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A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis

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Science China(Life Sciences) 2019年第1期62卷 112-118页

作者： Ziru Jiang Li Jin Weihui Shi Ji Xi Yulian Hu Xinmei Liu Jianzhong Sheng guolian ding Hefeng Huang The International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Institute of Embryo-Fetal Original Adult Disease Shanghai Key Laboratory for Reproductive Medicine School of Medicine Shanghai Jiao Tong University Department of Pathology and Pathophysiology School of Medicine Zhejiang University

To investigate the effect of basal hormone levels including follicle stimulating hormone(FSH) and estradiol(E2) and age on the pregnancy outcomes in women undergoing in vitro fertilization and embryo transfer(IVF-ET), we designed a retrospective cohort analysis and collected information of patients undergoing IVF between January 2014 and April 2017. We found that young women had much better pregnancy outcomes than older women regardless of the hormone levels. The pregnancy outcomes declined in young women with high basal E2, even though they had normal FSH. Older women with higher FSH had a worse outcome of pregnancy, especially with increased E2 level. The results suggest that a combination of FSH, E2 and age could effectively predict the pregnancy outcome for women undergoing IVF-ET, and we should encourage infertile women with diminished ovarian reserve, especially young infertile women, to try the assisted reproduction as early as possible. After 40-yearold, the cost-benefit ratio should be considered according to the ovarian function.

关键词： follicle stimulating hormone estradiol age pregnancy outcome assisted reproduction

Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants

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Science China(Life Sciences) 2019年第2期62卷 257-267页

作者： Ye Liu Yinyu Wang Fangfang Wang Jiexue Pan Jingjing Xu Jingyi Li Chengliang Zhou guolian ding Yanting Wu Xinmei Liu Jianzhong Sheng Hefeng Huang The International Peace Maternity and Child Health Hospital Shanghai Jiao Tong University School of Medicine The Key Laboratory of Reproductive Genetics (Ministry of Education) Zhejiang University Department of Pathophysiology Zhejiang University School of Medicine

As shown in our previous study, two alternatively spliced androgen receptor(AR) variants, which are exclusively expressed in the granulosa cells of patients with polycystic ovary syndrome, exhibit retarded nuclear translocation compared with wild-type AR. However, researchers have not yet determined whether these abnormalities correlate with heat shock protein 90(HSP90)and importin α(the former is a generally accepted co-chaperone of AR, and the latter is a component of classical nuclear import complexes). Here, these two variants were mainly retained in cytoplasm with HSP90 and importin α in the presence of dihydrotestosterone(DHT), and their levels in nucleus were significantly reduced, according to the immunofluorescence staining. The binding affinity of two AR variants for importin α was consistently decreased, while it was increased in WT-AR following DHT stimulation, leading to reduced nuclear import, particularly for the insertion-AR(Ins-AR). However, the binding affinities of two AR variants for HSP90 were increased in the absence of DHT compared with WT-AR, which functioned to maintain spatial structural stability, particularly for the deletion-AR(Del-AR). Therefore, the retarded nuclear translocation of two AR variants is associated with HSP90 and importin α, and the abnormal binding affinities for them play critical roles in this process.

关键词： androgen receptor splice variants nuclear translocation heat shock protein 90 importin α polycystic ovary syndrome

The epigenetic mechanisms underlying gamete origin of adult-onset diseases

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Science Bulletin 2022年第17期67卷 1724-1727页

作者： guolian ding Bin Chen John R.McCarrey Hefeng Huang Obstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200011China Research Units of Embryo Original Diseases Chinese Academy of Medical SciencesShanghai 200030China Key Laboratory of Reproductive Genetics(Ministry of Education) Department of Reproductive EndocrinologyWomen’s HospitalZhejiang University School of MedicineHangzhou 310006China Assisted Reproduction Unit Department of Obstetrics and GynecologySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityKey Laboratory of Reproductive Dysfunction Management of Zhejiang ProvinceHangzhou 310016China Department of Neuroscience Developmental and Regenerative BiologyUniversity of Texas at San AntonioSan Antonio 78249USA Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China

The events occurring before and soon after birth appear to impact an individual’s health throughout adulthood *** pioneering work of David *** studied the nutritional status of 2414 pregnant women and their offspring during the Dutch famine between 1944 and 1945,and convincingly connected undernutrition during pregnancy to the predisposition of offspring to many adult-onset diseases,including cardiovascular disease.

关键词：成人疾病 cardiovascular diseases

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生长激素在辅助生殖技术中的应用及作用机制

国际生殖健康／计划生育杂志 2008年第6期27卷 351-354页

作者：丁国莲黄荷凤浙江大学医学院附属妇产科医院 310006

生长激素(GH)在生殖过程中具有重要生理作用,辅助生殖技术中应用生长激素对诱导排卵有确切的治疗作用,有助于改善卵巢的反应性和卵细胞及胚胎的质量,提高妊娠率。体外及体内实验也证实生长激素可作用于卵巢,影响配子形成和甾体合成,促... 详细信息

生长激素(GH)在生殖过程中具有重要生理作用,辅助生殖技术中应用生长激素对诱导排卵有确切的治疗作用,有助于改善卵巢的反应性和卵细胞及胚胎的质量,提高妊娠率。体外及体内实验也证实生长激素可作用于卵巢,影响配子形成和甾体合成,促进小卵泡的生长并阻止其闭锁,有利于卵泡和配子的成熟,其在早期胚胎分化和代谢中也发挥重要作用,也可促进精子发生,就这些方面做一综述。如何选择最适宜治疗的患者群体及增加卵巢敏感性所需生长激素的最小剂量尚需进一步研究,生长激素作用机制及其是否通过胰岛素样生长因子I影响卵泡发育也需进一步探讨。

关键词：生长激素辅助生殖技术胰岛素样生长因子I 卵巢胚胎

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镁合金的熔炼铸造与焊接技术研究

中国铸造装备与技术 2022年第6期57卷 19-22页

作者：丁健包国连沈阳新松机器人自动化股份有限公司辽宁沈阳110167

镁合金是一种节能、环保新型结构材料,质量轻、硬度大,在强度、刚度、制造性、加工方式、导热性、稳定性等方面,与传统材料相比都具有明显的性能优势,已发展成为除钢铁、铝合金之外的第三大金属结构材料。通过对镁合金的常见焊接技术进... 详细信息

镁合金是一种节能、环保新型结构材料,质量轻、硬度大,在强度、刚度、制造性、加工方式、导热性、稳定性等方面,与传统材料相比都具有明显的性能优势,已发展成为除钢铁、铝合金之外的第三大金属结构材料。通过对镁合金的常见焊接技术进行分析研究,择优选用熔化极惰性气体保护焊进行试验研究验证,具体阐述了试验用镁合金板材的熔炼铸造,以及焊接过程中接头对接形式、焊丝选用、焊接电流设置、焊接速度、气流量、焊后热处理等焊接关键技术,最后对焊接接头的外观、力学性能及硬度进行测定,综合分析后表明镁合金根据文中焊接关键技术进行焊接操作,可以取得良好的焊接效果。

关键词：镁合金熔炼铸造焊接技术

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汽车发动机缸体的焊补技术研究

中国铸造装备与技术 2022年第5期57卷 53-57页

作者：包国连丁健沈阳新松机器人自动化股份有限公司辽宁沈阳110167

汽车发动机系统是汽车正常行驶的关键系统,缸体是汽车发动机系统的关键部件。因此,缸体质量必须严格把关,做到零缺陷才能进入下一道工序,流入下一条生产线。综合分析了汽车发动机系统及缸体对汽车正常行驶的重要性,进一步分析了缸体的... 详细信息

汽车发动机系统是汽车正常行驶的关键系统,缸体是汽车发动机系统的关键部件。因此,缸体质量必须严格把关,做到零缺陷才能进入下一道工序,流入下一条生产线。综合分析了汽车发动机系统及缸体对汽车正常行驶的重要性,进一步分析了缸体的生产加工工艺和焊补技术,总结出汽车发动机焊补的九项准备工作和焊补六步骤,可以作为发动机缸体及相关箱体类铸造件的焊补技术参考。

关键词：发动机缸体焊接工艺

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汽车发动机曲轴及其焊接修复技术研究

中国铸造装备与技术 2022年第5期57卷 80-84页

作者：丁健包国连沈阳新松机器人自动化股份有限公司辽宁沈阳110167

曲轴是汽车发动机系统的关键零部件,首先通过对汽车发动机曲轴的功能重要性、结构特殊性以及工作原理进行分析,突出了曲轴在汽车安全行驶过程中的关键性与重要性,然后简要概述了汽车发动机曲轴的装置结构及其生产加工特点,紧接着从焊接... 详细信息

曲轴是汽车发动机系统的关键零部件,首先通过对汽车发动机曲轴的功能重要性、结构特殊性以及工作原理进行分析,突出了曲轴在汽车安全行驶过程中的关键性与重要性,然后简要概述了汽车发动机曲轴的装置结构及其生产加工特点,紧接着从焊接修复方法的选择、焊条的性质、焊接修复工艺措施三个方面分析了曲轴焊接修复工艺设计,最后从曲轴焊接修复前五项准备工作和焊接修复过程六项重点工作,详细介绍了曲轴焊接修复过程实施细节及关键控制点,对同类结构件焊接修复具有重要参考意义。

关键词：曲轴焊接修复技术

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耐磨铸钢与高强耐磨钢板焊接工艺研究

中国铸造装备与技术 2022年第6期57卷 83-86页

作者：包国连丁健沈阳新松机器人自动化股份有限公司辽宁沈阳110169

高强度耐磨钢K360广泛应用在工程机械、矿山机械、农用机械上,低合金铸钢ZG30MnSi具有较高的强度和耐磨性,通过小铁研试验,评估了K360与ZG30MnSi钢的裂纹敏感性。

关键词： K360 耐磨钢焊接工艺

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魔芋葡甘聚糖的辐照降解研究

农产品加工（下） 2006年第10期 27-29,46页

作者：徐振林孙远明丁金龙沈玉栋庞杰王弘肖治理谌国莲华南农业大学食品学院广州510642 广州王老吉药业股份有限公司广州510060

研究了不同剂量的Coγ-射线对魔芋葡甘聚糖(KGM)的辐照降解作用。黏度测定结果表明,辐照后KGM60的黏度随着辐照剂量的增加而显著下降;凝胶渗透色谱(GPC)结果显示,KGM分子量随着辐照剂量的增加而下降,经5.0kGy和100.0kGy辐照后,KGM的重... 详细信息

研究了不同剂量的Coγ-射线对魔芋葡甘聚糖(KGM)的辐照降解作用。黏度测定结果表明,辐照后KGM60的黏度随着辐照剂量的增加而显著下降;凝胶渗透色谱(GPC)结果显示,KGM分子量随着辐照剂量的增加而下降,经5.0kGy和100.0kGy辐照后,KGM的重均分子量Mw从未辐照的4.81×105下降到3.70×105和3.98×104;热重分析(TG)结果表明,辐照并未对KGM的热性能造成显著影响,100.0kGy辐照后,KGM的热分解温度只比对照下降20℃。对KGM辐照前后的酶解结果表明,辐照提高了KGM对β-葡甘聚糖酶的敏感性,从一定程度上促进了酶解效果。

关键词：魔芋葡甘聚糖 γ-辐照 β-葡甘聚糖酶