检索结果-南通市图书馆

A synergetic strategy of NIR-Ⅱ squaraine dyes with ultrahigh photothermal conversion efficiency for photothermal therapy

引用

Science China Chemistry 2024年第2期67卷 612-621页

作者： Yigang Wang guomin xia Junhui Wang Mingda Wang Weihan Guo Manman Tan Leilei Si Yang Yang Hua Wang Hongming Wang Institute for Advanced Study and School of Chemistry and Chemical Engineering Nanchang UniversityNanchang330031China State Key Laboratory of Molecular Reaction Dynamics and Dynamics Research Center for Energy and Environmental Materials Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China The Second Affiliated Hospital of Nanchang University Nanchang330031China

Recent research on photothermal therapy(PTT) has sparked significant interest in the development of new organic photothermal agents(PTAs),ranging from single-molecule to aggregated ***,controlling aggregation pathways for PTAs with ultrahigh photothermal conversion efficiency(PCE) remains a major ***,a two-pronged approach utilizing “Haggregation” and “intramolecular motion” was employed to enhance the PCE of an acceptor-substituted squaraine dye(NSQs).The C2vmolecular symmetry of the NSQs,which possess a ground state dipole moment(μg),promotes H-dimeric aggregates through dipole-dipole *** triphenylethylene or diphenylamine groups were added to this H-dimeric *** was done to enhance intramolecular motions for heat generation and also to extend conjugation,which redshifted the optical absorption and balanced the blue-shift induced by *** this technique,an organic PTA with NIR-II absorption was developed,and its nanoparticle achieved a remarkable PCE of 86.3% under 1,064 nm laser *** transient absorption spectroscopy and quantum mechanical calculations demonstrated the accelerated internal conversion process in NIR-II PTAs for rapid heat *** NSQs nanoparticles exhibit superior photothermal therapeutic properties for in vivo photoacoustic imaging-guided PTT,demonstrating the potential of bottom-up design to enable synergistic engineering strategies towards efficient phototheranostic agents.

关键词： squaraine dyes second near-infrared window H-aggregation intramolecular motion photothermal therapy

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于智能制造信息平台的全产业链质量追溯管理

引用

中国井矿盐 2021年第1期52卷 43-46页

作者：席洋袁凯牛庆玖夏国民江苏苏盐井神股份有限公司江苏淮安223200

通过智能制造信息平台的建设,建立食用盐产品相关质控流程、项目和数据的电子档案,结合人工智能、大数据技术的深化应用,强化食用盐产品生产过程中的数据管理,打造产品质量记录、管控、追溯、分析与持续优化完善的智能数据管理系统,提... 详细信息

通过智能制造信息平台的建设,建立食用盐产品相关质控流程、项目和数据的电子档案,结合人工智能、大数据技术的深化应用,强化食用盐产品生产过程中的数据管理,打造产品质量记录、管控、追溯、分析与持续优化完善的智能数据管理系统,提高了产品全生命周期质量管理能力。

关键词：智能制造信息平台大数据质量追溯

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Scoping Review of Real-World Study in Vaccine Evaluation

引用

China CDC weekly 2024年第16期6卷 357-362页

作者： Lei Wang Hong Yang Lanfang xia Quanwei Song Na Liu guomin Zhang Fuzhen Wang Huaqing Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Real-world study(RWS)gained prominence starting with a significant investigation on ramipril’s impact on hypertension in 1993(1).A key advancement for the Food and Drug Administration(FDA)occurred with the enactment of the 21st Century Cures Act in 2016,emphasizing RWS(2).The FDA’s Real-world Evidence Program establishes real-world data(RWD)as“data relating to patient health status and/or the delivery of health care routinely collected from a variety of sources”,while real-world evidence(RWE)is“clinical evidence about the usage and potential benefits or risks of a medical product derived from analysis of RWD”(3).The proliferation of big data,electronic medical records(EMR),electronic health records(EHR),and medical claims data offers vast information resources facilitating *** access to RWD allows for worldwide monitoring of the impacts of various public health initiatives like vaccination *** randomized clinical trials(RCTs)traditionally gauge vaccine efficacy and shortterm safety,RWS can assess vaccine performance and safety across larger,more diverse populations and are adept at identifying rare events not easily discernible in RCTs due to their infrequency.

关键词： routine gained traditionally

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SARS-CoV-2 Aerosol Transmission Through Vertical Sanitary Drains in High-Rise Buildings--Shenzhen,Guangdong Province,China,March 2022

引用

China CDC weekly 2022年第23期4卷 489-493,I0002,I0003页

作者： Keyang Lyu Siyang Feng xia Li Qin Wang xiaoning Zhao Shuyuan Yu Ping Zheng Jiajia Ji guomin Chen Jing Liang Tao Lan Jinshu Feng Shuai Jiang Jianhua Lu Tianlong xia Chaoqiong Peng Tiejian Feng Dongqun Xu Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Shenzhen Center for Disease Control and Prevention Shenzhen CityGuangdong ProvinceChina Division of Chemical Analysis Biology and MedicineBeijing Institute of MetrologyBeijingChina Futian District Center for Disease Control and Prevention Shenzhen CityGuangdong ProvinceChina

Summary What is already known about this topic?Aerosol transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)via sanitary pipelines in high-rise buildings is possible,however,there is a lack of ex... 详细信息

关键词： Vertical Guangdong Summary

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Myeloid peroxisome proliferator-activated receptor α deficiency accelerates liver regeneration via IL-6/STAT3 pathway after 2/3 partial hepatectomy in mice

引用

Hepatobiliary Surgery and Nutrition 2022年第2期11卷 199-211,I0007页

作者： guomin Xie Yanting Song Na Li Zhenzhen Zhang xia Wang Ye Liu Shiyu Jiao Ming Wei Baoqi Yu Yan Wang Hua Wang Aijuan Qu Department of Physiology and Pathophysiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Key Laboratory of Remodeling-Related Cardiovascular Diseases Ministry of EducationBeijingChina Department of Endocrinology Beijing Chaoyang Hospital Affiliated to Capital Medical UniversityBeijingChina Department of Infectious Diseases Peking University First HospitalBeijingChina Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityHefeiChina

Background:Liver regeneration is a fundamental process for sustained body homeostasis and liver function recovery after *** evidence demonstrates that myeloid cells play a critical role in liver regeneration by secreting cytokines and growth *** proliferator-activated receptorα(PPARα),the target of clinical lipid-lowering fibrate drugs,regulates cell metabolism,proliferation,and ***,the role of myeloid PPARαin partial hepatectomy(PHx)-induced liver regeneration remains ***:Myeloid-specific PPARa-deficient(Ppara^(Mye−/−))mice and the littermate controls(Ppara^(fl/fl))were subjected to sham or 2/3 PHx to induce liver *** proliferation and mitosis were assessed by immunohistochemical(IHC)staining for 5-bromo-2'-deoxyuridine(BrdU)and Ki67 as well as hematoxylin and eosin(H&E)*** and neutrophil infiltration into livers were reflected by IHC staining for galectin-3 and myeloperoxidase(MPO)as well as flow cytometry *** migration ability was evaluated by transwell *** mRNA levels for cell cycle or inflammation-related genes were measured by quantitative real-time RT-PCR(qPCR).The protein levels of cell proliferation related protein and phosphorylated signal transducer and activator of transcription 3(STAT3)were detected by Western ***:Ppara^(Mye−/−)mice showed enhanced hepatocyte proliferation and mitosis at 32 h after PHx compared with Ppara^(fl/fl)mice,which was consistent with increased proliferating cell nuclear antigen(Pcna)mRNA and cyclinD1(CYCD1)protein levels in Ppara^(Mye−/−)mice at 32 h after PHx,indicating an accelerated liver regeneration in Ppara^(Mye−/−)*** staining showed that macrophages and neutrophils were increased in Ppara^(Mye−/−)liver at 32 h after *** of Ppara^(Mye−/−)mice also showed an enhanced infiltration of M1 macrophages at 32 h after *** vitro,Ppara-deficient bone marrow-derived macrophages(BMDMs)exhibited ma

关键词： Liver regeneration peroxisome proliferator-activated receptorα(PPARα) myeloid cell signal transducer and activator of transcription 3(STAT3) interleukin 6(IL-6)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extensive sequence divergence between the reference genomes of Taraxacum kok-saghyz and Taraxacum mongolicum

引用

Science China(Life Sciences) 2022年第3期65卷 515-528页

作者： Tao Lin xia Xu Huilong Du Xiuli Fan Qingwen Chen Chunyan Hai Zijian Zhou xiao Su Liquan Kou Qiang Gao Lingwei Deng Jinsheng Jiang Hanli You Yihua Ma Zhukuan Cheng Guodong Wang Chengzhi Liang guomin Zhang Hong Yu Jiayang Li State Key Laboratory of Plant Genomics National Center for Plant Gene ResearchInstitute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China State Key Laboratory of Agrobiotechnology College of HorticultureChina Agricultural UniversityBeijing 100193China University of Chinese Academy of Sciences Beijing 100049China Genomics and Genetic Engineering Laboratory of Ornamental Plants College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China Biotechnology Research Institute Heilongjiang Academy of Agricultural SciencesHarbin 150086China Guangdong Laboratory of Lingnan Modern Agriculture Guangzhou 510642China School of Life Sciences Institute of Life Sciences and Green DevelopmentHebei UniversityBaoding 071002China

Plants belonging to the genus Taraxacum are widespread all over the world,which contain rubber-producing and non-rubberproducing ***,the genomic basis underlying natural rubber(NR)biosynthesis still needs more ***,we presented high-quality genome assemblies of rubber-producing ***-saghyz TK1151 and non-rubber-producing *** *** analyses uncovered a large number of genetic variations,including inversions,translocations,presence/absence variations,as well as considerable protein divergences between the two *** gene duplication events were found in these two Taraxacum species,including one common ancestral whole-genome triplication and one subsequent round of gene *** genomes of both TK1151 and TM5,we identified the genes encoding for each step in the NR biosynthesis pathway and found that the SRPP and CPT gene families have experienced a more obvious expansion in TK1151 compared to *** study will have large-ranging implications for the mechanism of NR biosynthesis and genetic improvement of NR-producing crops.

关键词： reference genome Taraxacum kok-saghyz Taraxacum mongolicum comparative genomics natural rubber biosynthesis pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical Analysis of Levitation Force’s Dynamic Behavior in the HTS-magnet Levitation System

Numerical Analysis of Levitation Force’s Dynamic Behavior i...

引用

中国材料大会2012

作者： Wenfeng Zhang guomin Zhang Dong xia Qingquan Qiu Zhiqiang Yu Lei Hu Key Laboratory of Applied Superconduc-tivity&Institue of Electrical Engyneering Chinese Academy of Sciences University of Chinese Academy of Sciences No.19A YUniversity of Chinese Academy of Sciences

ISBN: (纸本)9783037856079

It is important to simulate the levitation force and its relaxation with time for the designers in the process of designing a HTS （high temperature superconductor）-magnet levitation bearing. In this paper, FEM （finite element method） based on HTS’s critical-state model using H formulation was introduced. In the zero field condition, the process of magnetization of a cylindrical HTS bulk was simulated. The result showed that, current would be induced when HTS bulk was put in the external magnetic field, and the induced current tried to prevent the change of the magnetic field in the HTS bulk. When the external field disappeared, HTS bulk trapped some of the field and the bulk was magnetized. HTS-magnet levitation models were built in both the axisymmetric field and the plane field. Forces and their relaxations with time were calculated. In the HTS-magnet levitation system, force faded with time and faded slower as time went on. The force was bigger when the HTS bulk was put closer to the magnet and relaxed a little more.

关键词： Superconductor FEM H formulation Levitation force.

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

教育评价变革背景下语文学科核心素养测评框架研究

引用

课程．教材．教法 2021年第2期41卷 95-102页

作者：李倩谭霞吴欣歆郑国民北京师范大学中国基础教育质量监测协同创新中心北京100875 北京师范大学文学院北京100875 北京教育学院人文与社会科学学院北京100120

建构语文学科核心素养的测评框架是落实高中语文课程变革理念的内在要求。课程观念变革之际,核心素养评价发展趋势为:评价目的由评价学习结果转向促进学习过程,强调测评框架的可解释性;评价内容由知识本位走向关注对学科本质的深度理解... 详细信息

建构语文学科核心素养的测评框架是落实高中语文课程变革理念的内在要求。课程观念变革之际,核心素养评价发展趋势为:评价目的由评价学习结果转向促进学习过程,强调测评框架的可解释性;评价内容由知识本位走向关注对学科本质的深度理解;评价工具的设计强调测试任务的综合性与实践性。据此,本研究建构以情境为依托,以语言实践活动为载体,以实践活动中表征出的关键认知能力为核心的测评框架。通过对测试数据的分析发现,构建的语文学科核心素养测评框架结构合理并具有可操作性,能够为语文学科核心素养的课程评价提供一定参考。

关键词：教育评价变革语文课程学科核心素养测评

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Von Hippel-Lindau disruption in macrophages promotes atherogenesis partially via NLRP3 inflammasome activation

Von Hippel-Lindau disruption in macrophages promotes atherog...

引用

2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者：焦时宇 Dan Qi Ming Wei Yanting Song guomin Xie xia Wang Baoqi Yu Qingbo Xu Frank J Gonzalez Jie Du Aijuan Qu Department of Physiology and Pathophysiology School of Basic Medical ScienceCapital Medical UniversityKey Laboratory of Remodeling Related Cardiovascular DiseaseMinistry of Education School of Cardiovascular medicine and sciences King's college of London Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart and Pulmonary Diseases

Background:Interleukin-1β(IL-1β)-mediated innate immunity plays an important role in *** studies reported that hypoxia could regulate the expression of IL-1β, but the precise mechanism is *** (Von Hippel-Lindau protein) is an important E3 ubiquitin ligase for HIFα(Hypoxia inducible factorα) stability and consequent cellular adaptive response to

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

跨海区域砾砂地层泥水盾构泥浆成膜效果试验研究

引用

辽宁工程技术大学学报（自然科学版） 2024年第2期43卷 171-178页

作者：李国敏朱训国夏洪春李伟大连大学建筑工程学院辽宁大连116622 辽宁省复杂结构灾害预测与防治重点实验室辽宁大连116622

为揭示泥水盾构开挖面泥浆成膜规律,以青岛地铁8号线泥水盾构掘进的跨海区间为工程背景,阐述不同级配下泥浆的渗透成膜过程,分析高聚物、处理剂作用下3种泥膜形成机理,并结合特定砾砂地层设计成膜装置,采用控制变量法开展室内试验,选用... 详细信息

为揭示泥水盾构开挖面泥浆成膜规律,以青岛地铁8号线泥水盾构掘进的跨海区间为工程背景,阐述不同级配下泥浆的渗透成膜过程,分析高聚物、处理剂作用下3种泥膜形成机理,并结合特定砾砂地层设计成膜装置,采用控制变量法开展室内试验,选用2种粒径细砂调节泥浆级配,分析不同掺量制浆材料(NSHS-3)作用下的泥浆性质。试验结果表明:与粒径小于0.01 mm的细砂相比,粒径小于0.25 mm的细砂形成的渗透带抓抱效果较好且更适配砾砂地层。地层的颗粒级配相同时,泥浆黏度越高,其稳定性越高,泥膜容易形成且厚度较薄、质密、滤水量低,但添加剂过量会引起部分土颗粒聚沉,未加压时便附着在开挖面,进而堵塞盾构管道运输系统,泥膜稳定性较差且造成资源浪费。B6号泥浆加压过程中滤水清澈,滤失量较小,形成的“泥皮+渗透带”型泥膜强度较高,能保证开挖面稳定且絮凝较少,经济性较好。研究结论为类似地层泥水盾构施工改良提供参考。

关键词：泥水盾构砾砂地层泥浆成膜渗透机理泥浆黏度

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：