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Chinese Journal of Chemistry 2016年第4期34卷 412-418页

作者： guoliang shen Jing Sun Chaoguo Yan College of Chemistry & Chemical Engineering Yangzhou University Yangzhou Jiangsu 225002 China

The three-component reaction of N-phenacylbenzothiazolium bromides, aromatic aldehydes and indane-l,3- dione in ethanol at room temperature in the presence of triethylamine as base afforded functionalized spiro[benzo- [d]pyrrolo[2,1-b]thiazole-3,2＇-indenes] in good yields and with high diastereoselectivity. The 1H NMR data and sin- gle crystal structure clearly indicated that the obtained spiro compounds predominately have one diastereoisomer.

关键词： multicomponent reaction nitrogen ylide spiro compound benzothiazole indan-1,3-dione

Synthesis of Functionalized 1-Benzamido-1,4-dihydropyridines via a One-Pot Two-Step Four-Component Reaction

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Chinese Journal of Chemistry 2014年第11期32卷 1143-1150页

作者： Jing Sun guoliang shen Yajing Xie Chaoguo Yan College of Chemistry&Chemical Engineering Yangzhou UniversityYangzhouJiangsu 225002China

The one-pot four-component reaction of benzohydrazide,acetylenedicarboxylate,aromatic aldehydes and malononitrile in ethanol with triethylamine as base catalyst afforded functionalized 1-benzamido-1,4-dihydropyridines in satisfactory *** similar conditions,picolinohydrazide or nicotinohydrazide can also be successfully utilized in the reactions to give corresponding functionalized 1,4-dihydropyridines.1H NMR data indicated that an equilibrium of cis/trans-conformations exist in 1-benzamido-1,4-dihydropyridines.

关键词： one-pot reaction multicomponent reaction 1 4-dihydropyridine benzohydrazide electron-deficient alkyne

Bowen’s disease with multiple lesions of the penis and scrotum:A case report

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Chinese Journal of Plastic and Reconstructive Surgery 2022年第2期4卷 79-81页

作者： Lixuan Zhang Wei Han guoliang shen Plastic Surgery Department The First Affiliated Hospital of Soochow UniversitySuzhou 215001JiangsuChina Group Regenerative Biology and Medicine Institute of Regenerative Biology and MedicineHelmholtz Zentrum MünchenNeuherberg D-85764Germany Department of Burns The First Affiliated Hospital of Soochow UniversitySuzhou 215001JiangsuChina

Bowen’s disease is a rare squamous cell carcinoma in situ of the skin,the etiology and pathogenesis of which remain unclear.A 57-year-old man presented with the penis and scrotum erythema,with indistinct boundaries with the surrounding *** and histopathology of the biopsy specimen revealed Bowen’s *** are many clinical treatments for Bowen’s disease,including surgical excision,liquid nitrogen freezing,electrocautery,laser therapy,topical application of 5-fluorouracil ointment,and photodynamic ***’s disease mostly involves solitary *** case involved multiple lesions,and its scope was extensive;therefore,surgical resection was performed.

关键词： Bowen’s disease Squamous cell cancer in situ Multiple lesions

Clinical applications of paraumbilical perforator flaps in multiple angiosomes for the reconstruction of the upper limbs

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Chinese Journal of Plastic and Reconstructive Surgery 2022年第1期4卷 1-5页

作者： Xiaojun Liu Rui Zhao Xinyuan Jin Lei Liu guoliang shen Department of Burn and Plastic Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215006JiangsuChina Department of Burn and Plastic Surgery North District of Suzhou Municipal HospitalSuzhou 215008JiangsuChina

Background:Repair of extensive deep wounds in the forelimb remains challenging for *** objective of this study was to evaluate the surgical technique and clinical significance of multiple-territory paraumbilical perforator(PUP)flaps in patients with massive soft tissue defects in the upper ***:Between January 2017 and September 2021,16 patients(6 women and 10 men)aged 24–54 years(average,41.4 years)who were hospitalized at the First Affiliated Hospital of Soochow University and the North District of the Suzhou Municipal Hospital were *** injuries included damage to the fingers,dorsal skin of the hands,wrist,or *** tendons or bones were exposed after *** some patients,multiple-territory PUP flaps that encompassed adjacent angiosomes were transplanted to cover the soft tissue ***:All flaps survived and healed *** a follow-up of 2–54 months,all patients recovered satisfactorily in terms of characteristic and functional ***:The application of PUP flaps,especially those encompassing multiple angiosomes(multiple-territory PUP flaps),can be an optimal reconstruction method for repairing massive soft tissue defects in the forelimb.

关键词： Angiosome Perforator flap Upper limb Reconstruction

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两部衡阳当代艺文集略评

图书馆 2008年第1期 124-125页

作者：申国亮衡阳市图书馆湖南衡阳421001

本文从内容、编辑、校勘、使用等方面对衡阳两本最有影响的当代艺文集进行了评介。

关键词：地方文献《历代咏衡州诗词楹联选》《南岳衡山古今诗词集成》

基于期望响应的预测函数控制参考轨迹自校正方法

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化工学报 2008年第1期59卷 118-125页

作者：沈国良赵均钱积新浙江大学工业控制技术研究所浙江杭州310027

采用指数律参考轨迹的传统预测函数控制(PFC),系统动态响应无法预先估计,不能直接按照指定的轨迹整定动态响应。本文提出了一种预测函数控制参考轨迹自校正策略。基于事先规定的期望响应,对指数律参考轨迹的衰减系数进行实时在线滚动优... 详细信息

采用指数律参考轨迹的传统预测函数控制(PFC),系统动态响应无法预先估计,不能直接按照指定的轨迹整定动态响应。本文提出了一种预测函数控制参考轨迹自校正策略。基于事先规定的期望响应,对指数律参考轨迹的衰减系数进行实时在线滚动优化,保证预测时域内的参考轨迹最大幅度地贴近期望轨迹,使得系统响应能够准确地跟踪期望轨迹,并在指定的时刻到达设定值,同时也保留了控制输出平滑的特性。仿真实验证实了该方法的有效性及其优点。

关键词：预测函数控制参考轨迹自校正

携带腓肠肌的腓动脉穿支腓肠神经营养血管双血供复合组织瓣修复足踝部腔隙性缺损的临床效果

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中华烧伤杂志 2019年第5期35卷 392-394页

作者：李攀登沈国良苏州大学附属第一医院烧伤整形外科 215006

目的探讨携带腓肠肌的腓动脉穿支腓肠神经营养血管双血供复合组织瓣修复足踝部腔隙性皮肤软组织缺损的临床效果。方法2015年9月—2017年9月,笔者单位收治10例踝部腔隙性皮肤软组织缺损患者,其中男7例、女3例,年龄17~62岁,交通事故伤8例... 详细信息

目的探讨携带腓肠肌的腓动脉穿支腓肠神经营养血管双血供复合组织瓣修复足踝部腔隙性皮肤软组织缺损的临床效果。方法2015年9月—2017年9月,笔者单位收治10例踝部腔隙性皮肤软组织缺损患者,其中男7例、女3例,年龄17~62岁,交通事故伤8例、重物压伤2例,清创后创面面积7cm×4cm^15cm×9cm、腔隙大小3.0cm×2.0cm×1.0cm^7.0cm×4.0cm×2.0cm。采用同时保留腓动脉穿支及腓肠神经营养血管并携带部分腓肠肌的岛状复合组织瓣Ⅰ期修复缺损,皮瓣面积为8cm×5cm^16cm×10cm、腓肠肌肌瓣面积为4cm×3cm^8cm×5cm。供瓣区取同侧大腿外侧中厚皮移植修复或直接拉拢缝合。记录血管蒂位置、组织瓣成活情况、随访情况、并发症发生情况。结果本组病例血管蒂位于外踝上5~15cm。10例患者组织瓣Ⅰ期术后完全成活。随访1~12个月,组织瓣修复处色泽、血运、质地良好,无破溃,恢复了不同程度的痛觉与深触觉,无近期或远期并发症发生。结论携带腓肠肌的腓动脉穿支腓肠神经营养血管双血供复合组织瓣血供良好,修复足踝部腔隙性皮肤软组织缺损可有效填塞无效腔,术后效果较好,值得临床推广应用。

关键词：创伤和损伤外科皮瓣修复外科手术腓肠神经腓肠肌

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Witten法DMT加压酯化反应塔的设计

合成纤维工业 1998年第4期21卷 41-43页

作者： shen guoliang (Liaoyang College of Petrochemical Technology)

讨了对二甲苯合并氧化产物加压酯化反应塔的设计思路、工艺设计和计算方法。所建立的设计方法，其计算结果与实际生产装置完全一致。

关键词：对二甲苯氧化酯化反应塔设计 Witten法 DMT

A Novel Subcarrier Allocation Scheme for Adaptive Multi-user MIMO-OFDM Systems to Maximize the System Capacity

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A Novel Subcarrier Allocation Scheme for Adaptive Multi-user...

CDCA5在皮肤恶性黑色素瘤中的表达及其与预后相关性的生物信息学分析

第十二届全国青年通信学术会议

作者： guoliang shen Shouyin Liu Dept.of Electronic and Information Engineering,Huazhong Normal University Wuhan 430079,China

＜正＞In this paper,we investigate the subcarrier allocation schemes for downlink adaptive multi-user multiple input multiple output-orthogonal frequency division multiplexing（MIMO-OFDM）*** categories of subcarrier assignment criteria to maximize the system capacity are obtained in this paper,that is,Frobenius norm criterion（FNC）and Infinite norm criterion（INC）.Our proposed algorithm is able to:①optimize the system capacity;②avoid the conflict between users;③ensure fairness of all the users;④satisfy the QoS requirements of the user whose channel condition is always *** is assumed that the transmitter and receiver both have the perfect channel state information（CSI）.Simulation results show that the system capacity which is achieved by our proposed subcarrier allocation criteria is much higher than fixed subcarrier allocation scheme.

关键词： Subcarrier Allocation Adaptive Multi-User

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现代肿瘤医学 2021年第7期29卷 1234-1240页

作者：韩未沈国良苏州大学附属第一医院江苏苏州215000

目的:探讨CDCA5在皮肤恶性黑色素瘤(cutaneous malignant melanoma,CMM)中的表达、相关信号通路及其与患者预后之间的关系。方法:应用Oncomine和GEPIA数据库研究CDCA5基因在不同肿瘤组织中的表达情况以及与患者预后关系。此外,还收集了... 详细信息

目的:探讨CDCA5在皮肤恶性黑色素瘤(cutaneous malignant melanoma,CMM)中的表达、相关信号通路及其与患者预后之间的关系。方法:应用Oncomine和GEPIA数据库研究CDCA5基因在不同肿瘤组织中的表达情况以及与患者预后关系。此外,还收集了我院41例黑色素瘤患者及41例正常皮肤病例进行免疫组化分析。cBioPortal数据库用于研究CDCA5基因突变情况。应用STRING数据库构建CDCA5相关蛋白-蛋白相互作用网络,并进行功能富集和通路分析。应用TISIDB数据库探究CDCA5与免疫浸润的关系。结果:CDCA5基因在大多数肿瘤组织包括CMM中的表达水平上调,高表达与患者的预后不良有关。免疫组化结果显示,CDCA5在CMM中表达也是明显高于正常皮肤组织。TCGA数据库中有8%的CDCA5基因在CMM组织中发生了突变。CDCA5相关蛋白-蛋白相互作用网络中,相互作用蛋白网络富集明显(P<1.0E-16)。CDCA5编码蛋白的分子功能主要为蛋白质结合、染色体结合、ATP结合以及蛋白激酶活性等。而生物学过程主要集中于姐妹染色单体凝聚力、有丝分裂核分裂、细胞分裂等。KEGG信号通路主要为细胞周期、卵母细胞减数分裂和孕激素介导的卵母细胞成熟。GSEA结果显示CDCA5相关显著变化的通路主要为炎症反应、TNFα-NF-κB通路、干扰素alpha通路、干扰素gamma通路、IL2-STAT5通路、IL6-JAK-STAT3通路、p53通路以及KRAS通路。此外,CDCA5基因与活化CD4^(+)T细胞成正相关,与不成熟B细胞、肥大细胞、1型辅助T细胞以及效应记忆CD8^(+)T细胞成负相关。结论:CDCA5在CMM患者肿瘤组织中表达较高,高表达与患者的预后不良有关。

关键词：黑色素瘤 CDCA5 生物信息学预后