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Herb induced liver injury by Xianling Gubao Tablets: A case assessed for causality using updated RUCAM and integrated evidence chain

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Chinese Herbal Medicines 2024年第2期16卷 301-309页

作者： Chunyu li Yingying li Zhaofang Bai Jiabo Wang guohui li Xiaohe Xiao National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Senior Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China School of Traditional Chinese Medicine Capital Medicinal UniversityBeijing 100069China

Objective:A typical case of Xianling Gubao(XLGB)Tablets-induced liver injury was systematically studied in the clinic and the laboratory.Methods:A patient with herb-induced liver injury(HIli)and a history of taking XLGB Tablets before disease onset was engaged as the study subject,and the case was diagnosed according to the updated Roussel Uclaf Causality Assessment Method(RUCAM)and the integrated evidence chain(iEC)method recommended by the Guidelines for Diagnosis and Treatment of Herb-induced liver Injury(HIli Guidelines).Results:Clinical history,biochemical indexes and imaging tests were used to exclude the influence of fundamental diseases and confusing liver diseases such as viral,alcoholic and autoimmune liver diseases on the diagnosis.Based on an investigation of the patient’s medication history,she was suspected to have HIli caused by XLGB Tablets,as the patient was only taking an oral preparation of XLGB Tablets,and the influence of other drugs on the diagnosis was excluded.This patient with alanine aminotransferase(ALT)3 upper limit of normal(ULN)and a calculated R of 6 was diagnosed with possible acute drug-induced hepatocellular injury.The relationship was considered“highly probable”(score of 9)using the updated RUCAM of 2016.Moreover,the fingerprint similarity between the preparation taken by the patient and a commercially available preparation was 0.99,suggesting that the patient was consuming XLGB Tablets rather than another drug.LC-MS technology and the Agilent Fake TCM-Drugs database were used to investigate the drug,and no chemical additions were found.Examination of the drug for pesticide residues,heavy metals,aflatoxins and other exogenous substances indicated compliance with the content limits of the Chinese Pharmacopoeia.Conclusion:In summary,the final diagnosis of XLGB-induced liver injury reached the clinical diagnosis of HIli and was acute severe hepatocellular injury type by the updated RUCAM and iEC.Therefore,this study provides scientific evidence regarding the causality evaluation o

关键词： chemical analysis compound preparations of traditional chinese medicines integrated evidence chain liver injury Roussel Uclaf Causality Assessment Method Xianling Gubao Tablets

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Lead-free perovskite Cs_(2)AgBiBr_(6)photodetector detecting NIR light driven by titanium nitride plasmonic hot holes

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Photonics Research 2024年第3期12卷 522-533页

作者： ZIJIAN liU YUYING XI WENBO ZENG TING JI WENYAN WANG SITONG GUO liNliN SHI RONG WEN YANXIA CUI guohui li College of Physics College of Electronic Information and Optical EngineeringKey Laboratory of Advanced Transducers and Intelligent Control System of Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Lead-free perovskite Cs_(2)AgBiBr_(6)manifests great potential in developing high-performance,environmentally friendly,solution-processable photodetectors(PDs).However,due to the relatively large energy bandgap,the spectrum responses of Cs_(2)AgBiBr_(6)PDs are limited to the ultraviolet and visible region with wavelengths shorter than 560 nm.In this work,a broadband Cs_(2)AgBiBr_(6)PD covering the ultraviolet,visible,and near infrared(NIR)range is demonstrated by incorporating titanium nitride(TiN)nanoparticles that are prepared with the assistance of self-assembled polystyrene sphere array.In addition,an atomically thick Al2O3layer is introduced at the interface between the Cs_(2)AgBiBr_(6)film and TiN nanoparticles to alleviate the dark current deterioration caused by nanoparticle incorporation.As a result,beyond the spectrum range where Cs_(2)AgBiBr_(6)absorbs light,the external quantum efficiency(EQE)of the TiN nanoparticle incorporated Cs_(2)AgBiBr_(6)PD is enhanced significantly compared with that of the control,displaying enhancement factors as high as 2000 over a broadband NIR wavelength range.The demonstrated enhancement in EQE arises from the photocurrent contribution of plasmonic hot holes injected from TiN nanoparticles into Cs_(2)AgBiBr_(6).This work promotes the development of broadband solution-processable perovskite PDs,providing a promising strategy for realizing photodetection in the NIR region.

关键词： perovskite titanium ultraviolet

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Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

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Frontiers of Medicine 2022年第3期16卷 307-321页

作者： Yingying li Shiyuan Wang Mengmeng lin Chunying Hou Chunyu li guohui li Pharmacy Department National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

The discovery of immune checkpoint inhibitors,such as PD-1/PD-L1 and CTLA-4,has played an important role in the development of cancer immunotherapy.However,immune-related adverse events often occur because of the enhanced immune response enabled by these agents.Antibiotics are widely applied in clinical treatment,and they are inevitably used in combination with immune checkpoint inhibitors.Clinical practice has revealed that antibiotics can weaken the therapeutic response to immune checkpoint inhibitors.Studies have shown that the gut microbiota is essential for the interaction between immune checkpoint inhibitors and antibiotics,although the exact mechanisms remain unclear.This review focuses on the interactions between immune checkpoint inhibitors and antibiotics,with an in-depth discussion about the mechanisms and therapeutic potential of modulating gut microbiota,as well as other new combination strategies.

关键词： tumor immunotherapy immune checkpoint inhibitor antibiotics gut microbiota drug–drug interaction

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Expert Recommendation in Community Question Answering via Heterogeneous Content Network Embedding

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Computers, Materials & Continua 2023年第4期75卷 1687-1709页

作者： Hong li Jianjun li guohui li Rong Gao lingyu Yan School of Computer Science and Technology Huazhong University of Science and TechnologyWuhan 430074China College of Computer Science and Technology Hubei University of TechnologyWuhan 430068China

ExpertRecommendation(ER)aims to identify domain experts with high expertise and willingness to provide answers to questions in Community Question Answering(CQA)web services.How to model questions and users in the heterogeneous content network is critical to this task.Most traditional methods focus on modeling questions and users based on the textual content left in the community while ignoring the structural properties of heterogeneous CQA networks and always suffering from textual data sparsity issues.Recent approaches take advantage of structural proximities between nodes and attempt to fuse the textual content of nodes for modeling.However,they often fail to distinguish the nodes’personalized preferences and only consider the textual content of a part of the nodes in network embedding learning,while ignoring the semantic relevance of nodes.In this paper,we propose a novel framework that jointly considers the structural proximity relations and textual semantic relevance to model users and questions more comprehensively.Specifically,we learn topology-based embeddings through a hierarchical attentive network learning strategy,in which the proximity information and the personalized preference of nodes are encoded and preserved.Meanwhile,we utilize the node’s textual content and the text correlation between adjacent nodes to build the content-based embedding through a meta-context-aware skip-gram model.In addition,the user’s relative answer quality is incorporated to promote the ranking performance.Experimental results show that our proposed framework consistently and significantly outperforms the state-of-the-art baselines on three real-world datasets by taking the deep semantic understanding and structural feature learning together.The performance of the proposed work is analyzed in terms of MRR,P@K,and MAP and is proven to be more advanced than the existing methodologies.

关键词： Heterogeneous network learning expert recommendation semantic representation community question answering

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Crystallization-assisted asymmetric assembly of polymer nanocrescents and fidelity carbon analogues:Experiment and simulation study

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Nano Research 2023年第8期16卷 11503-11510页

作者： Lu Hou Junfeng Wang Sijia Wang Wen-Cui li guohui li An-Hui Lu State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Catalytic Conversion of Carbon ResourcesSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China Laboratory of Molecular Modeling and Design State Key Laboratory of Molecular Reaction DynamicsDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China School of physics Liaoning UniversityShenyang 110036China

Anisotropic nanoparticles,giving rise to a large number of novel physicochemical properties and functionalities,have provoked increasing attentions in nanoscience and nanotechnology.The remained challenge is to develop synthetic methods for the fabrication of anisotropic nanoparticles with less symmetry under the principle of minimum surface free energy.Here,we established a crystallization-assisted asymmetric assembly method for the synthesis of anisotropic polymer nanocrescents and their carbonaceous analogues by using triblock copolymer F127 and octadecanol in aqueous solution.With the aid of molecular dynamics(MD)simulation,we demonstrate that the observed crescent structure is caused by asymmetry distribution of octadecanol crystal within the hydrophobic core of F127 micelles,via the formation of intermediate elliptic micelles bearing hydrophobic ends that further fuse with each other end-to-end at an angle into curing nanocrescent morphology.The influences of annealing time,annealing temperature,and mole ratios of precursors that govern the kinetics of the assembly and polymerization process were systematically investigated and a series of polymer nanocrescents with tunable length of~85 to~262 nm and aspect ratio of~1.1 to~3.0 were prepared.The ability to create novel crescent-shaped polymer and carbon nanoparticles and the identification of asymmetric assembly process by combining experiment and simulation study will provide a valuable contribution both to theoretical and technological researches.

关键词： polymer nanocrescent carbon nanocrescent asymmetric assembly micelle crystallization molecular simulation

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Source rupture characteristics of the September 5,2022 Luding M_(S)6.8 earthquake at the Xianshuihe fault zone in southwest China

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Earthquake Research Advances 2023年第2期3卷 8-14页

作者： guohui li Anjian Wang Yuan Gao Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing100036China

On September 5,2022,at Beijing time 12:52 p.m.,an M_(S)6.8 earthquake struck Luding County,GarzêTibetan Autonomous Prefecture,Sichuan Province.The epicenter of the earthquake was at the intersection of the Sichuan-Yunnan,Bayankala,and South China blocks.The tectonic background is extremely complex,and strong earthquakes occur frequently.Based on a predetermined focal location and focal mechanism solution for the earthquake,we reversed the focal depth and rupture process of the earthquake by fitting the teleseismic P and SH waves recorded by the global seismic network.The results show that the focal depth is 16 km,with the main rupture having a length of about 45 km near the epicenter,with a maximum displacement of 1.02 m.Although the rupture mainly propagates from the north–northwest(NNW)to the south–southeast(SSE)along the fault strike,there is a small-scale rupture slip zone at shallow depths in the north–northeast(NNE)direction along the epicenter of the seismogenic fault.This rupture image corresponds to the cluster distribution of aftershocks in the NNW and SSE directions starting from the epicenter,corresponding to the distribution of recorded landslides.The earthquake occurred on the Moxi fault,located in the southeastern section of the Xianshuihe fault.The major tectonic feature in this area is the southeastward movement of the Chuandian block relative to the Bayanhar block.

关键词： Luding M_(S)6.8 earthquake Rupture process Xianshuihe fault Southeastern margin Qinghai-Tibetan Plateau

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Predicting Critically Ill Patients Short-Term Mortality Risk Using Routinely Collected Data:Deep Learning Model Development,Validation,and Explanation

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Journal of Systems Science and Information 2023年第3期11卷 365-377页

作者： Shangping ZHAO Pan liU guohui li Yanming GUO Guanxiu TANG Laboratory for Big Data and Decision National University of Defense TechnologyChangsha 410003China Department of Critical Care Medicine the Third Xiangya HospitalCentral South UniversityChangsha 410013China Nursing Department the Third Xiangya HospitalCentral South UniversityChangsha 410013China

This paper aims to develop and validate a deep learning-based short-term mortality risk prediction model for critically ill patients by using routinely collected data in a large Chinese cohort and explore the explainability of the model decision.A total of 10925 critically ill patients between January 2014 and June 2020 are included in this study.Data routinely collected in the electronic health records(EHRs)system are extracted and used to develop a short-term mortality risk prediction model based on a deep artificial neural network(ANN).The features include demographic characteristics,vital signs,laboratory tests,and the daily dose of intravenous medications.The developed deep learning model(AUROC:0.88,AUPRC:0.63,Brier score:0.108)is superior to the model based on APACHEⅡscores(AUROC:0.78,AURPC:0.52,Brier score:0.124)in the prediction of hospital mortality for critically ill patients.Further attribution analysis based on the integrated gradients method shows that measurements observed at a later time seem to have a more significant influence on mortality,while earlier usage of amiodarone or dexmedetomidine contributed to lower mortality.This well-performing and interpretable model may have practical implications for improving the quality of care for critically ill patients.

关键词： Critically ill patients deep learning artificial neural network mortality prediction APACHEⅡ

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TCMSTD 1.0: a systematic analysis of the traditional Chinese medicine system toxicology database

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中国科学:生命科学英文版 2023年第9期66卷 2189-2192页

作者： lili Song Wenxiu Qian Hongqing Yin Yu Sun Xiuyan Sun guohui li Junjie He Yanxue Zheng Yue Zhang Jiayi Wang Yubo li Tianjin University of Traditional Chinese Medicine Tianjin 301617China Baokang Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300073China

Dear Editor,The safety and modernization of traditional Chinese medicine (TCM) are significant concerns for users’ lives and health. Recently, the adverse effects caused by TCM and traditional nontoxic TCM have been frequently reported (Joo et al., 2020;liu et al., 2021). As the safety of TCM continues to attract widespread attention, many researchers have been investigating the toxicity of TCM in regard to the toxic ingredients, effects, mechanisms, and detoxification strategies in TCM (Figure S1 in Supporting Information). Although some TCMs cause toxic reactions, they also play key roles in treating certain unignorable diseases (Fang et al., 2022).Therefore, toxicity research is crucial and urgently needed to develop and safely use TCM.

关键词： TCM Figure system

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碳中和目标下的全球海洋综合治理及中国贡献

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亚太安全与海洋研究 2024年第4期 76-92,I0003,I0004页

作者：李国辉山东大学东北亚学院国际政治与经济系威海264200 山东大学国际问题研究院威海264200

在应对全球气候变化、实现碳中和目标过程中,海洋扮演着至关重要的角色。当前,在碳中和目标之下,海洋的巨大潜力和海洋综合治理备受国际关注。保护和发展海洋碳汇、减少涉海活动的温室气体排放、充分利用海洋清洁能源,是通过海洋实现碳... 详细信息

在应对全球气候变化、实现碳中和目标过程中,海洋扮演着至关重要的角色。当前,在碳中和目标之下,海洋的巨大潜力和海洋综合治理备受国际关注。保护和发展海洋碳汇、减少涉海活动的温室气体排放、充分利用海洋清洁能源,是通过海洋实现碳中和目标的主要路径选择。基于碳中和的海洋综合治理,包括海洋生态环境治理、气候治理、海洋能源治理,不同领域的治理正推进“跨域整合”。气候治理对海洋的关注度在提升,碳中和的气候目标也在融入海洋治理机制中。推进海洋碳中和也面临治理机制体系复杂化、治理机制合作政治化加剧、治理合作实践国际协调困难、技术及成本问题突出等困境。在此背景下,我国可以为海洋综合治理提供理念支持,在治理机制构建中弘扬并践行多边主义、完善国内海洋综合治理体系。

关键词：碳中和海洋综合治理气候变化全球治理中国贡献

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Present-Day Japan’s Economic Diplomacy Toward Uzbekistan and Its Development

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Asian Journal of Middle Eastern and Islamic Studies 2022年第2期16卷 243-263页

作者： Zijing Gao guohui li Institute of International Studies Shandong UniversityWeihaiChina

Located in Central Asia connecting Eurasia,Uzbekistan not only occupies an important geographical position,but also has abundant energy resources,which makes it Japan’s important economic and diplomatic target country in Central Asia.Since the unfolding of the new century,Japan’s economic diplomacy with Uzbekistan has gone through several stages of development,from initial contact to gradual maturity,and has been undergoing twists and turns.Since Shinzo Abe came to power for the second time in 2012,Japan’s economic diplomacy with Uzbekistan has deepened significantly,showing more distinct characteristics of changes,including the substantial increase of the amount of aid to the Uzbek government,attaching importance to bilateral economic and trade cooperation,and flexibly utilising the‘Central AsiatJapan’regional cooperation mechanism.The strategic considerations behind these changes and adjustments are to deeply participate in the regional cooperation in Central Asia by building a bilateral economic and trade relationship network,ensure the security of energy and resource supply in the post-pandemic era,realise the strategy of becoming a great power,and balance the forces of foreign powers.

关键词： Japan Uzbekistan economic diplomacy ODA Central Asia

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