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Advances in Infectious Diseases 2022年第4期12卷 813-823页

作者： Rohit Mittal Harmel singh Chahal gurpreet singh sandhu University College of Pharmacy Guru Kashi University Talwandi Sabo India Government Polytechnic College for Girls Patiala India Khalsa College of Pharmacy Amritsar India

Coronavirus particles contain four main structural proteins. These are the spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins, all of which are encoded within the 3’ end of the viral genome. The S protein (~150 kDa) utilizes an N-terminal signal sequence to gain access to the ER, and is heavily N-linked glycosylated. In view of the increase in death due to COVID-19 (coronavirus disease), it is important to investigate the potential effects the coronavirus on different organs. A literature search was performed from Elsevier, Pubmed, Springer, and Hindawi, and literature is reviewed using customized search strategies. The search strategy included the following terms Cardiovascular effect, Neurological effect, and kidney. Myocardial damage is a common occurrence in patients with COVID-19 disease hospitalisation. This is characterized by a rise in troponin. Vascular endothelial damage in both small and mid-sized pulmonary vessels was noted together with Disseminated intravascular coagulation (DIC), Deep vein thrombosis (DVT), and Pulmonary embolism (PE), resulting in pulmonary infarction. Liver damage in patients with coronavirus infections might be directly caused by the viral infection of liver cells. Neuronal pathway is an important vehicle for neurotropic viruses to enter the CNS (Central Nervous system). Recent research studies show that apoptosis is implicated in a variety of ocular disorders, including glaucoma, retinitis pigmentosa, cataract development, retinoblastoma, retinal ischemia, diabetic retinopathy, and ocular murine glaucoma. The more the understanding about this new virus and its occurrence, the better the ability of people to cope with it. It’s far hoped that we will conquer COVID-19 soon with the invention of powerful vaccines, pills, and remedies.

关键词： Myocardial Damage Corona Virus Liver Kidney

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Plant based metabolomics:a future prospective and versatile tool for metabolite databases of Curcuma longa

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未来食品学报(英文) 2024年第1期4卷 37-47页

作者： Shuvendhu Gupta Amrat Pal singh gurpreet singh Xianting Ding Alok Sharma Department of Pharmacognosy ISF College of PharmacyMoga 142001India Department of Pharmaceutical Chemistry ISF College of PharmacyMoga 142001India School of Biomedical Engineering Med-X Research InstituteShanghai Jiao Tong UniversityShanghai 200030China

Sophisticated analytical instruments are used for quality evaluation and scientific validation to compliance the Sophisticated analytical instruments are used for quality evaluation and scientific validation to compliance the market ***,increase in demand of Curcuma longa has led to a high swing in small and medium food *** present review is devoted to an in-depth information on metabolite database of *** from different analytical techniques such as high-performance thin-layer chromatography(HPTLC),liquid chromatography-mass spectrometry,gas chromatography-mass spectrometry and nuclear magnetic *** work highlights different extraction methods,phytochemistry along with structure activity relationship,nutritional profiling,market viability and pharmacology of *** bioactives of *** depends on various factors such as plants growth,temperature,humidity,soil type,collection,drying and extraction *** factors can contribute in quality evaluation of the food supplements if need to be *** introduction of omics approaches can helpful to explore the quality and identification of potential lead of *** results could play an essential role in the area of food-phyto based ***,metabolomics techniques may provide a analytical platfom by combination of different"omics"data souces for future esearch to food sand herbal based products.

关键词： Curcuma longa Omics approaches Multidisciplinary method Quality control Metabolomics

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Endometrial stromal sarcoma presenting as multiple primary tumor

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Open Journal of Obstetrics and Gynecology 2013年第1期3卷 58-60页

作者： Rajiv Kumar Saxena gurpreet singh sandhu Karimbanamalayil Madhavi Babu Department of Obstetrics and Gynaecology 12 Air Force Hospital Gorakhpur India Department of Obstetrics and Gynaecology Command Hospital Air Force Bangalore India Department of Obstetrics and Gynaecology Vydehi Institute of Medical Sciences Bangalore India

Endometrial Stromal Sarcoma (ESS) is a rare uterine malignancy. The annual incidence of ESS has been reported as 1 - 2 per million women. In the general population approximately 10 percent of cancer patients may develop a second primary cancer. Synchronous multiple primary tumors constitute only 20% of all multiple primary tumors, and by definition, occur within a period of two month. This case report is presented to document the occurrence of ESS as a “Synchronous Multiple Primary Tumor”, which is an extremely rare event. Previously only one case report has documented such an occurrence. The literature is also briefly reviewed. This case underlines the requirement of a thorough initial evaluation for a patient with a gynecological malignancy and a regular follow-up. Follow-up includes patient education regarding symptoms of any recurrence, physical examination repeated at 6 - 12 monthly interval, along with imaging studies when indicated.

关键词： Endometrial Stromal Sarcoma Synchronous Multiple Primary Tumour Invasive Ductal Breast

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Colloidal quantum dots and two-dimensional material heterostructures for photodetector applications

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Electron 2024年第2期2卷 123-158页

作者： Jingying Luo gurpreet singh Selopal Xin Tong Zhiming Wang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengduChina Department of Engineering Faculty of AgricultureDalhousie UniversityTruroNova ScotiaCanada Key Laboratory of Quantum Physics and Photonic Quantum Information Ministry of EducationUniversity of Electronic Science and Technology of ChinaChengduChina Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhouChina Institute for Advanced Study Chengdu UniversityChengduChina

Photodetectors(PDs)are optoelectronic devices that convert optical signals into electrical ***,there has been a tremendous increase in research interest in PDs based on colloidal quantum dots(QDs)and two-dimensional(2D)material heterostructures owing to the strong light-absorption capacity and the well-adjustable band gap of QDs and the superior charge carriers transfer ability of 2D *** particular,the heterojunction formed between QDs and 2D materials can effectively enhance the separation and transport of photogenerated charge carriers,which is expected to establish PDs with ultrahigh photoconductive gain,high responsivity,and *** review aimed to summarize the state-of-the-art advances in the research of QDs/2D material nanohybrid PDs,including the device parameters,archi-tectures,working mechanisms,and fabrication *** prog-ress of hybrid PDs based on the heterojunction of QDs with different 2D materials,along with their innovative applications,are comprehensively *** the end,the challenges and feasible strategies in future research and development are briefly proposed.

关键词： heterostructures photodetectors quantum dots two-dimensional materials

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Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1835-1844页

作者： Simcha Weissman Muhammad Aziz Ayrton Bangolo Vignesh K Nagesh Htat Aung Midhun Mathew Lino Garcia Shiva A Chandar Praveena Karamthoti Harinder Bawa Aseel Alshimari Yabets Kejela Nazish Mehdi Chrishanti A Joseph Athri Kodali Rohan Kumar Priya Goyal Sanya Satheesha Fnu Nivedita Nicole Tesoro Tanni Sethi gurpreet singh Areej Belal Alina Intisar Hirra Khalid Samuel Cornwell Suchith B Suresh Kareem Ahmed Karabo K Marole Om P Anand Rahat B Reshi Tej I Mehta Sameh Elias Joseph D Feuerstein Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOH 43614United States Department of Medicine University of WashingtonSeattleWA 98195United States Department of Radiology Johns Hopkins University HospitalBaltimoreMD 21218United States Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States

BACKGROUND Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn’s disease(CD)remains *** To systematically review the global variation in the rates of surgery in *** A comprehensive search analysis was performed using multiple electronic databases from inception through July 1,2020,to identify all full text,randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with *** included continent based demographic data,CD surgery rates over time,as well as the geoepidemiologic variation in CD surgery *** analyses were conducted using *** Twenty-three studies spanning four continents were *** median proportion of persons with CD who underwent gastrointestinal surgery in studies from North America,Europe,Asia,and Oceania were 30%(range:1.7%-62.0%),40%(range:0.6%-74.0%),17%(range:16.0%-43.0%),and 38%*** clear association was found regarding the proportion of patients undergoing gastrointestinal surgery over time in North America(R^(2)=0.035)and Europe(R^(2)=0.100).A moderate,negative association was seen regarding the proportion of patients undergoing gastrointestinal surgery over time(R^(2)=0.520)in *** There appears to be significant inter-continental variation regarding surgery rates in *** evidencebased guidelines accounting for the geographic differences in managing patients with CD is ***,as a paucity of data on surgery rates in CD exists outside the North American and European continents,future studies,particularly in less studied locales,are warranted.

关键词： Gastrointestinal surgery Crohn’s disease Geoepidemiology Inflammatory bowel disease Prevalence

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Experimental investigation into the effects of Argemone biodiesel/diesel blends on cyclic variations in a multi-cylinder CRDI engine

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Clean Energy 2023年第2期7卷 363-374页

作者： Abhinav Sharma Prem Kumar Sarbjot singh sandhu Mandeep singh Department of Mechanical Engineering Dr B R Ambedkar National Institute of TechnologyJalandhar-144011PunjabIndia

Internal combustion engines suffer from high cyclic variations that result in higher emissions,lower efficiency,higher fuel consump-tion and poor *** purpose of this study is to investigate how Argemone mexicana biodiesel(AGB)/diesel blended fuels affect the cyclic variability of combustion parameters such as maximum cylinder pressure(Pmax)and indicated mean effective pressure(IMEP)in a four-cylinder turbocharged intercooled common-rail direct injection engine under various engine loading *** chemical and physical properties of AGB produced from *** oil were measured and compared according to the ASTM D6751 *** various volumetric ratios,AGB and diesel fuel were blended as D100,AB10(10%AGB+90%D100),AB20(20%AGB+80%D100)and AB30(30%AGB+70%D100).The IMEP and Pmax time-series data were collected over 200 consecutive cycles at low,partial and high engine loads at a constant engine speed of 2000 *** coefficients of variation(COV)of combustion parameters(Pmax and IMEP)were measured for different AGB/diesel blends and found to be within acceptable *** results show that COV_(Pmax) and COV_(IMEP) decrease as the engine load *** was observed that at low load,AB10 has the lowest COV(Pmax,IMEP),and at partial and high load,AB20 has the lowest COV(Pmax,IMEP)among all the blends.

关键词： indicated mean effective pressure cyclic variations biodiesel diesel engine Argemone mexicana biodiesel

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Genetic Variation for Anaerobic Germination and Emergence from Deeper Soil Depth in Oryza nivara Accessions

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Rice science 2022年第4期29卷 304-308页

作者： Revanayya MGOTHE Dharminder BHATIA Akashdeep KAMBOJ Nitika sandhu Buta singh DHILLON Department of Plant Breeding and Genetics Punjab Agricultural UniversityLudhiana 141004India School of Agricultural Biotechnology Punjab Agricultural UniversityLudhiana 141004India

Anaerobic germination and emergence from deeper soil depth are two important traits for breeding rice suitable for direct seeded *** order to evaluate genetic variation for these traits,a total of 300 Oryza nivara accessions were evaluated along with checks,of which,159 accessions germinated under anaerobic conditions indicating presence of immense variability in *** 159 accessions,69 germinated in submerged conditions and 90 germinated after removing water with availability of aerobic conditions,indicating two different mechanisms operating in ***,out of 300 *** accessions,218 germinated from 6 cm and 95 germinated from 8 cm soil *** accessions that germinated from deeper soil depth had longer mesocotyl and coleoptile lengths.

关键词： soil breeding removing

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In situ and operando infrared spectroscopy of battery systems:Progress and opportunities

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能源化学:英文版 2023年第6期81卷 472-491,I0011页

作者： Murilo M.Amaral Carla G.Real Victor Y.Yukuhiro Gustavo Doubek Pablo S.Fernandez gurpreet singh Hudson Zanin Advanced Energy Storage Division Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasCampinasSP 13083-852Brazil Alan Levin Department of Mechanical and Nuclear Engineering Kansas State UniversityManhattanKS 66506USA Chemistry Institute Center for Innovation on New EnergiesUniversity of CampinasCampinasSP 13083-970Brazil Advanced Energy Storage Division Center for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasCampinasSP 13083-852Brazil

In situ and operando infrared spectroscopies are powerful techniques to support the design of novel materials for batteries and the development of new battery *** techniques can support the study of batteries by identifying the formation of new species and monitoring electrochemical energy ***,few works have employed these techniques,which can be used to investigate various materials,including systems beyond lithium-ion technology,in the research of ***,this review presents a comprehensive overview focusing on the main contributions of in situ and operando infrared spectroscopy for lithium-ion batteries(LIBs)and other battery *** techniques can successfully identify the formation of species during the electrolyte reduction,electrode degradation,and the formation of the solid-electrolyte interphase(SEI)*** these outcomes,it is possible to conclude that this characterization approach should be employed as a protocol to overcome remaining issues in batteries,consequently supporting battery *** review aims to be a guide on how infrared spectroscopy can contribute to monitoring battery systems and to lead researchers interested in applying this technique.

关键词： In situ spectroscopy Operando spectroscopy FTIR Spectro-electrochemical cells Batteries

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Cardiovascular implications of inflammatory bowel disease: An updated review

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World Journal of Cardiology 2023年第11期15卷 553-570页

作者： Arshia Bhardwaj Arshdeep singh Vandana Midha Ajit Sood gurpreet singh Wander Bishav Mohan Akash Batta Department of Gastroenterology Dayanand Medical College and HospitalPunjabLudhiana 141001India Department of Internal Medicine Dayanand Medical College and HospitalPunjabLudhiana 141001India Department of Cardiology Dayanand Medical College and HospitalPunjabLudhiana 141001India

Emerging data highlights the heightened risk of atherosclerotic cardiovascular diseases(ASCVD)in patients with chronic inflammatory disorders,particularly those afflicted with inflammatory bowel disease(IBD).This review delves into the epidemiological connections between IBD and ASCVD,elucidating potential underlying ***,it discusses the impact of current IBD treatments on cardiovascular ***,the cardiovascular adverse effects of novel small molecule drugs used in moderate-to-severe IBD are investigated,drawing parallels with observations in patients with rheumatoid *** article aims to comprehensively evaluate the existing evidence supporting these *** achieve this,we conducted a meticulous search of PubMed,spanning from inception to August 2023,using a carefully selected set of *** search encompassed topics related to IBD,such as Crohn’s disease and ulcerative colitis,as well as ASCVD,including coronary artery disease,cardiovascular disease,atrial fibrillation,heart failure,conduction abnormalities,heart blocks,and premature coronary artery *** review encompasses various types of literature,including retrospective and prospective cohort studies,clinical trials,meta-analyses,and relevant guidelines,with the objective of providing a comprehensive overview of this critical intersection of inflammatory bowel disease and cardiovascular health.

关键词： Inflammatory bowel diseases Cardiovascular disorders Pericarditis myocarditis Thromboembolism Chronic inflammation Oxidative stress Endothelial dysfunction

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A genetic algorithm based improved optimal sizing strategy for solar-wind-battery hybrid system using energy filter algorithm

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Frontiers in Energy 2020年第1期14卷 139-151页

作者： Aeidapu MAHESH Kanwarjit singh sandhu Department of Electrical Engineering National Institute of TechnologyKurukshetra136119India

In this paper,the genetic algorithm(GA)is applied to optimize a grid connected solar photovoltaic(PV)-wind-battery hybrid system using a novel energy filter *** main objective of this paper is to minimize the total cost of the hybrid system,while maintaining its *** with the reliability constraint,some of the important parameters,such as full utilization of complementary nature of PV and wind systems,fluctuations of power injected into the grid and the battery’s state of charge(SOC),have also been considered for the effective sizing of the hybrid system.A novel energy filter algorithm for smoothing the power injected into the grid has been *** validate the proposed method,a detailed case study has been *** results of the case study for different cases,with and without employing the energy filter algorithm,have been presented to demonstrate the effectiveness of the proposed sizing strategy.

关键词： PV-wind-battery hybrid system size optimization genetic algorithm

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