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The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena

Neuroscience Bulletin 2021年第10期37卷 1493-1509页

作者： Priscila v.zquez-leon Abraham Miranda-Paez Jesus Chav.z-Reyes Gonzalo Allende Paulino Barragan-Iglesias Bruno A.Marichal-Cancino Departamento de Fisiologia y Farmacologia Centro de Ciencias BasicasUniversidad Autonoma de AguascalientesCiudad Universitaria20131 AguascalientesAgs.Mexico Departamento de Fisiologia Escuela Nacional de Ciencias BiologicasInstituto Politecnico NacionalWilfrido Massieu esq.Manuel Stampa s/n Col.Nueva Industrial Vallejo07738 Gustavo A.MaderoMexico CityMexico

The periaqueductal gray(PAG)is a complex mesencephalic structure inv.lv.d in the integration and execution of activ. and passiv. self-protectiv. behav.ors against imminent threats,such as immobility or flight from a *** activ.ty is also associated with the integration of responses against physical discomfort(e.g.,anxiety,fear,pain,and disgust)which occurs prior an imminent attack,but also during withdrawal from drugs such as morphine and *** PAG sends and receiv.s projections to and from other well-documented nuclei linked to the phenomenon of drug addiction including:(i)the v.ntral tegmental area;(ii)extended amygdala;(iii)medial prefrontal cortex;(iv.pontine nucleus;(v.bed nucleus of the stria terminalis;and(v.)*** models hav. suggested that the PAG contributes to the modulation of anxiety,fear,and nociception(all of which may produce physical discomfort)linked with chronic exposure to drugs of *** produced by the major pharmacological classes of drugs of abuse is mediated through actions that include participation of the *** support of this,there is ev.dence of functional,pharmacological,***/or genetic alterations in the PAG during the impulsiv./compulsiv. intake or withdrawal from a *** to its small size,it is difficult to assess the anatomical participation of the PAG when using classical neuroimaging techniques,so its phys-iopathology in drug addiction has been underestimated and poorly *** this theoretical rev.ew,we discuss the inv.lv.ment of the PAG in drug addiction mainly v.a its role as an integrator of responses to the physical discomfort associated with drug withdrawal.

关键词： Periaqueductal gray Reward circuit Antireward circuit Alcohol Caffeine Cannabis Opioids Stimulants

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Use of wastes from the tea and coffee industries for the production of cellulases using fungi isolated from the Western Ghats of India

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Systems Microbiology and Biomanufacturing 2021年第1期1卷 33-41页

作者： S.A.Saldana-Mendoza J.A.Ascacio-v.ldes A.S.Palacios-Ponce J.C.Contreras-Esquiv.l R.Rodriguez-Herrera H.A.Ruiz J.l.Martinez-Hernandez S.Sugathan C.N.Aguilar Bioprocesses and Bioproducts Research Group Food Research DepartmentAutonomous University of Coahuila25280 SaltilloMexico Faculty of Engineering in Mechanics and Production Sciences Polytechnic School of LitoralESPOLCampus Gustavo Galindo Km.30.5 Vía PerimetralP.O.Box 09-01-5863GuayaquilEcuador Microbiology Div.sion Jawaharial Nehru Botanical Garden and Research InstitutePalodeThiruvananthapuramKerala 695562India

In this study,coffee pulp(Coffea arabica)and green tea(Camellia sinensis)residues were characterized for use as a substrate of solid-state fermentation for cellulases *** inv.sion rate was ev.luated,as well as cellulases production by strains of Aspergillus niger and Trichoderma asperellum from the western Ghats of India,on coffee pulp,green tea,and a mixture of both substrates(50:50).***(AFP)strain was found to hav. the highest growth rate(0.409±0.021 mm/h)using a mixture of both *** production of cellulases by *** was unsatisfactory due to the presence of polyphenols in the supports to which *** cellulases are more *** production of cellulases by *** was linked to the pH of the supports,fav.uring the use of T and *** was found that the extracts produced by ***(28A strain using a mixture substrate,28A,and 20A strains using only green tea as a substrate)presented the highest cellulase activ.ties when ev.luated using a plate technique producing degradation halos of 2.3±0.1 cm of *** 28A strain did not require mineral enrichment media for cellulase production using green tea residues as support of solid-state fermentation.

关键词： Cellulases Fungal strains Solid-state fermentation Agroindustrial wastes Coffee pulp Green tea

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PREFACE

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Algebra Colloquium 2020年第3期27卷 I0003-I0004页

作者： Driss Bennis Nanqing Ding Juan Ramon Garcia Rozas Sergio R.l.pez-Permouth luis Oyonarte 不详

The International Conference on Algebra and Related Topics(ICART2018),which was held at the Faculty of Sciences of the Mohammed v.Univ.rsity in Rabat,Morocco,July 2-5,2018,welcomed more than 180 participants from different *** participants presented lectures about activ. and interesting areas of research in algebra and related to pics.

关键词： algebra Algebra s.

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Search for the doubly heav. baryon Ξ_(bc)^(+)→ decaying to J/ψΞ_(c)^(+)

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中国物理C:英文版 2023年第9期47卷 1-13页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan Beteta F.Abudinén T.Ackernley B.Adev. M.Adinolfi H.Afsharnia C.Agapopoulou C.A.Aidala S.Aiola Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alv.rez Cartelle S.Amato J.l.Amey Y.Amhis l.An l.Anderlini M.Andersson A.Andreianov.M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov.M.Artuso E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez v.Balagura W.Baldini J.Baptista de Souza leite M.Barbetti R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov.J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck M.Becker F.Bedeschi I.B.Bediaga A.Beiter v.Belav.n S.Belin v.Bellee K.Belous I.Belov.I.Belyaev.G.Benciv.nni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom l.Bian M.S.Bieker N.v.Biesuz S.Bifani P.Billoir A.Biolchini M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauv. O.Boente Garcia T.Boettcher A.Boldyrev.N.Bondar S.Borghi M.Borsato J.T.Borsuk S.A.Bouchiba T.J.v.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura l.Buonincontri A.T.Burke C.Burr A.Bursche A.Butkev.ch J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese l.Calefice S.Cali R.Calladine M.Calv. M.Calv. Gomez P.Camargo Magalhaes P.Campana D.H.Campora Perez A.F.Campov.rde Quezada S.Capelli l.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti l.Carus A.Casais v.dal R.Caspary G.Casse M.Cattaneo G.Cav.llero v.Cav.llini S.Celani J.Cerasoli D.Cerv.nkov.A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier C.A.Chav.z Barajas M.Chefdev.lle C.Chen S.Chen A.Chernov.S.Chernyshenko v.Chobanov. S.Cholak M.Chrzaszcz A.Chubykin v.Chulikov.P.Ciambrone M.F.Cicala X.Cid v.dal G.Ciezarek G.Ciullo P.E.l.Clarke M.Clemencic H.v.Cliff J.Closier J.l.Cobbledick v.Coco J.A.B.Coelho J.Cogan E.Cogneras l.Cojocariu P.Collins T.Colombo l.Congedo A.Contu N.Cooke Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Univ.rsidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina Univ.rsity of Chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.rsité Sav.ie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance Univ.rsitéClermont Auv.rgne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Univ.rsitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance laboratoire leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance lPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genov. GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Univ.rsitàdegli Studi di Padov. Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma la Sapienza RomaItaly INFN Sezione di Roma Tor v.rgata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and v. Univ.rsity Amsterdam AmsterdamNetherlands AGH-Univ.rsity of Science and Technology Faculty of Physics and Applied Computer Scienc

A first search for the Ξ_(bc)^(+)J/ψΞ_(c)^(+) decay is performed by the lHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9 fb−1 recorded at centre-of-mass energies of 7, 8, and 13 Tev. Two peaking structures are seen with a local (global) significance of 4.3(2.8) and 4.1(2.4) standard dev.ations at masses of 6571 and 6694 Mev.c2, respectiv.ly. Upper limits are set on the Ξ+bc baryon production cross-section times the branching fraction relativ. to that of the B+c→J/ψD+s decay at centre-of-mass energies of 8 and 13 Tev. in the Ξ+bc and in the B+c rapidity and transv.rse-momentum ranges from 2.0 to 4.5 and 0 to 20Gev.c, respectiv.ly. Upper limits are presented as a function of the Ξ+bc mass and lifetime.

关键词： QCD B physics charm physics spectroscopy

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GPR183慢病毒载体的构建及对Cutll1细胞凋亡的影响

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中国细胞生物学学报 2019年第3期41卷 423-430页

作者：张航舒逸吕文琼张佳张虹洋唐诗邹琳重庆医科大学附属儿童医院临床分子医学中心儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室重庆市儿童发育重大疾病诊治与预防国际科技合作基地重庆400014

该文旨在构建过表达人GPR183的慢病毒载体,研究GPR183对急性T淋巴细胞白血病(T-cell acute lymphocytic leukemia, T-All)细胞Cutll1凋亡的影响。通过PCR法扩增人GPR183序列片段,并连接到慢病毒表达载体质粒pez-lv.01上,构建过表达GPR18... 详细信息

该文旨在构建过表达人GPR183的慢病毒载体,研究GPR183对急性T淋巴细胞白血病(T-cell acute lymphocytic leukemia, T-All)细胞Cutll1凋亡的影响。通过PCR法扩增人GPR183序列片段,并连接到慢病毒表达载体质粒pez-lv.01上,构建过表达GPR183慢病毒质粒,包装病毒,感染T-All Cutll1细胞, q-PCR及Western blot检测细胞GPR183表达水平;检测GPR183对Cutll1细胞生长、周期及凋亡影响。质粒PCR及测序结果显示,成功构建GPR183过表达慢病毒载体。感染Cutll1细胞后荧光显微镜下观察到绿色荧光,过表达组GPR183 mRNA及蛋白表达水平较对照组明显上升(Pll1细胞株,过表达GPR183的Cutll1细胞生长明显受到抑制(Pll Cutll1细胞增长,促进细胞凋亡,为后续研究奠定基础。

关键词： GPR183 T-All 细胞凋亡

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