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2015中国遗传学会大会

作者： Caoyi Chen Nana Jin gustavo basurto-islas Jianlan Gu Cheng-Xin Gong Khalid Iqbal Fei Liu Jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationNantong University Department of Genetics School of Life ScienceNantongUniversity Department of Neurochemistry New York State Institute for Basic Research in Developmental Disabilities

Abnormally hyperphosphorylated microtubule-associated protein tau,the major protein of the intracellular neurofibrillary tangles in Alzheimer’s disease(AD)brain and related tauopathies,is most probably the result of an imbalance of tau kinase and phosphatase activities in the affected *** density of NFTs composed of hyperphosphorylated tau protein in the hippocampus and neocortical areas correlates well with the cognitive impairment in ***,hyperphosphorylation of tau is believed to be pivotal to AD pathogenesis,but the molecular mechanism has not been completely *** kinase 1 epsilon(CKle)belongs to CK1family of ubiquitous serine/mreonine-specific protein kinases and plays an essential role in cell regulation and disease pathogenesisOur study focused on its possible role in the tau pathology in *** levels of CKle in AD and control human brains were determined by Western blots and real-time *** amount of tau and phosphorylated tau were detected by immuno-dot blots and the relationship between CKle and tau phosphorylation was analyzed by correlation *** found that CKle was markedly increased in AD brain as compared with controls at both protein and mRNA ***,enhanced CKle expression mainly located in the cytoplasm of *** level was positively correlated to tau phosphorylation in human *** existed in tangle borne ***,over-expression of CKle in HEK-293FT cells or primary cultured neurons led to increased tau phosphorylation at many *** vivo,CKle overexpression in mice hippocampus increased tau phosphorylation level and impaired spontaneous alternation *** summary,in this study we found neuronal CKle augment in AD brain and verified that CKle was capable of phosphorylating tau at several epitopes of relevance to AD in cultured cells and in ***-expression of CKle in mice results in the development of several characteristics of AD neuropathology including elevated tau phosphoryla

关键词： casein kinase 1ε Alzheimer disease tauopathies

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Stage-Specific Changes on <i>Plasmodium yoelii yoelii </i>Following Treatment with <i>Hintonia latiflora</i>Stem Bark Extract and Phytochemical-Antioxidant Evaluation

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Pharmacology & Pharmacy 2017年第12期8卷 381-395页

作者： Elba Carrasco-Ramírez Perla Y. López-Camacho Armando Zepeda-Rodríguez Patricia Bizarro-Nevares Filiberto Malagón-Gutiérrez gustavo basurto-islas Norma Rivera-Fernández Laboratorio de Malariología Departamento de Microbiología y Parasitología Facultad de Medicina Universidad Nacional Autónoma de México CDMX México Departamento de Ciencias Naturales e Ingeniería Universidad Autónoma Metropolitana CDMX México Deparatmento de Biología Celular y Tisular Facultad de Medicina Universidad Nacional Autónoma de México CDMX México Departamento de Ingenierías Química Electrónica y Biomédica División de Ciencias e Ingeniería Universidad de Guanajuato Campus León Guanajuato México

Malaria endemic zones are mostly located on third world countries, where antimalarials are not easily found or patients cannot afford them, and in consequence, they must turn toward natural products or phytomedicines. In the present study, the effect of Hinotnia latiflora (Hl) methanolic stem bark extract (HlMeOHe) on the ultrastructure of the asexual intraerythrocytic stages of Plasmodium yoelii yoelii (Pyy) after a Peters’ four-day oral treatment was assessed by transmission electron microscopy (TEM), as well as the parasite development on blood smears, analyzed by light microscopy. Likewise, extract was subjected to qualitative tests adopting standard procedures for identification of phytoconstituents;its antioxidant activity was evaluated according to the method of Brand-Williams and by the radical cation decolorization assay. Results showed higher percentage of rings and lower percentage of trophozoites and schizonts in the treated animals, in comparison with those of the control groups, which demonstrated lower percentage of rings and trophozoites, and schizonts in higher number. Images of TEM showed in some treated parasites, mild parasite membranes, organelle swelling and ribosomal depletion. The phytochemical profile demonstrated that the extract contains alkaloids, tannis, steroids, terpenoids, flavonoids, phenolics and saponins. The obtained values of the half maximal inhibitory concentration (IC50) in μg/mL, for both antioxidant assays were of 423.83 and 202.95 respectively. It is concluded that HlMeOHe altered the development of the intraerythrocytic asexual stages and the ultrastructure of Pyy, and due to its phytochemical constituents, showed an in vitro antioxidant activity.

关键词： Hintonia latiflora Plasmodium yoelii yoelii Malaria Ultrastructural Changes Phytochemicals Antioxidant Natural Products

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High CO_(2)permeation using a new Ce_(0.85)Gd_(0.15)O_(2-δ)-LaNiO_(3)composite ceramic–carbonate dual-phase membrane

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Journal of Environmental Sciences 2024年第6期140卷 219-229页

作者： Daniela González-Varela JFrancisco Gómez-García gustavo Tavizon Heriberto Pfeiffer Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico Departamento de Física y Química Teórica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico 不详

This work shows the synthesis,characterization and evaluation of dense-ceramic membranes made of Ce_(0.85)Gd_(0.15)O_(2-δ)-LaNiO_(3)(CG-LN)composites,where the fluorite-perovskite ratio(CG:LN)was varied as follows:75:25,80:20 and 85:15 wt.%.Supports were initially characterized by XRD,SEM and electrical conductivity(using vacuum and oxygen atmospheres),to determine the composition,microstructural and ionic-electronic conductivity ***,supports were infiltrated with an eutectic carbonates mixture,producing the corresponding dense dual-phase membranes,in which CO_(2)permeation tests were ***,CO_(2)permeation experiments were performed from 900 to 700℃,in the presence and absence of oxygen(flowed in the sweep membrane side).Results showed that these composites possess high CO_(2)permeation properties,where the O_(2)addition significantly improves the ionic conduction on the sweep membrane ***,the GC80-LN20 composition presented the best results due to the following physicochemical characteristics:high electronic and ionic conductivity,appropriate porosity,interconnected porous channels,as well as thermal and chemical stabilities between the composite support and carbonate phases.

关键词： CO_(2)permeation Doped CeO_(2) LaNiO_(3) Impedance Ceramic carbonate membrane

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ChatGPT and exercise prescription:Human *** or human plus machine?

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Journal of Sport and Health Science 2024年第5期13卷 661-662页

作者： Timothy gustavo Cavazzotto Diego Bessa Dantas Marcos Roberto Queiroga Department of Physical Education Midwestern Parana State UniversityParana 85040-167Brazil Postgraduate Program in Physical Education UEM-UEL State University of LondrinaParana 86057-970Brazil

The power of artificial intelligence(AI)to create stories,music,art,and other creative projects has been demonstrated and criticized over recent decades in media,mainly because of the idea that AI will replace human *** recently,in November 2022,reactions to Chat Generative Pre-training Transformer(ChatGPT)release for public use reverberated in news and social media headlines,while its users exceeded100 million in just a few *** is a natural language processing program created by AI non-profit OpenAI Inc.

关键词： prescription replace Human

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Annual variation of adult survival of a south-temperate House Wren population in Argentina

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Avian Research 2024年第2期15卷 229-237页

作者： gustavo J.Fernandez Mariana E.Carro Paulo E.Llambías Grupo de Investigacion en Ecofisiología de Fauna Silvestre INIBIOMA-CONICETAsentamiento Universitario San Martín de los Andes(AUSMA)Universidad Nacional Del ComahuePasaje de la Paz 235(8370)San Martín de los AndesNeuquenArgentina Grupo de Investigacion de Biología de Aves IADIZA CCT-MendozaUniversidad Nacional de CuyoAvenida RuizLeal s/n Parque General San Martin5500MendozaArgentina

Identifying factors affecting the survival of individuals is essential for understanding the evolution of life-history traits and population *** numerous studies on this subject in north-temperate environments,there is a lack of equivalent studies at similar latitudes in the ***,we used a 14-year dataset of capture,banding,and resighting to estimate the annual variation in the apparent adult survival probability of a south-temperate population of House Wrens(Troglodytes aedon bonariae).We evaluated temporal variation in sur-vival and the effect of environmental(climatic)and demographic variables(adult abundance,total number of fledglings produced during each breeding season)on survival *** found that the probability of adult survival decreased as the abundance of breeding adults *** density-dependent effect could be related to the resident lifestyle of southern House Wrens,which could determine an intense competition for territories and resources that ultimately would affect their survival.

关键词： Annual variation CJS Density-dependence Survival Troglodytes aedon bonariae

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Seasonal variation and host sex affect bat–bat fly interaction networks in the Amazonian savannahs

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Integrative Zoology 2024年第3期19卷 400-416页

作者： Paulo MEJIA gustavo Lima URBIETA Bruna da Silva XAVIER IsaíJorge de CASTRO JoséJúlio DE TOLEDO gustavo GRACIOLLI Lucio AndréVIANA DIAS William Douglas CARVALHO Programa de Pós-Graduação em Biodiversidade Tropical Universidade Federal do Amapá(UNIFAP)MacapáAPBrazil Programa de Pós-Graduação em Ecologia Instituto de BiologiaCentro de Ciências da SaúdeUniversidade Federal do Rio de Janeiro(UFRJ)Rio de JaneiroRJBrazil Laboratório de Mamíferos Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá(IEPA)MacapáAPBrazil Programa de Pós-Graduação em Biologia Animal Laboratório de SistemáticaEcologia e Evolução(LSEE)Instituto de BiociênciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo GrandeMTBrazil Terrestrial Ecology Group(TEG-UAM) Departamento de EcologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain

Bats are the second-most diverse group of mammals in the world,and bat flies are their main ***,significant knowledge gaps remain regarding these antagonistic interactions,especially since diverse factors such as seasonality and host sex can affect their network ***,we explore the influence of such factors by comparing species richness and composition of bat flies on host bats,as well as specialization and modularity of bat–bat fly interaction networks between seasons and adult host *** captured bats and collected their ectoparasitic flies at 10 sampling sites in the savannahs of AmapáState,northeastern region of the Brazilian *** female bats being more parasitized and recording greater bat fly species richness in the wet season,neither relationship was statistically *** pooled network could be divided into 15 compartments with 54 links,and all subnetworks comprised>12 *** total number of links ranged from 27 to 48(for the dry and wet seasons,respectively),and female and male subnetworks had 44 and 41 links,*** values were very low for the pooled network and for all *** results revealed higher bat fly species richness and abundance in the wet season,whereas specialization and modularity were higher in the dry ***,the subnetwork for female bats displayed higher specialization and modularity than the male ***,both seasonality and host sex contribute in different ways to bat–bat fly network *** studies should consider these factors when evaluating bat–bat fly interaction networks.

关键词： Amapá Amazon biome bat flies bats interaction networks

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Effects of antioxidant‑rich Lactiplantibacillus plantarum inoculated alfalfa silage on rumen fermentation, antioxidant and immunity status, and mammary gland gene expression in dairy goats

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1227-1240页

作者： Yixin Zhang Samaila Usman Qiang Li Fuhou Li Xia Zhang Luiz gustavo Nussio Xusheng Guo State Key Laboratory of Grassland Agro‑ecosystems School of Life SciencesLanzhou UniversityLanzhou 730000PR China Probiotics and Life Health Institute Lanzhou UniversityLanzhou 730000PR China Probiotics and Biological Feed Research Centre Lanzhou UniversityLanzhou 730000PR China Department of Animal Science Luiz de Queiroz College of AgricultureUniversity of Sao PauloPiracicaba 13418‑900Brazil

Background Milk synthesis in lactating animals demands high energy metabolism,which results in an increased production of reactive oxygen metabolites(ROM)causing an imbalance between oxidants and antioxidants thereby inducing oxidative stress(OS)on the *** mitigate OS and postpartum disorders in dairy goats and gain insight into the impact of dietary choices on redox status during lactation,a feeding trial was conducted using alfalfa silage inoculated with a high-antioxidant strain of Lactiplantibacillus *** Twenty-four Guanzhong dairy goats(38.1±1.20 kg)were randomly assigned to two dietary treatments:one containing silage inoculated with *** MTD/1(RSMTD-1),and the other containing silage inoculated with high antioxidant activity *** 24-7(ES24-7).Results ES24-7-inoculated silage exhibited better fermentation quality and antioxidant activity compared to *** ES24-7 diet elevated the total antioxidant capacity(T-AOC),superoxide dismutase(SOD),glutathione peroxi-dase(GSH-Px),and catalase(CAT)activities in milk,serum,and feces of lactating goats(with the exception of T-AOC in milk).Additionally,the diet containing ES24-7 inoculated silage enhanced casein yield,milk free fatty acid(FFA)content,and vitamin A level in the goats’***,an increase of immunoglobulin(Ig)A,IgG,IgM,inter-leukin(IL)-4,and IL-10 concentrations were observed,coupled with a reduction in IL-1β,IL-2,IL-6,interferon(IFN)-γ,and tumor necrosis factor(TNF)-αconcentrations in the serum of lactating goats fed *** concentrations of total volatile fatty acid(VFA),acetate,and propionate were observed in the rumen fluid of dairy goats fed ES24-7 inoculated ***,the diet containing ES24-7 inoculated silage significantly upregulated the expression of nuclear factor erythroid 2 like 2(NFE2L2),beta-carotene oxygenase 1(BCO1),SOD1,SOD2,SOD3,GPX2,CAT,glu-tathione-disulfide reductase(GSR),and heme oxygenase 1(HMOX1)genes in the mammary gland,

关键词： Alfalfa silage Antioxidant activity Gene expression Goats Immunity Lactation

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The initial stages of Li_(2)O_(2) formation during oxygen reduction reaction in Li-O_(2) batteries:The significance of Li_(2)O_(2) in charge-transfer reactions within devices

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Journal of Energy Chemistry 2024年第1期88卷 223-231,I0006页

作者： Daniela M.Josepetti Bianca P.Sousa Simone A.J.Rodrigues Renato G.Freitas gustavo Doubek Advanced Energy Storage Division LABCenter for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasAv Albert Einstein 50013083-852CampinasSPBrazil Institute of Physics&Department of Chemistry Laboratory of Computational MaterialsFederal University of Mato Grosso78060-900CuiabáMTBrazil

Lithium-oxygen batteries are a promising technology because they can greatly surpass the energy density of lithium-ion ***,this theoretical characteristic has not yet been converted into a real device with high *** with air contamination,metallic lithium reactivity,and complex discharge and charge reactions are the main issues for this technology.A fast and reversible oxygen reduction reaction(ORR)is crucial for good performance of secondary batteries',but the partial knowledge of its mechanisms,especially when devices are concerned,hinders further *** this perspective,the present work uses operando Raman experiments and electrochemical impedance spectroscopy(EIS)to assess the first stages of the discharge processes in porous carbon electrodes,following their changes cycle by cycle at initial operation.A growth kinetic formation of the discharge product signal(Li_(2)O_(2))was observed with operando Raman,indicating a first-order reaction and enabling an analysis by a microkinetic *** solution mechanism in the evaluated system was ascribed for an equivalent circuit with three time *** the time constant for the anode interface reveals to remain relatively constant after the first discharge,its surface seemed to be more *** model indicated that the reaction occurs at the Li_(2)O_(2) surface,decreasing the associated resistance during the initial discharge ***,the growth of Li_(2)O_(2) forms a hetero-phase between Li_(2)O_(2)/electrolyte,while creating a more compact and homogeneous on the Li_(2)O_(2)/cathode *** methodology here described thus offers a way of directly probing changes in surface chemistry evolution during cycling from a device through EIS analysis.

关键词： Li-O_(2)battery Operando Raman analysis Equivalent circuit modeling Time-constant distribution

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Designing for well-Being: Using facial micro-expression analysis and EEG biosensor to evaluate human responses to 2D biophilically-driven geometries

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Frontiers of Architectural Research 2024年第2期13卷 219-234页

作者： Andrea Macruz Ernesto Bueno gustavo Sol Jaime Vega Ricardo Palmieri Bing Zhao College of Architecture and Urban Planning Tongji UniversityShanghaiChina Universidade Presbiteriana Mackenzie Sao PauloBrazil Centro Universitario Belas Artes Sao PauloBrazil Universidade Anhembi Morumbi Sao PauloBrazil Universidade Federal do ABC Santo AndreBrazil

This research explores the capacity of emerging technologies to enhance well-being. It involves the generation of 2D biophilically-driven geometries to represent human-response-oriented built environments and conducts inter and intra-individual analyses to assess human responses using a range of technologies within the realms of facial micro-expression analysis and EEG biosensor use. The outcomes of this analysis allow for the grading of these geometries in terms of emotional valences, meditation levels, and subjective preferences. These graded geometries can subsequently be employed in specific architectural contexts, such as interior decor, wallpapers, furniture surfaces, or other architectural and interior components. It is an interdisciplinary effort that underscores the importance of incorporating emerging technological means with human-response-oriented design approaches to foster built environments that promote well-being.

关键词： Biophilic design Geometrical algorithmicmodeling Facial micro-expressionanalysis EEG biosensor Neuroscience

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Concentration of dimension in extremal points of left-half lines in the Lagrange spectrum

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Acta Mathematica Sinica,English Series 2024年

作者： Carlos gustavo MOREIRA Christian Camilo SILVA VILLAMIL SUSTech International Center for Mathematics Shenzhen Guangdong People's Republic of China and IMPA SUSTech International Center for Mathematics Shenzhen Guangdong People's Republic of China and IMPA

We prove that for any η that belongs to the closure of the interior of the Markov and Lagrange spectra,the sets k-1(（-∞,η]） and k-1（η）,which are the sets of irrational numbers with best constant of Diophantine approximation bounded by η and exactly η respectively,have the same Hausdorff *** also show that,as η varies in the interior of the spectra,this Hausdorff dimension is a strictly increasing function.

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