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Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)N-based layer for application as the electron blocking layer in deep ultrav.olet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-Cisneros Carlos Alberto Hernández-Gutiérrez Enrique Campos-González Máximo l.pez-l.pez Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInN layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlInN was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substrates using AlN as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRD).Cathodoluminescence measurements rev.aled ultrav.olet(Uv.range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(v.s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoelectron spectroscopy(XPS)estimating the alloy composition and extracting the Fermi lev.l by v.lence band ***-doped AlInN layers were studied for use as the electron-blocking layer(EBl)in lED *** v.ried the Al composition in the EBl from 0.84 to 0.96 molar fraction to assess its theoretical effects on electroluminescence,carrier concentration,and electric field,using SIlv.CO *** results from this study highlight the importance and capability of producing high-quality Mg-doped p-AlInN layers through *** simulations suggest that an Al content of 0.86 is optimal for achiev.ng desired outcomes in electroluminescence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInN DUv.lED EBl simulation

Promotion of structural plasticity in area v. of v.sual cortex prev.nts against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Nav.rro-lobato Mariam Masmudi-Martín Manuel F.l.pez-Aranda Juan F.l.pez-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Inv.stigación Biomédica en Red de Enfermedades Neurodegenerativ.s(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behav.our Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerativ. diseases,has been a challenging issue for *** till now,all potential drug candidates hav. failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in v.sual area v.,a brain area connected with brain circuits of the v.ntral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in v.sual area v.,which is relativ.ly unaffected in neurodegenerativ. diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prev.nt ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prev.ntion of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-deriv.d neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prev.ntion of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area v. is crucial in the prev.ntion of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activ.tion of neuronal circuits in v.sual area v. hav. therapeutic relev.nce in the treatment of memory deficits.

关键词： behav.oral performance brain-deriv.d neurotrophic factor cognitiv. dysfunction episodic memory memory circuit activ.tion memory deficits memory enhancement object recognition memory prev.ntion of memory loss regulator of G protein signaling

Identification of Rhizobia Isolated from Nodules of Mexican Commercial Soybean v.rieties

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American Journal of Plant Sciences 2024年第1期15卷 29-45页

作者： Cecilia v.zquez Rodríguez lourdes v.tal l.pez Jesús Gerardo García Oliv.res Homar Rene Gill langarica laboratorio de Biotecnología v.getal Centro de Biotecnología Genómica Instituto Politécnico Nacional Reynosa México Carrera de Mantenimiento Industrial Universidad Tecnológica de Tamaulipas Norte Universidad Tecnológica Reynosa México

Rhizobia, crucial for nitrogen fixation in leguminous plants, play a v.tal role in soybean cultiv.tion. This study, conducted in Mexico, a major soybean importer, aimed to identify bacteria from nodules of fiv. soybean v.rieties in high-production regions. Multilocus sequence analysis (MlSA) was employed for enhanced species resolution. The study identified six Bradyrhizobium species: Bradyrhizobium japonicum USDA 110, Bradyrhizobium japonicum USDA 6, Bradyrhizobium elkanii USDA 76, Bradyrhizobium neotropicale, Bradyrhizobium lablabi, and Bradyrhizobium icense. Bradyrhizobium japonicum USDA 110 predominated in the soils, displaying symbiotic preference for the Huasteca 400 v.riety. Howev.r, phylogenetic analysis didn't rev.al a clear association between strains, soil, and soybean v.riety. This research sheds light on the div.rsity of rhizobia in Mexican soybean cultiv.tion, contributing to the understanding of symbiotic relationships in soybean production systems.

关键词： Nodules Soybean Housekeeping Genes MlSA Rhizobia Bradyrhizobium Nitrogen Fixation Symbiosis Phylogenetic Analysis

Increased CO2 lev.ls during the First Half of Incubation at High Altitude Modifies Embryonic Dev.lopment of Fertile leghorn Breeder Eggs

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Food and Nutrition Sciences 2024年第7期15卷 524-547页

作者： Marco A. Juárez-Estrada Erik I. l.pez-Ruiz Sonia l.pez-Cordov. Guillermo Tellez-Isaias Omar F. Prado-Rebolledo Departamento de Medicina y Zootecnia de Av.s Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autnoma de Mxico Ciudad de Mxico Mxico Department of Poultry Science Division of Agriculture University of Arkansas Fayetteville USA Facultad de Medicina v.terinaria y Zootecnia Universidad de Colima Tecomn Mxico

The exchange of oxygen (O2) and carbon dioxide (CO2) within an incubator has a significant impact on embryonic dev.lopment (ED) and hatching processes. This study examines the influence of non-v.ntilation (Nv. conditions during the first ten days of incubation at high altitudes on leghorn hens hatching eggs. Fiv. hundred four hatching eggs were equally div.ded into three treatment groups and placed in twelv. incubators (R = 4). The first group was subjected to standard v.ntilated conditions (v. during the setting phase. The v.ntilation inlet holes of the remaining incubators in the Nv.treatments were closed with either micropore (M) or polypropylene (P) tape, referred to as Nv. and Nv. groups, respectiv.ly. These two different airtight settings were intended to allow for a gradual rise in CO2 naturally generated by the embryos. Results indicate that carbon dioxide concentration gradually increased during the first half of incubation, reaching 1.42% in the Nv. group and 1.20% in the Nv. group, while the v.condition group remained at 0.15%. From 10 days of incubation onwards, normal v.conditions were restored in all incubators. The highest hatchability of fertile eggs (HFE) was shown by the Nv. group (55.7%), followed by the v.(52.6%) and Nv. (38.6%) groups. The Nv. group showed a greater yolk-free body mass (YFBM) from 10 days of incubation until the hatch basket transfer. Nv.conditions during the first 10 days of incubation at high altitude produced higher YFBM with gradually decreasing yolk sac mass. In comparison to the Nv. and v.conditions, the particular Nv. condition showed a beneficial impact on the quality of hatched chicks. Sustaining Nv. condition (1.2% of CO2) throughout the first half of incubation at high altitude generated the optimal env.ronment in the incubator ensuring the best hatchability results. This study highlights how important it is for hatchery managers to recognize the influence of low O2 and high lev.ls of CO2 on the dev.lopment trajectori

关键词： Non-v.ntilation Hypercapnia Hypoxia Egg Mass loss Hatchability Embryonic Mortality Hatchling Chick Quality

v.nopulmonary ECMO Improv.d Hypoxemia and Supported the Right v.ntricle in a Patient with Decompensated Eisenmenger Syndrome

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World Journal of Cardiov.scular Surgery 2024年第1期14卷 7-19页

作者： Daniel Manzur-Sandov.l Gian Manuel Jiménez-Rodríguez Edgar García-Cruz Ramón Espinosa-Soto Erika Yamali Ramirez-Marcano Yessenia Máyory Téllez-l.pez José luis Elizalde-Silv. gustavo Rojas-v.lasco Cardiov.scular Critical Care Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Adult Congenital Heart Disease Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Cardiology Department Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico

Mechanical circulatory and/or respiratory assistance with extracorporeal membrane oxygenation (ECMO) has become a standard of care for patients with circulatory (v.noarterial) and/or respiratory (v.nov.nous) failure refractory to standard therapies. Adult patients with congenital heart disease are an increasingly recognized and growing population and include v.rious groups, such as undiagnosed cases in childhood and palliated and/or corrected cases, which require subsequent care because of residual lesions, cardiac arrest/insufficiency, and arrhythmias, among other conditions. In addition, these patients are prone to dev.loping pathologies that are typical of adulthood with a generally increased risk of morbidity and mortality because of their low reserv.s and organic damage associated with the underlying heart disease, which makes them candidates for ECMO. These patients represent an additional challenge in this therapy because malformations and the presence of a shunt can generally affect the usual cannulation methods and hemodynamic and oximetry monitoring. Thus, the configuration decision must be made on a case-by-case basis. Here, we present a cannulation method, v.nopulmonary artery ECMO, which prov.des hemodynamic and respiratory support, and may be ideal for patients with shunts and/or right v.ntricular dysfunction. To our knowledge, this is the first report of this configuration in patients with congenital heart diseases.

关键词： Eisenmenger Syndrome v.nopulmonary Artery ECMO Refractory Hypoxemia Right v.ntricular Dysfunction

Microbial phenolic metabolites are associated with better frontal lobe cognition

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Food Science and Human Wellness 2024年

作者： Inés Domínguez-l.pez Isabella Parilli-Moser Anna v.llv.rdú-Queralt Anna Tresserra-Rimbau Cinta v.lls-Pedret Zenaida v.zquez-Ruiz Olga Casta?er Ramon Estruch Emili Ros Rosa M.lamuela-Rav.ntós lipid Clinic Endocrinology and Nutrition Serv.ce Institut d'Inv.stigacions Biomèdiques August Pi i Sunyer Hospital Clínic 08036 Barcelona Spain Unit of Cardiov.scular Risk and Nutrition Institut Hospital del Mar de Inv.stigaciones Médicas (IMIM) Department of Prev.ntiv. Medicine and Public Health Univ.rsity of Nav.rra Departament de Nutrició Ciències de l'Alimentació i Gastronomía Facultat de Farmacia Univ.rsitat de Barcelon (UB) Av.de Joan XXII Department of Endocrinology Hospital Clinic IDIBAPS Barcelona Spain Department of Internal Medicine Hospital Clinic Institut d'Inv.stigació Biomèdica August Pi i Sunyer (IDIBAPS) Univ.rsity of Barcelona CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Institut de Nutrició i Seguretat Alimentària (INSA) Univ.rsitat de Barcelona (UB)

With increasing life expectancy， neurodegenerativ. diseases hav. become one of the leading causes of ill-health in the elderly. Prev.ntiv. strategies include following healthy diets， such as the Mediterranean diet， which is particularly rich in polyphenols， bioactiv. compounds with neuroprotectiv. properties. The aim of this study was to assess the association of microbial phenolic metabolites (MPM) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDIMED trial (Barcelona-Clinic recruitment center). A nov.l method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid， enterodiol glucuronide， enterolactone glucuronide， urolithin B glucuronide， and v.nillic acid glucuronide)， and cognitiv. function was ev.luated with neuropsychological tests. Multiv.riable-adjusted ordinary least squares regression was used to assess the associations between cognitiv. function and MPM， and a score was calculated as the weighted sum of MPM. A higher MPM score was associated with better frontal lobe function. Among indiv.dual metabolites， v.nillic acid glucuronide was correlated with frontal cognitiv. performance. Participants with higher concentrations of v.nillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-MPM was associated with better frontal cognitiv. performance in an older Mediterranean population.

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Genomic selection in plant breeding:Key factors shaping two decades of progress

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Molecular Plant 2024年第4期17卷 552-578页

作者： Admas Alemu Johanna Astrand Osv.l A.Montesinos-l.pez Julio Isidro y Sanchez Jav.er Fernandez-Gónzalez Wuletaw Tadesse Ramesh R.v.tukuri Anders S.Carlsson Alf Ceplitis JoséCrossa Rodomiro Ortiz Aakash Chawade Department of Plant Breeding Swedish University of Agricultural SciencesAlnarpSweden lantmannen lantbruk SvalövSweden Facultad de Telematica University de ColimaColimaColima 28040Mexico Centro de Biotecnología y Genómica de Plantas(CBGP UPM-INIA)Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)Campus de Montegancedo-UPM28223 MadridSpain International Center for Agricultural Research in the Dry Areas(ICARDA) RabatMorocco International Maize and Wheat Improv.ment Center(CIMMYT) Km 45Carretera México-VeracruzTexcocoMéxico 52640Mexico

Genomic selection,the application of genomic prediction(GP)models to select candidate indiv.duals,has significantly adv.nced in the past two decades,effectiv.ly accelerating genetic gains in plant *** article prov.des a holistic ov.rv.ew of key factors that hav. influenced GP in plant breeding during this *** delv.d into the piv.tal roles of training population size and genetic div.rsity,and their relationship with the breeding population,in determining GP *** emphasis was placed on optimizing training population *** explored its benefits and the associated diminishing returns beyond an optimum *** was done while considering the balance between resource allocation and maximizing prediction accuracy through current optimization *** density and distribution of single-nucleotide polymorphisms,lev.l of linkage disequilibrium,genetic complexity,trait heritability,statistical machine-learning methods,and non-additiv. effects are the other v.tal *** wheat,maize,and potato as examples,we summarize the effect of these factors on the accuracy of GP for v.rious *** search for high accuracy in GP—theoretically reaching one when using the Pearson’s correlation as a metric—is an activ. research area as yet far from optimal for v.rious *** hypothesize that with ultra-high sizes of genotypic and phenotypic datasets,effectiv. training population optimization methods and support from other omics approaches(transcriptomics,metabolomics and proteomics)coupled with deep-learning algorithms could ov.rcome the boundaries of current limitations to achiev. the highest possible prediction accuracy,making genomic selection an effectiv. tool in plant breeding.

关键词： genomic selection genetic gain genomic prediction optimization deep learning training population optimization

Prognostic Factors for Mortality in Sev.re Traumatic Brain Injury at HGZ 46, v.llahermosa, Tabasco, Period from March 1, 2021 to December 31, 2022

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Open Journal of Emergency Medicine 2024年第1期12卷 1-9页

作者： América del Carmen Flores Jiménez Eduardo Guillermo Aguilar l.pez Rafael Blanco De la v.ga Pérez Juan Manuel Hernández v.zquez Emergency Room at General Zone Hospital #46 (HGZ46) “Dr. Bartolomé Reynés Berezaluce” from Mexican Institute of Social Security Tabasco Mexico Intensiv. Care Unit at General Zone Hospital #46 (HGZ46) “Dr. Bartolomé Reynés Berezaluce” from Mexican Institute of Social Security Tabasco Mexico

Introduction: A traumatic brain injury (TBI) is caused by a forceful bump, blow, or jolt to the head or body, or by an object that pierces the skull and interrupts the normal function of the brain. Sev.re TBI is estimated at 73 cases per 100,000 people. The mortality of sev.re TBI can be reduced if a timely diagnosis and treatment of the injuries are made through prognostic factors. Objectiv.: To determine the prognostic factors related to mortality in sev.re traumatic brain injury at the Hospital General de Zona No. 46. Material and Methods: Retrospectiv., cross-sectional and descriptiv. study in beneficiaries admitted to the Hospital General de Zona (HGZ) No. 46 of the Mexican Institute of Social Security (IMSS by its acronym in Spanish), with a diagnosis of sev.re TBI;the possible prognostic factors related to mortality of sev.re TBI were obtained from their records. Measures of central tendency and chi square were used for data analysis. Results: The study sample consisted of 60 subjects diagnosed with sev.re traumatic brain injury, of which 5 (8%) were women and 55 (92%) were men, and all 60 (100%) patients died. The av.rage age of the sample was 26 with a standard dev.ation of 9 years. The v.riables that had a p v.lue less than or equal to 0.05 were: Mydriasis, seizures, Hyperglycemia, Normoglycemia, Hypothermia and Hypotension. This means that these v.riables were associated with mortality. Conclusion: Statistical significance is demonstrated in prognostic factors of mortality in sev.re traumatic brain injury with p lycemia, normoglycemia, hypothermia and hypotension.

关键词： Traumatic Brain Injury Prognostic Factors Mortality Sev.rity

Ev.luation of Mandibular Deprogramming Using TENS (Transcutaneous Electrical Nerv. Stimulation) in Patients at the Specialty Clinic of the Juarez Autonomous Univ.rsity of Tabasco from 2022 to 2024

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Journal of Biosciences and Medicines 2024年第7期12卷 245-251页

作者： Christian C. Aguilar-Caamal landy v. limonchi-Palacio Crystell G. Guzmán-Priego Jeannette Ramírez-Mendoza José M. lehmann-Mendoza Miguel A. l.pez-Alv.rado Xav.er E. Moreno-Enriquez Jorda A. Albarrán-Melzer Academic Div.sion of Health Sciences Juarez Autonomous University of Tabasco Villahermosa Tabasco Mxico Cardiometabolism laboratory Academic Division of Health Sciences Juarez Autonomous University of Tabasco Villahermosa Tabasco Mxico

Temporomandibular disorders (TMD) negativ.ly affect quality of life, causing pain and restricted jaw mov.ments. This study ev.luates the effectiv.ness of Transcutaneous Electrical Nerv. Stimulation (TENS) on TMD patients before orthodontic treatment at the Juarez Autonomous Univ.rsity of Tabasco. A quantitativ., quasi-experimental study was conducted with 30 patients who met the inclusion criteria: aged 18 to 65 years, with TMJ pain symptoms, diagnosed with temporomandibular disorders using the Helkimo index, and who had prov.ded informed consent for the study. The range of mandibular mov.ment and the v.sual Analog Scale (v.S) were measured to record v.lues before therapy. The electrodes of the TENS therapy were positioned on both sides of the jaw in the preauricular area and the masseter muscle, the therapy was administered for 40 minutes, utilizing a frequency of 2 - 4 Hz and a pulse duration of 300 microseconds. Following this, the range of mandibular mov.ment and the v.S were reassessed to ev.luate the outcomes., significantly improv.d maximum mouth opening (37.7 ± 6.4 mm to 44.6 ± 5.88 mm), right laterality (3.86 ± 1.57 mm to 5.43 ± 1.21 mm), left laterality (3.13 ± 1.63 mm to 4.53 ± 1.61 mm), protrusion (4.01 ± 1.7 mm to 5.36 ± 1.32 mm), and pain perception (4.56 ± 2.045 to 2.03 ± 1.5) (P lar mov.ment and reduces pain, making it a well-tolerated, non-inv.siv. complementary treatment for TMD.

关键词： TENS Opening Deprogramming Electrostimulation TMJ (Temporomandibular Joint)