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Acta Pharmacologica Sinica 2003年第4期 10-14+96页

作者： yk gupta,Geeta CHAUDHARY Department of Pharmacology All India Institute of Medical Sciences New Delhi 110029 India Neuropharmacology Laboratory Department of Pharmacology All India Institute of Medical Sciences New Delhi 110029 India

AIM: To study the effect of pretreatment with different antiemetic drugs on the motion sickness-induced inhibition in gastric emptying. METHODS: The rats were rotated for a period of 45 min at the rate of 30 rotations per min. RESULTS: Rotating the rats caused a significant decrease in gastric emptying as compared to the non-rotated group. Pretreatment with scopolamine (5 mg/kg, ip) did not reverse the delay in gastric emptying, while it per se caused inhibition of gastric emptying in the non-rotated group. Similarly other drugs mepyramine, cisapride, and granisetron did not have any effect on delay in gastric emptying caused by rotation. However beta blocker propranolol could partially but significantly reverse the decrease in gastric emptying. CONCLUSION: The present study demonstrated the potential use of propranolol as adjuvant with conventional antiemetics for motion sickness to combat associated secondary symptoms.

关键词：胃排空晕动病西沙必利东莨菪碱普萘洛尔:美吡拉敏大鼠

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A NEW REVERSE PHASE HPLC METHOD FOR EXTRACTION,SEPARATION AND QUANTIFICATION OF MELATONIN,CARBAMAZEPINE EPOXIDE AND CARBAMAZEPINE SIMULTANEOUSLY IN SERUM SAMPLES.

A NEW REVERSE PHASE HPLC METHOD FOR EXTRACTION,SEPARATION AN...

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第十五届国际药理学大会

作者： gupta Madhur Kohli K gupta yk All India Institute of Medical Sciences New DelhiIndia. Lady hardinge Medical college New delhiIndia. All India Institute of Medical Sciences New DelhiIndia.

＜正＞ Carbamazepine is one of the commonly prescribed anticonvulsant in India. The active metabolite of carbamazepine - carbamazepine - 10 - 11 epoxide and recently,the pineal hormone,melatonin have also exhibited anticonvulsant effects. Waters millennium 2010 chromatography manager with a 515 HPLC pump and Waters 24879 dual absorbance UV detector was used. A 25 μ l of sample and standard were injected,and the contents of melatonin. carbamazepine epoxide and carbamazepine calculated. Chromatographic separation was achieved by Merck C18 reverse phase. It was quantitated subsequently by exposure to UV light at 210 nm. The retention tomes of melatonin. CBZ epoxide. and CBZ were 6.3 min. 7. 5 min. and 13. 9 min respectively. The Mobile Phase consisted of Water: Acetonitrile（70:30） at pH 3.0 adjusted with Orthophosphoric acid at the flow rate of 1ml/min. Standard curves of carbamazepine. carbamazepine epoxide. and melatonin were obtained. The Limits of detection of melatonin is about 800pg;carbamazepine epoxide 500pg and carbamazepine 1300pg. A new HPLC method has been developed for simultaneous extraction,separation and quantification of melatonin. carbamazepine epoxide and carbamazepine in serum samples.

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Effect of vine shoot extract-vineatrol against pentylenetetrazole induced seizures in rats

Effect of vine shoot extract-vineatrol against pentylenetetr...

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第十五届国际药理学大会

作者： Sharma Monisha Briyal Seema gupta yk. Department of Pharmacology All India Institute of Medical Sciences New Delhi - 110029 Department of Pharmacology All India Institute of Medical Sciences New Delhi - 110029 Department of Pharmacology All India Institute of Medical Sciences New Delhi - 110029

＜正＞ The effect of vineatrol. a polyphenolic compound with potent antioxidant activity was investigated against pentylenetetrazole （ PTZ） induced seizures in rats. Vineatrol at doses of 10. 20 and 40 mg/kg i. p. 20 min prior to convulsive challenge of PTZ （60 mg/kg, i.p.）, dose dependently increased the initial latency and reduced the percent incidence of generalized tonic clonic convulsions. There was insignificant difference between the initial latencies and percent incidence of convulsions of the PTZ （60 mg/kg）, i.p and the vehicle treated PTZ rats. Pretreatment of vineatrol at the doses 10 and 20 mg/kg, i. p significantly （p ＜ 0. 05） increased the initial latency of seizures in vehicle treated PTZ rats. The values being 115±5 and 345±45 s as compared to vehicle treated PTZ rats （81.6±11.4 s） respectively. The percent incidence of generalized tonic clonic convulsions was also significantly （p ＜ 0.05） reduced in the vineatrol treated groups as compared to the vehicle treated PTZ rats （100% ）. Vineatrol at the dose of 40 mg/kg offered 100 % protection against PTZ induced seizures in rats. The findings of the present study suggest that potential anti convulsant activity of vineatrol.

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Single dose pharmacokinetic study of thalidomide in patients with multiple myeloma.

Single dose pharmacokinetic study of thalidomide in patients...

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第十五届国际药理学大会

作者： Pathak A Malhotra J Raina V Arya DS gupta yk Department of Pharmacology All India Institute of Medical SciencesNew DelhiIndia-110029 Department of Pharmacology All India Institute of Medical SciencesNew DelhiIndia-110029 Department of Medical Oncology BRAIRCHAll India Institute of Medical SciencesNew DelhiIndia-110029. Department of Pharmacology All India Institute of Medical SciencesNew DelhiIndia-110029 Department of Pharmacology All India Institute of Medical SciencesNew DelhiIndia-110029

＜正＞ Thalidomide has recently been approved for use in patients of multiple myeloma （MM） in India, however the pharmacokinetic data in such patients is lacking. Therefore, a single dose pharmacokinetic study of thalidomide in MM patients was carried out. Nine MM patients satisfying the inclusion criteria were enrolled. After 10h fasting, thalidomide 200mg was administered and blood samples （0. 5ml） were withdrawn at 0, 0.5, 1, 1.5, 3. 4, 6, 8, 12, 24 and 30h in tubes containing citrate phosphate dextrose adenine solution. Twenty-four hours urine samples were collected in a container with 5 ml HC1, and thoroughly mixed. The thalidomide concentrations in plasma and urine were determined by a reverse phase HPLC assay developed by us. Based on single compartmental model, the pharmacokinetic parameters are Cmax 879.7±124 ng/ml, Tmax 4.8±0. 4h, κel 0.13±0.04/h and t1/2of 7.4±1.07h. The Vdand CL are202.1±37 1 and25. 4 l/h respectively, while 24h urinary excretion was 2.57±1.19mg. The high values of Vd and CL in our study can be attributed to a significant tissue distribution of thalidomide in MM patients.

关键词： Thalidomide Multiple myeloma Pharmacokinetics.

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