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Clinicopathological Significance of Mucin 2 Immuno-histochemical Expression in Colorectal Cancer: A Meta-Analysis

Chinese Journal of Cancer Research 2012年第3期24卷 190-195页

作者： Li Li Pei-lin Huang Xiao-jin Yu Xiao-dong bu Department of Pathology Affiliated First HospitalNanjing Medical UniversityNanjing 210006China Department of Pathology School of MedicineSoutheast UniversityNanjing 210009China Department of Epidemiology and Statistics School of Public HealthSoutheast UniversityNanjing 210009China

Objective： To evaluate the association between mucin 2 （MUC2） expression and clinicopathological characters of colorectal cancer. Methods： A literature search was performed on December 31, 2010 according to defined selection criteria. We evaluated the correlation between MUC2 （detected by immunohistochemistry） and clinicopathological characters of colorectal cancer. According to the tumor histological type, differentiation, location and TnM staging of colorectal carcinoma, we divided the clinicopathological characteristics into different subgroups. Fixed and random effects models were applied for estimation of the summarized risk ratios （RRs） and 95% confidence intervals （CIs） in different subgroups. Finally, forest plots and funnel plots were created to allow for visual comparison of the results or the effect of publication bias. Results： According with the inclusive criteria, fourteen studies （n=1,558） were eligible for the meta-analysis. We observed a trend towards a correlation of MUC2 higher positivity in mucinous than non-mucinous carcinoma （RR, 2.10; 95% CI, 1.30-3.40; P=0.002） and less positivity in distal than proximal colon （RR, 0.74; 95% CI, 0.64-0.85; P=0.000）. There was no statistically significance for the association between MUC2 expression and differentiation or TnM staging of colorectal cancer, but MUC2 overexpression tended to be associated with the presence of T stage tumor （RR, 1.17; P=0.052）. Conclusion： MUC2 overexpression was associated with the mucinous and proximal colorectal cancer.

关键词： Colorectal cancer MUC2 Immunohistochemistry Meta-analysis

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Amphiphilic miktoarm star copolymers can self-assemble into micelle-like aggregates in nonselective solvents: a case study of polyoxometalate based miktoarm stars

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Science China Chemistry 2020年第6期63卷 792-801页

作者： Jie Xiao Qun He Shengchao Qiu Haoquan Li Binghua Wang Bin Zhang Weifeng bu Key Laboratory of nonferrous Metals Chemistry and Resources Utilization of Gansu Province State Key Laboratory of Applied Organic Chemistryand College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China School of Materials Science&Engineering Zhengzhou UniversityZhengzhou 450002China

It is well-known that amphiphilic star-shaped copolymers can self-assemble in selective solvents to form complicated micellar constructs as a synergistic result of both the topological constraints and relative volume fractions of the *** the association phenomena of amphiphilic stars have been observed in nonselective solvents,both the structural detail and formation mechanism of these associates are not clear ***,these experimental observations are controversial with respect to molecularly dispersed starlike copolymers in nonselective solvents as is popularly *** clarify these issues,we have synthesized a series of polyoxometalate-based polystyrene-poly(ethylene glycol)(PS-PEG)miktoarm star supramolecular copolymers(SEW-1–5)by coupling a Keggin-type polyoxometalate of K4[α-SiW12O40]with 1,2,3-triazolium bridged block copolymers of-PSn-b+-PEGmI-(n=17,26,39,57,81;m=45)through ionic exchange reactions,*** imaging,contact angle and 1H nMR studies reveal that SEW-2–5 self-assemble in chloroform,THF,and toluene to create micellelike aggregates ranging from cylinder to sphere with a PS corona and a PEG core,while for SEW-1,reverse bilayers are captured with a PEG corona and a PS *** these aggregates,the Keggin clusters of[α-SiW12O40]4-localize at the core-corona interfaces between PS and *** terms of solvent quality,chloroform,THF,and toluene are only slightly poorer for PEG than that for PS with a relative order of chloroformnexpected aggregates originate from the topological constraints of the chemically different arms of PS and PEG in the miktoarm stars,where the weak incompatibility between the PS and PEG arms is intensified *** presence of the reverse bilayered structures of SEW-1 is due to the magnified steric hindrance of the PEG45 arm with decreasing the molecular weight of the PS17 ***,to the best of our knowledge,these are the first examples clearly indicating that miktoa

关键词： miktoarm star copolymer self-assembly micellelike aggregate nonselective solvent polyoxometalate

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血清miR-155、IL-17与急性心肌梗死患者心肌酶谱及预后的分析

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分子诊断与治疗杂志 2024年第7期16卷 1289-1293页

作者：邵从军卜文君胡恒贵秦淑国皖北煤电集团总医院检验科安徽宿州234011

目的分析研究血清微小RnA-155(miR-155)、白细胞介素-17(IL-17)与急性心肌梗死患者心肌酶谱及预后的相关性。方法选取2021年1月至2022年4月皖北煤电集团总医院收治的急性心肌梗死(AMI)患者作为研究对象,将其命名为AMI组(n=129),另选... 详细信息

目的分析研究血清微小RnA-155(miR-155)、白细胞介素-17(IL-17)与急性心肌梗死患者心肌酶谱及预后的相关性。方法选取2021年1月至2022年4月皖北煤电集团总医院收治的急性心肌梗死(AMI)患者作为研究对象,将其命名为AMI组(n=129),另选同期在本院体检的健康人群为对照组(n=80)。比较两组血清miR-155、IL-17及心肌酶谱[肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)及乳酸脱氢酶(LDH)]水平;采用Pearson相关系数分析AMI患者血清miR-155、IL-17与心肌酶谱的相关性;在治疗结束后对患者随访1年,以随访期间发生心源性休克、心力衰竭、复发性心肌梗死以及患者出现死亡等事件为预后不良,根据多因素Logistic回归分析AMI患者预后不良的影响因素,并绘制ROC曲线分析血清miR-155、IL-17水平对AMI患者预后不良的预测价值。结果 AMI组的血清miR-155、IL-17、CK、CK-MB、LDH水平均高于对照组,差异有统计学意义(t=28.233,Pn相关性分析显示,AMI患者血清miR-155、IL-17与CK、CK-MB、LDH呈正相关(均P60岁(OR=2.083)、有高血压病史(OR=1.687)、有糖尿病史(OR=1.740)、miR-155水平高表达(OR=2.312)、IL-17水平升高(OR=1.966)、CK水平升高(OR=2.098)、CK-MB水平升高(OR=2.067)及LDH水平升高(OR=2.300)均是AMI患者预后不良的独立危险因素(P<0.05);ROC曲线分析显示,血清miR-155、IL-17水平及二者联合检测的曲线下面积(AUC)分别为0.930、0.865、0.964,联合检测优于单一检测(P<0.05)。结论急性心肌梗死患者的血清miR-155、IL-17水平呈高表达,与心肌酶谱和预后情况密切相关。miR-155、IL-17可能成为急性心肌梗死患者预后不良的辅助预测指标。

关键词：微小RnA-155 白细胞介素-17 急性心肌梗死心肌酶谱

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Impact of pre-oxidation on the formation of byproducts in algae-laden water disinfection:Insights from fluorescent and molecular weight

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Journal of Environmental Sciences 2022年第7期34卷 21-27页

作者： Da Sheng Lingjun bu Shumin Zhu Yangtao Wu Jue Wang nan Li Shiqing Zhou Key Laboratory of building Safety and Energy Efficiency Ministry of EducationDepartment of Water Engineering and ScienceCollege of Civil EngineeringHunan UniversityChangsha 410082China

Pre-oxidation has been reported to be an effective way to remove algal cells in water, but the released algal organic matter (AOM) could be oxidized and lead to the increment in disinfection by-product (DBP) formation. The relationship between pre-oxidation and AOM-derived DBP formation needs to be approached more precisely. This study compared the impact of four pre-oxidants, ozone (O), chlorine dioxide (ClO), potassium permanganate(KMnO) and sodium hypochlorite (naClO), on the formation of nitrogenous (n-) and carbonaceous (C-) DBPs in AOM chlorination. The characterization (fluorescent properties,molecular weight distribution and amino acids concentration) on AOM samples showed that the characterization properties variations after pre-oxidation were highly dependent on the oxidizing ability of oxidants. The disinfection experiments showed that Oincreased DBP formation most significantly, which was consistent with the result of characterization properties variations. Then canonical correspondent analysis (CCA) and Pearson’s correlation analysis were conducted based on the characterization data and DBP formation. CCA indicated that C-DBPs formation was highly dependent on fluorescent data. The formation of haloacetic acids (HAAs) had a positive correlation with aromatic protein-like component while trichloromethane (TCM) had a positive correlation with fulvic acid-like ***’s correlation analysis showed that low molecular weight fractions were favorable to form n-DBPs. Therefore, characterization data could provide the advantages in the control of DBP formation, which further revealed that KMnOand ClOwere better options for removing algal cells as well as limiting DBP formation.

关键词： Algal organic matters Pre-oxidation Disinfection by-products

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基于水热法合成氮掺杂碳点荧光增强检测阿司匹林

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杭州师范大学学报（自然科学版） 2024年第4期23卷 388-394页

作者：卜晓阳李萍周思了陈云艳皖南医学院药学院安徽芜湖241002

以水杨酸为碳源,碳酸铵为氮源,通过一步水热法合成一种在365 nm紫外光下发蓝色荧光的水溶性氮掺杂碳量子点(n-CQDs).该量子点的荧光量子产率达19.8%,透射电镜(TEM)显示其形貌接近圆球形,平均粒径约为7.2 nm.利用X射线电子衍射仪(XRD)、... 详细信息

以水杨酸为碳源,碳酸铵为氮源,通过一步水热法合成一种在365 nm紫外光下发蓝色荧光的水溶性氮掺杂碳量子点(n-CQDs).该量子点的荧光量子产率达19.8%,透射电镜(TEM)显示其形貌接近圆球形,平均粒径约为7.2 nm.利用X射线电子衍射仪(XRD)、傅里叶变换红外分光光度计(FTIR)、紫外分光光度计、荧光分光光度计分别对其结构和性质进行表征.实验发现,阿司匹林(ASA)对n-CQDs的荧光有增敏作用.基于此建立了一种快速检测阿司匹林的定量方法,其线性范围为0~80μmol/L,检出限为0.046μmol/L.将该荧光传感器用于实际样品检测,回收率为95.3%~105.2%.

关键词：氮掺杂碳点阿司匹林荧光增强

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Enhanced Brightness and Efficiency in Organic Light-Emitting Devices Using an LiF-Doped Electron-injecting Layer with Aluminium Cathode

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Chinese Physics Letters 2001年第1期18卷 120-122页

作者： LI Chuan-nan XIAO bu-Wen LIU Shi-Yong Department of Electronics Engineering&national Laboratory of Integrated Optoelectronics Jilin UniversityChangchun 130023

Organic light-emitting devices(OLEDs)with enhanced brightness and efficiency were developed using an LiF-doped organic layer as an electron-injecting layer besides the aluminium *** typical device structure is glass substrate/indium-tin-oxide/n,n'-bis(3-methyphenyl)-n,n'-diphenylbenzidize/8-tris-hydroxyquinoline aluminium(Alq3)/LiF-doped Alq3/*** optimized device with an LiF-doped Alq3 layer showed brightness over 15300 cd/m^(2),while the device without the LiF-doped Alq3 layer exhibited only 3200 cd/m^(2),also,the luminance efficiency of the former was 4-5 times as that of the *** is another way to improve the OLEDs performance,especially in applications of OLEDs with a large active area.

关键词： Alq3 OLEDs Efficiency

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血浆氨基末端脑钠肽前体联合二维超声对二尖瓣反流术后患者左心室收缩功能改变的预测价值

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岭南心血管病杂志 2024年第1期30卷 14-21页

作者：解晓薇步建丽郄占军宁夏医科大学总医院心脑血管病医院超声心动图室银川750001

目的探讨血浆氨基末端脑钠肽前体(n-terminal pro-brain natriuretic peptide,nT-proBnP)联合二维超声对二尖瓣反流(mitral regurgitation,MR)术后左心室收缩功能改变的预测价值。方法选取2016年7月至2021年7月于宁医大总院心脑血管... 详细信息

目的探讨血浆氨基末端脑钠肽前体(n-terminal pro-brain natriuretic peptide,nT-proBnP)联合二维超声对二尖瓣反流(mitral regurgitation,MR)术后左心室收缩功能改变的预测价值。方法选取2016年7月至2021年7月于宁医大总院心脑血管病医院诊治的MR患者205名纳入MR组。依据术后14 d左心室射血分数(left ventricular ejection fraction,LVEF)变化情况,将205例MR组患者分为MR1组(119例,术后LVEF未降低或降低nT-proBnP浓度及常规超声指标、二维应变超声资料。使用Logistic回归分析筛选影响MR患者术后发生LVEF降低的独立危险因素。构建预测MR患者术后发生LVEF降低的列线图模型。使用受试者工作特征曲线(receiver operating characteristic curve,ROC)比较分析nT-proBnP、整体纵向应变(global longitudinal systolic strain,GLS)、基底段收缩期纵向峰值应变(basal peak longitudinal train,BLS)及其联合评价对MR术后患者左心室收缩功能改变的预测价值。结果 nT-proBnP、GLS、BLS是MR患者术后发生LVEF降低的独立危险因素(P0.05)。模型的ROC-曲线下面积(area under the curve,AUC)为0.934(95%CI:0.837~0.942,PnT-proBnP+GLS+BLS和列线图模型对MR术后患者左心室收缩功能改变的预测价值相当,且均大于各研究指标单独对MR术后左心室收缩功能改变的预测价值。结论术前GLS、BLS、nT-proBnP是中重度MR患者术后LVEF降低的独立影响因素。三者联合预测模型可有效预测中重度MR患者术后LVEF改变情况。

关键词：二尖瓣反流左心室收缩功能氨基末端脑钠肽前体二维超声预测价值

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全自动密度仪测定聚乙烯密度方法条件优化与评价

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当代化工研究 2024年第15期 63-65页

作者：吕正忠卜令坤刘亚超国家能源集团宁夏煤业煤制油化工质检计量中心宁夏750411

为了缩短聚乙烯密度分析的分析时间,降低人为误差提高方法准确度,本文选用配置了恒温系统、自动进样器、液面接触传感器、高精度电子天平等模块的全自动密度仪,聚乙烯粉粒料的制样及分析条件开展选择实验,得到在本实验室条件下的最优压... 详细信息

为了缩短聚乙烯密度分析的分析时间,降低人为误差提高方法准确度,本文选用配置了恒温系统、自动进样器、液面接触传感器、高精度电子天平等模块的全自动密度仪,聚乙烯粉粒料的制样及分析条件开展选择实验,得到在本实验室条件下的最优压片及分析条件,最优压片温度为190℃、压力220 kn,正十一烷为浸渍液,并对该方法开展方法评价,结果标明,在选定条件及样品下,该方法所测聚乙烯密度值与GB/T 1033.2—2010《塑料非泡沫塑料密度的测定第2部分:密度梯度柱法》方法间偏差均小于0.00060 g/cm^(3),方法标准偏差小于0.00010 g/cm^(3),测试结果稳定可靠、分析效率高。

关键词：聚乙烯密度全自动密度仪

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Value chain and statistical entropy analyses based on iron flows in China during 1990-2015

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Journal of Iron and Steel Research International 2021年第8期28卷 938-948页

作者： Qiang Yue Qing-cai bu Xue Li Feng Zhao Jun-hao He Yun Li State Environmental Protection Key Laboratory of Eco-Industry Northeastern UniversityShenyang 110819LiaoningChina School of Marine Engineering Jimei UniversityXiamen 361021FujianChina School of Energy and Power Engineering Dalian University of TechnologyDalian 116024LiaoningChina

The iron and steel industry in China has experienced vast changes over the past thirty *** have a precise knowledge of the circumstances behind its evolution,it is essential to perform an iron flow ***,iron flow analysis for the years 1990-2015 was ***,the iron natural resource efficiency,Chinese steel scrap index,and Chinese iron ore support ratio which can reflect the running status of China's iron and steel industry for these six years(1990,1995,2000,2005,2010,and 2015)were analyzed;thereafter,value chain and statistical entropy analyses were conducted based on the iron flow analysis,and some interesting results were *** and conclusions based on the results along with the recommendations for the China's iron and industry were proposed.

关键词： Iron and steel Iron flow Value chain Statistical entropy Steel scrap

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低温等离子体耦合微酸性电解水对三文鱼的保鲜作用

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中国食品学报 2024年第2期24卷 228-238页

作者：朱文慧谭桂芝步营李学鹏励建荣崔方超檀茜倩孟玉琼马睿郭晓华渤海大学食品科学与工程学院辽宁省高校重大科技平台“食品贮藏加工及质量安全控制工程技术研究中心” 辽宁锦州121013 海洋食品精深加工关键技术省部共建协同创新中心、大连工业大学辽宁大连116034 青海大学西宁810016 山东美佳集团有限公司山东日照276800

采用单因素和Box-Behnken响应面试验优化低温等离子耦合微酸性电解水对三文鱼杀菌的工艺条件,通过菌落总数、pH值、挥发性盐基氮(TVB-n)、硫代巴比妥酸反应产物(TBARS)值、羰基含量和色差等指标比较等离子体活化水、微酸性电解水及低温... 详细信息

采用单因素和Box-Behnken响应面试验优化低温等离子耦合微酸性电解水对三文鱼杀菌的工艺条件,通过菌落总数、pH值、挥发性盐基氮(TVB-n)、硫代巴比妥酸反应产物(TBARS)值、羰基含量和色差等指标比较等离子体活化水、微酸性电解水及低温等离子体耦合微酸性电解水对三文鱼4℃贮藏的保鲜效果。结果显示,当低温等离子体活化时间5 min,功率320 W,浸泡时间20 min,有效氯质量浓度50 mg/mL,料液比1∶6时杀菌效果最优,均可延长三文鱼贮藏期,而低温等离子体耦合微酸性电解水更有利于缓解脂肪和蛋白氧化。本研究为水产品保鲜提供了新思路。

关键词：三文鱼杀菌低温等离子体微酸性电解水保鲜

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