-abdominal infection

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Jejunal diverticulosis is not always a silent spectator:A report of 4 cases and review of the literature

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World Journal of Gastroenterology 2008年第38期14卷 5916-5919页

作者： Vishal Arun Patel Helen Jefferis ben Spiegelberg Quamar Iqbal Ashish Prabhudesai simon Harris Department of Colorectal Surgery Hillingdon Hospital UxbridgeMiddlesex UB8 3NN United Kingdom

Jejunal diverticulosis (JD) is a rare clinical entity. The potential complications of this condition are discussed here through a series of cases presented to our centre. A retrospective analysis of four cases, which were diagnosed and treated, was performed. These included two cases of gastrointestinal haemorrhage, one case of perforation and one case of enterolith obstruction. All of these cases were secondary to jejunal diverticulosis and treated surgically. This was accompanied by a literature search to identify the different modalities for diagnosis and treatment of this condition. JD is rare and may lead to a diagnostic delay. Awareness of the wide spectrum of potential complications can prevent this delay.

关键词： Jejunum Diverticulosis Gastrointestinal Haemorrhage Perforation Enterolith Obstruction

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Epidemiology and risk factors for mortality in critically ill patients with pancreatic infection

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Journal of Intensive Medicine 2024年第1期4卷 81-93页

作者： Marie Dejonckheere Massimo Antonelli Kostoula Arvaniti Koen Blot ben CreaghBrown Dylan Wde Lange Jan De Waele Mieke Deschepper Yalim Dikmen George Dimopoulos Christian Eckmann guy Francois Massimo Girardis Despoina Koulenti Sonia Labeau Jeffrey Lipman Fernando Lipovestky Emilio Maseda Philippe Montravers Adam Mikstacki JoseArtur Paiva Cecilia Pereyra Jordi Rello JeanFrancois Timsit Dirk Vogelaers Stijn Blot the Abdominal Sepsis Study(AbSeS)group on behalf of the Trials Group of the European Society of Intensive Care Medicine Department of Internal Medicine and Pediatrics Faculty of Medicine and Health SciencesGhent UniversityGhentBelgium Department of Anesthesiology Intensive Care and Emergency MedicineFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly UniversitàCattolica del Sacro Cuore RomeItaly Intensive Care Unit Papageorgiou University Affiliated HospitalThessaloníkiGreece Department of Epidemiology and Public Health SciensanoIxellesBelgium Surrey Perioperative Anaesthetic Critical Care Collaborative Research Group(SPACeR) Royal Surrey County HospitalGuildfordUK Department of Clinical and Experimental Medicine University of SurreyGuildfordUK Department of Intensive Care Medicine University Medical Center UtrechtUniversity UtrechtUtrechtthe Netherlands Department of Intensive Care Medicine Ghent University HospitalGhentBelgium Data Science Institute Ghent University HospitalGhentBelgium Department of Anesthesiology and Reanimation Cerrahpasa School of MedicineIstanbul University-CerrahpasaIstanbulTurkey rd Department of Critical Care “EVGENIDIO”HospitalNational and Kapodistrian University of AthensAthensGreece Department of General Visceral and Thoracic SurgeryKlinikum Hannoversch-MuendenGoettingen UniversityGöttingenGermany Division of Scientific Affairs-Research European Society of Intensive Care MedicineBrusselsBelgium Anesthesia and Intensive Care Department University Hospital of ModenaModenaItaly UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandBrisbaneQLDAustralia nd Critical Care Department Attikon University HospitalAthensGreece Department of Nursing Faculty of EducationHealth and Social WorkUniversity College GhentGhentBelgium Jamieson Trauma Institute The University of QueenslandBrisbaneQLDAustralia Nimes University Hospital University of MontpellierNimesFrance Critical Care Department Hospital of the Interamerican Open University(UAI)Buenos AiresArgentina Surgical Critical Care Department of AnesthesiaHospital Universitario

Background:The AbSeS-classification defines specific phenotypes of patients with intra-abdominal infection based on the(1)setting of infection onset(community-acquired,early onset,or late-onset hospital-acquired),(2)presence or absence of either localized or diffuse peritonitis,and(3)severity of disease expression(infection,sepsis,or septic shock).This classification system demonstrated reliable risk stratification in intensive care unit(ICU)patients with intra-abdominal *** study aimed to describe the epidemiology of ICU patients with pancreatic infection and assess the relationship between the components of the AbSeS-classification and ***:This was a secondary analysis of an international observational study(“AbSeS”)investigating ICU patients with intra-abdominal *** patients with pancreatic infection were included in this analysis(n=165).Mortality was defined as ICU mortality within 28 days of observation for patients discharged earlier from the *** with mortality were assessed using logistic regression analysis and reported as odds ratio(OR)and 95%confidence interval(CI).Results:The overall mortality was 35.2%(n=58).The independent risk factors for mortality included older age(OR=1.03,95%CI:1.0 to 1.1 P=0.023),localized peritonitis(OR=4.4,95%CI:1.4 to 13.9 P=0.011),and persistent signs of inflammation at day 7(OR=9.5,95%CI:3.8 to 23.9,P<0.001)or after the implementation of additional source control interventions within the first week(OR=4.0,95%CI:1.3 to 12.2,P=0.013).Gramnegative bacteria were most frequently isolated(n=58,49.2%)without clinically relevant differences in microbial etiology between survivors and ***:In pancreatic infection,a challenging source/damage control and ongoing pancreatic inflammation appear to be the strongest contributors to an unfavorable short-term *** this limited series,essentials of the AbSeS-classification,such as the setting of infection onset,diffuse

关键词： Pancreatic infection Intensive care unit Mortality Intra-abdominal infection Sepsis

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Structure and properties of graphullerene: a semiconducting two-dimensional C_(60) crystal

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npj Computational Materials 2023年第1期9卷 197-202页

作者： Uri Argaman guy Makov Dept.of Materials Engineering Ben-Gurion University of the NegevBeer-ShevaIsrael

Graphullerene is a recently discovered,two-dimensional allotrope of carbon formed from C_(60) *** has been synthesized in the form(C_(60)Mg4)n and subsequently transformed into(C_(60))n by removal of the Mg *** initio calculations are employed to examine the structure and properties of this ***,graphullerene is composed of strained C_(60) *** of these molecules is connected to six neighbors in a hexagonal network with a total of eight chemical *** find this structure to be meta-stable,owing to the strain produced by the covalent bonding of the ***,the inclusion of Mg atoms transforms the cohesion energy from negative to positive values by forming additional C-Mg bonds,creating an energetically stable *** the absence of Mg,this allotrope is a pure carbon semiconductor with an indirect band *** spectrum calculations confirm the dynamical stability of the material and yield its in-and out-of-plane sound *** addition,symmetry breaking of the C_(60) molecules results in a distribution of bond lengths and creates vibrational modes that serve as a signature of graphullerene.

关键词： material bonds crystal

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Management of skin toxicities during panitumumab treatment in metastatic colorectal cancer

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World Journal of Gastroenterology 2019年第29期25卷 4007-4018页

作者： Olivier Bouche Meher ben Abdelghani Jean-Luc Labourey simon Triby René-Jean bensadoun Thomas Jouary Gaétan Des Guetz Department of Gastroenterology and Digestive Oncology Hopital Robert Debre CHU ReimsReims 51000France Oncology Department Centre Paul StraussStrasbourg 67000France Oncology Department Centre HospitalierCarcassonne 11000France Medical Department AMGEN FranceBoulogne-Billancourt 92100France Radiation Oncology Centre de Haute EnergieNice 06000France Dermatology Department Hopital Saint-Andre CHU de BordeauxBordeaux 33000France Oncology Department Avicenne HospitalBobigny 93000France

BACKGROUND Anti-epidermal growth factor receptor therapy is associated with skin adverse events not previously reported with conventional chemotherapy. Prophylactic actions are recommended, but routine clinical management of these toxicities and their impact on quality of life remain unknown. AIM To assess the dermatological toxicities reported after panitumumab initiation, their impact on the quality of life and the clinical practices for their management. METHODS Patients included in this prospective multicenter observational study were over 18 years of age and began treatment with panitumumab for wild-type KRAS metastatic colorectal cancer. The incidence of dermatological toxicities, clinical practices for their management and impact on quality of life were recorded during a 6-mo follow-up. RESULTS Overall, 229 patients (males, 57.6%;mean age, 66.2 years) were included. At day 15, 59.3% of patients had dermatological toxicity;the rate peaked at month 2 (74.7%) and decreased at month 6 (46.5%). The most frequent dermatological toxicities were rash/acneiform rash, xerosis and skin cracks. At least one preventive treatment was administered to 65.9% of patients (oral antibiotics, 84.1%;emollients, 75.5%;both, 62.9%). The rates of patients who received at least one curative treatment peaked at month 2 (63.4%) and decreased at month 6 (44.8%). The impact of the dermatological toxicities on quality of life was limited as assessed with Dermatology Life Quality Index scores and inconvenience visual analogic scale score. The rates of topical corticosteroids administration and visits to specialists were low. CONCLUSION The rates of the different skin toxicities peaked at various times and were improved at the end of follow-up. Nevertheless, their clinical management could be optimized with a better adherence to current recommendations. The impact of skin toxicities on patient’s quality of life appeared to be limited.

关键词： Metastatic colorectal cancer Epidermal growth factor receptor inhibitors Panitumumab Skin toxicity Quality of life

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