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Ambient air pollution and lung disease in China： health effects, study design approaches and future research

Frontiers of Medicine 2015年第3期9卷 392-400页

作者： Jeffrey H. Mandel Christine Wendt Charles Lo Guangbiao Zhou Marshall Hertz gurumurthy ramachandran University of Minnesota School of Public Health Minneapolis MN 55455 USA University of Minnesota Medical School Veteran 's Administration Hospital Minneapolis MN 55455 USA University of Minnesota Mechanical Engineering Department Minneapolis MN 55455 USA State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences Beij ing 100101 China University of Minnesota Medical School Minneapolis MN 55455 USA

Ambient air pollution in China has worsened following dramatic increases in industrialization, automobile use and energy consumption. Particularly bothersome is the increase in the PM2.5 fraction of pollutants. This fraction has been associated with increasing rates of cardio-respiratory disease in China and elsewhere. Ambient pollutant levels have been described in many of China＇s cities and are comparable to previous levels in southern California. Lung cancer mortality in China has increased since the 1970s and has been higher in men and in urban areas, the exact explanation for which has not been determined. The estimation of individual risk for Chinese citizens living in areas of air pollution will require further research. Occupational cohort and casecontrol designs each have unique attributes that could make them helpful to use in this setting. Other important future research considerations include detailed exposure assessment and the possible use of biomarkers as a means to better understand and manage the threat posed by air pollution in China.

关键词： air pollution PM2.5 lung disease study design epidemiology

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