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A Fast and Effective Multiple Kernel Clustering Method on Incomplete Data

Computers, Materials & Continua 2021年第4期67卷 267-284页

作者： Lingyun Xiang guohan zhao Qian Li Gwang-Jun Kim Osama Alfarraj Amr Tolba Changsha Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation School of Computer and Communication EngineeringChangsha University of Science and TechnologyChangsha410114China Hunan Key Laboratory of Smart Roadway and Cooperative Vehicle-Infrastructure Systems Changsha University of Science and TechnologyChangsha410114China Faculty of Engineering and Information Technology Global Big Data Technologies CentreUniversity of Technology SydneyUltimoNSW2007Australia Department of Computer Engineering Chonnam National UniversityGwangju61186Korea Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Department of Mathematics and Computer Science Faculty of ScienceMenoua UniversityShebin-El-kom32511Egyp

Multiple kernel clustering is an unsupervised data analysis method that has been used in various scenarios where data is easy to be collected but hard to be ***,multiple kernel clustering for incomplete data is a critical yet challenging *** the existing absent multiple kernel clustering methods have achieved remarkable performance on this task,they may fail when data has a high value-missing rate,and they may easily fall into a local *** address these problems,in this paper,we propose an absent multiple kernel clustering(AMKC)method on incomplete *** AMKC method rst clusters the initialized incomplete ***,it constructs a new multiple-kernel-based data space,referred to as K-space,from multiple sources to learn kernel combination ***,it seamlessly integrates an incomplete-kernel-imputation objective,a multiple-kernel-learning objective,and a kernel-clustering objective in order to achieve absent multiple kernel *** three stages in this process are carried out simultaneously until the convergence condition is *** on six datasets with various characteristics demonstrate that the kernel imputation and clustering performance of the proposed method is signicantly better than state-of-the-art ***,the proposed method gains fast convergence speed.

关键词： Multiple kernel clustering absent-kernel imputation incomplete data kernel k-means clustering

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Application Example of Reinforced Concrete Frame Structure Waste Dam in the Proiect of Valley Sanitary Landfill

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International Journal of Technology Management 2014年第5期 36-41页

作者： zhao guohan Yang Shunshen Liu Fan Southwest Jiaotong University Chengdu 610031 China

waste dam is one of the most important infrastructures in the project of valley sanitary landfill. On one hand, it forms the landfill capacity required. On the other hand, it improves the slope stability of waste body. Consequently, I think it is very significant to maintain the stability of waste dana for the whole sanitary landfill. Combining with a project example, aiming at the special geological conditions, we have made three plans of waste dam structure, calculation and analysis comparison respectively. Reinforced concrete frame waste dam is highlighted in the project for its advantages, smoothly solving the three problems in the engineering.

关键词： valley sanitary landfill waste dam frame structure structure design

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基于FrFT和RVM的变压器局部放电模式识别

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广东电力 2024年第6期37卷 95-103页

作者：杨新志李利华陈锋赵国汉雷秉惠中国长江电力股份有限公司白鹤滩水力发电厂四川凉山615000

快速准确识别局部放电类型对于保证变压器安全稳定运行具有重要意义。针对局部放电信号模式识别中面临的最优特征参数提取和分类器设计难题,提出一种基于分数阶傅里叶变换(fractional Fourier transform,FrFT)和相关向量机(relevance ve... 详细信息

快速准确识别局部放电类型对于保证变压器安全稳定运行具有重要意义。针对局部放电信号模式识别中面临的最优特征参数提取和分类器设计难题,提出一种基于分数阶傅里叶变换(fractional Fourier transform,FrFT)和相关向量机(relevance vector machine,RVM)的局部放电模式识别方法。首先将FrFT引入局部放电信号分析领域,利用FrFT将局部放电信号转换至分数域并对其进行多尺度分析,在扩充信息提取维度的同时,提取可反映不同局部放电信号波形差异的14维特征构成特征向量;然后将特征向量作为输入,建立RVM模型进行最优特征选择和分类判决函数的联合优化,从而实现对不同局部放电信号的分类识别。建立电晕放电、沿面放电和气隙放电试验模型并采集局部放电超声信号开展试验,结果表明所提方法对于每种局部放电信号均能获得较高的识别精度,平均正确识别率相对于常规支持向量机(support vector machine,SVM)分类方法提升超过2.7%。

关键词：局部放电模式识别特征提取特征选择分数阶傅里叶变换

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Alkaline Intrusives at the East Foot of the Taihang-Da Hinggan Mountains:Chronology,Sr,Nd and Pb Isotopic Characteristics and Their Implications

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Acta Geologica Sinica(English Edition) 2000年第4期74卷 774-780页

作者： YAN guohan XU Baoliang MU Baolei WANG Guanyu CHANG zhaoshan CHEN Tingli zhao Yongchao WANG Xiaofang ZHANG Renhu QIAO Guangsheng CHU Zhuyin Department of Geology Peking UniversityBeijing 100871 Institute of Geology Chinese Academy of SciencesBeijing 100029

Based on the Rb-Sr isochron dating results, this paper suggests that the alkaline intrusive belt at the east foot of the Taihang-Da Hinggan Mountains were formed between 135 and 122 Ma. And the alkaline intrusives in the north and south sections of this belt have entirely different Sr, Nd and Pb isotopic characteristics, i.e., all the rocks in the south section have positive εSr(t) and negative εNd(t) values and all those in the north have the opposite values. On the εSr(t) versus εNd(t) correlation diagram, the samples from the south are concentrated along the enriched mantle evolution trend lines and nearby, while those from the north fall along the depleted mantle trend lines and nearby. On the Pb isotope composition diagram, most of the samples from the south section fall on the mantle Pb evolution line and nearby, while those from the north lie between the Pb evolution lines of the mantle and the erogenic belt. The above-stated isotopic characteristics not only indicate that the source rocks of the alkaline intrusives in the south section have a close connection to materials from the enriched mantle reservoir, while those in the north are related to materials from the depleted one, but also reveal that the upper mantle below the North China platform is enriched and that below the Inner Mongolia geosyncline is depleted.

关键词： alkaline intrusives chronology Sr Nd and Pb isotopes east foot of the Taihang-Da Hinggan Mountains

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冀北燕山期三个系列花岗质岩石的地球化学特征及其成因学意义

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岩石学报 1999年第2期15卷 208-216页

作者：许保良阎国翰徐振邦何中甫赵晖北京大学地质学系

燕山期花岗质岩石广泛出露在冀北地区，从中可以识别出碱钙性、过铝质和碱质三个岩石系列。本文系统报道了它们的产状、岩类学、主要元素、痕量元素、稀土元素、年代学和ＩＳｒ资料；重点讨论了它们的地球化学特征和成因类型问题。碱钙... 详细信息

燕山期花岗质岩石广泛出露在冀北地区，从中可以识别出碱钙性、过铝质和碱质三个岩石系列。本文系统报道了它们的产状、岩类学、主要元素、痕量元素、稀土元素、年代学和ＩＳｒ资料；重点讨论了它们的地球化学特征和成因类型问题。碱钙性岩石系列主要由石英二长闪长岩元素、二长花岗岩元素、正长花岗岩构成；ＳｉＯ２含量变化范围是６２％～７５％；Ｋ２Ｏ＋Ｎａ２Ｏ在７．６３％～８．８８％之间；Ａ／ＣＮＫ＜１．０５，ＣＡ指数５５。过铝质系列由流纹斑岩为代表，具有高硅（ＳｉＯ２＞７３％）、富钾低钠（Ｋ２Ｏ／Ｎａ２Ｏ为１．４４～９．１３）、过铝质（Ａ／ＣＮＫ是１．１７～１．４３）的特点。碱性系列的岩石组合是碱长正长岩（碱长粗面岩）－碱性石英正长岩（碱流岩）－碱性花岗岩（碱性流纹质熔结凝灰岩）。它们的ＳｉＯ２含量变化于５７％～７７％之间，Ｋ２Ｏ＋Ｎａ２Ｏ、Ｋ２Ｏ、Ｎａ２Ｏ分别大于９％、４％、５％，ＮＫ／Ａ为０．９～１．１２。以过铝质、碱钙性和碱性为序，三个岩石系列的Ｎｂ、Ｔａ、Ｚｒ、Ｈｆ、ＲＥＥ含量依序增高，显示出明显的区别。上述特征表明，三个岩石系列的性质和特征明显不同，分别属于三种岩石成因类型。

关键词：花岗质岩石系列地球化学成因意义花岗岩

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Neoadjuvant camrelizumab(an anti-PD-1 antibody)plus chemotherapy or apatinib(a VEGFR-2 inhibitor)for initially unresectable stage II–III non-small-cell lung cancer:a multicentre,two-arm,phase 2 exploratory study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3015-3023页

作者： Haoran Xia Han Zhang Zheng Ruan Huibiao Zhang Liangdong Sun Hezhong Chen Yongxin Zhou Lele Zhang Dongliang Bian Xinsheng Zhu Jing Zhang Fenghuan Sun Huansha Yu Nan Song Xiaogang Liu Yuming Zhu Haiping Zhang Wenxin He Jian Chen Jie Yang guohan Chen Shiliang Xie Dongfang Tang Xiaomiao Zhang Liang Duan Deping zhao Qinchuan Li Peng Zhang Gening Jiang Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Thoracic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghaiChina Department of Thoracic Surgery Changhai HospitalNaval Medical UniversityShanghaiChina Department of Thoracic-Cardiovascular Surgery Tongji HospitalTongji University School of MedicineShanghaiChina Central Laboratory Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Experimental Animal Center Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Oncology Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai East HospitalTongji University School of MedicineShanghaiChina

This multicentre,two-arm,phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell lung cancer(NSCLC).Eligible patients regardless of PD-L1 expression received neoadjuvant camrelizumab 200 mg and platinum-doublet chemotherapy every 3 weeks(arm A)or those with PD-L1-positive tumors received neoadjuvant camrelizumab and apatinib 250 mg once daily(arm B),for 2–4 cycles,followed by *** primary endpoint was major pathological response(MPR)*** patients in arm A and 21 in arm B were *** rates were 50.0%(15/30)in arm A and 42.9%(9/21)in arm B,with all patients achieving R0 *** these patients,the MPR and pathological complete response rates were both 20.0%(95%CI 4.3–48.1)in arm A and were 55.6%(95%CI 21.2–86.3)and 11.1%(95%CI 0.3–48.2)in arm B,*** corresponding objective response rates were 33.3%(95%CI 11.8–61.6)and 55.6%(95%CI 21.2–86.3).With a median follow-up of 22.4 months(95%CI 19.0–26.0),the median event-free survival was not reached(NR;95%CI 13.6-NR)in arm A and 16.8 months(95%CI 8.6-NR)in arm *** 3 or above treatment-related adverse events occurred in eight(26.7%)patients in arm A and three(14.3%)in arm *** analysis showed baseline TYROBP expression was predictive of treatment response in arm *** camrelizumab plus chemotherapy or apatinib exhibits preliminary efficacy and manageable toxicity in patients with initially unresectable stage II–III NSCLC.

关键词： Surgery chemotherapy treatment

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TP53 downregulation induces FGF2 expression to promotes resistance to EGFR inhibitor in glioblastoma

TP53 downregulation induces FGF2 expression to promotes resi...

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第十三届中国医师协会神经外科医师年会

作者： Junyu Wang Danfeng Zhang Chunlin Wang Kaiwei Han Yiming Li Liang zhao Jigang Chen Yicheng Lu Huanhai Liu guohan Hu Department of Neurosurgery Shanghai Changzheng HospitalSecond Military Medical University Department of Neurosurgery the 105th Hospital of PLA Department of Otorhinolaryngology(Head and Neck) Shanghai Changzheng HospitalSecond Military Medical University

EGFR activation is commonly observed in many types of tumor,and contributes to tumor becoming more ***,EGFR inhibitor has been considered as a promising therapeutic method for tumors including glioblastoma multiform（GBM）,which has frequent amplification of ***,the reluctant response or resistance to EGFR inhibitor remains to be ***,we show that FGF2/FGFR1 signaling contributes to resistance to EGFR inhibitor treatment in *** FGF2/FGFR1 signaling compromises inhibition of ERK1/2 and AKT activation in response to EGFR inhibitor treatment,and lead to EGFR inhibitor *** inactivated TP53 in GBM promotes FGF2 expression through transcriptionally regulation of mi R-107 to activate FGF2/FGFR1 signaling,thus finally leads to resistance to EGFR inhibitor *** study unveils a TP53/miR-107/FGF2/FGFR1 axis that contributes to EGFR inhibitor resistance in GBM,and provides a possible strategy to overcome EGFR inhibitor resistance in GBM with combination of FGFR *** also suggests that status of TP53 and FGFR signaling activity might serve as predictive factors for EGFR inhibitor ***:We show that TP53 inactivation in GBM activates FGFR signaling through mi R-107 regulated FGF2 expression to crosstalk with EGFR signaling,and subsequently compromise EGFR inhibitor sensitivity.

关键词： TP53 FGF2 EGFR inhibitor glioblastoma

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美国大气光化学监测点位布设的经验和启示

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中国环境监测 2024年第5期40卷 1-8页

作者：崔虎雄柴文轩赵月张国涵上海市环境监测中心上海200235 中国环境监测总站国家环境保护环境监测质量控制重点实验室北京100012 云南省生态环境厅驻昆明市生态环境监测站云南昆明650228

我国大气光化学污染问题仍然形势严峻,逐渐成为影响我国环境空气质量的重要因素之一。光化学监测点位的科学布设,有助于准确反映我国光化学污染状况,为研究光化学污染的形成机制、污染成因及控制策略提供技术支持。在总结美国光化学监... 详细信息

我国大气光化学污染问题仍然形势严峻,逐渐成为影响我国环境空气质量的重要因素之一。光化学监测点位的科学布设,有助于准确反映我国光化学污染状况,为研究光化学污染的形成机制、污染成因及控制策略提供技术支持。在总结美国光化学监测点位布设技术方法步骤和要求、点位布设发展历程基础上,结合我国光化学监测点位布设现状,探讨了我国光化学监测点位布设存在的问题,并提出了若干关于我国光化学监测点位布设的建议。

关键词：大气光化学监测点位布设

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肺癌免疫治疗进展

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中国胸心血管外科临床杂志 2022年第11期29卷 1517-1524页

作者：刘杰赵田李钦传陈国涵同济大学附属东方医院胸外科上海200120

肺癌是导致全球癌症患者死亡的最主要原因。尽管基于铂类的化学疗法和基于酪氨酸激酶抑制剂的分子靶向疗法取得了进展性的治疗效果,但它们也存在自身的局限性。免疫治疗最近已经成为一种非常有效的新型疗法,全球医务工作者对癌症免疫疗... 详细信息

肺癌是导致全球癌症患者死亡的最主要原因。尽管基于铂类的化学疗法和基于酪氨酸激酶抑制剂的分子靶向疗法取得了进展性的治疗效果,但它们也存在自身的局限性。免疫治疗最近已经成为一种非常有效的新型疗法,全球医务工作者对癌症免疫疗法的热情日益高涨。本文总结了免疫检查点抑制剂在临床试验中的效果,抗程序性死亡受体-1(programmed death-1,PD-1)/程序性死亡配体-1(programmed death-ligand 1,PD-L1)药物在肺癌治疗中的现状和进展,概述了影响抗PD-1/PD-L1治疗效果的不良事件以及减少这些事件发生的可能因素。

关键词：肺癌免疫治疗免疫检查点抑制剂程序性死亡受体-1 程序性死亡配体-1 不良事件综述

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阴山—燕山北麓富碱侵入岩体的岩石地球化学特征、锆石SHRIMP U-Pb年龄及构造意义

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地质论评 2019年第4期65卷 894-915页

作者：龚弥蔡剑辉阎国翰刘楚雄刘钊中国地质科学院矿产资源研究所自然资源部成矿作用与资源评价重点实验室北京100037 中国地质大学(北京) 北京100083 北京大学地球科学与空间科学学院北京大学造山带与地壳演化教育部重点实验室北京100871

本文研究的达茂旗黄合少、察哈尔右后旗古城和河北尚义县八道沟岩体位于华北克拉通北缘阴山—燕山北麓,索伦缝合带以南,沿近东西方向展布。主要岩石类型为正长岩、二长岩和石英二长岩。岩石地球化学研究表明其SiO2含量59.08%~66.52%,Al2... 详细信息

本文研究的达茂旗黄合少、察哈尔右后旗古城和河北尚义县八道沟岩体位于华北克拉通北缘阴山—燕山北麓,索伦缝合带以南,沿近东西方向展布。主要岩石类型为正长岩、二长岩和石英二长岩。岩石地球化学研究表明其SiO2含量59.08%~66.52%,Al2O3=15.34%~21.67%,A/CNK<1。属于准铝质中性岩范畴。全碱含量(Na2O+K2O)均在8%以上,在岩石的碱度率AR—SiO2图解上大多数样品落入碱性与过碱性区域,里特曼指数σ值从3.73~10.83均位于碱性或过碱性系列,属于碱性岩。岩体的微量元素以富集大离子亲石元素(LILE)如Rb、Ba和Sr等,亏损高场强元素(HFSE)如Ti、P、Nb和Ta等为特征。岩石稀土元素特征显示富集轻稀土元素(LREE),亏损重稀土元素(HREE)并且轻重稀土元素分馏比较明显的特征。除极个别样品外,岩石具有Eu负异常(δEu=0.35~0.91)。通过对察哈尔右后旗古城正长岩体和河北尚义县八道沟富碱侵入岩体的高精度测年研究,获得其SHRIMP锆石U-Pb年龄分别为413.2±3.3~415.0±5.9 Ma和366.8±5.2~372.3±4.7 Ma,表明其均为古生代泥盆纪富碱侵入岩浆活动的产物。结合前人关于阴山—燕山北麓其它富碱侵入岩体(内蒙古固阳东高家村碱性正长岩体、黄合少碱性正长岩和冀北水泉沟碱性杂岩体)的研究成果,推断在华北克拉通北缘阴山—燕山北麓一带,可能存在一条东西方向展布的晚古生代泥盆纪富碱侵入岩带。根据该岩带岩石地球化学特征,以及Ta/Yb—Th/Yb与Zr/Nb—Zr/Nb—Y/Nb判别图推测其岩浆物质来源可能与富集地幔有关,按照成岩温压环境指示,其形成深度位置约为下地壳,岩浆上升侵位过程中明显受到地壳物质的混染。依据前人关于碱性岩特征的研究,结合本文研究岩体的岩石化学特征和及Rb—Nb+Y构造判别图解指示,推测岩体形成于张性构造环境,可能与古生代志留纪末兴蒙造山带南部发育的白乃庙岛弧带和华北克拉通发生弧—陆碰撞后的伸展背景相关。

关键词：富碱侵入岩阴山—燕山北麓岩石地球化学 SHRIMP锆石U-Pb年龄古生代

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