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Science China Chemistry 2012年第8期55卷 1542-1547页

作者： XING XueQi ZHAO guoying CUI JianZhong Beijing Key Laboratory of lonic Liquids Clean Process Key Laboratory of Green Process and EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Department of Chemistry Tianjin UniversityTianjin 300072China

A series of triethylammonium-based chlorogallate（Ⅲ） ionic liquids with varied Lewis acidity was synthesized, characterized, and firstly applied to isobutane alkylation. The [Et3NHC1]-GaCl3 with XGaCl3 =0.65 displayed a potential catalytic activity for the alkylation. The addition of copper halide into the chlorogallate（Ⅲ） ionic liquids dramatically enhanced the alkylation reac- tion. Up to 70.1% Cs selectivity and 91.3 RON were achieved with the [Et3NHC1]-GaC13-CuC1 （XGaCl3 = 0.65, CuCI = 5% tool） under 0.5 MPa, 900 r/min, 15 min, 288 K using the industrial C4 cut （isobutane/butene = 10）. These results indicate that the chlorogallate（Ⅲ） system may be used as a promising catalyst for the C4 alkylation.

关键词： chlorogallate(Ⅲ) acidic ionic liquid Lewis acid alkylation isobutane

Upregulation of TMCO3 Promoting Tumor Progression and Contributing to the Poor Prognosis of Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 913-924页

作者： Tianxing Dai Linsen Ye Mingbin deng Guozhen Lin Rongqiang Liu Haoyuan Yu Wei Liu Yang Yang guoying Wang Department of Hepatic Surgery and Liver Transplant Program The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina Department of Hepatic Surgery The Third People’s Hospital of ShenzhenShenzhenGuangdongChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina

Background and Aims:TMCO3,a member of the monovalent cation:proton antiporter-2 family,has been annotated as a Na^(+)/H^(+)antiporter,but its pathophysiological role is still *** aimed to investigate the expression profile,prognostic significance,and oncogenic role of TMCO3 in hepatocellular carcinoma(HCC).Methods:Bioinformatic analyses were conducted using transcriptome data from public databases to determine the expression,prognosis,and functional enrichment of TMCO3 in ***3 expression was further validated in an independent HCC cohort from our *** oncogenic role of TMCO3 in HCC was evaluated using in vitro and in vivo ***:The upregulated expression of TMCO3 was identified and verified in multiple HCC cohorts,and worse overall survival and recurrence-free survival were observed in patients with high TMCO3 *** overexpression and knockdown of TMCO3 could affect the proliferation and metastasis of HCC cells,which might be associated with the p53-induced cell cycle regulation and epithelial-mesenchymal transition,***,significant correlations were found between dysregulated TMCO3 and various antitumor *** role in sorafenib sensitivity was further identified by in vitro experiments and the potential mechanism might be related to the regulation of *** correlations were also identified between upregulation of TMCO3 and the increased infiltration of various immune cells and the elevated expression of multiple immune checkpoint genes in ***:Upregulated TMCO3 could act as an oncogenic mediator and promote sorafenib resistance in HCC,providing a potential therapeutic target for HCC treatment.

关键词： Hepatocellular carcinoma TMCO3 Sorafenib Oncogene,prognosis

Antibacterial conductive self-healable supramolecular hydrogel dressing for infected motional wound healing

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Science China Chemistry 2022年第11期65卷 2238-2251页

作者： Rui Yu Zhenlong Li guoying Pan Baolin Guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi'an 710049China State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi'an710049China

Wounds on stretchable parts of the human body cause prolonged suffering and involve more severe healing processes than wounds on stationary parts. However, they have received insufficient attention compared with other types of chronic wounds. In this study, a novel supramolecular gelatin(GT) hydrogel composed of GT-graft-aniline tetramer and quaternized chitosan was presented. The hydrogel was crosslinked by monoaldehyde β-cyclodextrin via host-guest interaction and dynamic Schiff base and was free from permanent covalent bonds, heavy metals, and oxidants. Given its dynamic feature, the hydrogel exhibited flexibility, self-healing, and tissue adhesiveness and well adapted to motion wounds. Moreover, the hydrogel was bioactive with conductivity, antioxidant property, hemostatic effect, antibacterial, and photothermal effect(the killing ratio for methicillinresistant Staphylococcus aureus(MRSA) was higher than 99.8% after 5 min of near-infrared irradiation) and exhibited ondemand removability. In the full-thickness MRSA-infected motional wound healing experiment, this novel hydrogel exhibited a significantly enhanced wound healing efficacy with a fast wound closure ratio(about 99.0% for 14 days), mild inflammatory response, high level of collagen deposition, and enhanced re-epithelialization by downregulating interleukin-6 and CD68 and upregulating vascular endothelial growth factor. The results indicated that this hydrogel has great potential in wound healing and skin tissue engineering and serves as an inspiration for the design of supramolecular biomaterials.

关键词： supramolecular hydrogel self-healing tissue adhesion joint wound

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锌修饰硅酸钙生物陶瓷涂层的体外生物相容性研究

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组织工程与重建外科杂志 2015年第4期11卷 229-233页

作者：徐立璋余将明李恺郑学斌邓国英王伟恒黄晓东叶晓健第二军医大学附属长征医院骨科上海市200003 中国科学院上海硅酸盐研究所上海市200050

目的研究锌修饰硅酸钙生物陶瓷涂层的体外生物相容性,为该涂层临床应用的可行性提供实验依据。方法检测该涂层的物理表征;检测该涂层浸提液的离子浓度;用不同稀释比例的浸提液培养MC3T3-E1细胞,观察细胞形态,MTT法检测细胞相对增殖率,... 详细信息

目的研究锌修饰硅酸钙生物陶瓷涂层的体外生物相容性,为该涂层临床应用的可行性提供实验依据。方法检测该涂层的物理表征;检测该涂层浸提液的离子浓度;用不同稀释比例的浸提液培养MC3T3-E1细胞,观察细胞形态,MTT法检测细胞相对增殖率,并检测细胞凋亡水平;测定溶血率。结果该涂层浸泡72 h后,浸提液中钙、硅、锌离子浓度均明显升高;用不同稀释比例的浸提液培养的MC3T3-E1细胞都表现出正常的细胞形态,其中3.125%、6.25%组细胞量较多,相对增殖率高于阳性对照组,且细胞凋亡率低于阳性对照组(完全培养基);随浸提液浓度增加,可对细胞增殖产生轻度抑制作用,凋亡率逐渐升高;溶血试验结果显示,该涂层浸提液的溶血率为0.5%。结论锌修饰硅酸钙生物陶瓷涂层没有细胞毒性、生物相容性好,具有作为骨植入体及其他生物材料表面改性的生物学基础。

关键词：锌修饰硅酸钙生物陶瓷涂层细胞毒性凋亡生物相容性骨植入体

Insights into community-based bioassessment of environmental quality status using microphytobenthos in estuarine intertidal ecosystems

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Acta Oceanologica Sinica 2016年第6期35卷 112-120页

作者： DU guoying CHUNG Ik kyo XU Henglong College of Marine Life Science Ocean University of China Division of Earth Environmental System Pusan National University

The feasibility of community-based bioassessment of environmental quality status was studied using microphytobenthos（MPB） in estuarine intertidal *** sediment samples of MPB were collected monthly during a 1-year cycle（September 2006-August 2007） at four sampling stations in the Nakdong River Estuary,*** variables,such as salinity,radiation,grain size of sediment,Si（OH）4（Si）,nitrate（NO3^-）,nitrite（NO2^-）,ammonium（NH4~＋） and phosphates（PO4^（3-））,were measured synchronously for comparison with biotic *** statistical analyses were carried out for assessment the relationship between biotic and environmental *** results showed that：（1） the MPB community structures were significant differences among four sampling stations;（2） spatial variation in the MPB communities were significantly correlated with environmental variables,especially the nutrient NH4＋ in combination with salinity and grain size;（3） three species（Navicula lacustris,Pleurosigma anglulatum and Fragilaria sp.1） were significantly correlated with nutrients and/or Si;and（4） the species richness and diversity were significantly correlated with the grain *** is suggested that MPB communities may be used as a potentially robust bioindicator for assessing environmental quality status in estuarine intertidal ecosystems.

关键词： marine bioassessment field community microphytobenthos estuarine intertidal ecosystem Nakdong River

Influence of bath composition on the electrodeposition of cobalt-molybdenum amorphous alloy thin films

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Journal of University of Science and Technology Beijing 2008年第5期15卷 611-617页

作者： Qiaoying Zhou Hongliang Ge guoying Wei Qiong Wu College of Science China Jiliang University Hangzhou 310018 China

Cobalt-molybdenum （Co-Mo） amorphous alloy thin films were deposited on copper substrates by the electrochemical method at pH 4.0. Among the experimental electrodeposition parameters,only the concentration ratio of molybdate to cobalt ions （[MoO4^2-]/[Co^2＋]） was varied to analyze its influence on the mechanism of induced cobalt-molybdenum codeposition. Voltammetry was one of the main techniques,which was used to examine the voltammetric response,revealing that cobalt-molybdenum codeposition depended on the nature of the species in solution. To correlate the type of the film to the electrochemical response,various cobalt-molybdenum alloy thin films obtained from different [MoO4^2-]/[Co^2＋] solutions were tested. Crack-free homogeneous films could be easily obtained from the low molybdate concentrations （[MoO4^2-]/[Co^2＋]≈0.05） applying low deposition potentials. Moreover,the content of molybdenum up to 30wt% could be obtained from high molybdate concentration; in this case,the films showed cracks. The formation of these cracked films could be predicted from the observed distortions in the curves of electric current-time （j-t） deposition transients. The films with amorphous structure were obtained. The hysteresis loops suggested that the easily magnetized axis was parallel to the surface of the films. A saturation magnetization of 137 emu·g^-1 and a coercivity of 87 Oe of the film were obtained when the deposition potential was -1025mV,and [ MoO4^2-]/[Co^2＋] was 0.05 in solution,which exhibited a nicer soft-magnetic response.

关键词： Co-Mo alloy thin films amorphous electrodeposition soft magnetism

Low-resistance, high-force, and large-ROM fabric-based soft elbow exosuits with adaptive mechanism and composite bellows

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Science China(Technological Sciences) 2023年第1期66卷 24-32页

作者： HUANG WeiCheng FENG Miao YANG DeZhi GU guoying Robotics Institute School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Meta Robotics Institute Shanghai Jiao TongUniversityShanghai 200240China

Due to the lightweight and compliance, fabric-based pneumatic exosuits are promising in the assistance and rehabilitation of elbow impairments. However, existing elbow exosuits generally suffer from remarkable mechanical resistance on the flexion of the elbow, thus limiting the output force, range of motion(ROM), and comfortability. To address these challenges, we develop a fabric-based soft elbow exosuit with an adaptive mechanism and composite bellows in this work. With the elbow kinesiology considered, the adaptive mechanism is fabricated by sewing the interface of the exosuit into spring-like triangle pleats, following the profile of the elbow to elongate or contract when the elbow flexes or extends. The composite bellows are implemented by further sealing a single blade of bellows into two branches to enhance the output force. Based on these structural features, we characterize the mechanical performance of different soft elbow exosuits: exosuit with normal bellows-NB, exosuit with adaptive mechanism and normal bellows-AMNB, exosuit with adaptive mechanism and composite bellows-AMCB. Experimental results demonstrate that by comparing with NB, the mechanical resistance of AMNB and AMCB decreases by 80.6% and 78.6%, respectively;on the other hand, the output torque of AMNB and AMCB increases to 120.3% and 207.0%, respectively, at50 k Pa when the joint angle is 120°. By wearing these exosuits on a wooden arm model(1.25 kg), we further verify that AMCB can cover a full ROM of 0°–130° at the elbow with 500 g weight. Finally, the application on a health volunteer with AMCB shows that when the volunteer flexes the elbow to lift a weight of 500 g, the s EMG activity of the biceps and triceps is markedly reduced.

关键词： wearable robots rehabilitation robots soft robot applications soft actuators design

Simple Synthesis of Magnetic Mesoporous Carbons with High Surface Areas by Soft-template Method

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Journal of Wuhan University of Technology(Materials Science) 2013年第4期28卷 668-672页

作者：田勇 ZHONG guoying 王秀芳 College of Pharmacy Guangdong Pharmaceutical University

Magnetic Fe-containing ordered mesoporous carbons （Fe/OMCs） with high surface areas and pore volume were synthesized through a simple soft-template route, wherein phenolic resin was used as a carbon precursor, triblock copolymer F127 as a template agent, tetraethyl orthosilicate （TEOS） as a silica precursor and hydrated iron nitrate as an iron source. The effects of carbonization temperature, loading degree of TEOS on the structural parameters of these Fe/OMCs were evaluated by X-ray diffraction （XRD） and Nz sorption analysis. The ordering, the specific surface area and the total pore volumes increased with the increase of carbonization temperature from 600 to 850 ~C. And the specific surface area and the total pore volumes increased with the increase of TEOS loading.

关键词： mesoporous carbon iron synthesis

Trace Metals Analysis Along the Fildes Peninsula Coastline Using Two Red Algae, Rhodymenia antarctica and Iridaea cordata, as Monitors

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Journal of Ocean University of China 2018年第6期17卷 1487-1491页

作者： LIU Yang DU guoying MAO Yunxiang Key Laboratory of Marine Genetics and Breeding (Ocean University of China) Ministry of Education College of Marine Life Sciences Ocean University of China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology

Two red algae, Rhodymenia antarctica and Iridaea cordata(Rhodophyta), were employed to investigate the pollution situation along Fildes Peninsula coastline, King George Island. Ten sites from east and west coastlines were investigated, and the concentrations of Cu, Pb, Zn, Cd, Cr, As and Hg were determined. The metal pollution index(MPI) was used to evaluate the overall pollution level represented by the investigated sites and for interregional comparisons. The two algae exhibited different preference to special trace metal. R. antarctica could accumulate more Cd(0.63 mg kg^(-1)) and Hg(0.026 mg kg^(-1)) than I. cordata(Cd 0.34 mgkg^(-1), Hg 0.019 mg kg^(-1)). I. cordata could accumulate more As(15.53 mg kg^(-1)) than R. antarctica(10.11 mg kg^(-1)). There was no significant difference in accumulating Cu, Pb, Zn and Cr between the two algae. R. antarctica could be used to monitor Cd and Hg. I. cordata would be more appropriate for monitoring As. MPI monitored by the two algae were from 1.02 to 2.26(R. antarctica), and 1.03 to 1.25(I. cordata), respectively. Pollution situation of Fildes Peninsula was becoming serious, especially of the east coastline. The objective of this research was to gather the baseline information for trace metals investigation in Antarctic.

关键词： Fildes Peninsula Rhodymenia antarctica Iridaea cordata trace metal MPI

Global structure and seasonal variations of the migrating 6-h tide observed by SABER/TIMED

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Science China Earth Sciences 2015年第7期58卷 1216-1227页

作者： LIU MoHan XU JiYao YUE Jia JIANG guoying State Key Laboratory of Space Weather Center for Space Science and Applied ResearchChinese Academy of Sciences College of Earth Science University of Chinese Academy of Sciences Center for Atmospheric Science Hampton University

Ten years of SABER/TIMED temperature data are used to analyze the global structure and seasonal variations of the migrating 6-h tide from the stratosphere to the lower thermosphere. The amplitudes of the migrating 6-h tide increase with altitudes. In the stratosphere, the migrating 6-h tide peaks around 35°N/S. The climatologically annual mean of the migrating 6-h tide clearly shows the manifestation of the(4, 6) Hough mode between 70 and 90 km that peaks at the equator and near 35°N/S. Above 90 km, the 6-h tide shows more than one Hough mode with the(4, 6) mode being the dominant one. The migrating 6-h tide is stronger in the southern hemisphere. Annual, semiannual, 4-, and 3-month oscillations are the four dominant seasonal variations of the tidal amplitude. In the stratosphere and stratopause, the spring enhancement of the 6-h tide at middle latitudes is the most conspicuous feature. From the mesosphere to the lower thermosphere, the tidal amplitude at low latitudes is gradually in the scale of that at middle latitudes and exhibits different temporal variations at different altitudes and latitudes. Both ozone heating in the stratosphere and the background atmosphere probably affect the generation and the seasonal variations of the migrating 6-h tide. In addition, the non-linear interaction between different tidal harmonics is another possible mechanism.

关键词： migrating tide global structure seasonal variations non-linear interaction bispectral analysis