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Particuology 2024年第6期89卷 88-98页

作者： Ming Liu guoqiang shao Pengpeng Lv Jun Li Qingshan Zhu State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Two critical parameters:Glossiness and chromaticity space of pearlescent pigments were evaluated based on crystallinity and grain size.Both the roughness and the vertical distance evolution along the surface of deposited TiO_(2)film are affected by the crystallinity.The optimal crystallinity of TiO_(2)was deposited at the temperature of 350℃.The TiCl4 concentration effectively changed the grain size.However,the high flow rate of fluidizing gas and optimal gas–solid ratio(<0.11 m^(3)/(kg h))restricted the change of TiCl_(4)concentrations in fluidized bed reactor.In this case,the grain size of the deposited TiO_(2)film was about 55 nm.Depending on the grain size,the color of pearlescent pigments was adjusted by controlling the film thickness based on TiO_(2)concentration.Finally,the silver pearlescent pigment with high glossiness was prepared by chemical vapor deposition method in a fluidized bed reactor.

关键词： Fluidized bed chemical vapor deposition TiO_(2)film deposition Pearlescent pigment Free powder restrain Crystal growth

Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

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Frontiers of Medicine 2024年第1期18卷 109-127页

作者： guoqiang Li Peng Pu Mengqiao Pan Xiaoling Weng Shimei Qiu Yiming Li Sk Jahir Abbas Lu Zou Ke Liu Zheng Wang Ziyu shao Lin Jiang Wenguang Wu Yun Liu Rong shao Fatao Liu Yingbin Liu Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteShanghai200127China Shanghai Key Laboratory of Biliary Tract Disease Shanghai200082China Department of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai200082China Shanghai Tenth People’s Hospital of Tongji University Shanghai200072China Department of General Surgery Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200082China Department of Pharmacology Shanghai Jiao Tong University School of MedicineShanghai200025China

Altered three-dimensional architecture of chromatin influences various genomic regulators and subsequent gene expression in human cancer.However,knowledge of the topological rearrangement of genomic hierarchical layers in cancer is largely limited.Here,by taking advantage of in situ Hi-C,RNA-sequencing,and chromatin immunoprecipitation sequencing(ChIP-seq),we investigated structural reorganization and functional changes in chromosomal compartments,topologically associated domains(TADs),and CCCTC binding factor(CTCF)-mediated loops in gallbladder cancer(GBC)tissues and cell lines.We observed that the chromosomal compartment A/B switch was correlated with CTCF binding levels and gene expression changes.Increased inter-TAD interactions with weaker TAD boundaries were identified in cancer cell lines relative to normal controls.Furthermore,the chromatin short loops and cancer unique loops associated with chromatin remodeling and epithelial–mesenchymal transition activation were enriched in cancer compared with their control counterparts.Cancer-specific enhancer–promoter loops,which contain multiple transcription factor binding motifs,acted as a central element to regulate aberrant gene expression.Depletion of individual enhancers in each loop anchor that connects with promoters led to the inhibition of their corresponding gene expressions.Collectively,our data offer the landscape of hierarchical layers of cancer genome and functional alterations that contribute to the development of GBC.

关键词： 3D genome cancer TADs loop gene regulation

Uniform deposition of ultra-thin TiO_(2) film on mica substrate by atmospheric pressure chemical vapor deposition: Effect of precursor concentration

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中国化学工程学报:英文版 2023年第8期60卷 99-107页

作者： Ming Liu Ying Li Rui Wang guoqiang shao Pengpeng Lv Jun Li Qingshan Zhu State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical&Environmental Engineering China University of Mining and Technology-BeijingBeijing 100083China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The performance of pearlescent pigment significantly affected by the grain size and the roughness of deposited film. The effect of TiCl_(4) concentration on the initial deposition of TiO_(2) on mica by atmospheric pressure chemical vapor deposition(APCVD) was investigated. The precursor concentration significantly affected the deposition and morphology of TiO_(2) grains assembling the film. The deposition time for fully covering the surface of mica decreased from 120 to 10 s as the TiCl_(4) concentration increased from 0.38%to 2.44%. The grain size increased with the TiCl_(4) concentration. The AFM and TEM analysis demonstrated that the aggregation of TiO_(2) clusters at the initial stage finally result to the agglomeration of fine TiO_(2) grains at high TiCl_(4) concentrations. Following the results, it was suggested that the nucleation density and size was easy to be adjusted when the TiCl_(4) concentration is below 0.90%.

关键词： Chemical vapor deposition TiO_(2)thin film Nucleation reaction Precursor concentration Pearlescent pigment

A facile phototheranostic nanoplatform integrating NIR-Ⅱ fluorescence/PA bimodal imaging and image-guided surgery/PTT combinational therapy for improved antitumor efcacy

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Journal of Materials Science & Technology 2022年第35期130卷 208-218页

作者： Xiuping Han Wenyou Fang Tianqi Zhang Xuan Zhong Kun Qian Zhitao Jiang Rongfeng Hu guoqiang shao Lei Zhang Qing Zhang Department of Pharmaceutics and Key Laboratory of Cardiovascular&Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China Department of Nuclear Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 211166China Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Anhui Province Engineering Technology Research Center of Modern Pharmaceutical PreparationAnhui University of Chinese MedicineHefei 230012China Department of Nuclear Medicine Taizhou People’s HospitalNanjing University of Chinese MedicineTaizhou 225300China Center for Molecular Imaging Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Phototheranostic with highly integrated functions is an attractive platform for cancer management. It remains challenging to develop a facile phototheranostic platform with complementary bimodal imaging and combinational therapy capacity. Herein, the small-molecule cyanine IR780 loaded liposomes have been harnessed as a nanoplatform to simultaneously realize photoacoustic(PA)/the second near-infrared window(NIR-Ⅱ) fluorescence imaging and image-guided surgery/adjuvant photothermal therapy(PTT).This nanoplatform exhibits attractive properties like uniform controllable size, stable dispersibility, NIR-Ⅱ fluorescence emission, photothermal conversion, and biocompatibility. Benefiting from the complementary PA/NIR-Ⅱ fluorescence bimodal imaging, this nanoplatform was successfully applied in precise vasculature delineation and tumor diagnosis. Interestingly, the tumor was clearly detected by NIR-Ⅱ fluorescence imaging with the highest tumor-to-normal-tissue ratio up to 12.69, while signal interference from the liver was significantly reduced, due to the difference in the elimination rate of the nanoplatform in the liver and tumor. Under the precise guidance of the image, the tumor was accurately resected, and the simulated residual lesion after surgery was completely ablated by adjuvant PTT. This combined therapy showed improved antitumor efcacy over the individual surgery or PTT. This work develops a facile phototheranostic nanoplatform with great significance in accurately diagnosing and effectively treating tumors using simple NIR light irradiation.

关键词： NIR-Ⅱfluorescence imaging Photoacoustic imaging Image-guided surgery Adjuvant photothermal therapy Phototheranostics

Prediction of electrical contact endurance subject to micro-slip wear using friction energy dissipation approach

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Friction 2019年第6期7卷 537-550页

作者： Xiangjun JIANG Fengqun PAN guoqiang shao Jin HUANG Jun HONG Aicheng ZHOU Key Laboratory of Electronic Equipment Structural Design Xidian UniversityXi'an 710071China State Key Laboratory for Manufacturing System Xi’an Jiaotong UniversityXi'an 710049China State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024China Guilin University of Aerospace Technology Guilin 541004China

Fretting wear is a common cause of failure of an electrical contact(EC). In this study, we analyzed in detail the failure of EC induced especially by sliding using the representative electrical terminals. Furthermore, combining the friction energy dissipation theory, we proposed a prediction model to evaluate the electrical connector endurance(ECE) based on the contact stress and geometrical changes during the wear process obtained from a numerical model. The study helps establish that the friction energy dissipation theory is a powerful tool to analyze a contact failure due to wear. The proposed model proves to be effective in predicting the ECE for all considered cases such as micro-slip amplitude, contact force, overturning angle, superficial layer thickness, and friction/wear coefficients.

关键词： electrical connector endurance fretting wear friction energy dissipation finite element analysis

From laboratory research to industrial application:a green technology of fluidized mineral processing for manganese dioxide ore reduction

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Green Chemical Engineering 2020年第1期1卷 40-47页

作者： Zheng Zou guoqiang shao Yu Ge Shan Wang Zhaohui Xie Qingshan Zhu Hongzhong Li State Key Laboratory of Multi-phase Complex Systems Institute of Process EngineeringChinese Academy of SciencesP.O.Box 353Beijing100190PR China National Science Library Chinese Academy of SciencesBeijing100190PR China University of Chinese Academy of Sciences Beijing100049PR China

The efficient utilization of manganese dioxide(MnO_(2))ore is essential for the sustainable development of manganese(Mn)industry.Confronting the great challenge of chemical engineering scale-up,a commercial fluidized reduction project of MnO_(2)ore with the capacity of 200,000 t a^(-1)is carried out based on deep experimental investigation,extensive kilogram-scale test and detailed engineering design.Compared with other production technologies and equipment,it is proved that the fluidized process shows distinguished advantages of lower energy consumption,higher production efficiency,larger automation degree and less environmental pollution.The comprehensive studies of experiment,modeling,simulation and optimization are required for a more promising development of fluidization engineering in the future.

关键词： Fluidized reduction Manganese dioxide ore Green technology Process intensification System integration

难选高铁软锰矿流态化磁化焙烧-磁选浸出工艺

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中国粉体技术 2024年第1期30卷 36-45页

作者：邵国强邹正朱庆山中国科学院过程工程研究所多相复杂系统国家重点实验室北京100190

【目的】提高难选高铁软锰矿的资源利用效率,缓解我国锰矿资源依赖进口的现状。【方法】采用流化床反应器作为焙烧装置,模拟发生炉煤气气体组分作为还原气体,对云南省某地区的难选高铁软锰矿进行流态化磁化焙烧。对还原后的焙烧矿进行磨... 详细信息

【目的】提高难选高铁软锰矿的资源利用效率,缓解我国锰矿资源依赖进口的现状。【方法】采用流化床反应器作为焙烧装置,模拟发生炉煤气气体组分作为还原气体,对云南省某地区的难选高铁软锰矿进行流态化磁化焙烧。对还原后的焙烧矿进行磨矿-弱磁磁选,得到铁精矿和锰精矿。最后,对锰精矿中的锰进行酸浸浸出。【结果】在500℃流态化还原焙烧10 min,该难选高铁软锰矿即可达到最佳的还原状态效果,当样品的磨矿粒径<30μm的颗粒的质量分数为65%时,即可达到最佳的解离效果。选别后铁精矿铁品位和回收率分别为57.24%和76.55%,锰精矿锰品位和回收率分别为24.41%和73.84%,锰精矿的铁浸出率仅有1.94%。【结论】考察难选高铁软锰矿流态化磁化焙烧-磁选浸出规律,可以降低反应温度,缩短反应时间,低碳节能;抑制过还原反应的发生,可以提高铁资源利用率,降低浸出酸耗和除铁剂消耗。低能耗、低消耗和高利用率可以极大地提高难选高铁软锰矿的经济性,解决这部分资源难于利用的困境。

关键词：高铁软锰矿流态化磁化焙烧锰精矿铁精矿

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碳纳米管对酚醛树脂基复合材料性能的影响

兵工学报 2024年第5期45卷 1547-1554页

作者：孔国强安振河赵寰于秋兵邵蒙李莹魏化震王康刘文博山东非金属材料研究所山东济南250031 某军事代表局驻某地区军事代表室山东济南250031

为制备具有隔热、耐烧蚀、电磁屏蔽等多功能集成的结构复合材料,满足武器装备对多功能复合材料的迫切需求,采用超声波分散的工艺将碳纳米管(Carbon Nanotubes,CNTs)在树脂基体中进行分散,并制备CNTs改性国产碳布/酚醛复合材料。经对CNT... 详细信息

为制备具有隔热、耐烧蚀、电磁屏蔽等多功能集成的结构复合材料,满足武器装备对多功能复合材料的迫切需求,采用超声波分散的工艺将碳纳米管(Carbon Nanotubes,CNTs)在树脂基体中进行分散,并制备CNTs改性国产碳布/酚醛复合材料。经对CNTs改性国产碳布/酚醛复合材料的层间性能检测,当CNTs含量达到1.5%时,其层间剪切强度提高57.4%。对CNTs改性定向国产碳纤维/酚醛树脂复合材料的弯曲性能、层间性能和抗冲击性能都进行检测。检测结果表明,经CNTs改性后,定向国产碳纤维/酚醛复合材料的力学性能和模量均得到了大幅提高。对CNTs改性短切高强玻璃纤维/酚醛树脂基复合材料的导电性能和导热性能进行了研究。研究结果表明:随着CNTs含量的提高,短切高强玻璃纤维/酚醛树脂基复合材料的电阻率呈数量级速度降低,当CNTs含量达到14%时,复合材料的电阻率由10^(10)Ω·m降低到了10^(-2)Ω·m,复合材料由绝缘体转变为导体;当CNTs含量小于6%时,复合材料的导热系数虽有提高,但与复合材料电性能相比提高幅度不大。

关键词：碳纳米管碳布/酚醛复合材料碳纤维/酚醛复合材料导电隔热

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组合梁栓钉对高性能混凝土约束收缩效应研究

建筑科学与工程学报 2024年第2期41卷 49-57页

作者：占玉林王吉坤邵俊虎沈东荆国强贾银钧西南交通大学土木工程学院四川成都610031 西南交通大学土木工程材料研究所四川成都610031 成都大学建筑与土木工程学院四川成都610106 温州市七都大桥北汊桥建设有限公司浙江温州325052 中铁大桥科学研究院有限公司湖北武汉430034

为探究高性能混凝土在栓钉约束作用下的收缩特征及开裂行为,制作了钢-混凝土组合构件,通过试验研究了不同栓钉因素对高性能混凝土约束收缩应变、约束度及开裂风险的影响规律,运用正交试验方法研究了栓钉直径、间距、高度对高性能混凝土... 详细信息

为探究高性能混凝土在栓钉约束作用下的收缩特征及开裂行为,制作了钢-混凝土组合构件,通过试验研究了不同栓钉因素对高性能混凝土约束收缩应变、约束度及开裂风险的影响规律,运用正交试验方法研究了栓钉直径、间距、高度对高性能混凝土约束收缩的影响,得到了主要敏感因素。结果表明:高性能混凝土较普通混凝土的约束收缩应变发展趋势更为平滑;各栓钉因素对约束收缩的敏感性影响的主次顺序依次为直径、间距、高度;混凝土收缩在组合梁高度方向上呈现出一定的收缩梯度,混凝土约束收缩应变随高度增加而增大,但栓钉高度在30 mm处、间距在75 mm处、直径在150 mm处对高性能混凝土约束收缩几乎没有影响;栓钉对混凝土的约束作用可定义为3个阶段,即约束增强阶段、约束下降阶段和约束稳定阶段;组合梁构件最大开裂风险发生在栓钉的根部,当栓钉间距由150 mm减少到75 mm,直径由13 mm增加到22 mm时,最大开裂风险分别增加了20.03%和36.05%,栓钉高度的改变对最大开裂风险没有影响;采用高性能混凝土以及直径小、高度高的栓钉布置方式可以有效减小混凝土的收缩及开裂风险。

关键词：钢-混组合梁栓钉高性能混凝土正交试验约束收缩开裂风险

Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS

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生物活性材料(英文) 2023年第2期20卷 404-417页

作者： Jinping Wang Chang Qu Xinyue shao guoqiang Song Jingyu Sun Donghong Shi Ran Jia Hailong An Hongjun Wang Key Laboratory of Molecular Biophysics of Hebei Province Institute of BiophysicsSchool of Health Sciences and Biomedical EngineeringHebei University of Technology300401TianjinPR China Department of Biomedical Engineering Stevens Institute of TechnologyHobokenNJ07030United States Department of Chemistry and Chemical Biology Stevens Institute of TechnologyHobokenNJ07030United States Center for Healthcare Innovation Stevens Institute of TechnologyHobokenNJ07030United States Key Laboratory of Molecular Biophysics of Hebei Province Institute of BiophysicsSchool of SciencesHebei University of Technology300401TianjinPR China State Key Laboratory of Reliability and Intelligence of Electrical Equipment School of Electrical EngineeringHebei University of TechnologyTianjin300130PR China

Human cancers typically express a high level of tumor-promoting mutant p53 protein(Mutp53)with a minimal level of tumor-suppressing wild-type p53 protein(WTp53).In this regard,inducing Mutp53 degradation while activating WTp53 is a viable strategy for precise anti-tumor therapy.Herein,a new carrier-free nanoprodrug(i.e.,Mn-ZnO_(2)nanoparticles)was developed for concurrent delivery of dual Zn-Mn ions and reactive oxygen species(ROS)within tumor to regulate the p53 protein for high anti-tumor efficacy.In response to the mild tumor acidic environment,the released Zn^(2+)and H_(2)O_(2)from Mn-ZnO_(2)NPs induced ubiquitination-mediated proteasomal degradation of Mutp53,while the liberative Mn^(2+)and increased ROS level activated the ATM-p53-Bax pathway to elevate WTp53 level.Both in vitro and in vivo results demonstrated that pH-responsive decomposition of Mn-ZnO2 NPs could effectively elevate the intracellular dual Zn-Mn ions and ROS level and subsequently generate the cytotoxic hydroxyl radical(·OH)through the Fenton-like reaction.With the integration of multiple functions(i.e.,carrier-free ion and ROS delivery,tumor accumulation,p53 protein modulation,toxic·OH generation,and pH-activated MRI contrast)in a single nanosystem,Mn-ZnO_(2)NPs demonstrate its superiority as a promising nanotherapeutics for p53-mutated tumor therapy.

关键词： p53-mutated tumor therapy Wild-type p53 protein Carrier-free nanoprodrug Mn-ZnO_(2)nanoparticle Reactive oxygen species