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Macrolide-Clarithromycin Task-Force for the Treatment and Prophylaxis of Covid-19 as a Single Agent

Pharmacology & Pharmacy 2020年第6期11卷 85-104页

作者： Eduardo Mansilla Ricardo Rangel martínez gustavo horacio marín Idiberto Zotarelli Filho Elsa Rivas Jaime Rivas Katherine Athayde Teixeira de Carvalho Mohammad Reza Dayer Alí Samadikuchaksaraei Internal Medicine School of Medical Sciences UNLP La Plata Argentina ExomePharma Ciudad de México DF México Pharmacology School of Medical Sciences UNLP La Plata Argentina Faceres Medical School Sao José do Rio Preto Sao Paulo Brazil Intensive Care Units-Hospital de la Amistad Perú Corea II Santa Rosa and Salvador University Hospital Piura Perú Intensive Care Unit Hospital de la Amistad Perú Corea II Santa Rosa Piura Perú Pequeno Príncipe Faculty & Pelé Pequeno Príncipe Institute Curitiba Paraná Brazil Department of Biology Faculty of Science Shahid Chamran University of Ahvaz Ahvaz Iran Department of Tissue Engineering & Regenerative Medicine Iran University of Medical Sciences Tehran Iran

SARS-CoV-2 is a novel RnA coronavirus responsible of a deadly pandemic: the clinical illness COVID-19. With only one authorized drug for emergency use in critically ill patients: Remdesivir, there is not any other approved drug or vaccine yet with proven potential to overcome this infection. We exposed here many scientific evidences to support our novel idea that a macrolide, basically Clarithromycin, could be effective as a single agent for treatment and prophylaxis of COVID-19. Clarithromycin could change the history of this pandemic. It could reduce the costs of treatment and the potential adverse effects when combining more than one drug such as with Hydroxychloroquine. Clarithromycin treatment and prophylaxis as a single agent could be much more simple, safe and cheaper as giving Chloroquine or Hydroxychloroquine alone or in combination with Azithromycin as well as other therapeutic options.

关键词： COVID-19 Macrolides Clarithromycin Single Agent Therapy Prophylaxis

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Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy

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World Journal of Gastroenterology 2021年第28期27卷 4639-4652页

作者： Alberto E Muñoz Florencia D Pollarsky Mónica marino mariano Cartier horacio Vázquez Pablo Salgado gustavo Romero Sección Hepatología Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoFacultad de MedicinaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina Instituto de Investigaciones en Salud Pública Facultad de OdontologíaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1122Argentina Unidad Clínica Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoInvestigador Asociado del Gobierno de la Ciudad Autónoma de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina

This review summarizes the safety and efficacy of statins in patients with *** to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in *** most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver *** is the most serious and potentially life-threatening *** has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle ***,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle *** to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something *** these effects,statins could prevent liver-related morbidity and mortality in cirrhotic *** studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and *** few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic *** large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival *** these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies ***,it is advisable to per

关键词： Cirrhosis Liver disease Statins Safety Efficiency

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Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)n-based layer for application as the electron blocking layer in deep ultraviolet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： horacio Irán Solís-Cisneros Carlos Alberto Hernández-Gutiérrez Enrique Campos-González Máximo López-López Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInn layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlInn was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substrates using Aln as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRD).Cathodoluminescence measurements revealed ultraviolet(UV)range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoelectron spectroscopy(XPS)estimating the alloy composition and extracting the Fermi level by valence band ***-doped AlInn layers were studied for use as the electron-blocking layer(EBL)in LED *** varied the Al composition in the EBL from 0.84 to 0.96 molar fraction to assess its theoretical effects on electroluminescence,carrier concentration,and electric field,using SILVACO *** results from this study highlight the importance and capability of producing high-quality Mg-doped p-AlInn layers through *** simulations suggest that an Al content of 0.86 is optimal for achieving desired outcomes in electroluminescence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInn DUV-LED EBL simulation

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Ivermectin Efficacy against Triatoma infestans in vivo Using Hen Model

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Journal of Pharmacy and Pharmacology 2014年第6期2卷 353-358页

作者： martin Miguel Dade martin Rafael Daniele gustavo horacio marin maria Pia Silvestrini nora Mestorino Department of Pharmacology Faculty of Medicine Sciences National University of La Plata La Plata 1900 Buenos Aires Argentina Laboratory of Pharmacological and Toxicological Studies Faculty of Veterinary Sciences National University of La Plata La Plata 1900 Buenos Aires Argentina Biostatistic Department Faculty of Veterinary Sciences National University of La Plata La Plata 1900 Buenos Aires Argentina

Chagas disease is endemic in south America. One of the major preventive actions is removing the vector TI （Triatoma infestans） from household. Although households are frequently sprayed to eliminate TI, pets and domestic animals are natural storage for vector survival. This work proposes TI elimination from farm animals using IVM （ivermectin）, as a new strategy to Chagas disease control. Rhode island hens were divided into TG （treatment groups） and CG （control groups）. TG received IVM while CG received DMSO. TI used in the assay was fifth instar nymphs. Hens served as food source for TI. Blood was extracted for IVM chromatographic pharmacokinetic analysis. The pharmacokinetic models that best fitted the IVM plasma profiles were determined by means of the minimum Akaike information criterion estimation （MAICE） test. In TG nymphs mortality was 23.25% to 47.5% at 24-120 h, respectively. IVM plasma profile showed a first-order one-compartment model with a rapid absorption reaching a Cmax （maximum concentration） of 64.7 ± 15.4 ng/mL at 48 h （Troop） post-application. Our data shows that TI mortality is directly related to the plasma concentration of IVM and is up to 47.5% at 120 h. Therefore, ivermectin may have a potential effect on controlling TI vector in peri-domestic level.

关键词： Chagas control ivermectin Triatoma infestans.

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