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r＇ranscriptome assembly strategies for ）recision medicine

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Frontiers of Electrical and Electronic Engineering in China 2017年第4期5卷 280-290页

作者： lu Wang Lipi Acharya Changxin Bai Dongxiao Zhu department of Computer Science Wayne State University Detroit MI 48202 USA DOW AgroSciences lndianapolis IN 46268 USA

Background： Precision medicine approach holds great promise to tailored diagnosis, treatment and prevention. Individuals can be vastly different in their genomic information and genetic mechanisms hence having unique transcriptomic signatures. The development of precision medicine has demanded moving beyond DNA sequencing （DNA-Seq） to much more pointed RNA-sequencing （R_NA-Seq） [Cell, 2017, 168： 584--599]. Results： Here we conduct a brief survey on the recent methodology development of transcriptome assembly approach using RNA-Seq. Conclusions： Since transcriptomes in human disease are highly complex, dynamic and diverse, transcriptome assembly is playing an increasingly important role in precision medicine research to dissect the molecular mechanisms of the human diseases.

关键词： precision medicine transcriptome assembly RNA-Seq de novo De Bruijn

A survey of remote sensing-based aboveground biomass estimation methods in forest ecosystems

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International Journal of Digital Earth 2016年第1期9卷 63-105页

作者： Dengsheng lu Qi Chen Guangxing Wang Lijuan Liu Guiying Li Emilio Moran Zhejiang Provincial Key Laboratory of Carbon Cycling in Forest Ecosystems and Carbon Sequestration School of Environmental&Resource SciencesZhejiang A&F UniversityLin’AnChina Center for Global Change and Earth Observations Michigan State UniversityEast LansingMIUSA department of Geography University of Hawaii at MānoaHonoluluHIUSA department of Geography and Environmental Resources Southern Illinois University at CarbondaleCarbondaleILUSA

Remote sensing-based methods of aboveground biomass(AGB)estimation in forest ecosystems have gained increased attention,and substantial research has been conducted in the past three *** paper provides a survey of current biomass estimation methods using remote sensing data and discusses four critical issues–collection of field-based biomass reference data,extraction and selection of suitable variables from remote sensing data,identification of proper algorithms to develop biomass estimation models,and uncertainty analysis to refine the estimation ***,we discuss the impacts of scales on biomass estimation performance and describe a general biomass estimation *** optical sensor and radar data have been primary sources for AGB estimation,data saturation is an important factor resulting in estimation *** Detection and Ranging(lidar)can remove data saturation,but limited availability of lidar data prevents its extensive *** literature survey has indicated the limitations of using single-sensor data for biomass estimation and the importance of integrating multi-sensor/scale remote sensing data to produce accurate estimates over large *** research is needed to extract a vertical vegetation structure(*** height)from interferometry synthetic aperture radar(InSAR)or optical stereo images to incorporate it into horizontal structures(*** cover)in biomass estimation modeling.

关键词： aboveground biomass forest ecosystems parametric vs.nonparametric algorithms remote sensing uncertainty

Protective effect of total flavonoid C-glycosides from Abrus mollis extract on lipopolysaccharide-induced lipotoxicity in mice

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Chinese Journal of Natural Medicines 2014年第6期12卷 461-468页

作者： WANG Yun JIANG Zhen-Zhou CHEN mi WU Mei-Juan GUO Hong-Li SUN Li-Xin WANG Hao ZHANG Shuang WANG Tao ZHANG lu-Yong Jiangsu Center for Drug Screening China Pharmaceutical University Key Laboratory of Drug Quality Control and Pharmacovigilance China Pharmaceutical University department of Natural Medicinal Chemistry China Pharmaceutical University Jiangsu Center for Pharmacodynamics Research and Evaluation China Pharmaceutical University state Key Laboratory of Natural Medicines China Pharmaceutical University

Abrus mollis is a widely used traditional Chinese medicine for treating acute and chronic hepatitis, steatosis, and fibrosis. It was found that the total flavonoid C-glycosides from Abrus mollis extract(AME) showed potent antioxidant, anti-inflammatory, and hepatoprotective activities. To further investigate the hepatoprotective effect of AME and its possible mechanisms, lipopolysaccharide(LPS)-induced liver injury models were applied in the current study. The results indicated that AME significantly attenuated LPS-induced lipid accumulation in mouse primary hepatocytes as measured by triglyceride(TG) and total cholesterol(TC) assays and Oil Red O staining. Meanwhile, AME exerted a protective effect on LPS-induced liver injury as shown by decreased liver index, serum aminotransferase levels, and hepatic lipid accumulation. Real-time PCR and immunoblot data suggested that AME reversed the LPS-mediated lipid metabolism gene expression, such as sterol regulatory element-binding protein-1(SREBP-1), fatty acid synthase(FAS), and acetyl-CoA carboxylase 1(ACC1). In addition, LPS-induced overexpression of activating transcription factor 4(ATF4), X-box-binding protein-1(XBP-1), and C/EBP homologous protein(CHOP) were dramatically reversed by AME. Furthermore, AME also decreased the expression of LPS-enhanced interleukin-6(IL-6) and cyclooxygenase-2(COX-2). Here, it is demonstrated for the first time that AME ameliorated LPS-induced hepatic lipid accumulation and that this effect of AME can be attributed to its modulation of hepatic de novo fatty acid synthesis. This study also suggested that the hepatoprotective effect of AME may be related to its down-regulation of unfolded protein response(UPR) activation.

关键词： Flavonoid C-glycosides Endotoxin Unfolded protein response Lipid metabolism Inflammation

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盘点气候风险机遇,展望健康繁荣未来

科学通报 2024年第27期69卷 4005-4011页

作者：张诗卉张弛蔡闻佳白玉琪 Max Callaghan 常楠陈彬陈慧琪程亮亮戴瀚程代鑫范维澄房小怡高仝耿阳关大博胡艺馨华峻翊黄存瑞黄弘黄建斌黄小猛纪思翰蒋俏蕾姜晓朋 Gregor Kiesewetter 李湉湉梁璐林波荣林华亮刘欢刘起勇刘小波刘钊刘竹刘昱甫陆波鲁晨曦罗震宇马伟米志付任超 Marina Romanello 沈鉴翔苏婧孙语泽孙昕璐汤绪 Maria Walawender 王灿王情汪蕊 Laura Warnecke 魏汪宇文三妹谢杨熊辉徐冰颜钰杨秀姚芳虹俞乐袁嘉灿曾仪娉张镜张璐张锐张尚辰张少辉赵梦真郑大山周浩周景博周子乔罗勇宫鹏清华大学地球系统科学系北京100084 北京理工大学管理学院北京100081 Mercator Research Institute on Global Commons and Climate Change Mercator Research Institute on Global Commons and Climate ChangeBerlin 10829Germany 南京医科大学公共卫生学院南京211166 北京师范大学环境学院北京100875 中山大学公共卫生学院广州510080 北京大学环境科学与工程学院北京100871 清华大学公共安全研究所北京100084 清华大学工程物理系北京100084 中国气象科学研究院气象影响与风险研究中心北京100086 山东师范大学商学院济南250013 清华大学建筑学院北京100084 南方科技大学统计与数据科学系深圳518055 中国海洋大学国际事务与公共管理学院青岛266003 清华大学万科公共卫生学院北京100084 清华大学新闻与传播学院北京100084 世界卫生组织驻华代表处北京100600 Pollution Management Research Group EnergyClimateand Environment ProgramInternational Institute for Applied Systems Analysis(IIASA)Laxenburg 1-A-2361Austria 中国疾病预防控制中心环境与健康相关产品安全所环境健康风险评估室北京102206 department of Landscape Architecture&Environmental Planning University of CaliforniaBerkeley CA 94607USA 清华大学环境学院北京100084 中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室北京102206 北京经济管理职业学院临空经济管理学院北京100102 中国气象局国家气候中心北京100081 Geography College of Life and Environmental SciencesUniversity of ExeterExeter EX12LUUK 山东大学齐鲁医学院公共卫生学院流行病学系济南250002 The Bartlett School of Sustainable Construction University College LondonLondon WC1H 0ALUK 香港大学建筑学院中国香港999077 Institute for Global Health University College LondonLondon WC1H 0ALUK 清华大学人文学院北京100084 复旦大学大气与海洋系/大气科学研究院上海200438 复旦大学极端天气/气候事件与人体健康风险互联和治理国际卓越中心上海200438 北京航空航天大学经济与管理学院北京100083 香港科技大学计算机科学与工程系广州511453 清华大学气候变化与可持续发展研究院北京100084 北京大学体育教研部北京100871 清华大学苏世民学院北京100084 清华大学城市治理与可持续发展研究院北京100084 百度研究院北京100091 香港大学地球科学系和地理系中国香港999077

气候变化带来的健康风险与日俱增,煤炭消费及相关碳排放量的反弹,再度敲响了中国气候变化警钟.2022年,中国面临了严峻的气候挑战.极端天气事件发生的频率和强度不断上升,许多地区气温纪录屡创新高,全国平均气温攀升至历史第二高位,同时... 详细信息

气候变化带来的健康风险与日俱增,煤炭消费及相关碳排放量的反弹,再度敲响了中国气候变化警钟.2022年,中国面临了严峻的气候挑战.极端天气事件发生的频率和强度不断上升,许多地区气温纪录屡创新高,全国平均气温攀升至历史第二高位,同时降水量自2012年以来创新低,南方地区遭遇夏秋连旱,而湖南和东北地区则出现了极端降雨和洪涝灾害.采取及时、充分的措施不仅能减轻气候变化对健康的影响,还将保护基础设施不被极端天气破坏.

关键词：煤炭消费极端天气事件基础设施气候变化极端降雨碳排放量气候风险盘点

Protective Effect of Wenxin Granula on Heart from Myocardial Infarction through Regulating Intracellular Ca^(2+)

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Chinese Herbal Medicines 2011年第2期3卷 -页

作者： LI Xiao-xue1,LI Xue-lian1,CHU Wen-feng1,2,CAI Rui-jun1,SHI Yong-fang1,XU Chao-qian1,2,SHAN Hong-li1,2,WANG Xing-yang1,lu Yan-jie1,2,YANG Bao-feng1,2 1.department of Pharmacology,Harbin Medical university,Harbin 150081,China 2.The state-Province Key Laboratories of Biomedicine-Pharmaceutics of China,Key Laboratory of Cardiovascular Research,ministry of Education,Harbin Medical university,Harbin 150081,China department of Pharmacology Harbin Medical University Harbin 150081 China department of Pharmacology Harbin Medical University Harbin 150081 China The state-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular Research Ministry of Education Harbin Medical University Harbin 150081China

Objective To assess the anti-arrhythmic activity and cardioprotective effects of Wenxin Granula,a traditional Chinese formula(consisting of Salviae miltiorrhizae Radix,Polygonati Rhizoma,Notoginseng Radix et Rhizoma,Nardostachyos Radix et Rhizoma,Angelicae Sinensis Radix,and Succinum),on heart in ischemic-induced myocardial infarction(mi) rats and compare with those of Amiodarone which have been demonstrated in *** Rats were randomly divided into Sham-operated(control),mi + Amiodarone [5 mg/(kg.d)](mi),and mi + Wenxin Granula [10 mg/(kg.d)] groups and left anterior descending coronary artery was occluded in each *** left anterior descending for 12 h,standard lead II of administration electrocardiogram was recorded in order to analyze the occurrence of *** one month,the size of the infarct area of heart was evaluated by TTC staining method and haemodynamic function was assessed to detect the heart *** scanning confocal microscope and the technique of patch clamp were used to detect the intracellular Ca2+([Ca2+]i) and L-type calcium current(ICa-L),*** Both Wenxin Granula [10 mg/(kg.d)] and Amiodarone [5 mg/(kg.d)] could markedly decrease the incidence of arrhythmia in heart of rats which were subjected to ischemic *** one month,Wenxin Granula could significantly decrease mortality to 22.22% and reduce the infarct area(P miodarone did *** mechanism may involve that Wenxin Granula attenuated [Ca2+]i decreasing in mi ***,Wenxin Granula could obviously ameliorate the impaired heart function of mi rats by decreasing the elevated left ventricular end-diastolic pressure and increasing the attenuated maximum change velocity of left ventricular pressure in the isovolumic contraction or relaxation *** the other hand,electrophysiological experiment results revealed that Wenxin Granula administration one month later also increased the reduced ICa-L density in rat ventricular

关键词： heart failure intracellular Ca2+ L-type calcium current myocardial infarction Wenxin Granula

A new non-destructive readout by using photo-recovered surface potential contrast

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A new non-destructive readout by using photo-recovered surfa...

Injectable decellularized extracellular matrix hydrogel loaded with exosomes encapsulating curcumin for prevention of cardiac fibrosis after myocardial infarction

第十一届全国光学前沿问题讨论会

作者： WANG Le JIN Kuijuan GU Junxing MA Chao HE Xu ZHANG Jiandi WANG Can FENG Yu WAN Qian SHI Jin'an GU Lin HE Meng lu Huibin YANG guozhen Institute of Physics Chinese Academy of Sciences Collaborative Innovation Center of Quantum Matter department of Physics and Astronomy Louisiana State University

＜正＞Ferroelectric random access memory is still challenging in the feature of combination of room temperature stability,non-destructive readout and high intensity *** introducing a laser beam into the combination of...

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Journal of Materials Science & Technology 2023年第36期167卷 50-58页

作者： Yuanyuan Wang Jingjing Wang Chunxia Liu Jingjing Li Kunyan lu Qian Yu Yanxia Zhang Zhenya Shen department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215007China state and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Excessive cardiac fibrosis impairs cardiac repair after myocardial infarction(mi).In this work,an in-jectable composite hydrogel integrating natural biomaterials,exosomes,and bioactive molecules is de-veloped to prevent or alleviate cardiac ***,a natural molecule with antifibrotic activity,is encapsulated in the exosomes that are isolated from bone marrow-derived mesenchymal stem cells to enhance its water solubility and *** composite exosomes are efficiently internalised by fibroblasts and effectively inhibit their transition to myofibroblasts in *** porcine cardiac extracellular matrix(dECM)hydrogel is used as the carrier for delivering these composite exosomes to the infarcted myocardium,not only improving the retention of exosomes but also providing mechani-cal support and structural *** of this hydrogel into the infarcted heart of a mouse mi model leads to a decrease in collagen deposition,alleviation of fibrosis,a reduction in infarct size,and an improvement in cardiac *** reported composite hydrogel comprising natural materials and biomolecules exhibits good biocompatibility and ***,this study demonstrates that the dECM hydrogel is a suitable platform for the local delivery of antifibrotic biomolecule-encapsulating exo-somes to prevent myocardial fibrosis after mi and have great potential for the treatment of mi in clinical settings.

关键词： Myocardial fibrosis Myocardial infarction Decellularized extracellular matrix Exosomes Curcumin

POWER OPTImiZATION ALGORITHM BASED ON XNOR/OR LOGIC

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Journal of Electronics(China) 2009年第1期26卷 138-144页

作者： Wang Pengjun lu Jingang Xu Jian Dai Jing Institute of Circuits and Systems Ningbo University Ningbo 315211 China state Key Laboratory of ASIC ＆ System Fudan University Shanghai 201203 China

Based on the investigation of the XNOR/OR logical expression and the propagation al- gorithm of signal probability, a low power synthesis algorithm based on the XNOR/OR logic is pro- posed in this paper. The proposed algorithm has been implemented with C language. Fourteen mi- croelectronics Center North Carolina (MCNC) benchmarks are tested, and the results show that the proposed algorithm not only significantly reduces the average power consumption up to 27% without area and delay compensations, but also makes the runtime shorter.

关键词： Reed-Muller Logic synthesis XNOR/OR Low power synthesis

Biomaterials based cardiac patches for the treatment of myocardial infarction

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Journal of Materials Science & Technology 2021年第35期94卷 77-89页

作者： Tianqi Chang Chunxia Liu Kunyan lu Yong Wu mingzhu Xu Qian Yu Zhenya Shen Tingbo Jiang Yanxia Zhang department of Cardiovascular Surgery of the First Affiliated Hospital&Institute for Cardiovascular Science Soochow University.Suzhou 215006China department of Cardiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China state and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Myocardial infarction(mi)is one of the common cardiovascular diseases that occurs with a blockage in one or more of the coronary arteries to lead to the damage of the myocardium,resulting in a lifethreatening *** repair the damaged myocardium in mi,researchers are looking forwards to new ways to postpone the progression of myocardial *** patches,the scaffolds layered on the heart surface,can provide mechanical support for the infarction site and improve cardiac function by delivering various bioactive factors or cells,showing considerable curative effect in the treatment of *** with certain biocompatibility and mechanical properties have received widespread attention for the application in cardiac *** this review,we focus on the recent progress on these biomaterialsbased cardiac patches,which could be categorized into two types according to the sources of materials including(ⅰ)natural materials and(ⅱ)synthetic *** major advantages and current challenges of each type are discussed and a brief perspective on the future research directions is presented.

关键词： Biomaterials Cardiac patches Myocardial infarction