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Single Particle Colorimetric Acid Phosphatase Activity Assay with CeO_(2)-modified Gold Nanoparticles

Chemical Research in Chinese Universities 2024年第2期40卷 320-325页

作者： ZHU Tang Jiayao YUAN Xiang mao guojiang WEI Lin XIAO Lehui Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research National and Local Joint Engineering Laboratory for New Petrochemical Materials and Fine Utilization of ResourcesCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha410081P.R.China Henan Key Laboratory of Organic Functional Molecule and Drug Innovation Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang453007P.R.China College of Chemistry and Chemical Engineering Central South UniversityChangsha410083P.R.China

Acid phosphatase(ACP)is a ubiquitous phosphatase in living *** abnormal variation of ACP is related to various ***,we propose a colorimetric method based on CeO_(2)-modified gold core shell nanoparticles(Au@CeO_(2)NPs)to analyze ACP activity with high sensitivity and *** this design,2-phospho-L-ascorbic acid trisodium salt(AAP)is dephosphorylated by ACP and produces reductive ascorbic acid(AA),which makes the CeO_(2)shell decomposition.A remarkable blue shift of localized surface plasmon resonance peak(LSPR,from yellow to green)along with the scattering intensity ratio changes from individual Au@CeO_(2)NPs are *** activity can be quantified by calculating the ratio changes of individual Au@CeO_(2)*** assay reveals limit of detection(LOD)of 0.044 mU/mL and the linear range of 0.05–5.0 mU/mL,which are much lower than most of spectroscopic measurements in bulk ***,the recovery measurements in real samples are satisfactory and the capacity for practical application is *** a consequence,Au@CeO_(2)NPs used in this assay will find new applications for the ultrasensitive detection of enzyme activity.

关键词： Single particle imaging Dark field Gold nanoparticle Enzyme activity Colorimetric detection

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Recent Progress in Endoplasmic Reticulum-Targetable Small-Molecule Probes for Fluorescence Sensing and Phototherapy

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Journal of Analysis and Testing 2023年第3期7卷 304-324页

作者： Jing Chen Huihong Liu Wenzhi Xie maoxin Gu guojiang mao Sheng Yang Hunan Provincial Key Laboratory of Cytochemistry School of Chemistry and Chemical EngineeringChangsha University of Science and TechnologyChangsha 410114China Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Henan Key Laboratory of Organic Functional Molecule and Drug Innovation Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007China

The endoplasmic reticulum(ER)is the most widespread organelle within eukaryotic cells,performing various essential functions such as protein synthesis,post-translational modifications,and lipid *** fluctuations of biologically active species and microenvironments in the ER can disrupt homeostasis and eventually lead to ER stress,which is closely linked to the occurrence and progression of many human ***,the ER has been regarded as an important analytical object as well as a promising therapeutic target in both bio sensing and ***,there has been a growing interest in developing photon-excited molecular tools to uncover the physio pathological roles of ER and treat ERrelated *** review presents a comprehensive summary of recent advances in ER-targeted small-molecule probes and their applications for fluorescent sensing and phototherapy,mainly focusing on targeting strategies and probe design ***,we discuss the challenges involved with ER-targeted probes and highlight potential prospects in this field.

关键词： Endoplasmic reticulum Organelle-targetable fl uorescent probe Subcellular analysis Endoplasmic reticulum stress Phototherapy

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Ultrathin organic polymer with p-πconjugated structure for simultaneous photocatalytic disulfide bond generation and CO_(2)reduction

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Journal of Energy Chemistry 2023年第1期76卷 639-647,I0016页

作者： Linquan Hou Zhunyun Tang guojiang mao Shiheng Yin Bei Long Tao Ouyang Guo-Jun Deng Atif Ali Ting Song Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan 411105HunanChina Hunan Key Laboratory for Micro-Nano Energy Materials and Device School of Physics and OptoelectronicsXiangtan UniversityXiangtan 411105HunanChina School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanChina Analytical and Testing Center South China University of TechnologyGuangzhou 510640GuangdongChina Department of Chemistry and State Key Laboratory of Synthetic Chemistry The University of Hong KongPokfulam RoadHong Kong 999077China

Combining photocatalytic organic reactions with CO_(2)reduction is an efficient solar energy utilization mode,but it is still limited by the organic species that can be matched and the low ***,ultrathin organic polymer with p-πconjugated structure(TPP)was rationally designed and prepared,and showed a high yield of CO(15.2 mmol g^(-1))and conversion of SAS coupled products(100%),far exceeding the organic polymer with P=O *** enhanced photoredox activity of TPP is ascribed to the orbital interaction between the p-orbital on phosphorus and theπ-orbitals of aromatic,which can accelerate the photoinduced charge carrier separation and improve the CO_(2)adsorption *** can also be used for the dehydrocoupling of various benzyl mercaptans to the corresponding SAS bond *** work provides a new concept for the efficient synthesis of disulfide bonds combined with CO_(2)reduction in a photoreaction system.

关键词： Photocatalytic coupled reaction Disulfide bond CO_(2)reduction High activity Organic polymer

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Chemoselective synthesis of α-carboline derivatives via hypervalent iodine-catalyzed [3+3] annulation under metal-free conditions

Green Synthesis and Catalysis

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Green Synthesis and Catalysis 2024年第2期5卷 112-116页

作者： Shuowen Wang Rong Li Shanping Chen guojiang mao Wen Shao Guo-Jun Deng Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan 411105China Department School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

A strategy for the synthesis ofα-carboline derivatives from indole-3-carboxaldehydes and 3-aminocyclohex-2-enones under metal-free conditions has been *** combination use of phenyliodine(Ⅲ)diacetate(PIDA)and benzoic acid could significantly facilitate the corresponding[3+3]annulation *** newly developed strategy featured unextraordinary chemoselectivity,good functional group tolerance and the preservation of the carbonyl group of the ketone substrates,which offers the possibility for further transformation of the products.

关键词： Hypervalent iodine-catalysis Annulation Metal-free α-Carboline Chemoselectivity

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Synthesis of biheteroaryls via 2-methyl quinoline C(sp^(3))-H functionalization under metal-free conditions

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Green Synthesis and Catalysis 2024年第1期5卷 73-76页

作者： Dahan Wang Yuhan Yang Fuhong Xiao Jinbing Liu guojiang mao Guo-Jun Deng Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education Hunan Province Key Laboratory of Green Organic Synthesis and ApplicationCollege of ChemistryXiangtan UniversityXiangtan 411105China Department of Food and Chemical Engineering Shaoyang UniversityShaoyang 422100China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

An acetic acid-promoted C(sp^(3))-H functionalization of 2-methyl quinoline,enaminoesters and elemental sulfur for the synthesis of 3,4,5-trisubstituted isothiazoles under metal-free conditions has been *** approach provides viable access to various 5-(quinolin-2-yl)isothiazoles in moderate to good yields with good functional group ***,the success of the gram-scale reaction gives this reaction a great potential application.

关键词： C(sp^(3))-H functionalization Multicomponent reactions Biheteroaryls Elemental sulfur Metal-free

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Pictet-spengler/transamination cascade reaction of indoles for modular synthesis of marinoquinoline analogues

Green Synthesis and Catalysis

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Green Synthesis and Catalysis 2024年第4期5卷 310-314页

作者： Jinjin Chen Pingyu Jiang Xinping Liu Huawen Huang guojiang mao Guo-Jun Deng Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan411105China School of Pharmaceutical Science Hengyang Medical SchoolUniversity of South ChinaHengyang421001China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang453007China

The Pictet-Spengler/transamination cascade reaction enables modular synthesis of marinoquinoline analoguesthrough three-component indole ring-expansion/cyclization in the manner of novel N1–C2 cleavage of *** metal-free protocol exhibits very broad functional group tolerance with up to quantitative yields. Preliminarystudies on the antitumor activity of the resultant marinoquinoline analogues reveal that the indolyl-attachedpyrrolo[2,3-c]quinoline product (5d) shows great potential (IC50 of 0.32 μg/mL to HeLa cells) as a promisinganticancer agent in clinic.

关键词： Pictet-spengler reaction Indole ring-expansion N1-C2 cleavage Indole Marinoquinoline analogues

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小区非住宅电能类别刍议

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住宅与房地产 2016年第4X期 80-,99页

作者：毛国江安徽省地质矿产勘查局327地质队安徽合肥230011

通过工程实例和政策来探讨小区非住宅的电能类别,目的是控制电能类别设计或检查改造已使用的电能类别,对电能混用现象进行了原因分析、并提出一些协商处理建议,总结并兼顾投资、供给和用户的利益。

关键词：非住宅电能类别民用电能商业电能电能混用

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泵吸反循环钻进与R-618钻进成孔对比

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住宅科技 2001年第6期21卷 35-37页

作者：毛国江安徽地矿建设工程有限责任公司合肥230091

介绍了泵吸反循环和R - 6 1 8钻进成孔过程中出现的问题和所采取的措施。

关键词：泵吸反循环 R-618钻机钻斗泥浆成孔

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建筑施工合同中的质量保修问题探讨

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住宅与房地产 2016年第4X期 114-117页

作者：毛国江安徽省地质矿产勘查局327地质队安徽合肥230011

通过建筑施工合同中的保修条款和工程实体的一些保修实例,对质量保修期限、保修金、保修责任、保修费用、保修金返还进行了分析和探讨,对棘手保修事项进行了利益公平阐述及期待探究好办法,同时提出了《房屋建筑工程质量保修书》、《房... 详细信息

通过建筑施工合同中的保修条款和工程实体的一些保修实例,对质量保修期限、保修金、保修责任、保修费用、保修金返还进行了分析和探讨,对棘手保修事项进行了利益公平阐述及期待探究好办法,同时提出了《房屋建筑工程质量保修书》、《房屋建筑工程质量保修办法》和《建设工程质量管理条例》中存在的缺憾。

关键词：建筑施工合同质量保修质量保修责任保修费用保修事项

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新工科背景下化学专业研究生教学改革论析

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科教导刊 2021年第1期 29-30页

作者：吴呈珂毛国江河南师范大学化学化工学院河南新乡453007

2019年底以来,各行各业积极响应国家公共卫生安全措施,目前取得了举世卓越的成果.为维护社会公共安全,保持"社交距离"在未来很长一段时间将成为回归常态化社交行为模式.据不完全统计,我国体育舞蹈相关从业人员已逾三千万,庞大的参与基... 详细信息

2019年底以来,各行各业积极响应国家公共卫生安全措施,目前取得了举世卓越的成果.为维护社会公共安全,保持"社交距离"在未来很长一段时间将成为回归常态化社交行为模式.据不完全统计,我国体育舞蹈相关从业人员已逾三千万,庞大的参与基数形成了完整的体育舞蹈经济产业链.本文从体育舞蹈培训、赛事、舞蹈产品三大主要产业板块分析现今的生存现状,试图为体育舞蹈相关模块的资源合理配置,实现降低体育舞蹈产业经济损失及尽快恢复正常运作提供可行性建议.

关键词：新工科化学专业教学改革

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