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Effect of autologous NK cell immunotherapy on advanced lung adenocarcinoma with EGFR mutations

Precision Clinical Medicine 2019年第4期2卷 235-245页

作者： guodai hong Xuemei Chen Xizhuo Sun Meiling Zhou Bing Liu ZhuLi Zhendong Yu Wenbin Gao Tao Liu Department of Biotherapy and Oncology Shenzhen Luohu People’s HospitalThe Third Affiliated Hospital(The Affiliated Luohu Hospital)of Shenzhen UniversityShenzhen 518001China The Key Laboratory of Biomedical Information Engineering of the Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Public Service Platform for Cell Quality Testing and Evaluation of Shenzhen Shenzhen 518001China Central Laboratory Peking University Shenzhen HospitalShenzhen 518036China

This study investigated the efficiency of natural killer(NK)cell immunotherapy on non-small cell lung cancer with and without EGFRmutations in order to evaluate the response rate(RR)and progression-free survival(PFS).Among the 48 patients recruited,24 were clinically confirmed to be EGFR mutation *** study group was treated with autologous NK cell *** of the lymphocyte number,serum tumourrelated biomarkers,circulating tumour cells(CTC),Karnofsky Performance Status(KPS)and survival curves were carried out before and after NK cell *** safety and short-term effects were evaluated,followed by median PFS and RR *** serum CEA and CA125 values were found lower in the NK cell therapy group than that of the non-NK treatment group(p<0.05).Theχ2 test showed a 75%RR of the study group A,significantly higher than that of the control group B(16.7%;p<0.01).The RR of groups C(58.3%)and D(41.7%)were not statistically *** p values of the 4 groups were 0.012,0.012,0.166 and 1 from group A to group D,*** median PFS was 9 months in EGFR mutation positive group undergoing NK cell infusion *** evaluating the changes in immune function,tumour biomarkers,CTC,KPS and PFS,we demonstrated that NK cell therapy had better clinical therapeutic effects on EGFR mutation-positive lung adenocarcinoma.

关键词： Natural killer cells immunotherapy EGFR mutation lung cancer clinical efficacy clinical trial

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