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Chinese Chemical Letters 2022年第4期33卷 1895-1900页

作者： Xinying Yu Tongyi Shang Guodong Zheng Hailong Yang Yuwei Li Yanjun cai guoxi Xie Bin Yang The Sixth Affiliated Hospital Department of Biomedical EngineeringSchool of Basic Medical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Ferroustherapy has gained great attention for anti-cancer treatment in recent years. Enlightened by temperature-mediated Fenton reaction in industrial waste water removal, we designed a iron-based polyphenol-coordinated nanomedicines for mild hyperthermia-assisted anti-cancer ferroustherapy. In brief, Fe-GA@BSA nanoparticles was synthesized by self-assembly and sorafenib(SRF) was loaded into Fe-GA@BSA to establish Fe-GA@BSA-SRF nanomedicines. The result nanomedicines can induce ferroptosis in cancer cells by accelerating Fenton reaction. And the photothermal effect of Fe-GA@BSA-SRF was used for mild hyperthermia-assisted ferroustherapy. The nanomedicines performs good anti-cancer therapeutic efficacy by inducing the production of ROS and inhibiting glutathione peroxidase 4(GPX4) expression in vitro and in vivo. Besides, the broad absorption of Fe-GA@BSA-SRF in near infrared region endows it with photoacoustic imaging ability. This study provides ideas about rational design on iron-based nanoparticles for anti-cancer ferroustherapy.

关键词： Ferroptosis Metal-polyphenol nanomedicines Fenton reaction Mild hyperthermia Photoacoustic imaging

Robust Quantzation Index Modulation VIA Adaptive Watermarking

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China Communications 2008年第2期5卷 40-48页

作者： Wang, guoxi Ma, Lihong Yu, Decong cai, Kang Lu, Hanqing S China Univ Technol Dept Elect Engn GE Key Lab Comp Network Guangzhou 510641 Peoples R China Chinese Acad Sci Natl Lab Pattern Recognit Inst Automat Beijing 100080 Peoples R China Guangdong Telecom Guangzhou Guangdong Peoples R China

In this paper,we suggest an adaptive watermarkingmethod to improve both transparence and robustnessof quantization index modulation(QIM)scheme.Instead of a fixed quantization step-size,we apply astep-size adapted to image content in each 8×8block to make a balance of robust extraction andtransparent embedding.The modified step-size isdetermined by contrast masking thresholds ofWatson’s perceptual model.From a normalizedcrossed-correlation value between the original watermarkand the detected watermark,we could observethat our method is robust to attacks of additivewhite Gaussian noise(AWGN),Salt and Peppernoise and Joint Photographic Experts Group(JPEG)compression than the original QIM.By taking intoaccount the contrast insensitivity and visible thresholdsof human visual system,the suggested improvementachieves a maximum embedding strength andan appropriate quantization step-size which is consistentwith local values of a host signal.

关键词： Vector projected watermarking adaptive quantization index modulation contrast sensitivity masking

MODIFIED QUANTIZATION INDEX MODULATION WATERMARKING ADAPTIVE TO CONTRAST MASKING THRESHOLDS

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China Communications 2007年第1期4卷 75-84页

作者： Wang, guoxi Ma, Lihong Yu, Decong cai, Kang Lu, Hanqing S China Univ Technol GD Key Lab Comp Network Dept Elect Engn Guangzhou 510641 Peoples R China Chinese Acad Sci Natl Lab Pattern Recognit Inst Automat Beijing 100080 Peoples R China

In this paper,we suggest an adaptive watermarking method to improve both transparence and robustness of quantization index modulation(QIM) scheme. Instead of a fixed quantization step-size,we apply a step-size adapted to image content in each 8×8 block to make a balance of robust extraction and transparent embedding.The modified step-size is determined by contrast masking thresholds of Watson’s perceptual model.From a normalized crossed-correlation value between the original watermark and the detected watermark,we could observe that our method is robust to attacks of additive white Gaussian noise(AWGN),Salt and Pepper noise and Joint Photographic Experts Group(JPEG) compression than the original QIM.By taking into account the contrast insensitivity and visible thresholds of human visual system,the suggested improvement achieves a maximum embedding strength and an appropriate quantization step-size which is consistent with local values of a host signal.

关键词： vector projected watermarking adaptive quantization index modulation contrast sensitivity masking

COVID-19 vaccination intention and vaccine characteristics infuencing vaccination acceptance: a global survey of 17 countries

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Infectious Diseases of Poverty 2021年第5期10卷 85-86页

作者： Li Ping Wong Haridah Alias Mahmoud Danaee Jamil Ahmed Abhishek Lachyan Carla Zi cai Yulan Lin Zhijian Hu Si Ying Tan Yixiao Lu guoxi cai Di Khanh Nguyen Farhana Nishat Seheli Fatma Alhammadi Milkar D.Madhale Muditha Atapattu Tasmi Quazi‑Bodhanya Samira Mohajer Gregory D.Zimet Qinjian Zhao Department of Epidemiology and Health Statistics Fujian Provincial Key Laboratory of Environment Factors and CancerSchool of Public HealthFujian Medical UniversityFuzhou 350122FujianChina 不详

Background:The availability of various types of COVID-19 vaccines and diverse characteristics of the vaccines pre‑sent a dilemma in vaccination choices,which may result in individuals refusing a particular COVID-19 vaccine ofered,hence presenting a threat to immunisation coverage and reaching herd immunity.The study aimed to assess global COVID-19 vaccination intention,vaccine characteristics infuencing vaccination acceptance and desirable vaccine characteristics infuencing the choice of vaccines.Methods:An anonymous cross-sectional survey was conducted between 4 January and 5 March 2021 in 17 coun‑tries worldwide.Proportions and the corresponding 95%confdence intervals(CI)of COVID-19 vaccine acceptance and vaccine characteristics infuencing vaccination acceptance were generated and compared across countries and regions.Multivariable logistic regression analysis was used to determine the factors associated with COVID-19 vaccine hesitancy.Results:Of the 19,714 responses received,90.4%(95%CI 81.8–95.3)reported likely or extremely likely to receive COVID-19 vaccine.A high proportion of likely or extremely likely to receive the COVID-19 vaccine was reported in Australia(96.4%),China(95.3%)and Norway(95.3%),while a high proportion reported being unlikely or extremely unlikely to receive the vaccine in Japan(34.6%),the U.S.(29.4%)and Iran(27.9%).Males,those with a lower educational level and those of older age expressed a higher level of COVID-19 vaccine hesitancy.Less than two-thirds(59.7%;95%CI 58.4–61.0)reported only being willing to accept a vaccine with an efectiveness of more than 90%,and 74.5%(95%CI 73.4–75.5)said they would accept a COVID-19 vaccine with minor adverse reactions.A total of 21.0%(95%CI 20.0–22.0)reported not accepting an mRNA vaccine and 51.8%(95%CI 50.3–53.1)reported that they would only accept a COVID-19 vaccine from a specifc country‐of‐origin.Countries from the Southeast Asia region reported the highest proportion of not accepting mRNA technology.The highest proportion from Europe and the Ame

关键词： COVID-19 vaccine Vaccination intention Vaccine characteristics Vaccination acceptance Vaccine choice

CEPC positron source design

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Radiation Detection Technology and Methods 2019年第3期3卷 120-126页

作者： cai Meng Xiaoping Li guoxi Pei Jingru Zhang Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina

Purpose Circular Electron Positron Collider(CEPC)is a 100-km-ring e+e−collider for a Higgs factory.The injector is composed of a 10-GeV Linac and a 120-GeV Booster.The CEPC Linac is a normal conducting S-band Linac with frequency of 2860 MHz providing electron and positron beams at an energy up to 10 GeV with 100 Hz repetition frequency.The positron source is the most important part of the CEPC Linac,and the bunch charge of positron beam within some cut-off condition should be larger than 3 nC.Methods The positron source of CEPC is composed of a target,a flux concentrator,a capture section,a pre-accelerating section and a beam separation system.Higher positron yield and capture efficiency are the design goal.Based on simulation,the design will be presented and discussed in detail.Result The positron yield at the PSPAS exit is larger than 0.55,and the normalized rms emittance is 2370 mm-mrad with a strict cut-off condition.The detailed simulation results will be presented.Conclusions The design of the positron source including positron production and capture will be presented and can meet the requirements.

关键词： Positron source CEPC Linac AMD Emittance

EFFECTS OF STIMULATING PAG ON THE NOCICEPTIVE NEURON DISCHARGES OF PO NUCLEUS EVOKED BY STIMULATION OF SPLANCHNIC NERVE IN CAT

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针刺研究 1989年第Z1期 120-121页

作者： Zhang Ruide cai Kui Na Jie Ma Xiaoling Liu Shuzhen Wang Huan Teng guoxi Laboratory of Neurophysiology, China Medical University

The effects of stimulating PAG on the nociceptive neuron discharges of POnucleus evoked by stimulating the splanchnie nerve in cat were studied. Twokinds of inhibitory action were observed. One is called early phase or promptinhibition phase which occurs promptly within 30ms to 150ms after stimulationof PAG. The other is called slow-phase or sustained inhibition which occurs

关键词： PAG EFFECTS OF STIMULATING PAG ON THE NOCICEPTIVE NEURON DISCHARGES OF PO NUCLEUS EVOKED BY STIMULATION OF SPLANCHNIC NERVE IN CAT PO

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压铸铝、镁合金缸盖罩NVH性能对比

江苏大学学报（自然科学版） 2009年第2期30卷 134-137页

作者：景国玺郝志勇郭磊蔡军余波浙江大学机械与能源工程学院浙江杭州310027 重庆长安汽车股份有限公司重庆401120

对新型镁合金材料AZ91D在缸盖罩轻量化设计中的NVH性能进行了研究,采用有限元和边界元的方法对缸盖罩材料替代前后的NVH特性进行了对比分析.结果表明,原铝合金缸盖罩材料替换为镁合金后,结构各阶固有频率和刚度略有下降,但是由于镁合金... 详细信息

对新型镁合金材料AZ91D在缸盖罩轻量化设计中的NVH性能进行了研究,采用有限元和边界元的方法对缸盖罩材料替代前后的NVH特性进行了对比分析.结果表明,原铝合金缸盖罩材料替换为镁合金后,结构各阶固有频率和刚度略有下降,但是由于镁合金结构具有良好的阻尼特性,缸盖罩结构表面振动响应明显变弱,表面辐射噪声得到了抑制.同时对仿真结果进行了相关试验验证.

关键词：缸盖罩铝合金镁合金 NVH性能阻尼

腹腔镜远端胃癌根治术消化道重建中Billroth Ⅱ+Braun吻合与单纯Billroth Ⅱ吻合的疗效比较

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中国医师杂志 2023年第10期25卷 1464-1467页

作者：王怀帅蔡志聪林高枫许国玺庄奕翔李银林林奇忆叶再元晋江市医院(上海市第六人民医院福建医院)胃肠/疝与腹壁外科晋江362214 浙江省人民医院(杭州医学院附属人民医院)普通外科胃肠胰外科杭州310014

目的对比腹腔镜远端胃癌根治术消化道重建中BillrothⅡ+Braun吻合与单纯BillrothⅡ吻合的临床疗效及患者术后生活质量。方法选择2019年1月至2022年1月在晋江市医院行腹腔镜远端胃癌根治术治疗的68例患者的临床资料进行回顾性分析,将行Bi... 详细信息

目的对比腹腔镜远端胃癌根治术消化道重建中BillrothⅡ+Braun吻合与单纯BillrothⅡ吻合的临床疗效及患者术后生活质量。方法选择2019年1月至2022年1月在晋江市医院行腹腔镜远端胃癌根治术治疗的68例患者的临床资料进行回顾性分析,将行BillrothⅡ+Braun吻合方式进行消化道重建的40例患者纳入观察组,行单纯BillrothⅡ吻合方式进行消化道重建的28例患者纳入对照组。收集两组围手术期相关指标及术后1年相关指标,观察患者术后的安全性及疗效。结果两组患者手术时间、术中出血量、术后排气时间、拔胃管进流食时间、拔引流管时间、术后住院时间比较差异均无统计学意义(均P>0.05)。两组患者术后并发症发生情况及分级比较,差异均无统计学意义(P>0.05)。术后1年观察组食物潴留、残胃炎发生率均低于对照组(均P0.05)。术后1年观察组患者总蛋白下降量和预后营养指数(PNI)低于对照组,差异有统计学意义(均P<0.05);术后1年观察组腹胀、反流症状发生率低于对照组,差异有统计学意义(均P<0.05)。结论在腹腔镜远端胃癌根治术中,以BillrothⅡ+Braun吻合方式进行消化道重建安全性高,可以改善患者术后生活质量。

关键词：胃肿瘤胃切除术消化道重建 BillrothⅡ吻合术 Braun吻合

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关于买断式债券回购有关问题的探讨

证券市场导报 2005年第6期 47-56页

作者：蔡国喜包香明吴方伟中央国债登记结算公司北京100032

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关键词：债券回购买断式回购银行间债券市场会计处理方式法律内涵税收政策市场表现市场成员发展建议保证金收益率积极性管理

免疫检查点抑制剂在胃肠道肿瘤治疗的研究进展及安全性探讨

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中国医师杂志 2022年第3期24卷 338-340,345页

作者：庄奕翔林高枫许国玺王怀帅蔡志聪李银林林奇忆刘维波晋江市医院胃肠外科泉州362200

胃肠道肿瘤是最常见的消化道恶性肿瘤,其发病率呈逐年上升趋势。相对于其他实体肿瘤,胃肠道肿瘤中免疫检查点抑制剂的应用仍处于不断探索阶段。本文拟盘点免疫检查点抑制剂在晚期胃癌、错配修复功能缺陷/微卫星高度不稳定及错配修复功... 详细信息

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关键词：胃肠肿瘤免疫检查点抑制剂程序性细胞死亡受体1 微卫星不稳定性