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DNA damage in exfoliated buccal cells and antioxidant status of saliva in brain tumour patients

海南医学院学报 2010年第10期16卷 1269-1274页

作者： Revathi P Shenoy Anumeha Vatsa Swagatika Sahoo Rajashree Rana guruprasad Nayak Poorna Bhat guruprasad kalthur Anjali Rao Department of Biochemistry and Division of Reproductive Medicine Kasturba Medical College and Hospital Manipal University Department of Obstetrics and Gynecology Division of Reproductive MedicineKasturba Medical College and Hospital Manipal University

The present investigation was carried out in exfoliated buccal cells and saliva collected from pre-operative brain tumour patients. The DNA damage in these cells was assessed by alkaline comet assay and micronucleus (MN) assay. Salivary flow rate, pH, osmolality, total antioxidant activity (AOA) and vitamin C levels were also assessed in unstimulated whole saliva of these patients. In the comet assay a significant increase in the tail length (P<0.02) was observed when control and malignant groups were compared. A significant (P<0.02) difference in tail length was also noted between benign and malignant groups. Non significant results were found when control and benign groups were compared. Further, a marked increase in % MN (P<0.002) was observed when control and benign groups were compared. A significant increase in % MN (P<0.029) was also observed in benign cases when compared to malignant tumours. No significance was obtained when % MN in control and malignant cases was compared. Moreover, salivary flow rate and pH was significantly decreased and osmolality was markedly increased in brain tumour patients. The AOA levels in saliva were markedly decreased in brain tumours and vitamin C levels exhibited no change when compared to controls. Thus, as noted above susceptibility to free radical induced DNA damage also exists in the exfoliated buccal cells conducive to the lowered salivary antioxidant status of brain tumour patients.

关键词：脑肿瘤临床 DNA 治疗

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Switching effect on a two prey-one predator system with strong Allee effect incorporating prey refuge

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International Journal of Biomathematics 2024年第2期17卷 1-50页

作者： Sangeeta Saha guruprasad Samanta Department of Mathematics Indian Institute of Engineering Science and Technology Shibpur Howrah 711103India

In an environment,the food chains are balanced by the prey-predator *** a predator species is provided with more than one prey population,it avails the option of prey switching between prey species according to their ***,prey switching of predators mainly helps to increase the overall growth rate of a predator *** this work,we have proposed a two prey-one predator system where the predator population adopts switching behavior between two prey species at the time of *** the prey population exhibit a strong Allee effect and the predator population is considered to be a generalist *** proposed system is biologically well-defined as the system variables are positive and do not increase abruptly with *** local stability analysis reveals that all the predator-free equilibria are saddle points whereas the prey-free equilibrium is always *** intrinsic growth rates of prey,the strong Allee parameters,and the prey refuge parameters are chosen to be the controlling parameters *** numerical simulation reveals that in absence of one prey,the other prey refuge parameter can change the system dynamics by forming a stable or unstable limit ***,a situation of bi-stability,tri-stability,or even multi-stability of equilibrium points occurs in this *** in presence of the switching effect,the predator chooses prey according to their abundance,so,increasing refuge in one prey population decreases the count of the second prey *** is also observed that the count of predator population reaches a comparatively higher value even if they get one prey population at its fullest quantity and only a portion of other prey ***,in the scarcity of one prey species,switching to the other prey is beneficial for the growth of the predator population.

关键词： Prey-predator model switching effect strong Allee effect prey refuge

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Enhancement of seal life through carbon composite back-up rings under shock loading conditions in defence applications

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Defence Technology（防务技术） 2016年第1期12卷 39-45页

作者： Shankar BHAUMIK A.KUMARASWAMY S.guruprasad R&DE(Engrs.) Pune 411015MaharashtraIndiab defence institute of advanced technology(du) Pune 411025MaharashtraIndia

The life of Nitrile Butadiene Rubber(NBR) O-ring seal having shore hardness of A70 and A90 under shock loading conditions was investigated by a specially designed pneumo-hydraulic shock test rig. Shock tests have been carried out on bare seals, seal with conventional polytetrafluoroethylene(PTFE) back-up rings and seal with newly developed carbon composite back-up rings to study its behaviour under different operating conditions until failure. Experiments were conducted by varying annular gap ranging from 0.3 to 0.5 mm, oil temperature from 30 ℃ to 70 ℃ and rate of pressure rise from 600 to 2400 MPa/s. Significant enhancement in seal life was observed with carbon composite back-up ring at reduced annular clearances compared to seal life with conventional PTFE back-up ring and without back-up rings.

关键词：碳纤维复合材料密封寿命载荷条件冲击试验台压力上升应用国防 O型密封圈

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A Complete Analysis of Clarity(C50)Using I-SIMPA to Maintain Ideal Conditions in an Acoustic Chamber

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Sound & Vibration 2022年第1期56卷 51-64页

作者： R.Adithya Pillai S.Sakthivel Murugan guruprasad Gupta Department of Electrical and Electronics Engineering Sri Sivasubramaniya Nadar College of EngineeringChennai603110India Department of Electronics and Communication Engineering Sri Sivasubramaniya Nadar College of EngineeringChennai603110India

In any closed environment considered,it can be seen that the acoustic parameters are inherently not constant over the entire area *** a closed environment,it is ideally preferred to maintain the acoustic parameters as constant so that there exists better quality of sound leading to better auditory perception with respect to the ***,some of the acoustic parameters like reverberation time and clarity do not strictly pertain to the pattern obtained *** this paper,simulations are carried out using I-SIMPA under different values of Sound Transmission Class(STC),source position,distribution and the chamber dimensions and provides an insight into the behaviour of these acoustic parameters and the appropriate values that have to be infused into the system to build the *** acoustic environment is modelled keeping an actual closed room in mind and testing is done with respect to different values of surface absorption coefficients(practically indicated using Sound Transmission Class)and dimensions to determine ideal conditions.

关键词： Clarity C50 sound source surface receiver sound transmission class STC surface absorption percentages

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Antimalarial drug artesunate affords protection against carrageenan induced acute inflammation in rat

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BIOCELL 2014年第1期38卷 1-5页

作者： Vijay L.KUMAR B.guruprasad Priyanka CHAUDHARY Department of Pharmacology All India Institute of Medical SciencesAnsari NagarNew Delhi-110029India Department of Plant Molecular Biology Delhi University South CampusBenito Juarez RoadDhaula KuanNew Delhi-110021India.

Artesunate, an antimalarial drug, has been shown to inhibit the release of inflammatory mediators in various disease conditions. The present study was carried out to evaluate the anti-edematogenic effect of arte- sunate in the rat paw edema model. Inflammation was induced in the hind paw of rat by sub-plantar injection of 0.1 mL of 0.5% carrageenan and the paw volume was measured up to a fixed mark just before the injection and then after 3 h. The difference in two volumes gave a measure of edema formation. At 3h the level of TNF-α, PGE_(2) and myeloperoxidase were estimated in the inflamed paw tissue. Treatment of rats with single dose of artesunate at 50 and 150 mg/kg produced a dose-dependent inhibition in paw inflammation where a significant reduction in edema volume and mediator release was observed. Our study shows that by inhibiting the release of inflam- matory mediators artesunate affords protection against acute inflammation induced in the rat paw and suggests that it has a potential to be used in the treatment of inflammatory disease conditions.

关键词： Artesunate edema myeloperoxidase TNF-α PGE_(2)

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A case of clozapine-induced skin picking behaviour

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General Psychiatry 2018年第5期31卷 109-110页

作者： Balaswamy Reddy Soumitra Das Srinivas guruprasad Department of Psychiatry National Institute of Mental Health and Neurosciences(NIMHANS)BengaluruKarnatakaIndia G.K.Reddy Hospital KadapaAndhra PradeshIndia

There is some evidence consistently linking the occurrence of de novo obsessive-compulsive disorder(OCD) with clozapine. This skin-picking disorder is also known as impulsive-compulsive disorder-unspecified which with an increasing convergence with OCD has been placed in the current Diagnostic and statistical manual of mental disorders-fifth edition by American Psychiatric Association(DSM-5), in the category of the obsessive-compulsive and related disorders. To the best of our knowledge, there is no literature relating antipsychotics like clozapine with the occurrence of skin-picking behaviour. In this article, we present a case in whom skin-picking behaviour emerged during the upward dose titration of clozapine and was successfully treated with escitalopram.

关键词： impulsive-compulsive disorder-unspecified skin-picking behaviour

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Saponin synthesis and cotton growth is antagonistically regulated by solar UV-B radiation

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Journal of Cotton Research 2018年第3期1卷 30-40页

作者： DEHARIYA Priti KATARIA Sunita guruprasad Kadur Narayan PANDEY Govind Prakash School of Life Sciences Devi Ahilya University School of Biochemistry Devi Ahilya University Shri Vaishnav Vidyapeeth Vishwavidyalaya

Background: Earlier we have reported that the exclusion of solar UV-B increased the growth and yield of cotton plants as compared with ambient UV-B. The UV-B radiation effects on the saponins and the impact of ambient and reduced UV-B on the accumulation of saponins has not been investigated yet. Thus a field experiment was conducted to study the influence of solar UV-B on the growth response and saponin synthesis in cotton(Gossypium hirsutum) var. Vikram plants by the exclusion of UV-B. The cotton plants were grown in specially designed iron chambers, wrapped with filters that excluded UV-B(<315 nm), or transmitted ambient ***: Exclusion of ambient UV-B enhanced the growth of cotton plants in terms of plant height and leaf *** plant height in UV-B excluded plants was due to elongated internode and more number of *** in growth was accompanied by a decrease in the accumulation of saponins, which was quantified by the spectrophotometric, TLC and HPLC methods. Solvent extraction of saponins from the internodes and leaves were used for the bioassay of Amaranthus hypocotyl growth and expansion of cucumber cotyledons. Extracts obtained from the UV-B excluded plants(leaves and internodes) promoted the growth to a larger extent as compared with the extracts obtained from ambient grown ***: The result indicates that solar UV-B may possibly suppress the plant growth by regulating the synthesis of natural growth inhibitor’s like saponin.

关键词： Bioassay Cotton Growth Inhibitor Saponin UV radiation

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Feature-based augmentation and classification for tabular data

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CAAI Transactions on Intelligence Technology 2022年第3期7卷 481-491页

作者： Balachander Sathianarayanan Yogesh Chandra Singh Samant Prahalad S.Conjeepuram guruprasad Varshin B.Hariharan Nirmala Devi Manickam Amrita School of Engineering Amrita Vishwa VidyapeethamCoimbatoreIndia

Generating synthetic samples for a tabular data is a strenuous *** of the time,the columns(features)in the dataset may not follow an ideal distribution *** objective of the proposed algorithm,Histogram Augmentation Technique(HAT),is to generate a dataset whose distribution is similar to that of the original *** augmentation is achieved based on individual columns,where separate algorithms are designed for continuous and discrete *** also use features of an object for *** humans make a judgement,they notice prominent features and characterise the perceived ***,conventional Machine Learning classifiers are designed and trained on the basis of *** the features as the basis for classification,Feature Importance Classifier(FIC)has been attempted in this *** treats every feature independent of each other,and ranks the features based on its dependence with the classified *** has been found that the FIC has the highest accuracy and has improved the accuracy by 5.54%on average,when it's compared to other *** suggested algorithms have been experimented on five datasets and compared with two augmentation algorithms and four state-of-the-art ML classification algorithms.

关键词： function classifier columns

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Repurposing Pirfenidone for Nonalcoholic Steatohepatitis-related Cirrhosis:A Case Series

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Journal of Clinical and Translational Hepatology 2020年第1期8卷 100-105页

作者： Cyriac Abby Philips guruprasad Padsalgi Rizwan Ahamed Rajaguru Paramaguru Sasidharan Rajesh Tom George Pushpa Mahadevan Philip Augustine The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Gastroenterology Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Pathology Al Salam International HospitalBneid Al QarKuwaitIndia Department of Diagnostic and Interventional Radiology Department of Gastroenterology and The Liver UnitCochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Clinical Pathology VPS Lakeshore HospitalKochiKeralaIndia

We repurposed the antifibrotic drug pirfenidone—which is approved for treatment of idiopathic lung fibrosis—in a series of patients with nonalcoholic steatohepatitis-related *** report demonstrates the observed improvements in necroinflammation and regression of cirrhosis with pirfeni-done use for 12-weeks,associated with classical hepatic repair complex features on follow-up liver *** novel work could help stimulate further randomized trials of pirfe-nidone in patients with nonalcoholic steatohepatitis-related liver fibrosis or cirrhosis,for whom no recommended drug treatments exists currently.

关键词： NASH Fibrosis Antifibrotic Hepatitis Pirfenidone

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Growth, photosynthesis and nitrogen metabolism in soybean varieties after exclusion of the UV-B and UV-A/B components of solar radiation

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The Crop Journal 2014年第6期2卷 388-397页

作者： Sanjay Singh Baroniya Sunita Kataria Govind Prakash Pandey Kadur N. guruprasad Government Shri Krishnaji Rao Pawar Post Graduate College Photobiology Laboratory School of Life Sciences Khandwa Road Campus Devi Ahilya University

A field experiment was conducted to study the impact of the exclusion of the solar UV components on growth, photosynthesis and nitrogen metabolism in soybean(Glycine max)varieties PK-472, Pusa-24, JS 71-05, JS-335, NRC-7 and Kalitur. The plants were grown in specially designed UV exclusion chambers wrapped with filters to exclude UV-B or UV-A/B and transmitted all UV. Exclusion of UV significantly enhanced the growth of the aerial parts as well as the growth of the below ground parts in all of the six soybean *** reductase activity(NRA) was significantly reduced, whereas leghemoglobin(Lb)content, total soluble protein, net photosynthesis(Pn) and α-tocopherol content were enhanced after UV exclusion. The exclusion of solar UV-A/B enhanced all parameters to a larger extent than the exclusion of solar UV-B in four of the six varieties of soybean except for NRC-7 and Kalitur. These two varieties responded more to UV-B exclusion compared to UV-A/B exclusion. A significant inverse correlation between the NRA and the number of nodules per plant was observed. The extent of response in all parameters was greater in PK-472 and JS71-05 than that in Kalitur and JS-335 after UV exclusion. The exclusion of UV augmented the growth of nodules, Lb content and α-tocopherol levels and conferred higher rates of Pnto support better growth of nodules. Control plants(+ UV-A/B) seemed to fulfill their N demand through the assimilation of NO-3resulting in lower symbiotic nitrogen fixation and higher NR activity.

关键词： α-Tocopherol Nitrate reductase Nodules Photosynthesis UV exclusion

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