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Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

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Food Science and Human Wellness 2024年第2期13卷 842-855页

作者： Qihong Jiang Lin Chen Rui Wang Yin Chen Shanggui Deng guoxin Shen Shulai liu Xingwei Xiang College of Food Science and Technology Zhejiang University of TechnologyHangzhou 310014China Key Laboratory of Marine Fishery Resources Exploitment&Utilization of Zhejiang Province Hangzhou 310014China National R&D Branch Center for Pelagic Aquatic Products Processing(Hangzhou) Hangzhou 310014China Institute of Sericultural and Tea Zhejiang Academy of Agricultural SciencesHangzhou 310021China College of Food and Pharmacy Zhejiang Ocean UniversityZhoushan 316000China

Type 2 diabetes mellitus(T2DM)is a complex metabolic disease threatening human health.We investigated the effects of Tegillarca granosa polysaccharide(TGP)and determined its potential mechanisms in a mouse model of T2DM established through a high-fat diet and streptozotocin.TGP(5.1×10^(3) Da)was composed of mannose,glucosamine,rhamnose,glucuronic acid,galactosamine,glucose,galactose,xylose,and fucose.It could significantly alleviate weight loss,reduce fasting blood glucose levels,reverse dyslipidemia,reduce liver damage from oxidative stress,and improve insulin sensitivity.RT-PCR and Western blotting indicated that TGP could activate the phosphatidylinositol-3-kinase/protein kinase B signaling pathway to regulate disorders in glucolipid metabolism and improve insulin resistance.TGP increased the abundance of Allobaculum,Akkermansia,and Bifidobacterium,restored the microbiota abundance in the intestinal tracts of mice with T2DM,and promoted short-chain fatty acid production.This study provides new insights into the antidiabetic effects of TGP and highlights its potential as a natural hypoglycemic nutraceutical.

关键词： Tegillarca granosa polysaccharide Type 2 diabetes mellitus Glycolipid metabolism PI3K/Akt signaling pathway

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Strategies for improving extraction capacity through preorganization structure:A novel 5,6-bicyclicmalonamide extractant(THPPD)

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Journal of Rare Earths 2024年第4期42卷 768-774页

作者： Miaomiao Zhang Zhen Yang Yuhua Cui Jianhui Su Heng Zhao Chengjin Xu Xiaolei liu guoxin Sun Xiujing Peng Yu Cui School of Chemistry and Chemical Engineering University of JinanJinan250022China Institute for Smart Materials&Engineering University of JinanJinan250022China Shandong Institute for Food and Drug Control Jinan250101China

Rational design of extractant structure to improve the extraction and separation capacity of rare earth elements(REEs)is a long-standing challenge.Herein,a new strategy was proposed to improve the stability of the chelating structure formed by malonamide and REEs.The stability of the chelating structure is greatly improved by using a double-ring framework structure which makes the two carbonyl groups of malonamide unable to rotate freely and both of them point to the metal ion position.Three benzyl groups were used to construct the hydrophobicity of the extractant and the organic shell of the extracted species.Tribenzylhexahydro-pyrrolo-pyridine-dione(THPPD)was designed and synthesized.The structure reduces the energy consumed by rotating carbonyl group in the coordination with metal ions and then improves the extraction ability of extractant.The crystal structure was preorganized as expected,with the two carbonyls pointing in a favorable coordination direction to the structural complement of the metal ion.The extraction behaviors of REEs with THPPD in a nitric acid medium were studied.Compared with N,N’-dibenzyl-N,N’-dimethylmalonamide(DBDM-MA)with a chain structure,the extraction capacity of THPPD is 360 times higher than that of DBDM-MA at 5.0 mol/L sodium nitrate.Furthermore,the binding energy and Gibbs free energy were investigated by density functional theory(DFT)in conjunction with the B3LYP.The theoretical results show that THPPD has more effective interaction with Pr(NO_(3))3 than DBDM-MA.The construction of chelating groups conformation is a worthy direction to improve the coordination ability and even selectivity of extractant.

关键词： Rare earth elements Extraction separation 5,6-bicyclicdiamide extractant

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忆初创时期的《当代中国史研究》

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当代中国史研究 2024年第1期31卷 21-30,M0004页

作者：刘国新《当代中国史研究》

《当代中国史研究》创刊30周年了。30年,一个并不算短的时间刻度,在古人诗词中常带点忧伤和感怀,而我们则是怀着喜悦的心情回首以往。岁月悠悠,盘点当年,记忆的闸门一旦打开,一件件往事扑面而来,似乎一切还在眼前,一幅幅画面立刻灵动起... 详细信息

《当代中国史研究》创刊30周年了。30年,一个并不算短的时间刻度,在古人诗词中常带点忧伤和感怀,而我们则是怀着喜悦的心情回首以往。岁月悠悠,盘点当年,记忆的闸门一旦打开,一件件往事扑面而来,似乎一切还在眼前,一幅幅画面立刻灵动起来。千头万绪从哪说起呢?就说说《当代中国史研究》初创时期做过些什么,又是怎么做的吧。

关键词：时间刻度初创时期《当代中国史研究》灵动

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Exponential change of measure for general piecewise deterministic Markov processes

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Science China Mathematics 2019年第4期62卷 719-734页

作者： Zhaoyang liu Yuying liu guoxin liu School of Mathematics and Statistics Central South University Department of Mathematics and Physics Shijiazhuang Tiedao University

We consider a general piecewise deterministic Markov process(PDMP) X = {X_t}_(t≥0) with a measure-valued generator A, for which the conditional distribution function of the inter-occurrence time is not necessarily absolutely continuous. A general form of the exponential martingales that are associated with X is given by■By considering this exponential martingale to be a likelihood-ratio process, we define a new probability measure and show that the process X is still a general PDMP under the new probability measure. We additionally find the new measure-valued generator and its domain. To illustrate our results, we investigate the continuous-time compound binomial model.

关键词： exponential change of measure piecewise deterministic Markov process measure-valued generator Stieltjes exponential

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Blue LED promotes the chemosensitivity of human hepatoma to Sorafenib by inducing DNA damage

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BIOCELL 2023年第8期47卷 1811-1820页

作者： TONG WANG JINHUAN HONG JIAJIE XIE QIAN liu JINRUI YUE XUTING HE SHIYU GE TAO LI guoxin liu BENZHI CAI LINQIANG LI YE YUAN Department of Pharmacy(The University Key Laboratory of Drug Research Heilongjiang Province)The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of General Surgery The First Affiliated Hospital of Harbin Medical UniversityHarbinChina National Key Laboratory of Frigid Cardiovascular Disease HarbinChina Department of Pharmacology(The State-Province Key Laboratories of Biomedicine Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbinChina Department of Clinical Pharmacology College of PharmacyHarbin Medical UniversityHarbinChina

Background:Phototherapies based on sunlight,infrared,ultraviolet,visible,and laser-based treatments present advantages like high curative effects,small invasion,and negligible adverse reactions in cancer treatment.We aimed to explore the potential therapeutic effects of blue light emitting diode(LED)in human hepatoma cells and decipher the underlying cellular and molecular mechanisms.Methods:Wound healing and transwell assays were employed to probe the inhibition of the invasion and migration of hepatocellular carcinoma cells in the presence of blue LED.The sphere-forming test was used to evaluate the effect of LED blue light irradiation on cancer stem cell properties.Immunofluorescence and western blotting were used to detect the changes inγ-H2AX.The Cell Counting Kit-8 assay,5-ethynyl-2′-deoxyuridine staining,and colony formation assay were used to detect the combined effect of blue LED and sorafenib on cell proliferation inhibition.Results:We demonstrated that the irradiation of blue LED light in hepatoma cells could lead to cell proliferation reduction along with the increase of cell apoptosis.Simultaneously,blue LED irradiation also markedly suppressed the migration and invasion ability of human hepatoma cells.Sphere formation analysis further revealed the decreased cancer stemness of hepatoma cells upon blue LED irradiation.Mechanistically,blue LED irradiation significantly promoted the expression of the phosphorylation of the core histone protein H2AX(γ-H2AX),a sensitive molecular marker of DNA damage.In addition,we found that the combined treatment of blue LED irradiation and sorafenib increased cancer cell sensitivity to sorafenib.Conclusion:Collectively,we demonstrated that blue LED irradiation exhibited anti-tumor effects on liver cancer cells by inducing DNA damage and could enhance chemosensitivity of cancer cells,which represents a potential approach for human hepatoma treatment.

关键词： Blue LED Irradiation Liver cancer DNA damage Chemotherapy resistance

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Discussion on the application prospect of the transient electromagnetic method based on the dual launcher and mine advanced detection

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World Journal of Condensed Matter Physics 2024年第1期14卷 21-33页

作者： Zhen Yang Huizhou liu Shengqing Wang Yu Cao Ya Dong Chenghu Niu Weiwen Song guoxin Xie State Grid Energy Hefeng Coal Power Co. Ltd. Tacheng Prefecture and Bukeseer County Xinjiang China Anhui Huizhou Geology Security Institute Co. Ltd. Hefei China

The dual transmitter implements the equivalent anti-magnetic flux transient electromagnetic method, which can effectively reduce the scope of the transient electromagnetic detection blind area. However, this method is rarely reported in the detection of pipelines in urban geophysical exploration and the application of coal mines. Based on this, this paper realizes the equivalent anti-magnetic flux transient electromagnetic method based on the dual launcher. The suppression effect of this method on the blind area is analyzed by physical simulation. And the detection experiment of underground pipelines is carried out outdoors. The results show that the dual launcher can significantly reduce the turn-off time, thereby effectively reducing the impact of the blind area on the detection results, and the pipeline detection results verify the device’s effectiveness. Finally, based on the ground experimental results, the application prospect of mine advanced detection is discussed. Compared with other detection fields, the formation of blind areas is mainly caused by the equipment. If the dual launcher can be used to reduce the blind area, the accuracy of advanced detection can be improved more effectively. The above research results are of great significance for improving the detection accuracy of the underground transient electromagnetic method.

关键词： A Dual Launcher Physical Simulation Transient Electromagnetic Method Mine Geophysical Prospecting Detection Blind Area Application Prospect

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Ruin probability in Sparre Andersen risk model with claim inter-arrival times distributed as Erlang

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Frontiers of Mathematics in China 2015年第6期10卷 1433-1447页

作者： Guangkun SUN Shuaiqi ZHANG guoxin liu School of Science Hebei University of Technology Tianjin 300401 China School of Economics and Commerce Guangdong University of Technology Guangzhou 510520 China Department of Mathematics Shijiazhuang Tiedao University Shijiazhuang 050043 China

这篇文章与是在 piecewise 的框架散布的厄兰的内部主张的时间在一个斯帕雷·安德森风险过程处理毁灭概率确定的 Markov 过程(PDMP ) 。我们由 PDMP 的扩大发电机的优点构造指数的鞅改变这项措施。一些结果为毁灭可能性被导出，例如为... 详细信息

这篇文章与是在 piecewise 的框架散布的厄兰的内部主张的时间在一个斯帕雷·安德森风险过程处理毁灭概率确定的 Markov 过程(PDMP ) 。我们由 PDMP 的扩大发电机的优点构造指数的鞅改变这项措施。一些结果为毁灭可能性被导出，例如为毁灭概率， Lundberg 界限， Cramér-Lundberg 近似，和有限地平线的毁灭概率的一般表情。

关键词：破产概率索赔次数时间分布风险模型 Erlang分布马尔可夫过程一般表达式风险过程

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全碳纤维复合材料太阳能无人机机翼结构优化设计

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复合材料科学与工程 2024年第3期 79-83页

作者：苏桐胡果馨刘振西安交通大学物理学院西安710049 西安交通大学航天航空学院西安710049

针对大展弦比太阳能无人机的性能要求,开展碳纤维复合材料太阳能无人机机翼的优化设计。选用NACA4412为基准翼型,利用xfoil软件作为气动计算软件,基于NSGA-Ⅱ优化算法进行翼型优化。在此基础上对机翼进行三维建模,采用CFD软件进行气动... 详细信息

针对大展弦比太阳能无人机的性能要求,开展碳纤维复合材料太阳能无人机机翼的优化设计。选用NACA4412为基准翼型,利用xfoil软件作为气动计算软件,基于NSGA-Ⅱ优化算法进行翼型优化。在此基础上对机翼进行三维建模,采用CFD软件进行气动特性分析,并利用ANSYS Workbench静力学模块对机翼进行流固耦合分析。结果表明:翼型优化后,升力系数提高4.20%,阻力系数降低8.74%,升阻比提高14.18%;在气动载荷作用下,从翼根向翼尖方向压力逐渐增大,翼尖处最大压力相对外界大气压力为242 Pa;在外载荷作用下,最大应力显示在翼根附近,为61.397 MPa,翼变形的最大值为40.262 mm,整体满足太阳能无人机的允许变形量在5%以内即翼尖变形不得大于半翼展长度值的5%的刚度要求。研究结果可为碳纤维复合材料太阳能无人机设计和研制提供理论参考。

关键词：碳纤维复合材料太阳能无人机机翼结构流固耦合分析优化设计

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民营经济人士共同富裕认同的机制与路径

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江汉大学学报（社会科学版） 2024年第2期41卷 80-87页

作者：刘国新湖南省社会主义学院综合理论教研部湖南长沙410001

共同富裕认同本质上是在共同富裕问题上对“我是谁”的反思性、建构性理解,人们首先将自己认同为自由的能动者,进而才是共同富裕共同体中的一员,因而共同富裕认同是社会大众基于对共同富裕的认知和判断而信任并归属共同富裕共同体,并不... 详细信息

共同富裕认同本质上是在共同富裕问题上对“我是谁”的反思性、建构性理解,人们首先将自己认同为自由的能动者,进而才是共同富裕共同体中的一员,因而共同富裕认同是社会大众基于对共同富裕的认知和判断而信任并归属共同富裕共同体,并不断试图付诸实践的蓄势待发的心理状态,是走共同富裕道路的心理前提和实践基础。民营经济人士共同富裕认同是共同富裕认同的重要内容,其认同机制包括心理机制、利益机制、践行机制和保障机制,其路径设计应围绕共同富裕进程中与民营经济密切相关的利益问题,以优化营商环境、改善民生和法治建设为切入口,增进民营经济人士的现实利益,打造强有力的宣教机制,将共同富裕渗透到民营经济发展的方方面面,在制度保障上实现体现共同富裕理念的制度设计和得到制度保障的共同富裕行动的统一,最终形成顶层设计、各方联动、民营经济深度参与的共同富裕认同路径体系。

关键词：共同富裕认同民营经济自我认同认同路径

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新能源汽车驱动电机控制器深度解析

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汽车电器 2024年第2期 5-8页

作者：刘国新河北交通职业技术学院河北石家庄050035

文章针对新能源汽车驱动电机控制器的结构原理进行深度解析,阐述电机控制器的基本结构、基本功能,深入分析逆变电路的逆变原理、能量回收整流原理、正弦交流电产生原理和变压与变频原理,介绍电机控制器驱动电路与控制电路的基本组成与... 详细信息

文章针对新能源汽车驱动电机控制器的结构原理进行深度解析,阐述电机控制器的基本结构、基本功能,深入分析逆变电路的逆变原理、能量回收整流原理、正弦交流电产生原理和变压与变频原理,介绍电机控制器驱动电路与控制电路的基本组成与结构特点,对职业院校新能源汽车技术专业教师和新能源汽车维修行业维修人员具有一定的参考和借鉴意义。

关键词：电机控制器逆变变频变压隔离控制

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