检索结果-南通市图书馆

Copper homeostasis and neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang daidi Li Kaifei Xu guoqing Wang Feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,includ.ng copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper bind.ng to various proteins,includ.ng ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,includ.ng alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-bind.ng proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current find.ngs on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfold.ng,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang d.ngyu Wei guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** find.ngs indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

Combining slow-release fertilizer and plastic film mulching reduced the carbon footprint and enhanced maize yield on the Loess Plateau

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2025年第1期147卷 359-369页

作者： Xiaoqing Han Pengfei d.ng Lechen Liao Fangqi Song Miaomiao Zhang Maoxue Zhang guoqing Li Shuyue Wen Ning Yang Xiping Pan Xiaofan Wang WenWang Xiaoliang Qin Charles O.Joseph Kadambot H.M.Siddique College of Agronomy Key Laboratory of Crop Physi-ecology and Tillage Science in Northwestern Loess PlateauNorthwest A&F UniversityYanglingShaanxi 712100China department of Crop Sciences and Beekeeping Technology College of Agricultural Sciences and Food Technology University of Dar es SalaamMwalimu Julius Nyerere Mlimani CampusP.O.Box 35091Dar es SalaamTanzania College of Life Science Yulin UniversityChongwen Road No.4YulinShaanxi719000China The UWA Institute of Agriculture and School of Agriculture&Environment The University of Western AustraliaPerth WA 6001Australia

Agricultural practices significantly contribute to greenhouse gas(GHG)emissions,necessitating cleaner production technologies to reduce environmental pressure and achieve sustainable maize *** film mulching is commonly used in the Loess Plateau *** slow-release fertilizers as a replacement for urea within this practice can reduce nitrogen losses and enhance crop *** these techniques represents a novel agricultural approach in semi-arid ***,the impact of this integration on soil carbon storage(SOCS),carbon footprint(CF),and economic benefits has received limited research ***,we conducted an eight-year study(2015-2022)in the semi-arid northwestern region to quantify the effects of four treatments[urea supplied without plastic film mulching(CK-U),slow-release fertilizer supplied without plastic film mulching(CK-S),urea supplied with plastic film mulching(PM-U),and slow-release fertilizer supplied with plastic film mulching(PM-S)]on soil fertility,economic and environmental *** results revealed that nitrogen fertilizer was the primary contributor to total GHG emissions(≥71.97%).Compared to other treatments,PM-S increased average grain yield by 12.01%-37.89%,water use efficiency by 9.19%-23.33%,nitrogen accumulation by 27.07%-66.19%,and net return by 6.21%-29.57%.Furthermore,PM-S decreased CF by 12.87%-44.31%and CF per net return by 14.25%-41.16%.After eight years,PM-S increased SOCS(0-40 cm)by 2.46%,while PM-U decreased it by 7.09%.These find.ngs highlight the positive effects of PM-S on surface soil fertility,economic gains,and environmental benefits in spring maize production on the Loess Plateau,underscoring its potential for widespread adoption and application.

关键词： Plastic film mulching Slow-release fertilizer Maize grain yield Carbon footprint Economic benefits

Robustness of N=152 and Z=108 shell closures in superheavy mass region

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2025年第1期49卷 1-6页

作者： Buyu Chen Jianmin d.ng Yaqian Wang guoqing Wu department of Physics Hebei UniversityBaoding 071002China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

The neutron shell gap at N=152 has been experimentally confirmed through high-precision mass measurements on nobelium(Z=102)and lawrencium(Z=103)*** experimental measurements onα-decay properties suggest that deformed doubly-magic nature of ^(270)***,the magic gaps in the superheavy region are generally expected to be *** this study,we test the robustness of N=152 shell closure in N=152 isotones and Z=108 shell closure in Hs isotopes by employing an alternative approach where both theoretical analysis and available experimental data are *** with existing experimental measurements on a-decay energies,it is determined that robust N=152 neutron shell persists at least in Z=101-105 isotopes,and robust Z=108 proton shell persists in Hs isotopes with N=159,***,the relativistic mean-field model is determined as unable to provide N=152 ***,the conclusion that robust N=152 shell exists at least in Z=101-105 isotopes,provides crucial benchmarks for constraining effective interactions suitable for superheavy nuclei in nuclear energy-density functional theory in future.

关键词： superheavy nuclei shell gap a-decay decay energy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

地铁隧道洞内水平真空超前降水数值模拟

建筑结构 2025年第1期55卷 145-150页

作者：陈恺赵国庆唐汐杨扬北京市轨道交通建设管理有限公司北京100068 城市轨道交通全自动运行系统与安全监控北京市重点实验室北京100068 沈阳建筑大学土木工程学院沈阳110168

针对低渗透性粉细砂、砂质粉土交界面层间水抽排困难的问题,以北京地铁3号线某区间降水工程为背景,建立了水平真空降水三维数值模型。在与现场试验结果对比验证数值模型有效性的基础上,研究了抽水时间、抽水压力、水平井长和井间距等参... 详细信息

针对低渗透性粉细砂、砂质粉土交界面层间水抽排困难的问题,以北京地铁3号线某区间降水工程为背景,建立了水平真空降水三维数值模型。在与现场试验结果对比验证数值模型有效性的基础上,研究了抽水时间、抽水压力、水平井长和井间距等参数对水平真空降水效果的影响规律。结果表明:单井出水速度在抽水初期会快速衰减,抽水1d后出水速度降低约32%,此后抽水速度基本趋于稳定;水平真空抽水的出水量随抽水压力的增加而显著增大;水平井越长,其负压影响区范围越大,当单井长从5m增至25m,以0.04MPa为界的负压影响区宽度从4m增至13.5m,增幅237.5%;当双井间距从3m增至18m,双井间真空度0.055MPa的负压区从沿全长重叠逐渐发展至不再重叠,在设计井间距时宜考虑能够形成一定的负压重叠区以保证降水效果。研究成果可为该类降水设计和工程应用提供参考。

关键词：低渗透性粉细砂地层层间水水平真空井孔隙水压力数值模拟

Hailstorm Formation Enhanced by Meso-γ Vortices along a Low-Level Convergence Line

在线全文

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2020年第6期34卷 1271-1286页

作者： Honglei ZHAng Hangfeng SHEN guoqing ZHAI Zhejiang Institute of Meteorological Sciences Hangzhou 310017 department of Atmospheric Sciences School of Earth SciencesZhejiang UniversityHangzhou 310027 Hangzhou Weather Bureau Hangzhou 310007

during a hailstorm event,near-surface meso-γvortices along a convergence line interact with hail *** we investigate this interaction by using observational data and a high-resolution simulation of a hailstorm that occurred over Taizhou(Zhejiang,China)on 19 March *** 10-m surface wind data from automatic weather stations show that several meso-γvortices or vortex-like disturbances existed over the convergence zone and played a vital role in the evolution of the hailstorm and the location of the *** model results agree with the observations and present a closer correlation between the hail and the low-level meso-γvortices than those *** model simulation indicates that such low-level meso-γvortices can be used to predict the next 10-min hail fallout *** lowlevel meso-γvortices originated over the convergence zone and then fed back into the convergence field and provoked a stronger *** was initiated primarily by stretching and was extended by tilting.A three-dimensional(3-d)flow analysis shows that the existence of low-level meso-γvortices could help enhance a local ***,the simulation reveals that the low-level meso-γvortices formed in the bounded weak echo region(WER)at the front of the hail cell,enhancing convergence and strengthening *** was broadly located between the 0°C isothermal line and the top of the clouds,roughly between the 0 and-20°C isothermal ***,the hailstones grew *** suitable environment and the positive effect of the meso-γvortices on the updrafts enabled hailstorm formation.

关键词： hailstorm meso-γvortices special terrain high-resolution simulation strong updraft

A New Theoretical Framework of Pyramid Markov Processes for Blockchain Selfish Mining

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2021年第6期30卷 667-711页

作者： Quanlin Li Yanxia Chang Xiaole Wu guoqing Zhang School of Economics and Management Beijing University of TechnologyBeijing 100124China School of Management Fudan UniversityShanghai 200433China department of Mechanical Automotive&Materials EngineeringUniversity of WindsorWindsorOntarioCanada

In this paper,we provide a new theoretical framework of pyramid Markov processes to solve some open and fundamental problems of blockchain selfish mining under a rigorous mathematical *** first describe a more general model of blockchain selfish mining with both a two-block lead.ng competitive criterion and a new economic incentive *** we establish a pyramid Markov process and show that it is irreducible and positive recurrent,and its stationary probability vector is matrix-geometric with an explicitly representable rate ***,we use the stationary probability vector to study the influence of orphan blocks on the waste of computing ***,we set up a pyramid Markov reward process to investigate the long-run average mining profits of the honest and dishonest mining pools,*** a by-product,we build one-dimensional Markov reward processes and provide some new interesting interpretation on the Markov chain and the revenue analysis reported in the seminal work by Eyal and Sirer(2014).Note that the pyramid Markov(reward)processes can open up a new avenue in the study of blockchain selfish *** we hope that the methodology and results developed in this paper shed light on the blockchain selfish mining such that a series of promising research can be developed potentially.

关键词： Blockchain Proof of Work selfish mining main chain pyramid Markov process pyramid Markov reward process phase-type distribution Matrix-geometric solution

Nanotwining induced by tensile fatigue and dynamic impact of laser powder bed fusion additively manufactured CoCrFeNi high-entropy alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第16期183卷 241-257页

作者： guoqing Huang Bo Li Yinan Chen Fuzhen Xuan School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Additive Manufacturing and Intelligent Equipment Research Institute East China University of Science and TechnologyShanghai 200237China Shanghai Collaborative Innovation Center for High-end Equipment Reliability Shanghai 200237China

The laser powder bed fusion(L-PBF)additively manufactured CoCrFeNi high-entropy alloy(HEA),with face-centered cubic(FCC)crystal structure,demonstrates better comprehensive mechanical properties in the build.ng direction(Bd).Load.ng quasi-static,dynamic fatigue,and dynamic separated Hopkinson press bar(SHPB)impact stress conditions along the Bd of the L-PBF processed HEA exhibit intriguing mi-crostructural evolution *** L-PBF generates hierarchical dislocation grids containing nu-merous cell substructures within the HEA FCC grains,imped.ng dislocation motion during deformation and improving the *** subjected to dynamic fatigue load.ng,the dislocation grids restrict the mean free path of dislocations and thus trigger the activation of abundant stacking ***,nu-merous nanotwins form near the end of the fatigue *** twinning systems can also be activated under dynamic high-speed impact *** at a low temperature of 77 K,the stacking fault energy of the CoCrFeNi HEA decreases,resulting in increased activation of nanotwins,exhibiting excep-tional toughness and resistance to dynamic *** twin boundaries also impede dislocation movement for the strain *** find.ngs hold valuable implications for the study of additively manufactured HEA parts working in extreme environments.

关键词： High-entropy alloy Nanotwins Fatigue Impact behavior Additive manufacturing

Cluster model for wave patterns of a 3d vertically vibrated granular system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2011年第13期56卷 1340-1347页

作者： CAI Hui MIAO guoqing Institute of Acoustics and Key Laboratory of Modern Acoustics of Ministry of Education Nanjing University Nanjing 210093 China

Based on the cluster model for wave-like motions of a 2d vertically vibrated granular system we established previously (Chin Phys Lett,2010,27:124501),a generalization of the cluster model for a 3d granular system is presented in this *** 3d cluster model proposes frustums of pyramids as clusters of the 3d granular system,and explains wave patterns as the result of the cluster-boundary and cluster-plate *** analyzing the movement of one cluster in a collision period,we derive a basic equation,which relates the internal characteristic parameter to the external driving *** theoretical results reproduce the behaviors of wave patterns as changes in the driving parameters,and the 3d dispersion relation,which agree with the experimental results.

关键词：三维模型颗粒系统垂直振动集群波模板块碰撞驱动参数特征参数