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Endoscopic management of postcholecystectomy biliary leakage

Hepatobiliary & Pancreatic Diseases International 2010年第4期9卷 409-413页

作者： Virendra singh Gurpreet Singh Ganga R Verma Rajesh Gupta Departments of Hepatology Postgraduate Institute of Medical Education and Research Departments of Surgery Postgraduate Institute of Medical Education and Research

BACKGROUND: Biliary leak is an uncommon but significant complication following cholecystectomy. Endotherapy is an established method of treatment. However, the optimal intervention is not known. METHOD: Eighty-five patients with postcholecystectomy biliary leaks from July 2000 to March 2009 were retrospectively evaluated. RESULTS: The study population was 20 males and 65 females with a mean age of 42.47 years. Patients presented with abdominal pain (46), jaundice (23), fever (23), abdominal distension (42), or bilious abdominal drain (67). Endoscopic retrograde cholangiopancreatography detected a leak at the cystic duct stump in 45 patients, stricture with middle common bile duct leak in 4, leak from the right hepatic duct in 3, and a ligated common bile duct in 32. Twelve also had bile duct stones. One had a broken T-tube with stones Endotherapy was possible in 53 patients. Three patients with stones, one with a broken T-tube with stones, and 4 with stricture of the common bile duct with a leak were managed with sphincterotomy and stenting. Eight patients with a cystic duct stump leak with stones were managed with sphincterotomy and stone extraction. Three outpatients and 12 inpatients with a cystic duct stump leak were managed with sphincterotomy and stent and sphincterotomy and nasobiliary drain, respectively. Five patients with a cystic duct stump leak were managed with stenting. Sixteen with coagulopathy were managed with only nasobiliary drain (9) or stent (7). Leak closure was achieved in 100% patients Four developed mild pancreatitis which improved with conservative treatment.CONCLUSIONS: Endoscopic intervention is a safe and effective method of treatment of postcholecystectomy biliary leaks. However, management should be individualized based on factors such as outpatients or inpatients, presence of stone, stricture, ligature, or coagulopathy.

关键词： biliary fistulae endoscopic retrograde cholangiopancreatography sphincterotomy biliary stent nasobiliary drain biliary strictures

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Beyond Graphene Anode Materials for Emerging Metal Ion Batteries and Supercapacitors

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Nano-Micro Letters 2018年第4期10卷 228-254页

作者： Santanu Mukherjee Zhongkan Ren Gurpreet Singh Department of Mechanical and Nuclear Engineering Kansas State University

Intensive research effort is currently focused on the development of efficient, reliable, and environmentally safe electrochemical energy storage systems due to the ever-increasing global energy storage demand. Li ion battery systems have been used as the primary energy storage device over the last three decades. However, low abundance and uneven distribution of lithium and cobalt in the earth crust and the associated cost of these materials, have resulted in a concerted effort to develop beyond lithium electrochemical storage systems. In the case of non-Li ion rechargeable systems, the development of electrode materials is a significant challenge, considering the larger ionic size of the metal-ions and slower kinetics. Two-dimensional(2D) materials, such as graphene, transition metal dichalcogenides, MXenes and phosphorene, have garnered significant attention recently due to their multi-faceted advantageous properties: large surface areas, high electrical and thermal conductivity, mechanical strength, etc. Consequently, the study of 2D materials as negative electrodes is of notable importance as emerging non-Li battery systems continue to generate increasing attention. Among these interesting materials, graphene has already been extensively studied and reviewed, hence this report focuses on 2D materials beyond graphene for emerging non-Li systems. We provide a comparative analysis of 2D material chemistry, structure, and performance parameters as anode materials in rechargeable batteries and supercapacitors.

关键词： Two-dimensional materials Transition metal dichalcogenides MXene Exfoliation Top-down Anodes

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Contrast-free air cholangiography-assisted unilateral plastic stenting in malignant hilar biliary obstruction

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Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 88-92页

作者： Virendra singh Gurpreet Singh Vikas Gupta Rajesh Gupta Rakesh Kapoor Departments of Hepatology Postgraduate Institute of Medical Education and Research Departments of Surgery Postgraduate Institute of Medical Education and Research Departments of Radiotherapy Postgraduate Institute of Medical Education and Research

BACKGROUND:Endoscopic palliation in malignant hilar biliary obstruction requires endoscopic retrograde cholangiopancreatography (ERCP),whereas contrast injection leads to cholangitis.Contrast-free metal stenting with or without magnetic resonance cholangiopancreatography (MRCP) has shown encouraging results,but MRCP and metal stents are costly.There have been no reports on the use of air cholangiography.METHODS:We prospectively evaluated the role of air cholangiography-assisted unilateral plastic stenting in 10 patients with type Ⅱ malignant hilar biliary obstruction.A retrospectively analysed group of 10 patients treated with contrast-free unilateral metal stenting served as historical controls.RESULTS:Ten patients with unresectable type Ⅱ malignant hilar biliary obstruction were studied.Air cholangiography detected type Ⅱ obstruction in all patients,similar to MRCP.The patients underwent unilateral stenting.Successful endoscopic drainage was achieved in all patients.The mean patency of the stent was 95.8±17.5 days in the study group and 143.9±115.1 days in the control group (P=0.20).The mean survival was 121.8±41.6 days in the study group and 154.9±122.5 days in the control group (P=0.42).KaplanMeier analysis showed an estimated median survival of 100:95% CI (65.9,134.1) days in the study group and 98:95% CI (84.1,111.9) days in the control group (P=0.62).Cholangitis occurred in none of the patients and there were no 30-day deaths nor major complications.Air cholangiographyassisted unilateral plastic stenting was cheaper than contrastfree unilateral metal stenting.CONCLUSION:Air cholangiography-assisted unilateral plastic stenting is as safe and effective as contrast-free unilateral metal stenting in type Ⅱ malignant hilar biliary obstruction for palliating patients,but it is cheaper.

关键词： air cholangiogram hilar obstruction malignant plastic stent metal stent unilateral

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Plant based metabolomics:a future prospective and versatile tool for metabolite databases of Curcuma longa

未来食品学报(英文)

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未来食品学报(英文) 2024年第1期4卷 37-47页

作者： Shuvendhu Gupta Amrat Pal singh Gurpreet Singh Xianting Ding Alok Sharma Department of Pharmacognosy ISF College of PharmacyMoga 142001India Department of Pharmaceutical Chemistry ISF College of PharmacyMoga 142001India School of Biomedical Engineering Med-X Research InstituteShanghai Jiao Tong UniversityShanghai 200030China

Sophisticated analytical instruments are used for quality evaluation and scientific validation to compliance the Sophisticated analytical instruments are used for quality evaluation and scientific validation to compliance the market demands.Recently,increase in demand of Curcuma longa has led to a high swing in small and medium food industry.The present review is devoted to an in-depth information on metabolite database of C.longa from different analytical techniques such as high-performance thin-layer chromatography(HPTLC),liquid chromatography-mass spectrometry,gas chromatography-mass spectrometry and nuclear magnetic resonance.This work highlights different extraction methods,phytochemistry along with structure activity relationship,nutritional profiling,market viability and pharmacology of C.longa.The bioactives of C.longa depends on various factors such as plants growth,temperature,humidity,soil type,collection,drying and extraction process.These factors can contribute in quality evaluation of the food supplements if need to be included.The introduction of omics approaches can helpful to explore the quality and identification of potential lead of C.longa.The results could play an essential role in the area of food-phyto based profiling.Further,metabolomics techniques may provide a analytical platfom by combination of different"omics"data souces for future esearch to food sand herbal based products.

关键词： Curcuma longa Omics approaches Multidisciplinary method Quality control Metabolomics

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In situ and operando infrared spectroscopy of battery systems:Progress and opportunities

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能源化学:英文版 2023年第6期81卷 472-491,I0011页

作者： Murilo M.Amaral Carla G.Real Victor Y.Yukuhiro Gustavo Doubek Pablo S.Fernandez Gurpreet Singh Hudson Zanin Advanced Energy Storage Division Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasCampinasSP 13083-852Brazil Alan Levin Department of Mechanical and Nuclear Engineering Kansas State UniversityManhattanKS 66506USA Chemistry Institute Center for Innovation on New EnergiesUniversity of CampinasCampinasSP 13083-970Brazil Advanced Energy Storage Division Center for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasCampinasSP 13083-852Brazil

In situ and operando infrared spectroscopies are powerful techniques to support the design of novel materials for batteries and the development of new battery systems.These techniques can support the study of batteries by identifying the formation of new species and monitoring electrochemical energy stability.However,few works have employed these techniques,which can be used to investigate various materials,including systems beyond lithium-ion technology,in the research of batteries.Therefore,this review presents a comprehensive overview focusing on the main contributions of in situ and operando infrared spectroscopy for lithium-ion batteries(LIBs)and other battery systems.These techniques can successfully identify the formation of species during the electrolyte reduction,electrode degradation,and the formation of the solid-electrolyte interphase(SEI)layer.From these outcomes,it is possible to conclude that this characterization approach should be employed as a protocol to overcome remaining issues in batteries,consequently supporting battery research.This review aims to be a guide on how infrared spectroscopy can contribute to monitoring battery systems and to lead researchers interested in applying this technique.

关键词： In situ spectroscopy Operando spectroscopy FTIR Spectro-electrochemical cells Batteries

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Multiple-order line rogue wave,lump and its interaction,periodic,and cross-kink solutions for the generalized CHKP equation

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Propulsion and Power Research 2021年第3期10卷 277-293页

作者： Yufeng Qian Jalil Manafian Sherin Youns Mohyaldeen Liqaa S.Esmail Sergey Alekseevich Gorovoy Gurpreet Singh School of Science Hubei University of TechnologyWuhan430068China Department of Applied Mathematics Faculty of Mathematical SciencesUniversity of TabrizTabrizIran Natural Sciences Faculty Lankaran State University50H.Aslanov Str.LankaranAzerbaijan Business Administration Department Zakho Technical InstituteDuhok Polytechnic UniversityKurdistan RegionIraq Pharmacy Department Duhok Technical InstituteDuhok Ploytechnic UniversityKurdistan RegionIraq Department of Machine Repair and Materials Science Kuban State Agrarian University Named After I.T.TrubilinKrasnodarRussian Federation Department of Mathematics Sant Baba Bhag Singh UniversitiyJalandhar144030India

The multiple-order line rogue wave solutions method is emp loyed for searching the multiple soliton solutions for the generalized(2+1)-dimensional Camassa-HolmKadomtsev-Petviashvili(CHKP)equation,which contains first-order,second-order,and third-order waves solutions.At the critical point,the second-order derivative and Hessian matrix for only one point will be investigated and the lump solution has one minimum value.For the case,the lump solution will be shown the bright-dark lump structure and for another case can be present the dark lump structure-two small peaks and one deep hole.Also,the interaction of lump with periodic waves and the interaction between lump and soliton can be obtained by introducing the Hirota forms.In the meanwhile,the cross-kink wave and periodic wave solutions can be gained by the Hirota operator.The physical phenomena of these gained multiple soliton solutions are analyzed and indicated in figures by selecting suitable values.We alternative offer that the determining method is general,impressive,outspoken,and powerful and can be exerted to create exact solutions of various kinds of nonlinear models originated in mathematical physics and engineering.

关键词： Multiple rogue wave solutions Multiple soliton solutions Generalized CamassaHolm-KadomtsevPetviashvili equation Lump solution Hirota operator

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Cardiovascular implications of inflammatory bowel disease: An updated review

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World Journal of Cardiology 2023年第11期15卷 553-570页

作者： Arshia Bhardwaj Arshdeep singh Vandana Midha Ajit Sood Gurpreet Singh Wander Bishav Mohan Akash Batta Department of Gastroenterology Dayanand Medical College and HospitalPunjabLudhiana 141001India Department of Internal Medicine Dayanand Medical College and HospitalPunjabLudhiana 141001India Department of Cardiology Dayanand Medical College and HospitalPunjabLudhiana 141001India

Emerging data highlights the heightened risk of atherosclerotic cardiovascular diseases(ASCVD)in patients with chronic inflammatory disorders,particularly those afflicted with inflammatory bowel disease(IBD).This review delves into the epidemiological connections between IBD and ASCVD,elucidating potential underlying mechanisms.Furthermore,it discusses the impact of current IBD treatments on cardiovascular risk.Additionally,the cardiovascular adverse effects of novel small molecule drugs used in moderate-to-severe IBD are investigated,drawing parallels with observations in patients with rheumatoid arthritis.This article aims to comprehensively evaluate the existing evidence supporting these associations.To achieve this,we conducted a meticulous search of PubMed,spanning from inception to August 2023,using a carefully selected set of keywords.The search encompassed topics related to IBD,such as Crohn’s disease and ulcerative colitis,as well as ASCVD,including coronary artery disease,cardiovascular disease,atrial fibrillation,heart failure,conduction abnormalities,heart blocks,and premature coronary artery disease.This review encompasses various types of literature,including retrospective and prospective cohort studies,clinical trials,meta-analyses,and relevant guidelines,with the objective of providing a comprehensive overview of this critical intersection of inflammatory bowel disease and cardiovascular health.

关键词： Inflammatory bowel diseases Cardiovascular disorders Pericarditis myocarditis Thromboembolism Chronic inflammation Oxidative stress Endothelial dysfunction

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Natural history and outcomes of patients with liver cirrhosis complicated by hepatic hydrothorax

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World Journal of Gastroenterology 2022年第35期28卷 5175-5187页

作者： Sarah Romero Andy KH Lim Gurpreet Singh Chamani Kodikara Rachel Shingaki-Wells Lynna Chen Samuel Hui Marcus Robertson Department of Gastroenterology Monash HealthClayton 3168VictoriaAustralia Department of General Medicine School of Clinical SciencesMonash UniversityClayton 3168VictoriaAustralia Gastroenterology and Liver Transplant Unit Austin HealthHeidelberg 3084VictoriaAustralia

BACKGROUNDHepatic hydrothorax (HH) is an uncommon and difficult-to-manage complicationof cirrhosis with limited treatment options.AIMTo define the clinical outcomes of patients presenting with HH managed withcurrent standards-of-care and to identify factors associated with mortality.METHODSCirrhotic patients with HH presenting to 3 tertiary centres from 2010 to 2018 wereretrospectively identified. HH was defined as pleural effusion in the absence ofcardiopulmonary disease. The primary outcomes were overall and transplant-freesurvival at 12-mo after the index admission. Cox proportional hazards analysiswas used to determine factors associated with the primary outcomes.RESULTSOverall, 84 patients were included (mean age, 58 years) with a mean model forend-stage liver disease score of 29. Management with diuretics alone achievedlong-term resolution of HH in only 12% patients. At least one thoracocentesis wasperformed in 73.8% patients, transjugular intrahepatic portosystemic shuntinsertion in 11.9% patients and 33% patients received liver transplantation within12-mo of index admission. Overall patient survival and transplant-free survival at12 mo were 68% and 41% respectively. At multivariable analysis, current smoking [hazard ratio (HR) = 8.65, 95% confidence interval (CI): 3.43-21.9, P < 0.001) and acute kidneyinjury (AKI) (HR = 2.91, 95%CI: 1.21-6.97, P = 0.017) were associated with a significantly increasedrisk of mortality.CONCLUSIONCirrhotic patients with HH are a challenging population with a poor 12-mo survival despitecurrent treatments. Current smoking and episodes of AKI are potential modifiable factors affectingsurvival. HH is often refractory of diuretic therapy and transplant assessment should beconsidered in all cases.

关键词： Cirrhosis Portal hypertension Hepatic hydrothorax Ascites Liver transplantation

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实现优质诊断的五大策略

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英国医学杂志中文版 2022年第6期25卷 353-356页

作者： Hardeep singh Denise M Connor gurpreet Dhaliwal 蒋子涵(译) Center for Innovations in Quality Effectiveness and SafetyMichael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine HoustonTXUSA Department of Medicine University of California San FranciscoSan FranciscoCAUSA Medical Service San Francisco Veterans Affairs Medical CenterSan FranciscoCAUSA 中国医学科学院阜外医院心内科

优质的诊断是衡量高水平医疗的重要指标。然而,诊断错误(diagnostic errors)仍是全世界共同的医疗问题,损害着全球患者的健康1-2。诊断错误的定义为:未能准确且及时地做出诊断,或未能将这些疾病信息充分、有效地与患者沟通。英国最近的... 详细信息

优质的诊断是衡量高水平医疗的重要指标。然而,诊断错误(diagnostic errors)仍是全世界共同的医疗问题,损害着全球患者的健康1-2。诊断错误的定义为:未能准确且及时地做出诊断,或未能将这些疾病信息充分、有效地与患者沟通。英国最近的一项研究显示,4.3%的基层诊疗过程中会出现诊断错误3。而另一项meta分析显示,在美国每年有近25万起诊断错误事件对住院的成人患者造成了伤害4。美国国家科学、工程与医学研究院在报告《改进医疗保健中的诊断质量》中强调,大多数人一生中会至少经历一次诊断错误1。世界卫生组织也已将减少诊断错误作为提高全球患者安全的优先事项5。

关键词：诊断错误 meta分析诊断质量医学研究院医疗保健五大策略成人患者疾病信息

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Co-administration of rlpaB domain of Shigella with rGroEL of s. Typhi enhances the immune responses and protective efficacy against Shigella infection

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Cellular & Molecular Immunology 2015年第6期12卷 757-767页

作者： Sekar Tamil Selvi Chitradevi gurpreet Kaur Sivaramakrishna Uppalapati Anandprakash Yadav Dependrapratap singh1 Anju Bansal Division of Experimental Biology Defence Institute of Physiology and Allied Sciences Delhi India Division of Microbiology Defence Food Research Laboratory Mysore India Division of Immunomodulation Defence Institute of Physiology and Allied Sciences Delhi India

Shigella species cause severe bacillary dysentery in humans and are associated with high morbidity and mortality. The Invasion plasmid antigen （IpaB） protein, which is conserved across all Shigella spp., induces macrophage cell death and is required to invade host cells. The present study evaluates the immunogenicity and protective efficacy of the recombinant （r） domain region of IpaB （rlpaB） of S. flexneri, rlpaB was administered either alone or was co-administered with the rGroEL （heat shock protein 60） protein from S. Typhi as an adjuvant in a mouse model of intranasal immunization. The IpaB domain region （37 kDa） of S. flexneriwas amplified from an invasion plasmid, cloned, expressed in BL21 Escherichia colicells and purified. Immunization with the rlpaB domain alone stimulated both humoral and cell-mediated immune responses. Furthermore, robust antibody （IgG, IgA） and T-cell responses were induced when the rlpaB domain was co-administered with rGroEL. Antibody isotyping revealed higher IgG 1 and IgG2a antibody titers and increased interferon-gamma （IFN-γ） secretion in the co-administered group. Immunization of mice with the rlpaB domain alone protected 60%-70% of the mice from lethal infection by S. flexneri, S. boydiiand S. sonnei, whereas co-administration with rGroEL increased the protective efficacy to 80%-85%. Organ burden and histopathological studies also revealed a significant reduction in lung infection in the co-immunized mice compared with mice immunized with the rlpaB domain alone. This study emphasizes that the co-administration of the rlpaB domain and rGroEL protein improves immune responses in mice and increases protective efficacy against Shigella infection. This is also the first report to evaluate the potential of the GroEL （Hsp 60） protein of S. Typhi as an adjuvant molecule, thereby overcoming the need for commercial adjuvants.

关键词： GroEL heat shock protein IpaB Shigella S. Typhi

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