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Personalized nutrition for people with diabetes and at risk of diabetes has begun

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Journal of Future Foods 2022年第3期2卷 193-202页

作者： Raymond chen guoxun chen Department of Biochemistry University of Texas at AustinAustin 78705USA Department of Nutrition University of Tennessee at KnoxvilleKnoxville 37996USA

Food and nutrition are essential parts for the management of blood glucose of patients with diabetes and other metabolic *** results of recent human clinical studies have shown that the blood glucose levels change differently in different people in response to the same standardized *** phenomenon shows the challenges to find a one-size-fits-all approach to combat *** the development of technologies,personalized nutrition/precision nutrition has gradually become more practical in order to treat individual *** aim of this review article is to summarize personalized nutrition’s progress and potential in treating the diabetes *** have searched PubMed to identify relevant articles and found that personalized nutrition on multiple factors associated with an individual has started to draw attention to scientifi c *** seminal studies have shown that healthy adults show differential responses of postprandial blood glucose levels to the same standardized *** clinical trials have started to integrate sensor technologies such as continuous glucose monitoring and personal data such as genomic sequences and microbiome to provide personalized nutrition advice,and shown promises in intervention and management of type 2 *** appears that the interplays of diets and genomes,gut microbiome,gut transit time,insulin sensitivity,cultural,social,and economic factors should all be considered to create a personalized treatment for an individual’s chronic metabolic *** probably can be achieved through the integration of personalized nutrition and personalized food intervention with the development of technologies and advances in food and nutrition *** research should be anticipated soon.

关键词： Blood glucose Type 2 diabetes Insulin Microbiome Precision nutrition Personaliz

The current trend and challenges of developing red yeast rice-based food supplements for hypercholesterolemia

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未来食品学报(英文) 2023年第4期3卷 312-329页

作者： Gong chen Wanbo chen Jinhong Xu Guodong Ma Xinge Hu guoxun chen Department of Internal Medicine University of Texas Southwestern Medical Center at DallasDallas 75390USA Clinical School of Chinese Medicine Hubei University of Chinese MedicineWuhan 430022China College of Pharmacy South-Central University for NationalitiesWuhan 430074China Department of Nutrition University of Tennessee at KnoxvilleKnoxville 37996USA

Hypercholesterolemia is a risk factor of cardiovascular diseases,which have been managed using statin *** yeast rice(RYR)as a traditional food in the Eastern Asia countries has anti-hyperlipidemia ***,a variety of food supplement products containing RYR have been developed to lower blood cholesterol,which is attributed to the presence of monacolins,especially monacolin K(lovastatin,a statin drug).This review was aimed to summarize the clinical trials using RYR products to investigate their effects on lipid profiles in *** articles of human clinical trials were retrieved from PubMed and discussed *** showed that RYR and its extracts have been included in commercially available products alone and in combinations with various other materials,which include bioactive compounds such as coenzyme Q10 and berberine,vitamins,extracts from other plants such as phytosterols,polyunsaturated fatty acids or even *** durations of the trials ranged from 4 weeks to 60 *** content of monacolin K ranged from 0.32 mg/pack to 10 mg/*** data of these human clinical trials demonstrated that these RYR supplement products were sufficient to reduce blood cholesterol in different ***,the inclusions of certain materials might not have additive ***,studies including a lovastatin only positive control group with the equivalent dose as that of monacolin K in the RYR products remain to be ***,variations of monacolin K contents and presence of toxic citrinin are still ***,bioactivities of other components in RYR should be investigated as *** future studies will certainly help to fully explore the potentials of this traditional food in the combat against cardiovascular and other metabolic diseases.

关键词： Cardiovascular diseases Cholesterol Human clinical trials Food supplement Hypercholesterolemia Monacolins Red yeast rice

The challenges of future foods from prevention of nutrient deficiencies to the management of diabetes

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Journal of Future Foods 2021年第1期1卷 47-57页

作者： Christian Hamrick guoxun chen Department of Nutrition University of Tennessee at KnoxvilleKnoxvilleTennesseeUSA

With rise of globa1 populations,food demand is expected to increase ***,the number of people with chronic metabolic diseases,specifically diabetes,is also on the *** the discovery of insulin exactly 100 years ago,every aspect of society including food industry has evolved ***,and pesticides have been introduced constantly to increase food production for ***,the changes of biodiversity in agriculhure might have incorporated certain foods and excluded others selectively in diets,which probably results in the production of food with more calories,but 1ess essentia1 *** might have affected systemic functions in the body and contributed to the development of chronic metabolic ***,genetic and epigenetic factors have had impacts on disease susceptibility,which has challenged the protective mechanisms that have been estab1ished in the human genome during ***,we try to summarize certain changes of systematic,environmenta1,metabolic,and physiological factors that may have potential effects on human diets and metabolism,and in turn,contributed to the current epidemic of chonic metabolic diseases such as type 2 *** so doing,we hope to bring the attention of colleagues to develop future foods that not only eliminate malnutnition,but also reduce the incidence of metabolic diseases.

关键词： Food Nutrition Insulin Diabetes Agriculhure Metabolic diseases

Organising a juvenile ratio monitoring programme for 10 key waterbird species in the Yangtze River floodplain:analysis and proposals

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Avian Research 2021年第4期12卷 645-657页

作者： Yuxi Wang Iderbat Damba Qingshan Zhao Yanbo Xie Xueqing Deng Rdi Ga Guanhua Liu Zhiwen Xu Yue Li Dali Gao Wenbin Xu guoxun chen Lei Cao School of Life Science University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Urban and Regional Ecology Research Center for Eco Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Institute of Biology Mongolian Academy of SciencesUlaanbaatar 13330Mongolia Department of Modern Physics University of Science and Technology of ChinaHefei 230026China College of Life Sci-ence and Technology Inner Mongolia Normal UniversityHuhehaote 010000China Jiangxi Poyang Lake National Reserve Authority Nan Chang 330038China Authority of Jiangxi Duchang Provincial Natural Reserve Duchang 332600China Authority of East Dongting Lake National Nature Reserve Yueyang 414000China Anhui Shengjin Lake National Reserve Author-ity Dongzhi 247000China Authority of Longgang Lake National Nature Reserve Huanggang 435500China

Background:In the face of continued degradation and loss of wetlands in the Yangtze River floodplain(YRF),there is an urgent need to monitor the abundance and distribution of wintering *** understand fully observed annual changes,we need to monitor demographic rates to understand factors affecting global population *** reproduction success contributes to dynamic changes in population size and age structure,so an assessment of the juvenile ratio(*** winter birds as a proportion of total number aged)of overwintering waterbirds can be an important indicator of the reproductive success in the preceding breeding ***:During 2016-2019,we sampled juvenile ratios among 10 key waterbird species from the wetlands in the *** on these data,we here attempt to establish a simple,efficient,focused and reliable juvenile ratio monitoring scheme,to assess consistently and accurately relative annual breeding success and its contribution to the age structure among these waterbird ***:We compared juvenile ratio data collected throughout the winter and found that the optimal time for undertaking these samples was in the early stages of arrival for migratory waterbirds reaching their wintering area(early to mid-December).We recommend counting consistently at key points(*** where>1%biogeographical flyway population were counted)at sites of major flyway importance(Poyang Lake,East Dongting Lake,Shengjin Lake,Caizi Lake,Longgan Lake and chen Lake).Based on this,the error rate of the programme(155 planned points,the count of 10 waterbird species is 826-8955)is less than 5%.Conclusions:We established a juvenile ratio monitoring programme for 10 key waterbird species in the wetlands of the YRF,and discuss the feasibility and necessity of implementing such a future programme,and how to use these data in our monitoring and understanding of the population dynamics of these waterbird populations.

关键词： Juvenile ratio Monitoring scheme The Yangtze River floodplain Statistical independence

Metal-Organic Framework-Derived Metallic Carbon with Record High Radon Gas Capture Performance

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CCS Chemistry 2024年第7期6卷 1789-1797页

作者： Shicheng Gong Yi Tao Lixi chen Qiuting Xu Junhao Lu Fuyin Ma Xia Wang Guodong Li Jun Wan guoxun Ji Linfeng He Xiaohui Yu Duo Zhang Xuhui Sun Zhifang Chai Shuao Wang State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123 Institute of Functional Nano&Soft Materials Laboratory(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesJiangsu Key Laboratory of Advanced Negative Carbon TechnologiesSoochow UniversitySuzhou 215123 School of Environment and Material Engineering Yantai UniversityYantai 264005 Xi’an Research Institute of Hi-Technology Hong Qing TownXi’an 710025 Shanghai Institute of Measurement and Testing Technology Shanghai 201203 Engineering Institute of Advanced Manufacturing and Modern Equipment Technology Jiangsu UniversityZhenjiang 212013

Developing efficient adsorbents for radon(Rn)capture from the ambient environment is of paramount importance for public ***,it poses a great challenge due to the chemical inertness and extremely low molar concentration of Rn in ***,we report a zeolite imidazolate frameworkderived metallic carbon adsorbent(Zn@NPC)with record high Rn removal performance under ambient *** one-step pyrolysis,the prepared Zn@NPC possesses pores with a preference for Rn and atomically dispersed Zn sites,achieving a high Rn removal efficiency that doubles in adsorption coefficient(9.47 L·g^(−1))and triples in adsorption kinetic coefficient(20.25 mL·g^(−1)·min^(−1))over the benchmark Rn adsorbent coconut activated *** functional theory calculations elucidate the important role of the metal polarization effect,which cooperates with the pore size confinement effect to boost the overall Rn adsorption *** work launches a promising alternative for practical Rn capture.

关键词： radon removal metal-organic frameworks microporous carbon synergistic effect dynamic adsorption

水利工程基坑开挖对临近桥梁桩基的影响及对策分析

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水利建设与管理 2023年第2期43卷 31-37,10页

作者：许方安陈国勋温州市水利建设管理中心浙江温州325000 不详

水利工程基坑开挖容易引起临近建筑物基础变形甚至失稳。为探讨工程性应对举措,本文以在跨江桥梁匝道中开挖修建闸前湖为例,从湖泊开挖岸坡稳定、边界条件改变等角度分析对桥梁桩基承载力的变化影响,针对性地提出桩底及桩侧注浆、桩身... 详细信息

水利工程基坑开挖容易引起临近建筑物基础变形甚至失稳。为探讨工程性应对举措,本文以在跨江桥梁匝道中开挖修建闸前湖为例,从湖泊开挖岸坡稳定、边界条件改变等角度分析对桥梁桩基承载力的变化影响,针对性地提出桩底及桩侧注浆、桩身外包钢筋混凝土或玻纤套筒、增加桩基等加固方案。经比选后,采取受力明确且效果明显的“增加桩基+外包钢筋混凝土”方案加固,保证了已建桥梁运行安全,可供类似工程借鉴。

关键词：水利工程基坑开挖桩基影响对策分析

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英台地区水下决口扇特征及成因模式

大庆石油地质与开发 2011年第4期30卷 22-25页

作者：陈国勋大庆油田有限责任公司勘探开发研究院黑龙江大庆163712

针对英台地区开发井网与砂体匹配关系不适应的问题，在大量岩心观察分析的基础上，对研究区水下决口扇砂体的成因和特征进行了研究。描述了水下决口扇砂体的识别标志，并结合水动力分析，将水下决口扇的发育过程划分为发生期、稳定期和... 详细信息

针对英台地区开发井网与砂体匹配关系不适应的问题，在大量岩心观察分析的基础上，对研究区水下决口扇砂体的成因和特征进行了研究。描述了水下决口扇砂体的识别标志，并结合水动力分析，将水下决口扇的发育过程划分为发生期、稳定期和萎缩期3个阶段。根据3个阶段发育的不同序列特征，总结了水下决口扇砂体的典型沉积序列模式。根据典型沉积序列模式在英台地区识别出大量水下决口扇，较好地解释了该地区砂体广泛分布但连通性差和油水关系复杂的地质现象，水下决口扇的识别对开发井网优化设计具有重要意义。

关键词：浅水三角洲水下决口扇成因沉积序列英台地区

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大庆英台地区毫米级泥膜发育特征及储集意义

石油勘探与开发 2009年第4期36卷 442-447页

作者：王海侨刘国志陈国勋中国石油大庆油田公司勘探开发研究院中国科学院广州地球化学研究所

通过精细岩心观察发现，大庆油田西部英台地区白垩系粉砂岩中发育大量泥质薄层——泥膜，厚度在0．5～3．0mm。大部分泥膜平面并不平滑，而是发生了多种不同形状的微变形构造，其中相当一部分发生了上下砂岩的穿透。泥膜因其渗透性极差... 详细信息

通过精细岩心观察发现，大庆油田西部英台地区白垩系粉砂岩中发育大量泥质薄层——泥膜，厚度在0．5～3．0mm。大部分泥膜平面并不平滑，而是发生了多种不同形状的微变形构造，其中相当一部分发生了上下砂岩的穿透。泥膜因其渗透性极差而具有很强的垂向阻隔性，理想情况下一层稳定的泥膜能够将所在范围内的上下砂岩完全隔开，将一整套砂体分隔成上下两个独立的油水系统，大量稳定泥膜的发育则使区域内的油水分布变得非常复杂。而频繁发育的小规模或发生穿透的泥膜在油田开发时则阻隔了砂岩内部的油水运移路线，起到降低砂岩孔渗性的作用。研究区低角度浅水三角洲沉积背景是毫米级泥膜大量发育的主控因素，毫米级泥膜的发育频率与沉积微相和单层砂体厚度有密切联系，可以通过局部取心井的泥膜统计来对附近区域的泥膜发育数量进行预测。

关键词：英台地区毫米级泥膜阻隔非均质性剩余油

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水工隧洞交叉洞段布置及其施工控制探析

中国水能及电气化 2022年第11期 56-60页

作者：许方安王丽丽陈国勋温州市水利建设管理中心浙江温州325000 温州市水旱灾害防御中心浙江温州325000

新建水工隧洞与其他地下线性建筑物临近交叉布置时,其交叉段爆破开挖容易带来安全隐患。平阳南湖分洪工程北线分洪隧洞倒虹吸段下穿平阳引供水工程4号引水隧洞,通过优化交叉线路布置,并采取“超前探测、预注浆、短进尺、弱爆破、强支护... 详细信息

新建水工隧洞与其他地下线性建筑物临近交叉布置时,其交叉段爆破开挖容易带来安全隐患。平阳南湖分洪工程北线分洪隧洞倒虹吸段下穿平阳引供水工程4号引水隧洞,通过优化交叉线路布置,并采取“超前探测、预注浆、短进尺、弱爆破、强支护、重监测”的施工方案,降低了两者相互干扰和影响程度,保证了交叉洞段施工安全,可为其他类似工程提供借鉴。

关键词：水工隧洞交叉布置爆破控制系统支护安全监测