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Targeting oncogenic Myc as a strategy for cancer treatment

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Signal Transduction and Targeted Therapy 2018年第1期3卷 284-290页

作者： Hui Chen Hudan Liu guoliang qing Zhongnan Hospital of Wuhan University WuhanPeople’s Republic of China Medical Research Institute Wuhan UniversityWuhanPeople’s Republic of China

The MYC family oncogene is deregulated in>50%of human cancers,and this deregulation is frequently associated with poor prognosis and unfavorable patient *** has a central role in almost every aspect of the oncogenic process,orchestrating proliferation,apoptosis,differentiation,and *** Myc inhibition would be a powerful approach for the treatment of many types of cancers,direct targeting of Myc has been a challenge for decades owing to its“undruggable”protein ***,alternatives to Myc blockade have been widely explored to achieve desirable anti-tumor effects,including Myc/Max complex disruption,MYC transcription and/or translation inhibition,and Myc destabilization as well as the synthetic lethality associated with Myc *** this review,we summarize the latest advances in targeting oncogenic Myc,particularly for cancer therapeutic purposes.

关键词： structure. cancer treatment

Animal models of T-cell acute lymphoblastic leukemia: mimicking the human disease

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Journal of Bio-X Research 2018年第1期1卷 32-40页

作者： Qin You Hexiu Su Jingchao Wang Jue Jiang guoliang qing Hudan Liu Medical Research Institute Wuhan University Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

T-cell acute lymphoblastic leukemia(T-ALL)is a heterogeneous group of hematological tumors composed of distinct subtypes that vary in their genetic *** the past decade,large-scale genomic analysis has shed new light on providing potentially important oncogenic or tumor suppressive candidates involved in the disease *** in silico analysis,functional studies are usually performed to vigorously investigate the biological roles of candidate *** this purpose,animal models faithfully recapitulating the human disease are widely applied to decipher the mechanism underlying T-cell ***,an increased understanding of T-ALL biology,including identification of oncogene NOTCH1,TAL1 and MYC as well as tumor suppressor phosphatase and tensin homolog(PTEN),has significantly improved the development of T-ALL animal *** progresses have opened opportunities for development of new therapeutic strategy to benefit T-ALL *** this review,we particularly summarize the mouse and zebrafish models used in T-ALL research and also the most recent advances from these in vivo studies.

关键词： hematopoietic stem cell transplant T-cell acute lymphoblastic leukemia transgenetic mice transgenic zebrafish xenograft

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Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IκB kinase(IKK)

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Cell Research 2006年第11期16卷 895-901页

作者： guoliang qing~1 Pengrong Yan~1 Gutian Xiao ~1Department of Cell Biology and Neuroscience,Rutgers,The State University of New Jersey,604 Allison Road,Piscataway,08854,USA DepartmentofCellBiologyandNeuroscience RutgersTheStateUniversityofNewJersey604AllisonRoadPiscatawayNJ08854USA

Autophagic and proteasomal proteolysis are two major pathways for degradation of cellular *** suggest that autophagy is responsible for the nonselective bulk degradation of long-lived proteins and organelleswhile the proteasome specifically degrades short-lived proteins including misfolded proteins caused by the absence ofHsp90 ***,we show that the IκB kinase(IKK),an essential activator of NF-κB,is selectively degraded byautophagy when Hsp90 is inhibited by geldanamycin(GA),a specific Hsp90 inhibitor showing highly effective *** find that in this case inactivation of ubiquitination or proteasome fails to block IKK ***,inhibition of autophagy by an autophagy inhibitor or knockout of Atg5,a key component of the autophagy pathway,significantly rescues IKK from GA-induced *** findings provide the first evidence that an Hsp90 clientmay be degraded by a mechanism different from the proteasome pathway and establish a molecular link among Hsp90,NF-κB and autophagy

关键词： autophagy geldanamycin Hsp90 IκB kinase NF-κB proteasome selective degradation therapy

噬菌体显示法克隆RNA结合蛋白cDNA——表达文库的构建

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生物化学与生物物理进展 1997年第5期24卷 467-470页

作者：何元政倪晓东刘定干卿国良李载平中国科学院上海生物化学研究所上海200031

试图用噬菌体显示法 (phagedisplay)克隆编码与人白细胞介素 6核转录因子的 3′非翻译区(NF IL63′UTR)特异结合的蛋白的cDNA .构建了回复系RR细胞的cDNA的噬粒 ( phagemid)表达文库 ,并设法除去了cDNA的大部分终止密码子 .鉴定表明 ,... 详细信息

试图用噬菌体显示法 (phagedisplay)克隆编码与人白细胞介素 6核转录因子的 3′非翻译区(NF IL63′UTR)特异结合的蛋白的cDNA .构建了回复系RR细胞的cDNA的噬粒 ( phagemid)表达文库 ,并设法除去了cDNA的大部分终止密码子 .鉴定表明 ,该文库中含有各种大小的cDNA插入片段 ,并能够表达外源cDNA 。

关键词： RNA结合蛋白噬菌体显示 cDNA 克隆

一类低粘度高弹性常数液晶的合成和性能的应用研究

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河北师范大学学报（自然科学版） 2017年第5期41卷 392-397页

作者：王奎员国良崔青张兴华瑞茂石家庄诚志永华显示材料有限公司河北石家庄050091 河北省平板显示材料工程技术研究中心河北石家庄050091 清华大学化学系北京100084

液晶的弹性常数影响到液晶的阈值电压、响应时间、电光曲线,是一类很重要的参数,设计开发了具有高折射率、低γ_1/K_(11)的液晶单体.四环液晶可以用于提升液晶的使用温度范围及液晶的弹性常数,是混合液晶设计的一类常用的单体.设计合成... 详细信息

液晶的弹性常数影响到液晶的阈值电压、响应时间、电光曲线,是一类很重要的参数,设计开发了具有高折射率、低γ_1/K_(11)的液晶单体.四环液晶可以用于提升液晶的使用温度范围及液晶的弹性常数,是混合液晶设计的一类常用的单体.设计合成、评测了一类侧向双氟三联苯四环液晶单体,并考察了其在液晶混合物中的应用,相对于常见单体,具有较大的弹性常数K_(11),K_(33)、较大的介电各向异性Δε、较高的清亮点CP,并对其表现出的性能参数与液晶分子结构之间的关系作了初步分析,通过GC-MS,~1HNMR,^(13)CNMR,DSC等分析方法对结构进行了表征.

关键词：弹性常数液晶四环液晶三联苯

Control of subduction rate on Tonga-Kermadec arc magmatism

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Journal of Oceanology and Limnology 2018年第3期36卷 687-699页

作者： LUO qing ZHANG guoliang Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Laboratory of Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China Deep-Sea Extreme Environment and Life Processes Center Institute of OceanologyChinese Academy of SciencesQingdao 266071China

Dehydration/melting of oceanic crusts during returning to the mantle in subduction zones are related to origin of arc lavas. The factors that influence arc magmatism include compositions of the subducting slabs, mantle wedge and subduction rates. However, distinguishing these factors remains difficult and highly debated. Subducting rate is related to the total mass of inputs and controls thermal structure, thus plays a crucial role in arc magmatism. Here we explore the relationships between geochemical variations of arc lavas and convergence rates(increasing from 46 mm/a to the south to 83 mm/a to the northward) in the Tonga-Kermadec arc system. Data of geochemistry for lava samples from nine islands of this arc system are collected and compiled to investigate the role of subduction rate in arc magmatism. Lavas from the northern Tonga arc with a faster subduction rate show broadly lower concentrations of TiO_2 and highfield-strength elements(HFSEs, e.g. Nb, Ta, Zr, Hf), and higher Ba/Th, U/Th ratios than the Kermadec Arc to the south. Some of the Kermadec lavas show the highest values of Th/Nb ratio. We suggest that the northern Tonga arc with a higher subduction rate has been influenced by a stronger role of subductionreleased fluid, which results in stronger large-ion-lithophile elements(LILEs) and relatively weaker HFSEs contribution. It is interpreted that faster subduction rate tend to create a cooler subduction zone, leading to stronger dehydration subduction slab contribution with, thus, higher LILE/HFSE ratios of arc lavas. The conclusion contributes to a better understanding of arc magmatism, and ultimately the long-term chemical differentiation of the Earth. More supplementary geochemical data along Tonga-Kermadec arc and tests in other arcs are needed.

关键词： subduction rate arc magmatism Tonga-Kermadec Arc

The precipitation behaviours and strengthening mechanism of a Cu-0.4 wt% Sc alloy

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Journal of Materials Science & Technology 2022年第3期98卷 1-13页

作者： Zifan Hao guoliang Xie Xinhua Liu qing Tan Rui Wang State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing100083China Key Laboratory for Advanced Materials Processing of Ministry of Education Institute of Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing100083China

The precipitation behaviours during the aging process and the corresponding strengthening mechanism of a Cu-0.4 wt%Sc alloy were systematically investigated in this *** phase transformation sequence of the precipitation in the aging process of the Cu-0.4 wt%Sc alloy was found to be:supersaturated solid solution→Sc-enriched atomic clusters→metastable phase→Cu4Sc *** tetragonal structured lamellar Cu4Sc precipitates,with a habit plane parallel to the{111}plane of the Cu matrix and orientation relationships of(022)_(α)//(211)_(Cu4Sc)and[011]_(α)//[113]_(Cu4Sc),are found homogeneously distributed in the matrix.A combined process of cryogenic rolling(CR)and aging was designed for optimization of the mechanical and electrical *** integration of yield strength(696 MPa)and electrical conductivity(62.8%IACS)of this alloy was achieved by cryogenic rolling and subsequent aging process at 400℃for 4 *** significant precipitation strengthening effect of this alloy is attributed to the Cu4Sc precipitates with an extremely small size of only 1.5–3 *** leading strengthening mechanism is considered as the superposition of both coherent strengthening and Orowan strengthening effects.

关键词： Cu-Sc alloy Precipitation Aging process Strengthening mechanism

Consensus Control of Multi-Agent Systems Using Fault-Estimation-in-the-Loop:Dynamic Event-Triggered Case

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IEEE/CAA Journal of Automatica Sinica 2022年第8期9卷 1440-1451页

作者： Yamei Ju Derui Ding Xiao He qing-Long Han guoliang Wei Shanghai Key Lab of Modern Optical System the Department of Control Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Department of Control Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourneVIC 3122Australia Department of Automation BNRistTsinghua UniversityBeijing 100084China College of Science University of Shanghai for Science and TechnologyShanghai 200093China

The paper develops a novel framework of consensus control with fault-estimation-in-the-loop for multi-agent systems(MASs)in the presence of faults.A dynamic event-triggered protocol(DETP)by adding an auxiliary variable is utilized to improve the utilization of communication ***,a novel estimator with a noise bias is put forward to estimate the existed fault and then a consensus controller with fault compensation(FC)is adopted to realize the demand of reliability and safety of addressed ***,a novel consensus control framework with fault-estimation-in-the-loop is developed to achieve the predetermined consensus performance with the l_(2)-l_(∞)constraint by employing the variance analysis and the Lyapunov stability ***,the desired estimator and controller gains are obtained in light of the solution to an algebraic matrix equation and a linear matrix inequality in a recursive way,***,a simulation result is employed to verify the usefulness of the proposed design framework.

关键词： Consensus control dynamic event-triggered protocol(DETP) fault compensation(FC) fault estimation multi-agent systems(MASs)

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MM4数值模式在曙光1000机上的并行化

数值计算与计算机应用 2001年第2期22卷 87-96页

作者：李国杰李柏翟武全赵建勇陈国良刘清石春娥安徽省气象科研所合肥230061 中国科技大学计算机系合肥260061

In the light of the function and characteristics of the Dawning-1000 paral- lel computer made in China, we designed the parallel calculation scheme of the MM4 mesoscale numerical model. Because of the technological processing and meticulously remaking of the data organization and program flow of the sequential program, it reaches reliable calculation results and the SPEEDUP ratio rises obviously at last. When sixteen processing nodes are used, the SPEEDUP ratio reaches 1:6.7. In finite region, the model needs only less than 30 minutes to integrate 36 hours, and the operational parallel calculation environment for application of MM4 mesoscale model is preliminarily set up.

关键词：数值模式并行计算曙光-1000 加速比中尺度数值模式 MM4模式