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RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization

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Light(Science & Applications) 2024年第2期13卷 366-386页

作者： Jiaqi Hu Gina Jinna Chen Chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi guoying liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu Hong Dang Wen Zhang Junfan Chen Quan Tang Penglai Guo Ho-Pui Ho Yuchao Li Longqing Cong Perry Ping Shum State Key Laboratory of Optical Fiber and Cable Manufacture Technology Guangdong Key Laboratory of Integrated Optoelectronics IntellisenseDepartment of EEESouthern University of Science and TechnologyShenzhen 518055China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Nephrology Chaozhou People’s HospitalChaozhou 521011China Clinical Research Design Division Sun Yatsen Memorial HospitalGuangzhouGuangdong 510120China School of Automation Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Biomedical Engineering The Chinese University of Hong KongHong KongChina Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan UniversityGuangzhou 511443China

Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and technology.It is also an emerging omics technique for metabolic profiling to shape precision medicine.However,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is problematic.Intelligent Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information extraction.Here,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral fidelity.It can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human interference.The experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm(L__(∞))compared to established techniques.With this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint region.It precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse applications.This scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications.

关键词： spectral scheme resolution

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Automatic Monitoring System for 3-D Deformation of Crustal Fault Based on Laser and Machine Vision

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Instrumentation 2024年第2期 44-52页

作者： Qingshan Wang guoying Su Qingzun Ma Haiquan Yin Zhihang liu Chuanzhen Lv The First Monitoring and Application Center China Earthquake Administration

An automatic monitoring method of the 3-D deformation is presented for crustal fault based on laser and machine vision. The laser source and screen are independently set up in the headwall and footwall, the collimated laser beam creates a circular spot on the screen, meanwhile, the industrial camera captures the tiny deformation of the crustal fault by monitoring the change of the spot position. This method significantly reduces the cost of equipment and labor, provides daily sampling to ensure high continuity of data. A prototype of the automatic monitoring system is developed, and a repeatability test indicates that the error of spot jitter can be minimized by consecutive samples. Meanwhile, the environmental correction model is determined to ensure that environmental changes do not disturb the system. Furthermore, the automatic monitoring system has been applied at the deformation monitoring station(KJX02) of China Beishan underground research laboratory, where continuous deformation monitoring is underway.

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The Practice and Method of Integrating Fine Traditional Culture into Data Structure Course Teaching

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计算机教育 2023年第12期 31-36页

作者： Qianqian Zhen guoying liu the School of Software Engineering Anyang Normal UniversityAnyang455000China

To capitalize on the primary role of major course teaching and to facilitate students’understanding of abstract concepts in the data structure course,it is essential to increase their interest in learning and develop case studies that highlight fine traditional culture.By incorporating these culture-rich case studies into classroom instruction,we employ a project-driven teaching approach.This not only allows students to master professional knowledge,but also enhances their abilities to solve specific engineering problems,ultimately fostering cultural confidence.Over the past few years,during which educational reforms have been conducted for trial runs,the feasibility and effectiveness of these reform schemes have been demonstrated.

关键词： Curriculum ideological and political education Fine traditional culture Data structure Case teaching

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覆膜方法对纳米纤维膜除尘滤料动态过滤性能的影响

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中国环境科学 2024年第4期44卷 1995-2002页

作者：郭颖赫赫伟东柳静献沈阳理工大学环境与化学工程学院辽宁沈阳110159 东北大学资源与土木工程学院辽宁沈阳110819

为解决聚四氟乙烯(PTFE)覆膜滤料使用中阻力增长快且膜易破损问题,基于静电纺丝技术制备了涤纶(PET)纳米纤维膜,通过直接覆膜法、热处理覆膜法及一步共纺覆膜法将PET纳米纤维膜作为表面膜与聚苯硫醚(PPS)针刺毡滤料进行复合,并对比研究... 详细信息

为解决聚四氟乙烯(PTFE)覆膜滤料使用中阻力增长快且膜易破损问题,基于静电纺丝技术制备了涤纶(PET)纳米纤维膜,通过直接覆膜法、热处理覆膜法及一步共纺覆膜法将PET纳米纤维膜作为表面膜与聚苯硫醚(PPS)针刺毡滤料进行复合,并对比研究3种覆膜方法制备的PET纳米纤维膜滤料、PPS滤料以及PTFE覆膜滤料的动态过滤性能,结果表明,与PTFE覆膜滤料相比,3种覆膜方法制备的PET纳米纤维膜滤料均表现出优异的过滤性能.稳定过滤阶段,一步共纺覆膜法制备的PET/TPU纳米纤维膜滤料完成单个周期所需时间是PTFE覆膜滤料的2倍,粉尘剥离率为99.79%,其阻力增长速率低、完成单个周期所需时间平稳,降低能耗并减少了气流对膜造成的磨损,在工业除尘领域具有较大应用潜力.

关键词：工业除尘过滤材料覆膜纳米纤维膜动态过滤性能

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Permafrost carbon cycle and its dynamics on the Tibetan Plateau

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Science China Life Sciences 2024年

作者： Leiyi Chen Guibiao Yang Yuxuan Bai Jinfeng Chang Shuqi Qin Futing liu Mei He Yutong Song Fan Zhang Josep Pe?uelas Biao Zhu guoying Zhou Yuanhe Yang Key Laboratory of Tibetan Medicine Research Chinese Academy of Sciences State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences China National Botanical Garden College of Environmental and Resource Sciences Zhejiang University Key Laboratory of Forest Ecology and Environment of National Forestry and Grassland Administration Ecology and Nature Conservation Institute Chinese Academy of Forestry University of Chinese Academy of Sciences Consejo Superior de Investigaciones Científicas (CSIC) Global Ecology Unit CREAF-CSIC-UAB (Universitat Autònoma de Barcelona) Centre for Ecological Research and Forestry (CREAF) Barcelona Institute of Ecology College of Urban and Environmental Sciences and Key Laboratory for Earth Surface Processes of the Ministry of Education Peking University Northwest Institute of Plateau Biology Chinese Academy of Sciences

Our knowledge on permafrost carbon（C） cycle is crucial for understanding its feedback to climate warming and developing nature-based solutions for mitigating climate change. To understand the characteristics of permafrost C cycle on the Tibetan Plateau, the largest alpine permafrost region around the world, we summarized recent advances including the stocks and fluxes of permafrost C and their responses to thawing, and depicted permafrost C dynamics within this century. We find that this alpine permafrost region stores approximately 14.1 Pg(1 Pg=1015g) of soil organic C（SOC） in the top 3 m. Both substantial gaseous emissions and lateral C transport occur across this permafrost region. Moreover, the mobilization of frozen C is expedited by permafrost thaw, especially by the formation of thermokarst landscapes,which could release significant amounts of C into the atmosphere and surrounding water bodies. This alpine permafrost region nevertheless remains an important C sink, and its capacity to sequester C will continue to increase by 2100. For future perspectives, we would suggest developing long-term in situ observation networks of C stocks and fluxes with improved temporal and spatial coverage, and exploring the mechanisms underlying the response of ecosystem C cycle to permafrost thaw. In addition, it is essential to improve the projection of permafrost C dynamics through in-depth model-data fusion on the Tibetan Plateau.

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Effect of Zhutan Tongluo Tang on fibrinolytic activity following intracerebral hemorrhage in rats

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Neural Regeneration Research 2011年第21期6卷 1640-1645页

作者： Yongxi Jin Xu Li Gaowen Li Lei Guo Fang Li guoying liu Songfang Chen Shijue liu Department of Rehabilitation Wenzhou Municipal Hospital of Traditional Chinese Medicine Wenzhou 325005 Zhejiang Province China Department of Physiology Wenzhou Medical College Wenzhou 325035 Zhejiang Province China Department of Pharmacology Ningbo Tian Yi Vocational and Technical College Ningbo 315100 Zhejiang Province China Department of Urology Central Hospital of Xinyang Xinyang 464000 Henan Province China The Second Affiliated Hospital of Wenzhou Medical College Wenzhou 325027 Zhejiang Province China

The neuroprotective effect of Zhutan Tongluo Tang is associated with the activities of the fibrinolytic system. Thus the present study was designed to investigate therapeutic effects of Zhutan Tongluo Tang on intracerebral hemorrhage in rats, induced by injecting collagenase into one side of the caudate nucleus. Fibrinolytic indices including tissue plasminogen activator, plasminogen activator inhibitor-1 and D-Dimer were determined. The results obtained demonstrated that Zhutan Tongluo Tang treatment could alleviate the neural and behavioral impairments of intracerebral hemorrhaging rats. Increased frequencies of placing their forelimb correctly and decreased frequencies of turning left were observed. Enzyme linked immunosorbent assay showed that Zhutan Tongluo Tang could significantly elevate the concentration of plasma tissue plasminogen activator and D-Dimer, while depress plasminogen activator inhibitor-1. Immunohistochemistry demonstrated increased levels of catalase and glutathione in whole brain rat tissue following intracerebral hemorrhage. In addition, elevated expression of Bcl-2 in various hippocampal regions was seen. These findings describe the ability of Zhutan Tongluo Tang to activate the fibrinolytic system, and suggests that antioxidant and apoptosis inhibitory mechanisms may be playing a crucial role in protecting against collagenase-induced intracerebral hemorrhage.

关键词： Zhutan Tongluo Tang intracerebral hemorrhage tissue plasminogen activator plasminogen activator inhibitor-1 D-Dimer hippocampus apoptosis neural regeneration

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A novel non-stoichiometric medium-entropy carbide stabilized by anion vacancies

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Journal of Materials Science & Technology 2020年第16期47卷 161-166页

作者： Chong Peng Hu Tang Yu He Xiaoqian Lu Peng jia guoying liu Yucheng Zhao Mingzhi Wang State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China Center for High Pressure Science and Technology Advanced Research Beijing 100190China

Recently,high-entropy ceramics have attracted considerable attentions because of comprehensive physical and chemical properties of high hardness,fracture toughness,and conductivity.However,as a newly emerging class of materials,the synthesis,performance and applications of high-entropy ceramics are subject to further development.Here,we reported a new non-stoichiometric TiC0.4/WC/0.5Mo2C medium-entropy carbide(MEC)with a rock-salt structure.Attributed to the solid solution strengthening and twinning strengthening,the TiCO0.4/WC/0.5Mo2C sintered at 1900℃by spark plasma sintering(SPS)shows superior mechanical behaviors of microhardness(21.7 GPa),which exceeds that expected from the rule of mixture(ROM)of three individual metal carbides(19.1 GPa)and good fracture toughness(5.3 MPa m1/2).Significantly,the bulk synthesized via high-pressure and high-temperature(HPHT)sintering possesses smaller grain size and shows better comprehensive mechanical properties of microhardness(23.7 GPa)and fracture toughness(6.2 MPa m1/2).In addition,the effect of anion vacancies on the thermodynamic stability and synthesizability of TiC0.4/WC/0.5Mo2C was analyzed via quantitatively calculated entropy.Vacancies could significantly enhance the configuratio nal entropy of mixing of the solid phase.The introduction of vacancy defects may expand synthetic path for entropy-stabilized ceramics,especially for multi-component high tempe rature refractory ceramics.

关键词： Anion vacancies Medium-entropy carbide Solid solution strengthening Twinning

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萆薢总皂苷调控AMPK/SREBP-1c/ACC信号通路改善小鼠非酒精性脂肪性肝炎

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中国实验方剂学杂志 2024年第8期30卷 41-48页

作者：刘玉嫣汪丹丹王昕李国莺陈光亮安徽中医药大学中西医结合学院合肥230012 安徽省中药复方研究重点实验室合肥230012

目的:研究萆薢总皂苷(TSD)改善小鼠非酒精性脂肪性肝炎(NASH)的作用及机制。方法:将48只C57BL/6J小鼠随机分为正常组和造模组,采用高脂高胆固醇饲料+20%果糖水喂养16周,将造模组小鼠随机分为模型组、阿托伐他汀组(4 mg·kg^(-1)·d^(-1)... 详细信息

目的:研究萆薢总皂苷(TSD)改善小鼠非酒精性脂肪性肝炎(NASH)的作用及机制。方法:将48只C57BL/6J小鼠随机分为正常组和造模组,采用高脂高胆固醇饲料+20%果糖水喂养16周,将造模组小鼠随机分为模型组、阿托伐他汀组(4 mg·kg^(-1)·d^(-1))、TSD高、中、低剂量组(200、60、20 mg·kg^(-1)·d^(-1)),灌胃给药,连续8周。测定小鼠活动度、肝脏系数、肝脏总胆固醇(TC)、甘油三酯(TG)、游离脂肪酸(FFA)及血清TC、TG、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、γ-谷氨酰转移酶(GGT)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平;苏木素-伊红(HE)染色、Masson染色、油红O染色和透射电子显微镜观察肝组织和肝细胞病理变化、脂质蓄积情况和肝脏超微结构形态学变化;蛋白免疫印迹法(Western blot)检测肝脏组织AMP活化蛋白激酶(AMPK)、固醇调节元件结合蛋白-1c(SREBP-1c)、乙酰辅酶A羧化酶(ACC)及其磷酸化形式的蛋白表达。结果:与正常组比较,模型组小鼠活动度明显降低(P<0.05,P<0.01),小鼠肝脏TC、TG、FFA和血清TC、TG、ALT、AST、GGT、IL-1β、TNF-α水平、肝脏系数、肝脏病理评分均明显升高,肝脏组织p-AMPK/AMPK、p-ACC蛋白表达明显降低,SREBP-1c、ACC蛋白表达明显升高(P<0.05,P<0.01)。与模型组比较,阿托伐他汀组小鼠活动度明显增加(P<0.05),TSD各剂量组小鼠活动度无明显改变;TSD及阿托伐他汀组小鼠肝脏TC、TG、FFA和血清TC、TG、ALT、AST、GGT、IL-1β、TNF-α水平、肝脏系数、肝脏病理评分均明显降低,肝脏组织p-AMPK/AMPK、p-ACC蛋白表达明显升高,SREBP-1c、ACC蛋白表达明显降低(P<0.05,P<0.01)。结论:TSD可能通过调控AMPK/SREBP-1c/ACC信号通路减少脂质合成,从而改善小鼠NASH。

关键词：非酒精性脂肪性肝炎萆薢总皂苷 AMP活化蛋白激酶(AMPK)/固醇调节元件结合蛋白-1c(SREBP-1c)/乙酰辅酶A羧化酶(ACC)信号通路脂质合成实验研究

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中医药防治胃黏膜“炎-癌转化”研究进展

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中医学报 2024年第8期39卷 1670-1678页

作者：刘金凤梁国英黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第一医院黑龙江哈尔滨150040

胃癌的发生需经过“慢性萎缩性胃炎肠上皮化生-异型增生-胃癌”的“炎-癌转化”过程,因此,学者们一直致力于防治胃黏膜“炎-癌转化”的研究。目前,西药以根除幽门螺杆菌、抑酸、保护胃黏膜等对症治疗为主,不能从根本上阻止胃癌的发生发... 详细信息

胃癌的发生需经过“慢性萎缩性胃炎肠上皮化生-异型增生-胃癌”的“炎-癌转化”过程,因此,学者们一直致力于防治胃黏膜“炎-癌转化”的研究。目前,西药以根除幽门螺杆菌、抑酸、保护胃黏膜等对症治疗为主,不能从根本上阻止胃癌的发生发展;中医治疗该病具有更小的不良反应及不良反应,但其作用机制尚不完全明确。代谢组学作为新兴的组学技术,与中医药多靶点、多途径的作用特点相匹配。运用代谢组学探究中医药防治胃黏膜“炎-癌转化”的作用机制可知,中医药防治胃黏膜“炎-癌转化”过程的主要机制与调节能量代谢、氨基酸代谢和脂质代谢等通路关系紧密,这为从微观角度解读中医药的复杂机理和科学内涵提供了新的方法和理论视角。

关键词： “炎-癌转化” 胃黏膜胃癌代谢组学脾虚证脾胃湿热证胃络瘀血证脾胃虚寒证

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应用型高校产教融合双创教育研究与探索

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安阳师范学院学报 2024年第2期26卷 144-149页

作者：吴亮刘国英安阳师范学院软件学院河南安阳455000 河南省甲骨智能产业工程研究中心河南安阳455000

数智时代产教融合背景下,应用型高校面向区域经济发展需求进行行业特色人才的创新创业培育是高质量发展转型的必由之路。针对高校、企业双创教育内驱力不足和双创人才培育机制问题,应用型高校首先应聚焦优势明确双创目标,其次基于整体... 详细信息

数智时代产教融合背景下,应用型高校面向区域经济发展需求进行行业特色人才的创新创业培育是高质量发展转型的必由之路。针对高校、企业双创教育内驱力不足和双创人才培育机制问题,应用型高校首先应聚焦优势明确双创目标,其次基于整体性机制理清“校—企—政”在课程、思维、实践、评价四项双创子系统中的关系,构建融合双创能力和专业能力的教学体系,最终实现双创人才培养“共建共管共赢”的现代产业学院长效发展模式。

关键词：应用型高校创新创业教育产教融合

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