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Advancements in life-on-a-chip: The impact of “Beyond Limits Manufacturing” technology

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Chinese Chemical Letters 2024年第5期35卷 13-16页

作者： Weiwei He Hongbo Zhang Xudong Lin Lili Zhu Tingting Zheng Hao Pei Yang Tian Min Zhang guoyue shi Lei Wu Jianlong Zhao Gulinuer Wumaier Shengqing Li Yufang Xu Honglin Li Xuhong Qian Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518000China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 200050China Department of Pulmonary and Critical Care Medicine Huashan HospitalFudan UniversityShanghai 200040China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China Lingang Laboratory Shanghai 200031China

This review explores the concept of life-on-a-chip,which involves the creation of miniaturized biological systems,such as organs,tissues,and model organisms,on microscale platforms called microfluidic *** chips consist of intricately etched channels,wells,and chambers that enable precise control and observation of fluids,cells,and biochemical reactions,facilitating the simulation of various aspects of human or animal physiology and the study of responses to different stimuli,drugs,or disease *** review highlights the application of a novel technology,“Beyond Limit Manufacturing”(BLM),in the development of sophisticated three-dimensional cell models and model organism ***-on-a-chip and organ-on-a-chip(OoC)are among the thriving developments in the field of microfluidics,allowing for the reconstruction of living microenvironments and implementation of multiple *** review discusses the latest advancements in life-on-a-chip technology using BLM and outlines potential future research directions,emphasizing the significant role of these chips in studying complex biological processes in a controlled and scalable manner.

关键词： Beyond Limit Manufacturing Model-organism-on-a-chip Organ-on-a-chip

Micro/nano flow chemistry by Beyond Limits Manufacturing

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Chinese Chemical Letters 2024年第5期35卷 3-12页

作者： Peiwen Liu Fang Zhao Jing Zhang Yunpeng Bai Jinxing Ye Bo Bao Xinggui Zhou Li Zhang Changlu Zhou Xinhai Yu Peng Zuo Jianye Xia Lian Cen Yangyang Yang guoyue shi Lin Xu Weiping Zhu Yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for BiomanufacturingEast China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China

In September 2018,we proposed the cutting-edge concept of“Beyond Limits Manufacturing”(BLM).BLM technology is based on the three-dimensional inner engraving or precise outer engraving of ultra-fast laser,to invent micro/nano scale flow chips or devices,which makes it possible for the microform,integration,economy,safety,high efficiency,green and intelligence of research,development and manufacturing process,so as to realize transformational manufacturing in the era of Industry *** this paper,we reviewed the representative results we made in the field of micro/nano flow chemistry during the implementation of the BLM major project(December 2019 to August 2023),and discussed its application prospects in micro/nano flow chemistry.

关键词： Beyond Limits Manufacturing Flow chemistry Pharmaceutical manufacturing Microreactor

Femtosecond laser-engineered 3D microfluidic chips: Synthesis system sprouting highly efficient multiphase organic reactions

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Chinese Chemical Letters 2023年第4期34卷 338-344页

作者： Jing Ren Kexin Niu Miao Wu Ya Cheng guoyue shi School of Chemistry and Molecular Engineering Shanghai Key Laboratory for Urban Ecological Processes and Eco-RestorationEast China Normal UniversityShanghai 200241China School of Physics and Electronic Science East China Normal UniversityShanghai 200241China

Recent developments in the utilization of microfluidic chips(MFCs) have shown their potential utility in multiphase organic synthesis by enabling efficient organic reactions in flow chemistry. However, MFCs technology has been wandering in the laboratory of small dose synthetic routes, which is limited to the level of "tiny" fluid flux. To address this issue, we herein report the first case of the chips with highthroughput 3D channels produced by femtosecond laser being used to create a time-saving, cost-effective and risk-free approach suitable for large-scale flow synthesis. Several multiphase reactions have been successfully prepared on demand in our designed flow synthesis system containing 3D MFCs: 1) benzyl alcohol was converted to benzaldehyde in 3 min with a yield of 97.50% by liquid-liquid two-phase transfer catalytic oxidation;2) organozinc reagents and α-cyano carbonyl carbon compounds were synthesized by solid-liquid two-phase metal insertion reaction in 7 min, and the yield was up to 100%;3) benzoic acid was synthesized by gas-liquid two-phase carboxylation reaction in 2.8 s with a yield of 96%. Significant gains in production rate result from the effective scaling of flow reactors from microliters per hour in MFCs to intermediate milliliters per minute without affecting mass transport performance. Meanwhile,our 3D MFCs show excellent mass and heat transfer efficiency in large-scale industrial units, breaking through the bottleneck in this field. As a result, it is possible to imagine the creation of a new, streamlined flow synthetic technique via MFCs for green multiphase organic synthesis.

关键词： 3D microfluidic chips Femtosecond laser micromachining Flow synthesis Multiphase reaction Organometrical reagents

Tailoring Food Biopolymers into Biogels for Regenerative Wound Healing and Versatile Skin Bioelectronics

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Nano-Micro Letters 2023年第9期15卷 461-478页

作者： Qiankun Zeng Qiwen Peng Fangbing Wang guoyue shi Hossam Haick Min Zhang School of Chemistry and Molecular Engineering Shanghai Key Laboratory for Urban Ecological Processes and Eco-RestorationEast China Normal UniversityShanghai 200241People’s Republic of China Department of Chemical Engineering and Russell Berrie Nanotechnology Institute Technion-Israel Institute of Technology320003 HaifaIsrael

An increasing utilization of wound-related therapeutic materials and skin bioelectronics urges the development of multifunctional biogels for personal therapy and health ***,conventional dressings and skin bioelectronics with single function,mechanical mismatches,and impracticality severely limit their widespread applications in ***,we explore a gelling mechanism,fabrication method,and functionalization for broadly applicable food biopolymers-based biogels that unite the challenging needs of elastic yet injectable wound dressing and skin bioelectronics in a single *** combine our biogels with functional nanomaterials,such as cuttlefish ink nanoparticles and silver nanowires,to endow the biogels with reactive oxygen species scavenging capacity and electrical conductivity,and finally realized the improvement in diabetic wound microenvironment and the monitoring of electrophysiological signals on *** line of research work sheds light on preparing food biopolymers-based biogels with multifunctional integration of wound treatment and smart medical treatment.

关键词： Food biopolymers Biogels Skin bioelectronics Deep wound Superficial wound

Hybrid supraparticles of carbon dots/porphyrin for multifunctional tongue-mimic sensors

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Chinese Chemical Letters 2022年第5期33卷 2715-2720页

作者： Rong Hu Xingchun Zhai Yubin Ding guoyue shi Min Zhang School of Chemistry and Molecular Engineering Shanghai Key Laboratory for Urban Ecological Processes and Eco-RestorationShanghai Key Laboratory of Multidimensional Information ProcessingEngineering Research Centre for Nanophotonics and Advanced Instrument(Ministry of Education)East China Normal UniversityShanghai 200241China Department of Chemistry College of SciencesNanjing Agricultural UniversityNanjing 210095China

Supraparticles(SPs),such as assembly of inorganic components with organic,have made tremendous attention in biochemical analysis,which represents a novel but challenging research ***,a single-SPs multifunctional fluorescent sensor array has been developed for high-throughput detection of heavy metal ions in biofluids,which is based on an inorganic/organic hybrid SPs consisting of carbon dots(CDs)and an easily available porphyrin[5,10,15,20-tetra(4-carboxyphenyl)porphyrin(TCPP)].TCPP can aggregate with the CDs to form the assembly(CDs/TCPP SPs)through the electrostatic andπ-πstacking *** are two independent and clearly separated fluorescence emission peaks at 470 and 668 nm in the resultant CDs/TCPP SPs under 380 nm *** a proof-of concept design,F 470,F 668,F 668/F 470 of SPs are chosen as three sensor components to constitute our sensor *** the addi-tion of metal ions,three sensor components can generate different fluorescence response patterns for discriminating 11 heavy metal ions via principal component analysis(PCA).Additionally,thiols can read-ily capture Cu^(2+)to switch the fluorescence of CDs/TCPP initially altered by Cu^(2+).Hence,CDs/TCPP-Cu^(2+)ensemble is further demonstrated to be a powerful sensor array for pattern recognition of 7 thiols and even chiral recognition of cysteine *** novel strategy avoids the tanglesome synthesis of multiple sensing probes and dedicates an innovative method for the facile establishment of tongue-mimic sensors,which would prospectively sprout more homologous assumptions to broaden its application toward more biosensing fields.

关键词： Supraparticles Carbon dots Porphyrin Pattern recognition sensor array Heavy metal ions Thiols

Highly efficient synthesis and application of aryl diazonium salts via femtosecond laser-tailored 3D flow microfluidic chips

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Chinese Chemical Letters 2023年第4期34卷 326-331页

作者： Jing Ren Miao Wu Kaiwu Dong Min Zhang Ya Cheng guoyue shi School of Chemistry and Molecular Engineering Shanghai Key Laboratory for Urban Ecological Processes and Eco-RestorationEast China Normal UniversityShanghai 200241China School of Physics and Electronic Science East China Normal UniversityShanghai 200241China

The first example of the microfluidic chips(MFCs) consisting of centimeter-level 3D channels with highdensity and large-volume fabricated by femtosecond laser micromachining were utilized to develop a time-saving, economical and hazardless flow synthesis process, and its advantages have been proved by in situ formation of aryldiazonium salts and subsequent borylation with bis(pinacolato)diboron. There are several important advantages in our 3D MFC-based flow synthesis technology, including the following:(1) the reaction temperature was altered from ice bath to room temperature;(2) the residence time was reduced by 10 times;(3) the yield was greatly improved, that is, several arylboronates were successfully obtained with higher yield compared to traditional batch process. Therefore, it can be envisioned that a novel, simplified flow synthetic protocol will be developed toward green organic synthesis via MFCs.

关键词： 3D microfluidic chips Femtosecondlasermicromachining Flow synthesis Aryldiazoniumsalts Roomtemperature

Recent advances in chemical fixation of CO_(2)based on flow chemistry

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Chinese Chemical Letters 2023年第5期34卷 16-24页

作者： Hui Luo Jing Ren Ying Sun Yunlin Liu Feng Zhou guoyue shi Jian Zhou School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200062China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China Institute of Eco-Chongming Shanghai 202162China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Carbon dioxide(CO_(2))is an attractive C1 building block in chemical synthesis due to its abundance,availability and ***,the low reactivity and high stability generally limits its transformations under mild conditions to value added *** advances in flow chemistry provide effective means for the chemical transformation of CO_(2),and many new methods and techniques that fully utilized the advantages of continuous flow platforms for the chemical fixation of CO_(2)have been *** view of the rapid development and the urgent need for continuous transformation of CO_(2),herein we wish to present an update of the recent advances in this research area.

关键词： CO_(2)fixation C1 synthon Flow chemistry Cyclic carbonate Carboxylic acid

A multifunctional upconversion nanoparticles probe for Cu^(2+)sensing and pattern recognition of biothiols

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Chinese Chemical Letters 2022年第8期33卷 3782-3786页

作者： Qian-Qian Wang Rong Hu Zheng-Qi Fang guoyue shi Shengqiang Zhang Min Zhang School of Chemistry and Molecular Engineering Shanghai Key Laboratory for Urban Ecological Processes and Eco-RestorationEast China Normal UniversityShanghai 200241China Fujian Provincial Key Laboratory of Resources and Environment Monitoring&Sustainable Management and Utilization College of resource and chemical engineeringSanming UniversitySanming 365004China

Lanthanide-doped upconversion nanoparticles(Ln-UCNPs)are a new type of nanomaterials with excellent fluorescence properties,which are well applied in fluorescent *** we developed a multifunctional probe based on the surface engineering of core-shell structure UCNPs with polyacrylic acid(PAA).The developed PAA/UCNPs probe could be highly selective to detect and respond to Cu^(2+) at different ***^(2+) could easily combine with the carboxylate anion of PAA to quench the fluorescence of ***,we creatively proposed a fluorescent array sensor(PAA/UCNPs-Cu^(2+)),in which the same material acted as the sensing element by coupled with pH regulation for pattern recognition of 5 *** could also easily identify the chiral enantiomer of cystine(L-Cys-and D-Cys),and distinguish their mixed samples with different concentrations,and more importantly,it could be combined with urine samples to detect actual level of homocysteine(Hcys)to provide a new solution for judging whether the human body suffers from homocystinuria.

关键词： Upconversion nanomaterials Polyacrylic acid Copper ion Pattern recognition sensor array Biothiols

An investigation on a novel PDLC film's fabrication and its electro-optical properties

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Science China Chemistry 2007年第3期50卷 358-363页

作者： DING HongLiu, ZHAO Ting, CHENG YuXiao, PANG YueHong, XU He, shi guoyue & JIN LiTong Chemistry Department of East China Normal University, Shanghai 200062, China Chemistry Department of East China Normal University Shanghai 200062China

A polymer dispersed liquid crystal (PDLC) film that has good electro-optical properties is produced by the method of polymerized-induced phase separation. Based on the application foreground, its capability parameters, such as contrast ratio, work voltage, and visual angle, are characterized for the first time by a white light but not a fixed wavelength light. The results show the PDLC film has a low work-voltage of 20 V, more than 150° visual angle, high stability, and long lifetime. The differences between plastic and glass ITO-coated substrates of PDLC films are also studied in this paper. The plastic substrate has better property and will have a wider perspective especially in the portable, tender and folded display devices. Due to adjustable properties of film by electric field, PDLC has the potential application for display device, sensor, switch, grating, and new generation analytical apparatus.

关键词： polymer dispersed liquid crystal (PDLC) bisphenol-A epoxy resin nematic liquid crystal electro-optical properties