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牡蛎肽对酒精性肝损伤与体力疲劳的影响

中国食品学报 2024年第7期24卷 201-207页

作者：江新辉江敏江铭福蓝登杭温海兰郑加彬江秋萍兰成木张国强刘海霞福建大众健康生物科技有限公司福州350000 福州日兴水产食品有限公司福州350000 江南大学未来食品科学中心江苏无锡214122

研究牡蛎肽对酒精性肝损伤和体力疲劳的影响。采用液相色谱测定牡蛎肽的分子质量和氨基酸含量,并通过动物实验研究牡蛎肽缓解小鼠酒精性肝损伤和体力疲劳的作用。设置低(0.25 g/kg bw)、中(0.5 g/kg bw)、高(1.0 g/kg bw)3个剂量组,以... 详细信息

研究牡蛎肽对酒精性肝损伤和体力疲劳的影响。采用液相色谱测定牡蛎肽的分子质量和氨基酸含量,并通过动物实验研究牡蛎肽缓解小鼠酒精性肝损伤和体力疲劳的作用。设置低(0.25 g/kg bw)、中(0.5 g/kg bw)、高(1.0 g/kg bw)3个剂量组,以及模型对照组。研究结果显示:牡蛎肽的分子质量<1500 u的占比85%;氨基酸总量为58.44 g/100g;体内实验结果显示,缓解酒精性肝损伤实验中,3个剂量组小鼠肝脏的丙二醛(MDA)、甘油三酯(TG)含量显著低于对照组,谷胱甘肽(GSH)含量显著高于对照组。肝脏组织病理切片结果显示,高剂量组小鼠肝脏组织病理损伤有不同程度的改善;缓解体力疲劳动物实验中,中、高剂量组的小鼠游泳时间显著提升,3个剂量组小鼠血乳酸、血清尿素含量与对照组相比显著性下降。结论:牡蛎肽的分子质量较小,氨基酸含量较高,具有缓解酒精性肝损伤和体力疲劳的作用。

关键词：牡蛎肽分子质量氨基酸酒精性肝损伤缓解体力疲劳

LPC教学模式在五年制儿科外科学总论见习教学中的应用研究

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中华医学教育探索杂志 2024年第5期23卷 627-630页

作者：张国强吴鸿伟谢学虎刘宁首都医科大学附属北京友谊医院骨科中心北京100050 首都医科大学附属北京友谊医院普通外科北京100050

目的:探讨LPC即以课堂授课为基础的模式(lecture-based learning)、以问题为基础的模式(problem-based learning)和以案例为基础的模式(case-based learning)综合教学模式在五年制儿科外科学总论见习教学中的应用及教学效果。方法:选择... 详细信息

目的:探讨LPC即以课堂授课为基础的模式(lecture-based learning)、以问题为基础的模式(problem-based learning)和以案例为基础的模式(case-based learning)综合教学模式在五年制儿科外科学总论见习教学中的应用及教学效果。方法:选择在北京友谊医院见习外科学总论的首都医科大学2019、2020级五年制儿科专业69名学生作为研究对象。将其分为2组,33名学生作为试验组,采用LPC综合教学模式;36名学生作为对照组,采用LBL传统教学模式。分期完成授课及考核。对比两组学生的临床技能操作评分、临床思维能力、见习的积极性、对见习带教的满意度。采用SPSS 25.0进行t检验、卡方检验或秩和检验。结果:LPC组学生的临床技能操作评分为(99.91±0.29)分、临床思维能力评分为(91.06±5.93)分,都高于LBL组的(84.72±10.21)分和(84.31±7.98)分。见习的积极性良好,且差异具有统计学意义(P<0.05)。LPC组学生掌握外科学技能操作比例(100.0%vs.63.9%)、掌握外科学无菌原则比例(100.0%vs.69.4%)、增强临床能力比例(97.0%vs.66.7%)、提高沟通能力比例(93.9%vs.72.2%)、增强查阅文献的兴趣比例(90.9%vs.63.9%)、增强科研的兴趣比例(93.9%vs.69.4%)、满意教学氛围比例(100.0%vs.72.2%)、满意见习带教方法比例(100.0%vs.63.9%)均优于LBL组。结论:LPC教学模式在五年制儿科外科学总论见习教学中的应用效果较LBL教学模式好,值得推广。

关键词： LBL教学模式 LBL+PBL+CBL 儿科外科学总论见习教学

Artificial intelligence powered large-scale renewable integrations in multi-energy systems for carbon neutrality transition: Challenges and future perspectives

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能源与人工智能(英文) 2022年第4期10卷 242-261页

作者： Zhengxuan Liu Ying Sun Chaojie Xing Jia Liu Yingdong He Yuekuan Zhou guoqiang zhang College of Civil Engineering National Center for International Research Collaboration in Building Safety and EnvironmentHunan UniversityChangsha410082China Faculty of Architecture and the Built Environment Delft University of TechnologyJulianalaan 1342628 BLDelftNetherlands Energy and Environment Group Department of BuildingCivil and Environmental EngineeringConcordia UniversityMontrealCanada College of Civil Engineering Guangzhou UniversityGuangzhouChina Department of Building Environment and Energy Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina Guangdong Provincial Key Laboratory of Building Energy Efficiency and Application Technologies Guangzhou UniversityGuangzhouChina Sustainable Energy and Environment Thrust Function HubThe Hong Kong University of Science and Technology(Guangzhou)Nansha511400GuangdongChina Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyClear Water BayHong Kong Special Administrative RegionChina HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute ShenzhenChina

The vigorous expansion of renewable energy as a substitute for fossil energy is the predominant route of action to achieve worldwide carbon neutrality. However, clean energy supplies in multi-energy building districts are still at the preliminary stages for energy paradigm transitions. In particular, technologies and methodologies for large-scale renewable energy integrations are still not sufficiently sophisticated, in terms of intelligent control management. Artificial intelligent (AI) techniques powered renewable energy systems can learn from bioinspired lessons and provide power systems with intelligence. However, there are few in-depth dissections and deliberations on the roles of AI techniques for large-scale integrations of renewable energy and decarbonisation in multi-energy systems. This study summarizes the commonly used AI-related approaches and discusses their functional advantages when being applied in various renewable energy sectors, as well as their functional contribution to optimizing the operational control modalities of renewable energy and improving the overall operational effectiveness. This study also presents practical applications of various AI techniques in large-scale renewable energy integration systems, and analyzes their effectiveness through theoretical explanations and diverse case studies. In addition, this study introduces limitations and challenges associated with the large-scale renewable energy integrations for carbon neutrality transition using relevant AI techniques, and proposes further promising research perspectives and recommendations. This comprehensive review ignites advanced AI techniques for large-scale renewable integrations and provides valuable informational instructions and guidelines to different stakeholders (e.g., engineers, designers and scientists) for carbon neutrality transition.

关键词： Artificial intelligent techniques Renewable energy Large-scale integration Energy transition Carbon neutrality

EPS外墙外保温系统聚氨酯粘结胶加固后受力性能试验研究

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新型建筑材料 2024年第8期51卷 18-24,37页

作者：李安起郑义张国强韩志国李靖山东建筑大学山东济南250101 山东建筑大学工程鉴定加固研究院有限公司山东济南250013

通过EPS保温板抗拉试验、疲劳试验、加固疲劳试验,研究粘贴率、粘贴方式对EPS板及聚氨酯粘结胶加固试样的抗拉承载力和疲劳性能影响。结果表明:除满粘外,在相同条件下,EPS板抗拉承载力平均值由大到小为:条粘>点粘>十字粘>点框粘;EPS板... 详细信息

通过EPS保温板抗拉试验、疲劳试验、加固疲劳试验,研究粘贴率、粘贴方式对EPS板及聚氨酯粘结胶加固试样的抗拉承载力和疲劳性能影响。结果表明:除满粘外,在相同条件下,EPS板抗拉承载力平均值由大到小为:条粘>点粘>十字粘>点框粘;EPS板疲劳次数与粘贴率呈正相关,条粘法疲劳性能最好;采用聚氨酯粘结胶加固后的试样抗拉承载力平均值均符合要求,且达到满粘抗拉承载力的90%;初始疲劳对加固效果的影响最大仅7%,加固后点粘、条粘、十字粘、点框粘的疲劳次数分别达到满粘的87%、89%、87%、75%;聚氨酯粘结胶加固后累计疲劳次数更多,EPS板整体使用寿命得到延长,加固方法较为可靠。

关键词： EPS保温板抗拉承载力疲劳试验受力性能聚氨酯粘结胶加固

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无铝内衬纸复合涂层对阻隔性能的影响研究

包装工程 2024年第5期45卷 118-125页

作者：吴春梅翁聪泽李茜鲁仲学舒芳誉黄朝章张国强福建鑫叶投资管理集团有限公司福建厦门361022 福建中烟工业有限责任公司福建厦门361022

目的研究无铝内衬纸使用不同类型油墨及涂布层数的组合,得到阻隔性能优良的样品,推动无铝内衬纸的生产应用。方法采用扫描电子显微镜、水蒸气透过率测试仪、透气性测试仪测试内衬纸的表面微观结构、透湿率和透气性,考察对比不同来源内... 详细信息

目的研究无铝内衬纸使用不同类型油墨及涂布层数的组合,得到阻隔性能优良的样品,推动无铝内衬纸的生产应用。方法采用扫描电子显微镜、水蒸气透过率测试仪、透气性测试仪测试内衬纸的表面微观结构、透湿率和透气性,考察对比不同来源内衬原纸、单层多层涂布无铝内衬纸的阻隔性能,并与其他类型内衬纸性能做比对分析。结果无铝内衬纸在原纸基础上涂布多层油墨,可显著提升产品的阻隔性能。单层涂布透湿率最大降低了59.80%,透气性最大降低了98.37%;三层涂布后透湿率趋于稳定,降幅为79.70%,而随涂布层数的增加,阻气效果提升不明显。结论纸张涂布多层油墨能获得阻隔性能优良的无铝内衬纸,其阻隔性能与常规直镀内衬纸相近。

关键词：涂布内衬纸阻隔性油墨

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LNG接收站BOG压缩机的实践与应用

化工管理 2024年第14期 118-121页

作者：冯子栋李俊杨树陶正晖张国强海洋石油工程股份有限公司天津300461

文章主要探讨了LNG接收站中BOG压缩机的应用与研究。BOG压缩机是LNG接收站中的关键设备之一,用于处理LNG储罐中的蒸发气体。通过对BOG压缩机的工作原理、性能特点和应用场景进行分析,总结了其在LNG接收站运营时存在的问题以及提高运行... 详细信息

文章主要探讨了LNG接收站中BOG压缩机的应用与研究。BOG压缩机是LNG接收站中的关键设备之一,用于处理LNG储罐中的蒸发气体。通过对BOG压缩机的工作原理、性能特点和应用场景进行分析,总结了其在LNG接收站运营时存在的问题以及提高运行稳定性的解决措施。同时,文章还根据实际应用案例,探索了BOG压缩机的操作和维护等方面的问题,提出了一些优化改进建议。

关键词： BOG压缩机 LNG接收站运营与操作维护与优化石油化工

Screening and Assessing 11 Mycobacterium tuberculosis Proteins as Potential Serodiagnostical Markers for Discriminating TB Patients from BCG Vaccinees

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Genomics, Proteomics & Bioinformatics 2009年第3期7卷 107-115页

作者： guoqiang zhang Lingxia zhang Mingcheng zhang Linlin Pan Fengyu Wang Jun Huang Guoli Li Jun Yu Songnian Hu CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100029 China Graduate University of Chinese Academy of Sciences Beijing 100049 China The Second Hospital Affiliated to the General Hospital of the People＇s Liberation Army Beijing 100091 China

Purified protein derivative （PPD） skin tests often yield poor specificity, so that to develop new serological antigens for distinguishing between Mycobacterium tuberculosis infection and Bacille Calmette-Guerin （BCG） vaccination is a priority, especially for developing countries like China. We predicted the antigenicity for selected open reading frames （ORFs） based on the genome sequences of M. tuberculosis H37Rv and M. boris BCG, as well as their functions and differences of expression under different stimulus. The candidate ORFs were cloned from H37Rv sequences and expressed as recombinant proteins in Escherichia coli. We studied the serodiagnostic potential of 11 purified recombinants by using enzyme-linked immunosorbent assay （ELISA） and involving a cohort composed of 58 TB patients （34 males and 24 females）, 8 healthy volunteers and 50 PPD-negative individuals before and after BCG vaccination. For all the 11 antigens, the median OD values for the sera from TB patients were statistically significantly higher than those for PPD-negative individuals before or after BCG vaccination （P〈0.01）. They had at least 92% specificity in healthy controls and six seroantigens （Rv0251c, Rv1973, Rv2376c, Rv2537c, Rv2785c and Rv3873A） were never reported with seroantigenicities previously. Thus the approach combining comparative genomics, bioinformatics and ELISA techniques can be employed to identify new seroantigens distinguishing M. tuberculosis infection from BCG vaccination.

关键词： comparative genomics M. tuberculosis BCG seroantigen ELISA

Statistical study of magnetic holes in the upstream region of Mercury’s bow shock

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Earth and Planetary Physics 2024年第2期8卷 326-337页

作者： guoqiang Wang SuDong Xiao MingYu Wu YuanQiang Chen TieLong zhang Institute of Space Science and Applied Technology Harbin Institute of TechnologyShenzhen 518055China Shenzhen Key Laboratory of Numerical Prediction for Space Storm Harbin Institute of TechnologyShenzhen 518055China Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences Center for Excellence in Comparative Planetology Hefei 230026China Space Research Institute Austrian Academy of SciencesGrazAustria

Magnetic holes are magnetic depression structures that exist widely in many plasma *** magnetic holes with durations of>1 s in the solar wind at Mercury’s orbit have drawn much attention,but the properties of the magnetic holes with shorter durations are still ***,we investigate the magnetic holes with durations of 0.1-100 s in the upstream region of Mercury’s bow shock based on observations by the MESSENGER(MErcury Surface,Space ENvironment,GEochemistry,and Ranging)*** can be divided into two groups according to the distribution of their duration:small-duration magnetic holes(SDMHs,0.6 s).The duration of each group approximately obeys a log-normal distribution with a median of~0.25 s and 3 s,*** 1.7%(32.6%)of the SDMHs(LDMHs)reduce the magnetic field strength by more than 50%.For both groups,some structures have a linear or quasi-linear polarization,whereas others have an elliptical *** magnetic hole events in both groups tend to have a higher rate of occurrence when the interplanetary magnetic field strength is *** occurrence rates are also affected by Mercury’s foreshock,which can increase(decrease)the occurrence rate of the SDMHs(LDMHs).This finding suggests that Mercury’s foreshock might be one source of the SDMHs and that the foreshock can destroy some *** observations suggest that a new group of magnetic holes with durations of<0.6 s exist in the upstream region of Mercury’s bow shock.

关键词： magnetic hole solar wind Mercury foreshock

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昆仑山北坡黑刺沟大型天然矿泉水成因分析

盐湖研究 2024年第3期32卷 21-31页

作者：祁泽学汪生斌刘魁张国强李尚蔚陈龙中国地质调查局西宁自然资源综合调查中心青海西宁810000 青海省环境地质勘查局青海西宁810000 西南交通大学四川成都611756 青海省地质调查局青海西宁810000

昆仑山区现代冰川林立,构造及地貌的发育形成了西大滩大型矿泉水、昆仑圣泉以及昆仑山等诸多优质天然矿泉水源。目前仅昆仑山矿泉水进行了较大规模的开发,其余大量的矿泉水尚处于未开发的原始状态,矿泉水资源十分丰富。通过EH-4音频大... 详细信息

昆仑山区现代冰川林立,构造及地貌的发育形成了西大滩大型矿泉水、昆仑圣泉以及昆仑山等诸多优质天然矿泉水源。目前仅昆仑山矿泉水进行了较大规模的开发,其余大量的矿泉水尚处于未开发的原始状态,矿泉水资源十分丰富。通过EH-4音频大地电磁测深、水化学分析及动态监测等手段,采用Piper三线图解法、Gibbs图解法、同位素分析等方法对昆仑山北坡黑刺沟大型天然矿泉水的导水与控水断裂、水化学特殊组分来源及形成机制进行分析研究。结果显示矿泉群主要补给水源为刚欠查鲁马峰一带现代冰川底部冰雪覆盖融区水,冰雪融水通过多期活动的正断层组向深部运移,径流至北侧南倾阻水断层后形成富水区和上涌通道,并沿着通道溢出地表形成矿泉群;泉水中锶元素来源于南部昆仑山硅酸盐组与地下水的水-岩相互作用。

关键词：饮用天然矿泉水水化学特征成因冰川锶