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浅谈如何指导学生在钳工实训中增强创新意识

科教文汇 2018年第6期 65-67页

作者：秦康生章平朱桂云魏国辉张志高许勇军扬州大学机械工程学院江苏扬州225127 中国煤炭地质总局一四七勘探队江苏徐州221611

在机械制造业加工中,钳工的应用十分广泛,涉及的零件多种多样,学生不可能对各种零件都能全面了解,本文试阐述了笔者多年来在教学一线工作中得到的体会,针对性阐述了如何适应新形势和与时俱进,在钳工实训中增强学生的创新意识。

关键词：钳工动手能力创新

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研究生医学影像计算课程教学实践

医学信息学杂志 2019年第3期40卷 90-93页

作者：魏国辉李延军马志庆曹慧赵文华刘静山东中医药大学理工学院济南250355 山东省分布式计算机软件新技术重点实验室济南2503553

以山东中医药大学研究生医学影像计算课程为例,从课程教学内容、教学模式、课后作业库建立以及教学效果评价4方面阐述该课程教学过程,结果表明该实践方案取得较好的效果。

关键词：研究生医学影像计算教学实践

Systematic Exploration of Optimized Base Editing gRNA Design and Pleiotropic Effects with BExplorer

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Genomics, Proteomics & Bioinformatics 2023年第6期21卷 1237-1245页

作者： Gongchen Zhang Chenyu Zhu Xiaohan Chen Jifang Yan Dongyu Xue Zixuan wei guohui Chuai Qi Liu Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Base editing technology is being increasingly applied in genome engineering,but the current strategy for designing guide RNAs(gRNAs)relies substantially on empirical experience rather than a dependable and efficient in silico ***,the pleiotropic effect of base editing on disease treatment remains unexplored,which prevents its further clinical ***,we presented BExplorer,an integrated and comprehensive computational pipeline to optimize the design of gRNAs for 26 existing types of base editors in *** BExplorer,we described its results for two types of mainstream base editors,BE3 and ABE7.10,and evaluated the pleiotropic effects of the corresponding base editing *** revealed 524 and 900 editable pathogenic single nucleotide polymorphism(SNP)loci in the human genome together with the selected optimized gRNAs for BE3 and ABE7.10,*** addition,the impact of 707 edited pathogenic SNP loci following base editing on 131 diseases was systematically explored by revealing their pleiotropic effects,indicating that base editing should be carefully utilized given the potential pleiotropic ***,the systematic exploration of optimized base editing gRNA design and the corresponding pleiotropic effects with BExplorer provides a computational basis for applying base editing in disease treatment.

关键词： Gene editing Base editing Pleiotropy CRISPR/Cas9 gRNAdesign

竖脊肌平面阻滞对胸腔镜下肺叶切除术患者超声四肢动脉血流动力学及生化应激指标的影响

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实用临床医药杂志 2024年第14期28卷 49-53页

作者：未国徽孙颜刘志杰吕航宇陈永学王新波河北省邯郸市中心医院麻醉科河北邯郸056001

目的探讨竖脊肌平面阻滞对胸腔镜下肺叶切除术患者超声四肢动脉血流动力学及生化应激指标的影响。方法将120例行胸腔镜下肺叶切除术治疗的患者随机分为研究组和对照组,每组60例。研究组术中采用竖脊肌平面阻滞,对照组采用常规麻醉措施... 详细信息

目的探讨竖脊肌平面阻滞对胸腔镜下肺叶切除术患者超声四肢动脉血流动力学及生化应激指标的影响。方法将120例行胸腔镜下肺叶切除术治疗的患者随机分为研究组和对照组,每组60例。研究组术中采用竖脊肌平面阻滞,对照组采用常规麻醉措施。比较2组不同时点[麻醉诱导前(T_(0))、术后拔管后(T_(1))、术后拔出引流管(T_(2))]的肺功能指标[呼气峰流速(PEFR)、用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))]、超声四肢动脉血流动力学指标(收缩期最大流速、舒张期最低流速、平均流速、动脉搏动指数以及动脉阻力指数)、应激指标[皮质醇(Cor)、去甲肾上腺素(NE)、血管紧张素Ⅱ(AngⅡ)以及促肾上腺皮质激素(ACTH)]、镇痛效果。结果2组T_(1)、T_(2)时FEV_(1)、FVC、PEFR均低于T_(0)时,且研究组T_(1)、T_(2)时FEV_(1)、FVC、PEFR均高于对照组,差异有统计学意义(P<0.05)。2组T_(1)、T_(2)时收缩期最大流速、动脉阻力指数均低于T_(0)时,舒张期最低流速、平均流速、动脉搏动指数均高于T_(0)时,差异有统计学意义(P<0.05);研究组T_(1)、T_(2)时收缩期最大流速、动脉阻力指数均高于对照组,但舒张期最低流速、平均流速、动脉搏动指数均低于对照组,差异有统计学意义(P<0.05)。2组T_(2)时Cor、ACTH、AngⅡ、NE高于T_(0)时,且研究组T_(2)时Cor、ACTH、AngⅡ、NE均低于对照组,差异有统计学意义(P<0.05)。研究组Prince-Henry疼痛评分、有效按压次数、实际按压次数低于对照组,差异有统计学意义(P<0.05)。结论胸腔镜下肺叶切除术中应用竖脊肌平面阻滞的四肢动脉血流动力学及生化应激指标波动较小,麻醉效果较好。

关键词：胸腔镜下肺叶切除术竖脊肌平面阻滞血流动力学生化应激指标麻醉效果

First-principles study on Fe_(2)B_(2)as efficient catalyst for nitrogen reduction reaction

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Chinese Chemical Letters 2021年第10期32卷 3137-3142页

作者： wei Song Jia Wang Ling Fu Chaozheng He Chenxu Zhao Yongliang Guo Jinrong Huo guohui Dong School of Science Henan Institute of TechnologyXinxiang 453003China Shaanxi Key Laboratory of Optoelectronic Functional Materials and Devices School of Materials Science and Chemical EngineeringXi'an Technological UniversityTianshui 741001China Institute of Environmental and Energy Catalysis School of Materials Science and Chemical EngineeringXi'an Technological UniversityXi'an 710021China College of Resources and Environmental Engineering Tianshui Normal UniversityXi’an 710021China School of Sciences Xi'an Technological UniversityXi'an 710021China School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi’an 710021China

[18_(T)D$IF]Ammonia(NH_(3))is considered an attractive candidate as a clean,highly efficient energy *** electrocatalytic nitrogen reduction reaction(NRR)can reduce energy input and carbon footprint;therefore,rational design of effective electrocatalysts is essential for achieving high-efficiency electrocatalytic NH_(3)***,we report that the enzymatic mechanism is the more favourable pathway for NRR,due to lower limiting potential(-0.44 V),lower free energy(only 0.02 eV)of the first hydrogenation step(*N–N to*NH–N),and more electron transfer from Fe_(2)B_(2)to the reaction *** addition,both vacancies and dopants can be helpful in reducing the reaction energy barrier of the potential-determining ***,we have demonstrated that Fe_(2)B_(2)is a potential new candidate for effective NRR and highlighted its potential for applications in electrocatalytic NH_(3)synthesis.

关键词： Nitrogen reduction reaction Electrocatalysts Free energy DFT calculations Magnetism

前置胎盘并发脐带脱垂行剖宫产术中不同麻醉药物及穿刺间隙联合适合目标导向式控制腰麻平面效果

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中国计划生育学杂志 2022年第2期30卷 339-343页

作者：未国徽孙颜刘志杰吕航宇陈永学王新波河北省邯郸市中心医院 056001

目的:分析不同麻醉药物及穿刺间隙联合适合目标导向式控制腰麻平面在前置胎盘并发脐带脱垂患者剖宫产术中应用效果。方法:本院2017年1月-2021年1月收治的行剖宫产终止妊娠的前置胎盘合并脐带脱垂患者80例纳为研究对象,电脑随机软件分两... 详细信息

目的:分析不同麻醉药物及穿刺间隙联合适合目标导向式控制腰麻平面在前置胎盘并发脐带脱垂患者剖宫产术中应用效果。方法:本院2017年1月-2021年1月收治的行剖宫产终止妊娠的前置胎盘合并脐带脱垂患者80例纳为研究对象,电脑随机软件分两组各40例,术中均行腰麻-硬膜外联合阻滞,分别采用0.67%罗哌卡因(罗哌卡因组),穿刺间隙为L3~4或0.5%布比卡因(布比卡因组),穿刺间隙为L2~3,两组均通过体位调节控制麻醉阻滞平面至目标,统计两组切皮时刻及胎儿娩出时刻阻滞平面,术中牵拉情况以及术中低血压发生率。结果:两组切皮时刻及胎盘娩出时刻阻滞平面均存在差异(P0.05),胎盘娩出时刻布比卡因组(25.0%)多于罗哌卡因组(5.0%)(P<0.05),胎盘娩出时刻出现牵拉反应布比卡因组(32.5%)多于罗哌卡因组(12.5%)(P<0.05)。术中体位改变的两个时刻低血压发生率均罗哌卡因组低于布比卡因组(10.0%比30.0%,27.5%比50.0%)(P<0.05)。结论采用0.67%罗哌卡因联合体位调节的目标导向平面阻滞,能有效控制剖宫产阻滞平面,降低术中低血压发生,在保障前置胎盘并发脐带脱垂患者剖宫产安全性中效果更佳。

关键词：胎盘前置并发脐带脱垂剖宫产术麻醉适合目标导向式平面控制罗哌卡因布比卡因效果比较

IDENTIFICATION OF INPAINTED IMAGES AND NATURAL IMAGES FOR DIGITAL FORENSICS

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Journal of Electronics(China) 2009年第3期26卷 341-345页

作者： Wu Qiong Sun Shaojie Zhu wei Li guohui College of Information System and Management National University of Defense Technology Changsha 410073 China

Image forensics is a form of image analysis for finding out the condition of an image in the complete absence of any digital watermark or *** can be used to authenticate digital images and identify their *** the technology of exemplar-based inpainting provides an approach to remove objects from an image and play visual *** this paper, as a first attempt, a method based on zero-connectivity feature and fuzzy membership is proposed to discriminate natural images from inpainted ***, zero-connectivity labeling is applied on block pairs to yield matching degree feature of all blocks in the region of suspicious, then the fuzzy memberships are computed and the tampered regions are identified by a cut *** results demonstrate the effectiveness of our method in detecting inpainted images.

关键词： Image authentication Image inpainting Fuzzy membership

A whole-genome association approach for large-scale interspecies traits

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Science China(Life Sciences) 2021年第8期64卷 1372-1374页

作者： Huizhong Fan Lei Chen Yibo Hu guohui Shi Yi Dai Fuwen wei Qi Wu Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China JUniversity of Chinese Academy of Sciences Beijing I0010IChina ANorthwestern Polytechnical University Xi'an 710129China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

Dear Editor,The genetic mechanism of large-scale interspecies traits,including evolutionary novelties and the characteristics of high taxa,is a central issue in evolutionary *** present,genome-wide association studies(GWAS)are known as one of the most powerful and affordable tools for understanding the association between heritable variations and phenotypic changes in populations of single ***,it would be interesting to determine whether GWAS can be applied to study large-scale interspecies traits.

关键词： scale evolutionary interspecies

Novel Rotors with Low Eddy Current Loss for High Speed Permanent Magnet Machines

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CES Transactions on Electrical Machines and Systems 2019年第2期3卷 187-194页

作者： Xin Cheng wei Xu Guanghui Du guohui Zeng Jianguo Zhu School of Electrical and Electronic Engineering Shanghai University of Engineering ScienceShanghai201620China State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan430074China School of Electrical and Information Engineering University of SydneyAustraliaNSW2006Australia

Due to the large rotor eddy current loss and low thermal conductivity of carbon fiber sleeve,the high temperature usually occurs in high speed permanent magnet machines(HSPMMs)at the rated operation condition,resulting in irreversible demagnetization of the permanent magnet(PM).To obtain low rotor temperature,two novel rotor structures with low rotor eddy current loss are proposed in this *** the output torque and air gap flux density unchanged,the performance of HSPMMs with the two proposed rotor structures are analyzed based on finite element algorithm(FEA),including eddy current loss and ***,the appropriate parameters of the proposed rotor structures are selected,and the electromagnetic(EM)performance,rotor stress and temperature are compared with those of the conventional rotor *** Terms-Eddy current loss,finite element algorithm(FEA),electromagnetic(EM)performance,high speed permanent magnet machines(HSPMMs).

关键词： Eddy current loss finite element algorithm(FEA) electromagnetic(EM)performance high speed permanent magnet machines(HSPMMs).