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新型降脂药物PCSK9抑制剂在动脉粥样硬化心血管疾病的研究现状

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药学研究 2024年第5期43卷 487-494页

作者：马国文刘世昌王海亮姜文妍王学健山东第二医科大学药学院山东潍坊261053 潍坊市人民医院山东潍坊261041 潍坊市精神卫生中心山东潍坊261072

动脉粥样硬化是许多心血管疾病的早期病理改变,脂质代谢紊乱是动脉粥样硬化性心血管疾病(ASCVD)最重要的危险因素之一。前蛋白转化酶枯草杆菌蛋白酶/kexin 9型(PCSK9)是血脂调节的关键因子,可以通过与低密度脂蛋白受体(LDLR)结合,降解L... 详细信息

动脉粥样硬化是许多心血管疾病的早期病理改变,脂质代谢紊乱是动脉粥样硬化性心血管疾病(ASCVD)最重要的危险因素之一。前蛋白转化酶枯草杆菌蛋白酶/kexin 9型(PCSK9)是血脂调节的关键因子,可以通过与低密度脂蛋白受体(LDLR)结合,降解LDLR从而阻止低密度脂蛋白的清除,导致低密度脂蛋白胆固醇(LDL-C)水平升高,增加心血管疾病的风险。PCSK9也参与炎症细胞因子的生成、内皮功能障碍和动脉粥样硬化斑块的形成。多项研究显示,PCSK9是治疗ASCVD的一个有希望的新靶点。PCSK9抑制剂是目前治疗高胆固醇血症的新型药物。本文就PCSK9抑制剂在动脉粥样硬化中的作用及药物研究进展做一综述,为临床用药提供参考。

关键词：前蛋白转化酶枯草杆菌蛋白酶/kexin 9型抑制剂动脉粥样硬化人前蛋白转化酶枯草溶菌素9 动脉粥样硬化性心血管疾病胆固醇低密度脂蛋白胆固醇

Unveiling an S-scheme F–Co_(3)O_(4)@Bi_(2)WO_(6) heterojunction for robust water purification

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eScience 2024年第1期4卷 104-113页

作者： Linhan Jian guowen Wang Xinghui Liu Hongchao ma School of Light Industry&Chemical Engineering Dalian Polytechnic UniversityNo.1 QinggongyuanGanjingzi DistrictDalian 116034People's Republic of China Department of Chemistry Sungkyunkwan University(SKKU)Jangan-GuSuwon 16419Republic of Korea Division of Research and Development Lovely Professional UniversityPhagwaraIndia Science and Technology on Aerospace Chemical Power Laboratory Xiangyang 441003People's Republic of China Hubei Institute of Aerospace Chemotechnology Xiangyang 441003People's Republic of China

Devising a desirable nano-heterostructured photoelectrode based on the charge transfer kinetics mechanism is a pivotal strategy for implementing efficient photoelectrocatalytic(PEC)technology,since the charge separation and utilization efficiency of a photoelectrode is critical to its PEC ***,we fabricate a F–Co_(3)O_(4)@Bi_(2)WO_(6) core–shell hetero-array photoanode by coupling Bi_(2)WO_(6) nanosheets with F–Co_(3)O_(4) nanowires using a simple solvothermal solution *** three-dimensional hierarchical heterostructure has a homogeneous chemical interface,helping it to promote an S-scheme-based carrier transport kinetics and maintain excellent cycling *** density difference calculations verify the electron migration trend from F–Co_(3)O_(4) to Bi_(2)WO_(6) upon hybridization and the formation of an internal electric field in the heterojunction,consistent with the S-scheme mechanism,which is identified by in situ irradiation X-ray photoelectron spectroscopy and by ultraviolet photoelectron *** optimized F–Co_(3)O_(4)@Bi_(2)WO_(6)-2 photoelectrode achieves high carrier utilization efficiency and exhibits superior PEC degradation performance for various organic pollutants,including reactive brilliant blue KN-R,rhodamine B,sulfamethoxazole,and bisphenol *** work not only reveals that F–Co_(3)O_(4)@Bi_(2)WO_(6)-2 is effective for PEC water remediation but also provides a strategy to enhance carrier transport kinetics by designing binary oxides.

关键词： S-scheme Internal electric field Bi_(2)WO_(6) Water purification Photoelectrocatalysis

High Density 3D Carbon Tube Nanoarray Electrode Boosting the Capacitance of Filter Capacitor

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Nano-Micro Letters 2024年第11期16卷 242-254页

作者： Gan Chen Fangming Han Huachun ma Pei Li Ziyan Zhou Pengxiang Wang Xiaoyan Li guowen Meng Bingqing Wei Key Laboratory of materials Physics and Anhui Key Laboratory of Nanomaterials and NanotechnologyInstitute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031People’s Republic of China Department of materials Science and Engineering University of Science and Technology of ChinaHefei 230026People’s Republic of China Department of Mechanical Engineering University of DelawareNewarkDE 19716USA Mechano‑X Institute Applied Mechanics LaboratoryDepartment of Engineering MechanicsTsinghua UniversityBeijing 100084People’s Republic of China

Electric double-layer capacitors(EDLCs)with fast frequency response are regarded as small-scale alternatives to the commercial bulky aluminum electrolytic *** carbon-based nanoarray electrodes with precise alignment and smooth ion channels is crucial for enhancing EDLCs’***,controlling the density of macropore-dominated nanoarray electrodes poses challenges in boosting the capacitance of line-filtering ***,a simple technique to finely adjust the vertical-pore diameter and inter-spacing in three-dimensional nanoporous anodic aluminum oxide(3D-AAO)template is achieved,and 3D compactly arranged carbon tube(3D-CACT)nanoarrays are created as electrodes for symmetrical EDLCs using nanoporous 3D-AAO template-assisted chemical vapor deposition of *** 3D-CACT electrodes demonstrate a high surface area of 253.0 m^(2) g^(−1),a D/G band intensity ratio of 0.94,and a C/O atomic ratio of *** a result,the high-density 3D-CT nanoarray-based sandwich-type EDLCs demonstrate a record high specific areal capacitance of 3.23 mF cm^(-2) at 120 Hz and exceptional fast frequency response due to the vertically aligned and highly ordered nanoarray of closely packed CT *** 3D-CT nanoarray electrode-based EDLCs could serve as line filters in integrated circuits,aiding power system miniaturization.

关键词： Compactly arranged Three-dimensional carbon tube nanoarray Dimensional carbon tube nanoarray Fast frequency response Electric double-layer capacitors Layer capacitors AC line-filtering Filtering

InGaAs/GaAs/InGaP Strained Quantum Well Lasers Grown by Metalorganic Chemical Vapor Deposition

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Journal of Semiconductors 1998年第7期 69-72页

作者： Yang guowen Xu Zuntu ma Xiaoyu Xu Junying Zhang Jingming Chen Lianghui (Institute of Semiconductors, The Chinese Academy of Sciences, Beijing 100083)

１ＩｎｔｒｏｄｕｃｔｉｏｎＳｔｒａｉｎｅｄＩｎＧａＡｓ／ＧａＡｓｑｕａｎｔｕｍｗｅｌ（ＱＷ）ｌａｓｅｒｓｗｉｔｈｅｍｉｓｉｏｎｗａｖｅｌｅｎｇｔｈｏｆ９８０ｎｍａｒｅｃｕｒｅｎｔｌｙｒｅｃｅｉｖｉｎｇｃｏｎｓｉｄｅｒ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＳｔｒａｉｎｅｄＩｎＧａＡｓ／ＧａＡｓｑｕａｎｔｕｍｗｅｌ（ＱＷ）ｌａｓｅｒｓｗｉｔｈｅｍｉｓｉｏｎｗａｖｅｌｅｎｇｔｈｏｆ９８０ｎｍａｒｅｃｕｒｅｎｔｌｙｒｅｃｅｉｖｉｎｇｃｏｎｓｉｄｅｒａｂｌｅａｔｅｎｔｉｏｎｂｅｃａｕ...

关键词： InGaAs/GaAs/InGaP Strained Quantum Well Metalorganic Chemical Deposition

Shadow Removal Using Retinex Theory

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Shadow Removal Using Retinex Theory

The ENSO event and rice planthopper occurrence in China

2011 Third Chinese Conference on Intelligent Visual Surveillance

作者： guowen ma Jinfeng Yang Tianjin Key Lab of Advanced Signal Processing Civil Aviation University of China

Shadows in images always cause problems to computer visual tasks,so how to remove shadow is an important topic of image *** this paper,we propose a new shadow removal method based on Retinex *** firstly use the gradient edge detection combined with 1-D illumination invariant image to detect the shadow area,then remove the shadow with Retinex algorithm,finally adjust the brightness of the shadow *** transforming the RGB image into HSV space,we compute the average brightness of the non-shadow area in original image and shadow-free image,adjust the brightness of the image to coordinate with the original *** experiment results show that our method can provide a good effect in shadow images.

关键词： Retinex theory gradient edge detect illumination invariant image brightness adjustment HSV space

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Rice Science 1996年第1期 9-10页

作者： ZHU Min,HU guowen,TANG Jian,ma Jufa,and TANG Qiyi,Department of Plant Protection,CNRRI,Hangzhou 310006,China

The rice planthopper,including brown plan-thopper(Nilaparvata hugens Stal)and white-backed planthopper(Sogata furcifera Hor-vath),is one kind of tropical *** im-migrate with the southeast monsoon from low-latitude are... 详细信息

关键词： Ni The ENSO event and rice planthopper occurrence in China EIN ENSO

水电站进水口边坡滑坡体地质的稳定性敏感度分析

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水利科学与寒区工程 2021年第4期4卷 32-35页

作者：马国文新疆水利水电勘测设计研究院新疆乌鲁木齐830000

隧洞的进水口段一般位于受地表水高度侵蚀的坡面上,通常埋深较浅,隧洞入口结构上承载岩石拱难以形成,因此很难得到其稳定性保证。本文结合已建的复杂边坡工程实例,对于用有限元法与极限平衡法研究工程边坡实例的精确性进行对比分析,研... 详细信息

隧洞的进水口段一般位于受地表水高度侵蚀的坡面上,通常埋深较浅,隧洞入口结构上承载岩石拱难以形成,因此很难得到其稳定性保证。本文结合已建的复杂边坡工程实例,对于用有限元法与极限平衡法研究工程边坡实例的精确性进行对比分析,研究计算方法及土体的强度参数对土坡稳定安全系数的影响。结果表明,Bishop法得出的稳定安全系数居中,Janbu法得出的稳定安全系数最大。

关键词：水电站滑坡体敏感度

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保持架铆钉孔加工方法改进

哈尔滨轴承 2011年第2期32卷 50-51页

作者：马国文马洪全哈尔滨轴承集团公司工模装制造分公司黑龙江哈尔滨150036 中航工业哈尔滨轴承有限公司研发中心黑龙江哈尔滨150036

通过改变钻头的常规磨削方法,来达到镗或铰达不到的目的,最终取得了良好效果,从而达到提高生产效率、缩短制造周期的目的。

关键词：半保持架镗刀钻头

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褐色饮用型酸奶的研制

中国乳品工业 2017年第5期45卷 56-58页

作者：倪丹李宁张海斌马国文内蒙古乳业技术研究院有限责任公司呼和浩特010110

研制褐色饮用型酸奶,确定了一种褐色饮用型酸奶的生产工艺和配方。最佳配方:生牛乳88%,白砂糖8%、无水葡萄糖2.5%(均为质量分数,下同),脱脂奶粉∶浓缩乳清蛋白粉:浓缩牛奶蛋白粉=1∶1∶1(按蛋白含量)。发酵菌种为Premium 1.0。同时确定... 详细信息

研制褐色饮用型酸奶,确定了一种褐色饮用型酸奶的生产工艺和配方。最佳配方:生牛乳88%,白砂糖8%、无水葡萄糖2.5%(均为质量分数,下同),脱脂奶粉∶浓缩乳清蛋白粉:浓缩牛奶蛋白粉=1∶1∶1(按蛋白含量)。发酵菌种为Premium 1.0。同时确定了一种获得最佳口感的工艺方案,褐变牛奶:稳定剂牛奶=3∶1,剪切细化时间为20 min。

关键词：褐色饮用型酸奶生产工艺优化