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Medicinal properties of Angelica archangelica root extract: Cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development

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Journal of Integrative Medicine 2019年第2期17卷 132-140页

作者： Carlos R.Oliveira Daniel G.Spindola Daniel M.Garcia Adolfo Erustes Alexandre Bechara Caroline Palmeira-dos-Santos Soraya S.Smaili gustavo J.S.Pereira André Hinsberger Ezequiel P.viriato Maria Cristina Marcucci Alexandra C.H.F.Sawaya Samantha L.Tomaz Elaine G.Rodrigues Claudia Bincoletto Departamento de Farmacologia Escola Paulista de Medicina (EPM) Universidade Federal de Sao Paulo (UNIFESP) Grupo de Fitocomplexos e Sinalizacao Celular Escola de Ciências da Saúde Universidade Anhembi Morumbi Faculdade de Ciências Farmacêuticas e Bioquímicas Oswaldo Cruz Laboratório de Produtos Naturais e Quimiometria Programa de pós-graduacao em Farmácia e Biotecnologia Universidade Anhanguera de Sao Paulo Faculdade de Ciências Farmacêuticas Universidade Estadual de Campinas (UNICAMP) Unidade de Oncologia Experimental EPM Universidade Federal de Sao Paulo (UNIFESP)

Objective: Although Angelica archangelica is a medicinal and aromatic plant with a long history of use for both medicinal and food purposes, there are no studies regarding the antineoplastic activity of its *** study aimed to evaluate the cytotoxicity and antitumor effects of the crude extract of A. archangelica root(CEAA) on breast ***: The cytotoxicity of CEAA against breast adenocarcinoma cells(4T1 and MCF-7) was evaluated by a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide(MTT) assay. Morphological and biochemical changes were detected by Hoechst 33342/propidium iodide(PI) and annexin v/PI staining. Cytosolic calcium mobilization was evaluated in cells staining with FURA-4 NW. Immunoblotting was used to determine the effect of CEAA on anti-and pro-apoptotic proteins(Bcl-2 and Bax, respectively).The 4 T1 cell-challenged mice were used for in vivo ***: Using ultra-high-performance liquid chromatography–mass spectrometry analysis, angelicin, a constituent of the roots and leaves of A. archangelica, was found to be the major constituent of the CEAA evaluated in this study(73 mg/mL). The CEAA was cytotoxic for both breast cancer cell lines studied but not for human fibroblasts. Treatment of 4 T1 cells with the CEAA increased Bax protein levels accompanied by decreased Bcl-2 expression, in the presence of cleaved caspase-3 and cytosolic calcium mobilization, suggesting mitochondrial involvement in breast cancer cell death induced by the CEAA in this cell line. No changes on the Bcl-2/Bax ratio were observed in CEAA-treated MCF7 cells. Gavage administration of the CEAA(500 mg/kg) to 4T1 cell-challenged mice significantly decreased tumor growth when compared with untreated ***: Altogether, our data show the antitumor potential of the CEAA against breast cancer cells in vitro and in vivo. Further research is necessary to better elucidate the pharmacological application of the CEAA in breast cancer therapy.

关键词： Angelica archangelica Umbelliferae Apoptosis Cell death Breast cancer Angelicin

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Situations of Domestic violence against Children and Adolescents in a Northeastern Brazilian Capital

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Open Journal of Nursing 2016年第9期6卷 633-642页

作者： Eliane Santos Cavalcante Francisco Arnoldo Nunes de Miranda Lannuzya v. e Oliveira Glauber W. dos Santos Silva gustavo Ávila Dias Romeika C. F. de Sena Suerda Lillian da Fonseca Lins Cleonice A. A. Cavalcante Izaura Luzia Silvério Freire João E. da Costa Health School Federal University of Rio Grande do Norte Natal Brazil Nursing Department Postgraduate Program in Nursing Federal University of Rio Grande do Norte Natal Brazil Natal Health City Department Natal Brazil

Objective: To describe the epidemiological profile of children and adolescents who are victims of domestic violence. Method: This is a cross sectional and descriptive study, following a quantitative approach, conducted from September to December 2013, at the SOS CHILD service, in the city of Natal, Rio Grande do Norte, Brazil. The research protocol was approved by CEP/UFRN under CAAE 0166.***.051.000-11. Results: In the analysis of 69 children, the results were presented from three points of view: 1) the victim—female (56.5%), aged one to 11 years old (66.7%) and lived with one of the parents (43.5%);2) the abuser—female (60.9%) in the 14 - 23 years old and 34 - 43 years old, with the same percentage (24.6%), history of alcohol use and abuse (42.0%), the mother was the one who attacked the most (34.7%);3) types of violence, among the physical ones, the most frequent were slaps (43.2%) and punches (18.9%);the prevalence, among the psychological violence, were curses (35.4%) and abuse (27.8%);negligence, omission of care (73.5%), deprivation of care for personal appearance (18.4%);among sexual violence: sexual caresses (57.1%) and forced sex (42.9%). Conclusion: Children and adolescents placed in an unfavorable social-economic context, under the care of mothers with a history of use and abuse of alcohol and other drugs, are more vulnerable to intra-domiciliary violence.

关键词： Exposure to violence Domestic violence Child Health Adolescent Health

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Characterization of Chemical Bath Deposited CdSe Thin Films Doped with S^2-

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材料科学与工程（中英文B版） 2011年第5期1卷 657-666页

作者： Jorge Indalecio Contreras Rascon Oscar Portillo Moreno gustavo Abarca Avila Jorge R. Cerna Juan Hernandez Tecorralco Javler Martinez Juare Rosendo Lozada Morales Orlando Zelaya Angel CIDS-ICUAP Benemerita Universidad Autonoma de Puebla 14 Sur y Av. Sn. Claudio Col. Sn. Manuel Puebla Pue. Mexieo Facultad de Ciencias Quimicas Benemerita Universidad Autonoma de Puebla 14 Sur y Av. Sn. Claudio Col. Sn. Manuel Puebla Pue. Mexico Facultad de Ciencias Fisicomatematicas Postgrado en Optoelectroniea Benemerita Universidad Autonoma de Puebla 14 Sur y A v Sn. Claudio Col. Sn. Manuel Puebla Pue. Mexico Departamento de Fisiea del Centro de Investigacion y de Estudios Avanzados del IPN 07360 Mexico D. F. Mexico

CdSe thin films doped with S2-, growing on glass substrates using the chemical bath deposition (CBD) at temperature of T = 80 oC, with precursor solutions: CdCl2 0.01 M, KOH 0.1 M, 0.5 M, SeC(NH2)2 0.04 M, NH4NO3, SC(NH2)2 0.2 M, 5, 10, 15, 20, 25 and 30 mL of doping. The concentration of atoms was obtained by Scanning Electron Microscopy (SEM), S = 14.11-42.57, Cd = 49.11-59.59, and Se = 50.99-2.29, X-ray diffraction, identifies mixture of Wurzite/Zinc blende doped films phases and size of grain of 24-15 nm. Optical Absorption Spectra have redshifts of the forbidden band gap (Eg) of 1.8-2.3 ev. Raman spectra (RS) show the Raman shift, confirming formation of nanocrystals. From the dark conductivity vs. 1/kT behavior on the 100-500 K range, attributed to doping effects at the grain boundaries and quantum confinements. A thermodynamic model is proposed using the equation of Nernst to evaluate changes in the Gibbs free energy and investigate the spontaneity of reactions.

关键词：硒化镉薄膜化学浴沉积掺杂效应 CdSe 扫描电子显微镜 X射线衍射分析表征吉布斯自由能

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Effect of Blends Gasoline with Oxygenated Additives in the Performance of Internal Combustion Engine

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Journal of Power and Energy Engineering 2021年第7期9卷 1-9页

作者： Suzara Rayanne de Castro Sena André Luis Oliveira de Almeida Leonara Luizza da Costa Leite Jean gustavo de Melo Araujo Eduardo Lins de Barros Neto Camila Gambini Pereira Centre of Education and Research in Oil and Gas Federal University of Rio Grande do Norte (UFRN) Natal Brazil

The objective of this study was to evaluate the effect of blends of different oxygenated additives on gasoline in SI engine Otto cycle. The formulations analyzed were: pure gasoline (type A), common gasoline (type C), gasoline type A + 15% (v/v) oxygenated additives (ethanol, ethyl octanoate, ethyl oleate). The experiments were performed using engine Branco 4-stroke and 2-cylinder, electric dynamometer, exhaust system, control unit composed of Multi-K unit, variable selector and load cell, stroboscope tachometer, fuel supply system and stopwatch. The rotation was conserved at 4400 rpm and wheel power varied from 3 kW to 12 kW, with intervals of 3 kW to obtain hourly consumption curves and brake specific fuel consumption. Even esters and ethanol having lower heat of combustion, hourly consumption was similar to pure gasoline (type A). In relation to the brake specific fuel consumption, increasing the wheel power had a better conversion of the mass of fuel burned into energy. Thus, this study showed that the mixture of gasoline and esters (ethyl octanoate and ethyl oleate) presented good efficiency in terms of consumption. This research contributes to the needs and to the current studies in which industries started to add renewable products to petroleum-derived fuels;in order to obtain more sustainable fuels at lower costs.

关键词： Gasoline Oxygenated Additives Consumption

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Use of High Definition Multileaf Colimator for the Treatment of Trigeminal Neuralgia

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2022年第3期11卷 150-159页

作者： Eduardo Cabello Murillo Ana Milanés Gaillet gustavo Pozo Rodriguez Ángel Gaitán Simón Pedro Adaimi Hernández Marta Manzano Rodríguez Alejandro Ferrando Sánchez Raúl Díaz Fuentes Medical Physicist Department Hospital 12 de Octubre Madrid Spain

In the present work, a treatment technique for trigeminal neuralgia (TN) using LINAC radiosurgery is shown. The technique is based on the optimization of ten static arcs in such a way as to minimize the overlapping of the treatment fields with the brainstem. We will call this technique brainstem-optimized (BO). The results are compared with another technique described in the literature known as a virtual cone (vC). The comparison of dosimetry results that have been carried out essentially shows that the doses in the brainstem v12Gy-brainstem, D0.5cm3-brainstem and D0.035 cm3-brainstem are lower in the BO versus vC technique, and with the parameters v50% (whole brain) and v12Gy-cerebrum higher in BO versus vC. Our goal is to keep the dose to the brainstem as low as possible and, if possible, at most between 12 Gy and 15 Gy. The BO technique meets our purposes and is considered clinically acceptable at our institution.

关键词： Trigeminal Neuralgia Radiosurgery Brainstem Brainstem-Optimized Technique (BO) virtual Cone (vC)

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2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理

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中华精神科杂志 2019年第1期52卷 5-49页

作者： Lakshmi N Yatham Sidney H Kennedy Sagar v Parikh Ayal Sehaffer David J Bond Benicio N Frey verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen v Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam gustavo.vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) 加拿大卑诗省温哥华市英属哥伦比亚大学精神病学系加拿大金斯敦皇后大学精神病学与心理学系加拿大卑诗省温哥华英属哥伦比亚大学人口与公共卫生学院日本福冈九州大学神经精神学系巴西圣保罗大学精神病学系美国斯坦福大学精神病学和行为科学系双相障碍和抑郁症研究组美国俄亥俄州克利夫兰凯斯西储大学医院医疗中心精神科西班牙巴塞罗那大学神经科学研究所双相障碍科澳大利亚悉尼大学精神病学系美国乔治华盛顿大学精神病学系澳大利亚迪肯大学医学院IMPACT策略研究中心加拿大多伦多大学精神病学系首都医科大学附属北京安定医院美国密歇根州密歇根大学精神病学系美国明尼阿波利斯明尼苏达大学精神病学系加拿大汉密尔顿麦克马斯特大学精神病学和行为神经科学系加拿大伦敦市西方大学精神病学和妇产科系加拿大蒙特利尔麦吉尔大学精神病学系加拿大新州哈利法克斯达尔豪西大学精神病学系加拿大卡尔加里大学精神病学系

加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(Inter... 详细信息

加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。

关键词：治疗指南双相障碍焦虑障碍疾病管理心境障碍加拿大学会国际

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Growth of PbS： Ni2＋ Nanocrystals Thin Films by Chemical Bath

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材料科学与工程（中英文A版） 2012年第5期2卷 410-422页

作者： Melissa Chavez Portillo Javier Martinez Juarez gustavo Abarca Avila Marcial Zamora Tototzintle MacarioMartinez Barragan Jorge. R. Cema Martin Lazcano Hernandez Salvador Rosas Castilla Brenda CrespoSnchez Andrea Celeste Palacios Lopez and Oscar Portillo Moreno CIDS-ICUAP Benemerita Universidad Autonoma de Puebla (BUAP) Mexico Facultad de Ciencias Quimicas Benemdrita Universidad Autonoma de Puebla (BUAP) Moxico.C. U. Puebla Moxico

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Risk perception and knowledge of COvID-19 in patients with celiac disease

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World Journal of Gastroenterology 2021年第12期27卷 1213-1225页

作者： Jamie Zhen Juan Pablo Stefanolo María de la Paz Temprano Caroline L Seiler Alberto Caminero Enrique de-Madaria Miguel Montoro Huguet vivas Santiago Sonia Isabel Niveloni Edgardo gustavo Smecuol Luis Uzcanga Dominguez Elena Trucco virginia Lopez Carolina Olano Pasquale Mansueto Antonio Carroccio Peter H Green Donald Duerksen Andrew S Day Jason A Tye-Din Julio César Bai Carolina Ciacci Elena F verdú Benjamin Lebwohl M Ines Pinto-Sanchez Department of Medicine Farncombe Family Digestive Health Research InstituteMcMaster University Medical CenterHamilton Health SciencesHamilton L8S4K1ONCanada Department of Medicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Department of Pancreatic Unit Hospital General Universitario de AlicanteAlicante 03010Spain Department of Medicine Instituto Aragonés de Ciencias de la Salud(IACS)Zaragoza 50009Spain Department of Medicine Hospital Universitario San Jorge.HuescaZaragoza 50004Spain Department of Gastroenterology Univ Hosp LeonGastroenterol UnitAltos de Nava S-NLeon 24071Spain Department of Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico DF 14080Mexico Department of Medicine Universidad de la RepublicMontevideo 11800Uruguay Department of Internal Medicine PROMISE DepartmentUniversity of PalermoPalermo 90127Italy Department of Internal Medicine V.Cervello HospitalPROMISE DepartmentUniversity of PalermoPalermo 90127Italy Celiac Disease Center Columbia University Medical CenterColumbia UnivCeliac Dis CtrDiv Digest and Liver DisNew YorkNY 10032United States Department of Medicine St Boniface Gen HospUniversity of ManitobaWinnipeg R2H 2A6Canada Department of Paediatrics University of Otago ChristchurchChristchurch 8041New Zealand Department of Gastroenterology Royal Melbourne HospitalImmunology DivisionWalter and Eliza Hall InstituteMelbourne 3052Australia Department of Medicine Surgery and DentryScuola Medica SalernitanaUniversity of SalernoCeliac Center at the University Hospital San Giovanni di Dio e Ruggi di AragonaSalerno 84131Italy Department of Medicine Farncombe Family Digestive Research InstituteMcMaster UniversityHamilton L8S4K1ONCanada The Celiac Disease Center Columbia UniversityNew YorkNY 10032United States

BACKGROUND We recently demonstrated that the odds of contracting coronavirus disease 2019(COvID-19)in patients with celiac disease(CeD)is similar to that of the general ***,how patients with CeD perceive their COvID-19 risk may differ from their actual *** To investigate risk perceptions of contracting COvID-19 in patients with CeD and determine the factors that may influence their *** We distributed a survey throughout 10 countries between March and June 2020 and collected data on demographics,diet,COvID-19 testing,and risk perceptions of COvID-19 in patients with *** were recruited through various celiac associations,clinic visits,and social *** perception was assessed by asking individuals whether they believe patients with CeD are at an increased risk of contracting COvID-19 when compared to the general *** regression was used to determine the influencing factors associated with COvID-19 risk perception,such as age,sex,adherence to a gluten-free diet(GFD),and comorbidities such as cardiac conditions,respiratory conditions,and *** was presented as adjusted odds ratios(aORs)RESULTS A total of 10737 participants with CeD completed the *** them,6019(56.1%)patients with CeD perceived they were at a higher risk or were unsure if they were at a higher risk of contracting COvID-19 compared to the non-CeD population.A greater proportion of patients with CeD perceived an increased risk of contracting COvID-19 when compared to infections in general due to their CeD(56.1%vs 26.7%,PvID-19 precautions as a result of their *** of celiac associations were less likely to perceive an increased risk of COvID-19 when compared to non-members(49.5%vs 57.4%,P<0.0001).Older age(aOR:0.99;95%CI:0.99 to 0.99,P<0.001),male sex(aOR:0.84;95%CI:0.76 to 0.93,P=0.001),and strict adherence to a GFD(aOR:0.89;95%CI:0.82 to 0.96,P=0.007)were associated

关键词： Celiac disease Gluten Risk Infection Knowledge Perception Coronavirus COvID-19

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Solvent-Free Synthesis of Carboxylic Acids and Amide Analogs of CAPE(Caffeic Acid Phenethyl Ester)under Infrared Irradiation Conditions

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Green and Sustainable Chemistry 2015年第2期5卷 81-91页

作者： Pablo A.Martínez-Soriano Jose R.Macías-Perez Ana Maria velazquez Brigida del Carmen Camacho-Enriquez gustavo Pretelin-Castillo Monica B.Ruiz-Sanchez victor H.Abrego-Reyes Saul villa-Trevino Enrique Angeles Laboratorio de Quimica Medicinal y Teorica Departamento de Ciencias QuimicasFES CuautitlanUniversidad Nacional Autonoma de MexicoCuautitlan IzcalliMexico Departamento de Biologia celular Centro de Investigacion y Estudios AvanzadosInstituto Politecnico NacionalMexicoD.F.Mexico Qsar Analytics S.A.de C.v.Ciudad Satelite Naucalpan de JuarezMexico

A convenient and easy method is described for the formation of carboxamides from carboxylic acids and primary amines in solventless conditions using infrared (IR) light. Thus, under IR light, cinnamic acid derivatives... 详细信息

关键词： Amides Carboxylic Acids Amines Infrared Light Solventless CAPE CAPA Cinnamic Acid Analogs

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润滑条件对304L钢丝拉拔参数的影响

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金属制品 2004年第B5期30卷 35-36页

作者： gustavo Aristides Santana Martínez Sérgio Tonini Button Roger N.Wright 赵玉兰

1试验设备试验使用可调速的单卷筒拉丝机.直流电机功率14.7 kW,最大转速为2 000 r/min.拉丝速度1～22m/s,由数字调速器控制.拉丝模和润滑剂的温度变化由热电偶检测控制,额定值为500 N的测压元件和敏感度为2 mv/v的压力传感器测量拉拔力.

关键词：润滑剂 304L 拉拔速度影响

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