检索结果-南通市图书馆

联合应用生长激素和促性腺激素释放激素治疗领养女孩性早熟的最终身高

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 11-12页

作者： Tuvemo T. j.nsson B. gustafsson j. 李开 Dept. of Women's/Children's Hlth. Uppsala University Uppsala Sweden

研究背景:从发展中国家领养的女孩,常存在发育提前或性早熟,需进行促性腺激素释放激素(GnRH)类似剂治疗。此类药物治疗期间,常见发育速度降低。目的:研究生长激素(GH)附加GnRH类似剂的应用,是否可促进发育提前或性早熟女性患儿的身高发... 详细信息

研究背景:从发展中国家领养的女孩,常存在发育提前或性早熟,需进行促性腺激素释放激素(GnRH)类似剂治疗。此类药物治疗期间,常见发育速度降低。目的:研究生长激素(GH)附加GnRH类似剂的应用,是否可促进发育提前或性早熟女性患儿的身高发育。方法:研究从发展中国家领养的46例女性患儿病例,年龄均≤9.5岁。

关键词：性早熟发育速度 analogue alone deviation requiring possibly 医疗干预亚组 young

对低出生体重儿单独母乳喂养的出生后专业咨询:一个随机、对照试验

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 24-25页

作者： Agrasada G.V. gustafsson j. Kylberg E. Ewald U. 郭战宏 Department of Women’s and Children’s Health Uppsala University SE-751 85 Uppsala Sweden

Aim: Exclusive breastfeeding increases survival and optimizes growth of low-birthweight (LBW) infants. If supported, mothers can overcome the unique difficulties associated with breastfeeding from birth to 6 mo. We tested the efficacy of postnatal peer counselling among first-time mothers that aimed to increase exclusive breastfeeding of term LBW infants. Methods: In a Manila hospital, 204 mothers were randomized into three groups. Two intervention groups receiving home-based counselling visits, one by counsellors trained in breastfeeding counselling (n = 68), the other by counsellors trained in general childcare (n = 67), were compared with a control group of mothers (n = 69) who did not receive counselling. Results: Eighty-eight per cent of the participating pairs completed the trial. At 6 mo, 44%of the breastfeeding counselled mothers, 7%childcare-counselled mothers and none of the mothers in the control group were exclusively breastfeeding. More mothers in the breastfeeding counselled group than in the other groups were still breastfeeding at 6 mo. Twenty-four infants who were exclusively breastfed for 6 mo did not have any diarrhoea. All groups had improved mean weight-for-age Z-scores at 6 mo. Conclusion: This study has provided fundamental evidence of successful intervention to achieve 6mo of exclusive breastfeeding among term LBW infants. By improving health outcomes, enhanced breastfeeding offers a distinct possibility of disrupting the intergenerational cycle of undernourished women giving birth to LBW infants.

关键词：母乳喂养对照试验专业咨询出生后儿童保健生长发育干预组咨询员一所咨询组

Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

在线全文

学校读者我要写书评

暂无评论

The Innovation 2024年第2期5卷 107-114页

作者： j.han gustafsson Fariba Roshanzamir Anders Hagnestål Sagar M.Patel Oseeyi I.Daudu Donald F.Becker j.nathan L.Robinson j.ns Nielsen Department of Life Sciences Chalmers University of TechnologySE-41296 GothenburgSweden Hagnesia AB SE-43854 HindåsSweden Department of Biochemistry and Redox Biology Center University of Nebraska-LincolnLincolnNE 68588USA BioInnovation Institute DK2200 CopenhagenDenmark

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation,but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in ***-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell ***,we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion *** addition,we developed an approach to efficiently apply enzyme usage constraints in a comprehensive metabolic model of human *** combined modeling reproduced severe hypoxic conditions and the Warburg effect,and we found that limitations in enzymatic capacity contribute to cancer cells’preferential use of glutamine as a substrate to the citric acid ***,we investigated the common hypothesis that some stromal cells are exploited by cancer cells to produce metabolites useful for the cancer *** identified over 200 potential metabolites that could support collaboration between cancer cells and cancer-associated fibroblasts,but when limiting to metabolites previously identified to participate in such collaboration,no growth advantage was *** work highlights the importance of enzymatic capacity limitations for cell behaviors and exemplifies the utility of enzyme-constrained models for accurate prediction of metabolism in cells and tumor microenvironments.

关键词： metabolism effect limitations

Mucosa-associated bacteria in two middle-aged women diagnosed with collagenous colitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World j.urnal of Gastroenterology 2012年第14期18卷 1628-1634页

作者： Rita j.gustafsson Bodil Ohlsson Cecilia Benoni Bengt j.ppsson Crister Olsson Department of Clinical Sciences Gastroenterology SectionSkne University HospitalLund University20502 MalmSweden Department of Surgery Skne University HospitalLund University20502 MalmSweden Food Technology Engineering and Nutrition Lund University22100 LundSweden

AIM:To characterize the colon microbiota in two women histologically diagnosed with collagenous colitis using a culture-independent ***:Biopsies were taken from the ascending colon and the total DNA was *** bacterial primers were used to amplify the bacterial 16S rRNA *** amplicons were then cloned into competent Escherichia coli *** clones were sequenced and identified by comparison to known ***:The clones could be divided into 44 different *** microbiota was dominated by Firmicutes and *** phylotypes werefound in both patients and constituted 47.5% of the total number of *** these,the most dominating were clones similar to Bacteroides cellulosilyticus,Bacteroides caccae,Bacteroides thetaiotaomicron,Bacteroides uniformis and Bacteroides dorei within *** similar to Faecalibacterium prausnitzii and Clostridium citroniae were also found in both ***:A predominance of potentially pathogenic Bacteroides spp.,and the presence of clones showing similarity to Clostridium clostridioforme were found but the overall colon microbiota showed similarities to a healthy *** for collagenous colitis other than an adverse bacterial flora must also be considered.

关键词： Microscopic colitis Collagenous colitis Lymphocytic colitis Colonic microbiota 16S rRNA sequencing

Sexual dichromatism,size dimorphism,and microscale anatomy of white wing stripe in blue tits

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2021年第6期67卷 585-596页

作者： Katarzyna j.NAS Paulina GAWEł AnnaŁATKIEWICZ Dorota LUTYK Lars gustafsson Mariusz CICHON Szymon M.DROBNIAK Institute of Environmental Sciences Faculty of BiologyJagiellonian UniversityGronostajowa 730-387Krako´wPoland Institute of Geological Sciences Faculty of Geography and GeologyJagiellonian UniversityGronostajowa 730-387KrakówPoland Department of Animal Ecology/Ecology and Genetics Uppsala UniversityNorbyvägen 18 D75236UppsalaSweden School of Biological Environmental and Earth SciencesUniversity of New South WalesBiological Sciences Building(D26)Kensington SydneyNSW 2052 Australia

Achromatic patches are a common element of plumage patterns in many bird species and there is growing body of evidence that in many avian taxa they can play a signaling role in mate *** the blue tit Cyanistes caeruleus is a well-established model species in the studies on coloration,its white wing patch has never been examined in the context of sex-specific trait *** this exploratory study,we examined sexual size dimorphism and dichromatism of greater covert’s dots creating white wing patch and analyzed its correlations with current body condition and crown coloration—a trait with established role in sexual ***,we qualitatively analyzed microstructural barb morphology underlying covert’s *** found significant sexual dimorphism in the dot size independent of covert size and sexual dichromatism in both white dot and blue outer covert’s vane spectral *** structure of covert barbs within the white dot was similar to the one found in barbs from the blue part that is,with a medullary area consisting of dead keratinocytes containing channel-typeß-keratin spongy nanostructure and centrally located air ***,it lacked melanosomes which was the main observed ***,UV chroma of covert’s blue vane was positively correlated with crown UV chroma and current condition(the latter only in males),which should be a premise for further research on the signal function of the wing stripe.

关键词： achromatic coloration blue tit dichromatism dimorphism structural coloration wing stripe

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

瑞典森林土壤中有机质对硒的吸持作用

土壤学进展 1995年第2期23卷 43-49页

作者： j.P.gustafsson L.j.hnsson 王美珠

瑞典森林酸性灰化土的有机质能大量快速地固定硒,土壤中的硒主要以有机结合态存在,大量的硒被土壤有机质富集在阴离子吸附容量大的 B_s 层中.土壤中有机质的大量积累将降低硒对作物的有效性.土柱试验结果还表明,森林土壤的硒主要以有机... 详细信息

瑞典森林酸性灰化土的有机质能大量快速地固定硒,土壤中的硒主要以有机结合态存在,大量的硒被土壤有机质富集在阴离子吸附容量大的 B_s 层中.土壤中有机质的大量积累将降低硒对作物的有效性.土柱试验结果还表明,森林土壤的硒主要以有机硒化合物形态迁移或被淋洗.

关键词：森林土壤有机质硒吸持作用

森林生态系统中硒与腐殖物质之间缔合作用的实验证据

在线全文

学校读者我要写书评

暂无评论

土壤学进展 1995年第3期23卷 36-41页

作者： j.P.gustafsson L.j.hnsson 王美珠

在针叶林土壤和水系统中,硒通常与腐殖物质缔合存在,为进一步澄清有关机理,作者将标记亚硒酸盐和非标记亚硒酸盐加入两个林地表土和一个棕色湖水样品中,并应用连续提取方法和色谱分析技术对硒和腐殖物质间的缔合作用进行了测定,结果表明... 详细信息

在针叶林土壤和水系统中,硒通常与腐殖物质缔合存在,为进一步澄清有关机理,作者将标记亚硒酸盐和非标记亚硒酸盐加入两个林地表土和一个棕色湖水样品中,并应用连续提取方法和色谱分析技术对硒和腐殖物质间的缔合作用进行了测定,结果表明,通过微生物的还原作用,加人的亚硒酸盐大部分被林地表土所固定,硒优先进人了低分子量的腐殖物质组分中,相反,在棕色湖水样品的试验中,硒的还原反应速率慢。因此,在所试验的条件下当竞争的配位体浓度较低时,硒与金属腐殖质复合体的无机复合作用,是硒与腐殖质缔合的重要作用。

关键词：森林生态系统硒腐殖质土壤

Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue

在线全文

学校读者我要写书评

暂无评论

j.urnal of Molecular Cell Biology 2016年第6期8卷 518-529页

作者： Hu Xu j.a-Lin Fu Yi-Fei Miao Chun-j.ong Wang Qi-Fei Han Sha Li Shi-Zheng Huang Sheng-Nan Du Yu-Xiang Qiu j.-Chun Yang j.n-Ake gustafsson Richard MBreyer Feng Zheng Nan-Ping Wang Xiao-Yan Zhang You-Fei Guan Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Center for Nuclear Receptors and Cell Signaling Department of Biology and BiochemistryUniversity of HoustonHoustonTX 77204USA Department of Veterans Affairs Tennessee Valley Health Authorityand Department of MedicineVanderbilt University Medical CenterNashvilleTN 37232USA Advanced Institute for Medical Sciences Dalian Medical UniversityDalian 116044China Department of Physiology AstraZeneca–Shenzhen University Joint Institute of NephrologyShenzhen University Health Science CenterShenzhen 518060China

Among the four prostaglandin E2 receptors,EP3 receptor is the one most abundantly expressed in white adipose tissue(WAT).The mouse EP3 gene gives rise to three isoforms,namely EP3α,EP3β,and EP3γ,which differ only at their C-terminal *** date,functions of EP3 receptor and its isoforms in WAT remain incompletely *** this study,we found that the expression of all EP3 isoforms were downregulated in WAT of both db/db and high-fat diet-induced obese *** ablation of three EP3 receptor isoforms(EP3^(−/−)mice)or EP3αand EP3γisoforms with EP3βintact(EP3βmice)led to an obese phenotype with increased food intake,decreased motor activity,reduced insulin sensitivity,and elevated serum *** the differentiation of preadipocytes and mouse embryonic fibroblasts to adipocytes was markedly facilitated by either pharmacological blockade or genetic deletion/inhibition of EP3 receptor via the cAMP/PKA/PPARγpathway,increased adipogenesis may contribute to obesity in EP3^(−/−)and EP3β***,both EP3^(−/−)and EP3βmice had increased lipolysis in WAT mainly due to the activated cAMP/PKA/hormone-sensitive lipase *** together,our findings suggest that EP3 receptor and itsαandγisoforms are involved in both adipogenesis and lipolysis and influence food intake,serum lipid levels,and insulin sensitivity.

关键词： arachidonic acid EP3 receptor isoform PKA PPARγ insulin resistance obesity

Multiple Flux Rope Events on j.n.26,2001Observed at High-Latitude Magnetopause:Cluster/RAPID Measurements（Ⅱ）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multiple Flux Rope Events on Jan.26,2001Observed at High-Lat...