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Risk of interstitial lung disease with the use of programmed cell death 1 (PD-1) inhibitor compared with programmed cell death ligand 1 (PD-L1) inhibitor in patients with breast cancer: A systematic review and meta-analysis

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Cancer Pathogenesis and Therapy 2024年第2期2卷 91-102页

作者： Lijuan Guo Xiaoyi Lin Xin Lin Yulei Wang Jiali Lin Yi zhang Xiangqing Chen Miao Chen guochun zhang Yifang zhang Department of Breast Surgery Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510000China Schol of Medicine South China University of TechnologyGuangzhouGuangdong 510000China Medical College Shantou UniversityShantouGuangdong 515000China The Second School of Clinical Medicine Southerm Medical UniversityGuangzhouGuangdong 510000China Department of Breast Cancer Guangdong Provincial People's Hospital's Nanhai HospitalFoshanGuangdong 528000China Department of Emergency Medicine Guangdong Provincial People's Hospitals Nanhai HospitalFoshanGuangdong 528000China

Background:Programmed cell death 1(PD-1)and programmed cell death ligand 1(PD-L1)inhibitors have become integral elements within the current landscape of breast cancer treatment modalities;however,they are associ-ated with interstitial lung disease(ILD),which is rare but potentially ***,only a few studies have compared the difference in ILD incidence between PD-1 and PD-L1 ***,this study aimed to assess the discrepancies regarding ILD risk between the two immune checkpoint *** also reported three cases of ILD after PD-1 inhibitor ***:We comprehensively searched PubMed,EMBASE,and the Cochrane Library to identify clinical trials that investigated PD-1/PD-L1 inhibitor treatment for patients with breast *** overall estimates of incidence and risk ratio(RR)were calculated with a 95%confidence interval(CI),and a mirror group analysis was per-formed using eligible ***:This meta-analysis included 29 studies with 4639 patients who received PD-1/PD-L1 inhibitor treatment.A higher ILD incidence was observed among 2508 patients treated with PD-1 inhibitors than among 2131 patients treated with PD-L1 inhibitors(0.05 vs.0.02).The mirror group analysis further revealed a higher ILD event risk in patients treated with PD-1 inhibitors than in those treated with PD-L1 inhibitors(RR=2.34,95%CI,1.13-4.82,P=0.02).Conclusion:Our findings suggest a greater risk of ILD with PD-1 inhibitors than with PD-L1 *** findings are instrumental for clinicians in treatment deliberations,and the adoption of more structured diagnostic approaches and management protocols is necessary to mitigate the risk of ILD.

关键词： Programmed cell death 1 inhibitor Programmed cell death ligand 1 inhibitor Interstitial lung disease Breast cancer Immune-related adverse events

孕晚期妇女母胎依恋现状及其与分娩恐惧的相关性研究

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军事护理 2024年第3期41卷 1-4页

作者：李海云张国春褚梁梁王君芝山东第一医科大学第一附属医院护理部山东济南250014

目的了解孕晚期妇女母胎依恋现状,分析其影响因素,并探讨其与分娩恐惧的相关性,为实施干预措施提供科学的依据。方法2023年1-2月,采用便利抽样法选取济南市某三级甲等医院就诊的孕晚期妇女329名为研究对象,采用分娩态度量表、产前依恋... 详细信息

目的了解孕晚期妇女母胎依恋现状,分析其影响因素,并探讨其与分娩恐惧的相关性,为实施干预措施提供科学的依据。方法2023年1-2月,采用便利抽样法选取济南市某三级甲等医院就诊的孕晚期妇女329名为研究对象,采用分娩态度量表、产前依恋问卷等对其调查。结果孕晚期妇女分娩恐惧总分为(29.12±6.39)分,母胎依恋总分为(48.54±7.85)分。不同年龄、胎次、文化程度以及是否计划内妊娠、有无孕期并发症和孕期抑郁情绪等的孕晚期妇女,母胎依恋得分差异均有统计学意义(均P<0.05)。分娩恐惧与母胎依恋得分呈负相关(r=-0.471,P<0.001)。年龄、胎次、长期居住地、文化程度、是否计划内妊娠、孕期睡眠时间≥10 h/d、有无孕期并发症和孕期抑郁情绪是母胎依恋的主要影响因素(均P<0.05)。结论孕晚期妇女分娩恐惧和母胎依恋处于中等水平,两者呈负相关。医护人员可采取针对性的干预预防孕妇分娩恐惧,从而改善母胎依恋关系。

关键词：孕晚期分娩恐惧母胎依恋横断面研究相关性

PREPARATION OF Co50Ni50 ULTRAFINES BY CO-REDUCTION OF SOLUTION IN PRESENCE OF POLYMER

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中国有色金属学会会刊：英文版 1999年第1期9卷 3-5,7+6页

作者： Chen, Zuyao zhang, guochun Zhu, Yurui Jiang, Wanquan Tang, Xinlu Univ of Science and Technology of China Hefei China

ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｍｅｔａｌＣｏ，ａｓｏｎｅｏｆｆｅｒｏｍａｇｎｅｔｉｃｔｒａｎｓｉｔｉｏｎｅｌｅｍｅｎｔｓ，ａｎｄｉｔｓａｌｏｙｓａｎｄｃｏｍｐｏｕｎｄｓ，ｅｓｐｅｃｉａｌｙｉｔｓｕｌｔｒａｆｉｎｅｐ... 详细信息

ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｍｅｔａｌＣｏ，ａｓｏｎｅｏｆｆｅｒｏｍａｇｎｅｔｉｃｔｒａｎｓｉｔｉｏｎｅｌｅｍｅｎｔｓ，ａｎｄｉｔｓａｌｏｙｓａｎｄｃｏｍｐｏｕｎｄｓ，ｅｓｐｅｃｉａｌｙｉｔｓｕｌｔｒａｆｉｎｅｐａｒｔｉｃｌｅｓａｎｄｐｏｗｄｅｒ...

关键词： Co50Ni50 magnetic alloy ultrafines Co reduction of solution polymer(CRSPP)

Phonon engineering in Yb:La_(2)CaB_(10)O_(19)crystal for extended lasing beyond the fluorescence spectrum

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Light(Science & Applications) 2023年第9期12卷 1921-1929页

作者： Yanling Cheng Fei Liang Dazhi Lu Jingcheng Feng guochun zhang Haohai Yu Huaijin zhang Yicheng Wu State Key Laboratory of Crystal Materials and Institute of Crystal Materials Shandong UniversityJinan 250100China Key Lab Functional Crystals and Laser Technology Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Since the first invention of the laser in 1960,direct lasing outside the fluorescence spectrum is deemed impossible owing to the“zero-gain”***,when electron-phonon coupling meets laser oscillation,an energy modulation by the quantized phonon can tailor the electronic transitions,thus directly creating some unprecedented lasers with extended wavelengths by phonon ***,we demonstrate a broadband lasing(1000-1280 nm)in a Yb-doped La_(2)CaB_(10)O_(19)(Yb:LCB)crystal,far beyond its spontaneous fluorescence *** calculations and in situ Raman verify that such a substantial laser emission is devoted to the multiphonon coupling to lattice vibrations of a dangling“quasi-free-oxygen”site,with the increasing phonon numbers step-by-step(n=1–6).This new structural motif provides more alternative candidates with strong-coupling laser ***,the quantitative relations between phonon density distribution and laser wavelength extension are *** results give rise to the search for on-demand lasers in the darkness and pave a reliable guideline to study those intriguing electron-phonon-photon coupled systems for integrated photonic applications.

关键词： beyond lasing spectrum

Dendrochronology-based stand growth estimation of Larix olgensis forest in relation with climate on the eastern slope of Changbai Mountain, NE China

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Frontiers of Earth Science 2013年第4期7卷 429-438页

作者： Bo LIN Qianqian XU Wenhui LIU guochun zhang Qiongyao XU Qijing LIU Key Laboratory of Forest Cultivation Department of Forest Sciences Beijing Forestry University Beijing 100083 China

The eastern slope of Changbai Mountain is characterized by pure larch forest （Larix olgensis） with little human disturbance. Response of tree growth to climate in this area remains unknown. Meanwhile, little is known about how climate variations affect the biomass increase which could be recognized as a three-dimensional tree growth index. The objective of this study is to investigate the climate effects on the radial and biomass growth of larch on eastem slope of Changbai Mountain. Tree-ring width chronologies and mean annual biomass increment were established using tree-ring data. We used correlation analysis and multiple regression analysis to explore the relationship between larch growth and climatic factors from 1957 to 2009. Results show that tree-ring growth and mean annual biomass increment were primarily and significantly affected by previous year climatic variables with slight difference among months. Temperatures were more consistently and strongly corre- lated to the chronologies and mean annual biomass increment than was precipitation. Temperature is the main factor limiting larch growth on Changbai Mountain and the ongoing climate warming may accelerate the growth of the species. The current stand biomass of the area was ***-1 and the annual stand biomass increment in 2009 was 2.91 ***-1. In conclusion, the old-growth forest in the study area is still accumulating carbon efficiently.

关键词： Larix olgensis tree ring climatic factors,biomass China

Hydrothermal Synthesis, Structure and Property of Transition Metal（Mn, Zn, Cd or Pb） Coordination Frameworks Using Quinoline-8-oxy-acetate Acid and Dicarboxylic Acid as Ligands

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Chemical Research in Chinese Universities 2015年第4期31卷 489-497页

作者： zhang guochun QIAO Chengfang LIANG Jiehui WEI Qing XIA Zhengqiang CHEN Sanping Shaanxi Key Laboratory of Comprehensive Utilization of Tailings Resources College of Chemical Engineering and Modern Materials Shangluo University Shangluo 726000 P. R. China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry Ministry of Education College of Chemistry and Materials Science Northwest University Xi'an 710127 P. R. China

Five transition metal coordination compounds, [Mn2（8-qoac）E（bdc）（H2O）4]（1）（8-qoacH=quinoline-8-oxy- acetate acid, H2bdc=benzene-1,4-dicarboxylic acid）, [Zn4（8-qoac）4（bdc）2]n（2）, {[CdE（8-qoac）E（Hip）2（H2O）2]·（H2O）4}n（3）（H2ip=benzene-1,3-dicarboxylic acid）, [Pb3（8-qoac）2（bdc）1.5（HEO）Cl]n（4） and [Zn2（8-qoac）（8-ql）（bdc）]n （5）（8-Hql=8-hydroxyquinoline）, were synthesized by hydrothermal syntheses of metal salts with benzenedicarboxy- lic acid and 8-qoacH. Compound 1 possesses a discrete dimer bridged by bdc2- ligand. Compound 2 presents a 2D layer network constructed from bdc2- linkers and 1D infinite ribbons, in which Zn（II） centers are bridged by 8-qoac- with a tetradentate binding mode. Compound 3 displays a 1D zigzag chain, with adjacent chains further connected via extensive O-H…O hydrogen bonds to generate a 3D supramolecular structure. Compound 4 shows a 3D framework containing trinuclear lead secondary building units and bdc2- linkers, in which a new coordination mode of 8-qoac- ligand is observed. In compound 5, Zn（II） ions are simultaneously bridged by 8-qoac-, 8-ql- and bdc2- ligands to form tetranuclear zinc units, which are further interlinked by bdc2- linkers to yield a 2D wave-like layer. Based on intrali- gand（IL）（π-π＊） fluorescent emission, compounds 1--5 possess strong purple fluorescent emissions. In addition, the thermal stabilities of compounds 1--5 were studied.

关键词： Coordination compound Quinoline-8-oxy-acetate acid Crystal structure Photoluminescence property

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异色瓢虫对甜菜夜蛾和草地贪夜蛾的捕食潜能

植物保护 2024年第5期50卷 171-179页

作者：吴钰薇郑林浩高鹏朱立贺张国春李飞武夏蔚徐文静吉林省农业科学院农业质量标准与检测技术研究所长春136100 浙江农林大学现代农学院杭州311300 吉林省农业科学院植物保护研究所公主岭136100 前郭县前郭尔罗斯镇综合服务中心松原131100

为明确异色瓢虫Harmonia axyridis对甜菜夜蛾Spodoptera exigua和草地贪夜蛾Spodoptera frugiperda的捕食潜能,本文在室内条件下研究了异色瓢虫对上述2种鳞翅目害虫2龄幼虫的捕食功能反应和搜寻效应;在网室条件下测定了异色瓢虫对2种害... 详细信息

为明确异色瓢虫Harmonia axyridis对甜菜夜蛾Spodoptera exigua和草地贪夜蛾Spodoptera frugiperda的捕食潜能,本文在室内条件下研究了异色瓢虫对上述2种鳞翅目害虫2龄幼虫的捕食功能反应和搜寻效应;在网室条件下测定了异色瓢虫对2种害虫低龄幼虫的防控效果。室内研究结果表明,异色瓢虫雌雄成虫对这2种害虫2龄幼虫的捕食功能反应均属于HollingⅡ型圆盘方程,其中雌成虫对甜菜夜蛾和草地贪夜蛾2龄幼虫的瞬时攻击率(a)分别为1.120和0.987,控害效能(a/T_(h))分别为134.514头和154.408头,日最大捕食量(1/T_(h))分别为120.124头和156.437头;雄成虫对甜菜夜蛾和草地贪夜蛾2龄幼虫的瞬时攻击率(a)分别为1.071和0.830,控害效能(a/T_(h))分别为116.262头和124.568头,日最大捕食量(1/T_(h))分别为108.540头和150.039头。网室试验结果表明,2∶300、4∶300和8∶300的益害比下异色瓢虫均能有效控制甜菜夜蛾和草地贪夜蛾低龄幼虫的数量,释放后8 d防效分别在65%、80%和95%以上。综上所述,异色瓢虫具备对甜菜夜蛾和草地贪夜蛾低龄幼虫有效控害的潜力,试验结果可为利用异色瓢虫防控甜菜夜蛾和草地贪夜蛾提供理论依据。

关键词：异色瓢虫甜菜夜蛾草地贪夜蛾捕食功能反应生物防治

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孕产妇母婴连结的研究进展

中华现代护理杂志 2024年第7期30卷 961-966页

作者：李海云张国春褚梁梁王君芝山东第一医科大学第一附属医院护理部济南250014

母婴连结关系的建立与孕产妇心理健康及婴儿早期生长发育密切相关。本文对母婴连结的概念、评估工具、影响因素及干预措施进行综述,以期为促进产后母婴关系的正常建立和母婴健康提供依据。

关键词：综述产妇母婴连结评估工具影响因素

糖源对“东方黏虫-异色瓢虫”饲养体系的影响

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中国生物防治学报 2024年第4期40卷 828-833页

作者：吴钰薇商晔郑林浩李姝睿朱立贺张国春李飞武徐文静吉林省农业科学院农业质量标准与检测技术研究所浙江农林大学现代农学院吉林农业大学园艺学院前郭县前郭尔罗斯镇综合服务中心

为了优化“东方黏虫-异色瓢虫”饲养体系中卵粒对异色瓢虫的饲喂效果，同时解决异色瓢虫取食低龄幼虫和高龄幼虫仅交配不产卵的问题。本文在该体系的基础上通过补充蜂蜜、蔗糖和葡萄糖3种水溶液，研究糖源物质对异色瓢虫生长发育及繁殖... 详细信息

为了优化“东方黏虫-异色瓢虫”饲养体系中卵粒对异色瓢虫的饲喂效果，同时解决异色瓢虫取食低龄幼虫和高龄幼虫仅交配不产卵的问题。本文在该体系的基础上通过补充蜂蜜、蔗糖和葡萄糖3种水溶液，研究糖源物质对异色瓢虫生长发育及繁殖的影响。研究结果表明：以卵粒为饲料，添加糖源物质后异色瓢虫世代发育历期显著缩短、繁殖力显著提升，其中以葡萄糖饲喂效果最优（世代发育历期为20.71 d,30d单雌平均产卵量937.00粒）；以低龄幼虫和高龄幼虫为饲料，添加糖源后异色瓢虫出现产卵行为，且均以蜂蜜饲喂繁殖力最强（30 d单雌平均产卵量分别为434.80和645.11粒）。综合试验结果和饲养效果来看，糖源物质对“东方黏虫-异色瓢虫”饲养体系具有促进作用，不仅提升卵粒的饲喂效果，而且解决了取食低龄幼虫和高龄幼虫异色瓢虫仅交配不产卵的问题，优化后能代替“植物-蚜虫-异色瓢虫”的饲养模式。这一体系打破了寄主植物和环境的限制，在异色瓢虫人工饲料的研究中取得突破，为日后室内规模化生产异色瓢虫提供借鉴。

关键词：异色瓢虫东方黏虫糖源生长发育繁殖能力