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金纳米向日葵用于免标记SERS检测电刺激细胞凋亡过程中DNA损伤

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光散射学报 2024年第1期36卷 38-43页

作者：齐国华金永东中国科学院长春应用化学研究所电分析化学国家重点实验室吉林省长春市130012 深圳大学生物医学工程学院广东省深圳市518060

精准的诊断以及分析癌细胞死亡过程中复杂基因组DNA损伤,对肿瘤的治疗至关重要,但是仍然面临着重要的挑战。本研究设计了尺寸均一的等离子体金纳米向日葵,该纳米结构主要是通过修饰多肽的金纳米粒子静电组装的方法制备,形成热点结构丰富... 详细信息

精准的诊断以及分析癌细胞死亡过程中复杂基因组DNA损伤,对肿瘤的治疗至关重要,但是仍然面临着重要的挑战。本研究设计了尺寸均一的等离子体金纳米向日葵,该纳米结构主要是通过修饰多肽的金纳米粒子静电组装的方法制备,形成热点结构丰富的SERS基底,用于捕获基因组DNA,实现高灵敏度基因组中DNA的SERS检测。我们的研究发现在恒压1.2 V刺激5 min的条件下,癌细胞比正常细胞更容易死亡。通过SERS光谱分析,我们可以看出,在电刺激癌细胞凋亡过程中,基因组中DNA的双链断裂,且腺嘌呤的缺失,这些加速了癌细胞的死亡过程,进而影响DNA的复制和转录。我们开发的传感平台对研究基因相关的疾病提供了重要的应用价值。

关键词：表面增强拉曼光谱电刺激基因组DNA 细胞凋亡

A green, efficient and precise hydrogen therapy of cancer based on in vivo electrochemistry

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National Science Review 2020年第3期7卷 660-670页

作者： guohua qi Bo Wang Xiangfu Song Haijuan Li Yongdong Jin State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences School of Public Health Jilin University University of Chinese Academy of Sciences

By combined use of traditional Chinese acupuncture Fe needle electrode and in vivo electrochemistry, we achieved in vivo Hgeneration in tumors in a controllable manner and exploited it for effective and green therapy of tumors for the first time. The cathodic acupuncture electrodes working under an applied voltage of ~3 V(with minimal damage to the living body) undergo effective electrochemical reactions in the acidic tumor area that produce sufficient Hlocally to cause cancer cells to burst and die. Due to puncture positioning, the acidic tumor microenvironment and gas diffusion effect, the developed Hgeneration electrochemotherapy(H2-ECT) strategy enables precise and large-scale tumor therapy, as demonstrated by in vivo treatment of diseased mice(glioma and breast cancers). Such green H-ECT is simple, highly efficient and minimally invasive, requiring no expensive medical equipment or nano materials and medication, and is therefore very promising for potential clinical applications.

关键词： hydrogen therapy of cancer in vivo electrochemistry acupuncture Fe needle

Applications of hollow nanomaterials in environmental remediation and monitoring： A review

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Frontiers of Environmental Science & Engineering 2015年第5期9卷 770-783页

作者： Yuankai ZHANG Zhijiang HE Hongchen WANG Lu qi guohua LIU Xiaojun ZHANG School of Environment & Natural Resource Renmin University of China Beijing 100872 China

Hollow nanomaterials have attracted signifi- cant attention because of their high chemical and thermal stability, high specific surface area, high porosity, low density, and good biocompatibility. These state-of-the-art nanomaterials have been shown to efficiently adsorb heavy metals, and volatile hazardous substances, photodegrade persistent organic pollutants, and other compounds, and inactivate bacteria. Such properties have enabled the use of these materials for environmental remediation, such as in water/wastewater treatment, soil remediation, air purifica- tion, and substance monitoring, etc. Hollow nanomaterials showed higher photocatalytic activity than those without hollow structure owing to their high active surface area, reduced diffusion resistance, and improved accessibility. And, the Doping method could improve the photocatalytic performance of hollow nanomaterials further under visible light. Moreover, the synthetic mechanisms and methods of these materials are important because their size and morphology help to determine their precise properties. This article reviews the environmental applications and potential risks of these materials, in addition to their syntheses. Finally, an outlook into the development of these materials is provided.

关键词： hollow nanomaterials environmental reme-diation nanotechnology nanostructures morphology

Regulating Oxygen Vacancy Defects in Heterogeneous NiO-CeO_(2)−δ Hollow Multi-shelled Structure for Boosting Oxygen Evolution Reaction

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Chemical Research in Chinese Universities 2024年第3期40卷 475-483页

作者： WANG Huan GONG Guannan SUN guohua qi Jian YU Ranbo WANG Dan Hebei Key Laboratory of Flexible Functionals Materials School of Materials Science and EngineeringHebei University of Science and TechnologyShijiazhuang 050000P.R.China Department of Physical Chemistry School of Metallurgical and Ecological EngineeringUniversity of Science&Technology BejingBeijing 100083P.R.China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China

CeO_(2) with excellent oxygen storage-exchange capacity and NiO with excellent surface activity were used to construct a heterogeneous NiO-CeO_(2)−δhollow multi-shelled structure(HoMS)by spray *** turned out that as the proportion of CeO_(2) increases,the overpotential and Tafel slope of NiO-CeO_(2)−δHoMSs first decreased and then *** is mainly because the construction of the NiO-CeO_(2)−δHoMSs not only increases the specific surface area,but also introduces oxygen vacancy defects,thus improving the interface charge transfer capability of the materials and further improving the oxygen evolution reaction(OER)***,the increase of the calcination temperature will induce the decay of the OER performance of NiO-CeO_(2)−δHoMSs,which is mainly due to the decrease of the specific surface area,the reduction of oxygen vacancy defects,and the weakening of interface charge transfer ***,a series of heterogeneous composite HoMSs,such as Ni/Co,Mo/Ni,Al/Ni and Fe/Ni oxides was successfully constructed by spray drying,which enriched the diversity of HoMSs.

关键词： Heterogeneous composite structure Hollow multishelled structure Oxygen vacancy defect Oxygen evolution reaction

Unveiling the relationship between structural evaluation and catalytic performance of InOOH during electroreduction of CO_(2)to formate

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Green Carbon 2024年第1期2卷 124-130页

作者： Caijun Deng Chaofan qi Xiaomin Wu guohua Jing Huawang Zhao Department of Environmental Science&Engineering College of Chemical EngineeringHuaqiao UniversityXiamenFujian 361021 China

The electrochemical CO_(2)reduction reaction(ECO_(2)RR)to formate is perceived as a technoeconomic pathway for transforming renewable electricity into ***,the indeterminate mechanism underlying structural self-reconstruction obstructs the strategic design of a high-performance In catalyst for the ECO_(2)*** this study,we chose InOOH as the model catalyst to illustrate the dynamic structure of In-based catalysts during reconstruction in the ECO_(2)*** findings of the current study indicate that the in situ electrochemical reconstruction of crystalline InOOH results in the creation of crystalline In clusters/InOOH,followed by In/InOOH heterostructures,and finally,metallic In over *** efficiencies of the different phases conformed to the sequence:In clusters/InOOH>In/InOOH heterostructures>metallic *** progression leads to a continuous drop in maximum current density and Faradaic efficiency from 29.6 mA/cm2 and 87%to 6.3 mA/cm^(2) and 75%,respectively with time extending to 7200 s,at-1.0 V relative to the reversible hydrogen *** in situ characterization and theoretical studies highlighted the crucial role of the In-cluster/InOOH interface in CO_(2)activation and conversion.

关键词： Indium Carbon dioxide reduction electrochemistry Formic acid Heterogeneous catalysis

基于多源遥感数据的巢湖水华长时序时空变化(2009-2018年)分析与发生概率预测

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湖泊科学 2021年第2期33卷 414-427页

作者：祁国华马晓双何诗瑜吴鹏海安徽大学资源与环境工程学院合肥230601 安徽大学湿地生态保护与修复安徽省重点实验室合肥230601

湖泊富营养化导致的水华问题严重影响了淡水资源的利用和保护,快速、全面、准确的监测水华信息对于湖泊水环境的治理具有十分重要的意义.本文以巢湖为研究区域,利用多源光学遥感影像和时空融合技术,采用波段融合的方式将NDVI指数波段加... 详细信息

湖泊富营养化导致的水华问题严重影响了淡水资源的利用和保护,快速、全面、准确的监测水华信息对于湖泊水环境的治理具有十分重要的意义.本文以巢湖为研究区域,利用多源光学遥感影像和时空融合技术,采用波段融合的方式将NDVI指数波段加入到遥感影像当中,并通过监督分类解译水华信息,以此揭示2009-2018年10年间巢湖水华的时空变化规律.结果表明:巢湖发生的水华以零星和局部水华为主,2012年巢湖水体首次出现区域蓝藻水华;巢湖水华的季节变化性强,夏、冬半年水华变化差异大,其中2018年季节间的差异最为显著;巢湖水华后五年发生频率明显高于前五年,西半湖水华较东半湖严重,且巢湖西北部是水华的高发区域,2011年水华开始向沿岸蔓延,2014年水华首次出现在西南湖区,2016年巢湖水华高发区域新增巢湖东部和中部地区.另外,本文根据巢湖的相关气象数据,构建了Logistic水华气象风险概率预测模型,模型平均预测准确率高达87.52%.探究巢湖水华长时序的时空变化规律有助于从宏观上把握其动态趋势,为后续湖区治理以及周边生态环境建设提供理论依据,水华气象风险概率预测模型可为巢湖水华的预警和防控提供决策支持.

关键词：巢湖水华遥感监测监督分类时空变化气象数据 Logistic模型

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论史铁生的爱情婚姻观

齐鲁师范学院学报 2014年第3期29卷 115-121页

作者：戚国华广东省科技干部学院人文学院广东广州510640

爱情与婚姻在史铁生"心魂"的执着追问下焕发出奇异的神彩,他认为"残疾与爱情是上帝为人性写下的最本质的两条密码",爱情既是人的孤独体现,也是对人类残疾拯救的途径。他常引用圣经原文,以之为比照、映衬、要求,试图印证爱情与婚姻在上... 详细信息

爱情与婚姻在史铁生"心魂"的执着追问下焕发出奇异的神彩,他认为"残疾与爱情是上帝为人性写下的最本质的两条密码",爱情既是人的孤独体现,也是对人类残疾拯救的途径。他常引用圣经原文,以之为比照、映衬、要求,试图印证爱情与婚姻在上帝的原初设计中是统一的,男女只有在心魂合一中方能体味到爱的真谛,以此纠正人的恶与疏失,暗示出理想的爱情婚姻应有神圣根基,引发人们对爱情与婚姻本原的沉思与反省。

关键词：史铁生爱情婚姻孤独合一

微通道SERS器件的制备及对有害化学品的检测

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高等学校化学学报 2015年第2期36卷 254-259页

作者：杨永安徐抒平王昱扬齐国华徐蔚青吉林大学超分子结构与材料国家重点实验室长春130012 楚雄师范学院物理与电子科学系楚雄675000

在微通道内表面通过化学吸附组装上银纳米粒子制成了微通道表面增强拉曼散射(SERS)器件,其对常见探针分子罗丹明6G(R6G)和4-巯基吡啶(4-MPY)的最低检测浓度分别达到10-11和10-8mol/L,说明其具有很好的增强效果.用该器件对2种有害化学药... 详细信息

在微通道内表面通过化学吸附组装上银纳米粒子制成了微通道表面增强拉曼散射(SERS)器件,其对常见探针分子罗丹明6G(R6G)和4-巯基吡啶(4-MPY)的最低检测浓度分别达到10-11和10-8mol/L,说明其具有很好的增强效果.用该器件对2种有害化学药品进行了检测,三聚氰胺的最低检测浓度可到10-6mol/L,而福美双的最低检测浓度可达到10-7mol/L,说明所制备的微通道器件可用于对有害化学品的检测.微通道SERS器件具有体积小、取样少、制备简单、能够进行现场实时动态检测等特点,具有广阔的应用前景.

关键词：表面增强拉曼散射微通道器件三聚氰胺福美双

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SERS生物传感技术及其应用进展

高等学校化学学报 2015年第11期36卷 2134-2147页

作者：付翠翠梁丽佳齐国华徐抒平徐蔚青吉林大学理论化学研究所超分子结构与材料国家重点实验室长春130012

表面增强拉曼散射(SERS)生物传感技术是以生物成分为敏感元件或探测对象,研究生物分子间相互作用的重要工具之一,被广泛应用于环境监测、食品安全、临床检验及疾病诊断等众多领域.本文总结了耦合增强SERS生物传感技术方面的进展及其在... 详细信息

表面增强拉曼散射(SERS)生物传感技术是以生物成分为敏感元件或探测对象,研究生物分子间相互作用的重要工具之一,被广泛应用于环境监测、食品安全、临床检验及疾病诊断等众多领域.本文总结了耦合增强SERS生物传感技术方面的进展及其在分析检测和癌症诊断方面的应用.主要包括基于耦合增强SERS生物传感技术方法、高灵敏度的SERS传感芯片的制备及其应用和新型SERS技术研究癌细胞及组织.

关键词：表面增强拉曼散射生物传感 SERS芯片免疫反应癌症