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A pillar[5]arene-based molecular grapple of hexafluorophosphate

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Chinese Chemical Letters 2019年第5期30卷 957-960页

作者： Zibin Zhang Kechang Sun Shijun Li guocan yu Hangzhou Normal University Hangzhou 310036China Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and BioengineeringNational Institutes of HealthBethesda 20892United States

A symmetric pillararene-based receptor containing ten triazole units was ***,it formed 1:1 complexes instead of 1:2 with different halide *** was caused by the cooperative multivalent hydrogen-bond interactions between the triazole protons on one side of the receptor and the halide anion,which changed its structure from pillar to ***,by the regulation of the effector F-,it can work like an excavator grapple selectively grasps a PF6-anion.

关键词： Pillararene Molecular machine Anion receptors Molecular recognition

Lipid nanomaterials-based RNA therapy and cancer treatment

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Acta Pharmaceutica Sinica B 2023年第3期13卷 903-915页

作者： Xingcai Zhang Luo Hai Yibo Gao guocan yu Yingli Sun School of Engineering and Applied Sciences Harvard UniversityCambridge 02138MAUSA Central Laboratory National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Laboratory of Translational Medicine National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China University of Chinese Academy of Sciences Beijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences/China National Center for BioinformationBeijing 100101China

We summarize the most important advances in RNA delivery and *** describe lipid nanoparticle-based RNA therapeutics and the impacts on the development of novel *** fundamental properties of the key RNA members are *** introduced recent advances in the nanoparticles to deliver RNA to defined targets,with a focus on lipid nanoparticles(LNPs).We review recent advances in biomedical therapy based on RNA drug delivery and state-of-the-art RNA application platforms,including the treatment of different types of *** review presents an overview of current LNPs based RNA therapies in cancer treatment and provides deep insight into the development of future nanomedicines sophisticatedly combining the unparalleled functions of RNA therapeutics and nanotechnology.

关键词： Antisense oligonucleotides siRNA miRNA mRNA Cancer treatment Nanomedicine RNA therapy Lipid nanoparticles

Numerical Simulation of Flow between Rotating Cylinders

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Communications in Nonlinear Science and Numerical Simulation 1998年第1期3卷 50-52页

作者： Chunwei yu and guocan LING (LNM, Institute of Mechanics, CAS, Beijing, 100080, China) LNM Institute of Mechanics CAS Beijing 100080 China

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ＩｎｔｒｏｄｕｃｔｉｏｎＦｌｏｗｂｅｔｗｅｅｎｒｏｔａｔｉｎｇｃｙｌｉｎｄｅｒｓｗｉｔｈｓｍａｌｈ／Ｒ（ｈｉｓｔｈｅｇａｐｂｅｔｗｅｅｎｃｙｌｉｎｄｅｒｓａｎｄＲｉｓｔｈｅｉｎｎｅｒｃｙｌｉｎｄｅｒｒａｄｉｕｓ）ｈａｓｂｅｅｎｗｉｄｅｌｙｓｔｕｄｉｅ...

关键词： spectral element method rotating flow mode competition

Pillararene-based supramolecular systems for theranostics and bioapplications

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Science China Chemistry 2021年第5期64卷 688-700页

作者： Huangtianzhi Zhu Qi Li Laila E.Khalil-Cruz Niveen M.Khashab guocan yu Feihe Huang State Key Laboratory of Chemical Engineering Key Laboratory of Excited-State Materials of Zhejiang ProvinceDepartment of ChemistryZhejiang UniversityHangzhou 310027China Smart Hybrid Materials Laboratory(SHMs) Advanced Membranes and Porous Materials CenterKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

As an emerging type of important macrocycles for supramolecular chemistry,pillararenes and their derivatives have been widely studied and applied in numerous fields,which intensively promotes the development of chemistry,materials science and ***-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising *** to easy preparation,reliable guest affinity,good biocompatibility and stability,pillararenes are frequently used to construct functional *** one hand,pillararenes can either be used individually or form diversiform self-assemblies such as micelles,nanoparticles and vesicles to increase water solubility and biocompatibility of *** the other hand,it is promising to modify solid materials like framework materials,silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and *** this review,we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery/chemotherapy,photodynamic/photothermal therapy,antimicrobials,bioimaging,*** introducing several typical examples,the design principles,preparation strategies,identifications and bio-applications of these pillararene-based supramolecular systems are *** challenges and directions of this field are also outlined.

关键词： pillararenes self-assembly theranostics drug delivery supra-amphiphiles

Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy

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Chinese Chemical Letters 2024年第10期35卷 205-212页

作者： Ying Gao Rong Zhou Qiwen Wang Shaolong Qi yuanyuan Lv Shuang Liu Jie Shen guocan yu Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhou 310015 China Department of Cardiology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China MOE Key Laboratoryof Bioorganic Phosphorus Chemistry & Chemical Biology Department of ChemistryTsinghua UniversityBeijing04Chin Emergency Department State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

Photodynamic therapy(PDT)has garnered significant attention as a promising approach to cancer therapy,harnessing the combined benefits of localized light treatment and the accompanying host immune *** this study,we engineered an immuno-enhanced PDT nanoplatform,denoted as HM@p-MOF(hybrid membrane@porphyrin-metal organic framework).The core porphyrin-MOF was cloaked with a hybrid membrane derived from B16F10 cancer cells and NK cells,resulting in enhanced *** both in vitro and in vivo experiments,our finding demonstrated that the hybrid membrane conferred dual targeting capabilities to the nanoplatform,leveraging the unique properties of the B16F10 membrane and NK membrane to augment immunogenic cell death(ICD)induced by photodynamic ***,in conjunction with the immunomodulatory functions of the NK cell membrane,we observed an expansion of in situ immune infiltration leading to a systemic immune *** HM@p-MOF nanoplatform exhibited the capacity to not only inhibit the growth of mouse melanoma but also suppress *** innovative HM@p-MOF nanoplatform present a viable strategy to enhance phototherapeutic efficacy for both localized and metastatic *** provides a direction for the fabrication of biomimetic nanomedicines possessing immuno-modulatory function.

关键词： Biomimetic Cell membrane Metal-organic framework Phototherapy Tumor targeting

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外科治疗结核性缩窄性心包炎69例

中华胸心血管外科杂志 2020年第10期36卷 627-630页

作者：陈刚叶波方礼逵喻国灿浙江省中西医结合医院胸外科杭州310003

回顾性分析我科近年来经我科治疗的69例结核性缩窄性心包炎的临床资料,总结临床经验,探讨结核性缩窄性心包炎患者术前抗结核药物治疗时间的制定和手术时机的选择。本组患者术前抗结核药物治疗时间为(6.86±9.11)周,其中≤2周者31例(44.9... 详细信息

回顾性分析我科近年来经我科治疗的69例结核性缩窄性心包炎的临床资料,总结临床经验,探讨结核性缩窄性心包炎患者术前抗结核药物治疗时间的制定和手术时机的选择。本组患者术前抗结核药物治疗时间为(6.86±9.11)周,其中≤2周者31例(44.9%),>2周者38例(55.1%),术后均经病理学、分子生物学或病原学确诊为结核性心包炎,其中经病理学检查确诊者66例(95.7%),经抗酸杆菌涂片或培养等常规病原学检查确诊者21例(34.8%),经结核DNA、RNA、Xpert等病原分子生物学检测确诊者55例(79.7%)。所有患者术后症状均明显缓解,术后住ICU时间(3.48±2.63)天,总住院时间(11.52±4.62)天,术后出现并发症19例(27.5%),其中低心排血量综合征10例(14.5%),肺部感染8例(11.6%),肾功能衰竭2例(2.9%),切口愈合不良2例(2.9%),无围手术期死亡。对于结核性心包炎,尽早明确病因,并及时给予有效的抗结核治疗,一旦心包缩窄形成,应综合结核感染活动度及心包缩窄程度制定合适的治疗策略,合理的安排术前抗结核药物治疗时间和选择手术时机。

关键词：结核性心包炎结核感染术后症状切口愈合不良肾功能衰竭分子生物学检测手术时机治疗策略

Supramolecular engineering of cell membrane vesicles for cancer immunotherapy

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Science Bulletin 2022年第18期67卷 1898-1909,M0004页

作者： Shaolong Qi Haiyan Zhang Xueyan Zhang Xinyang yu Yajun Wang Qian-Fang Meng Kai Yang Bing Bai Rui Tian Shoujun Zhu Lang Rao Feihe Huang guocan yu Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518132China State Key Laboratory of Chemical Engineering Stoddart Institute of Molecular ScienceDepartment of ChemistryZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China

The clinical translation of nanomedicines has been strongly hampered by the limitations of delivery vehicles,promoting scientists to search for novel *** cell membrane-based delivery systems have attracted extensive attention,further functionalizations are urgently desired to augment their theranostic *** propose a cell-friendly supramolecular strategy to engineer cell membranes utilizing cyclodextrin-based host–guest molecular recognitions to fix the defects arising from chemical and genetic *** this study,the supramolecular cell membrane vesicles(SCMVs)specifcally accumulate in tumors,benefting from tumor-homing capability and the enhanced permeability and retention *** co-delivering indocyanine green and an indoleamine 2,3-dioxygenase inhibitor effectively ablate tumors combining photodynamic therapy and *** by host–guest inclusion complexation,SCMVs successfully encapsulate resiquimod to repolarize tumor-associated macrophages into M1 phenotype,synergizing with immune checkpoint blockade *** supramolecular engineering methodology based on noncovalent interactions presents a generalizable and cell-friendly tactic to develop living cell–originated nanomaterials for precise cancer therapy.

关键词： Cancer theranostics Host–guest systems Immunotherapy Nanomedicine Supramolecular chemistry

金融工具摊余成本计量中实际利率法的运用研究

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财务管理研究 2021年第5期 100-104页

作者：于国灿北京北控能源投资有限公司北京100124

实际利率的实质是金融工具所内含的市场化利率,只有明确的实际利率才能可靠计量金融资产或金融负债的实际利息收入与费用,进而确定其摊余成本。所以,金融工具摊余成本计量过程中实际利率法的合理运用是关键。通过重新解读实际利率法,加... 详细信息

实际利率的实质是金融工具所内含的市场化利率,只有明确的实际利率才能可靠计量金融资产或金融负债的实际利息收入与费用,进而确定其摊余成本。所以,金融工具摊余成本计量过程中实际利率法的合理运用是关键。通过重新解读实际利率法,加深对这一概念的理论认识,并重点通过案例方式探究其实际运用,从实务操作方面为相关企业的业务处理提供参考与借鉴。

关键词：实际利率法摊余成本金融工具

持续和间断静注顺式阿曲库铵对老年患者肌松效果的评价

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中国现代医生 2011年第29期49卷 93-94页

作者：胡芳余国灿浙江省富阳市人民医院麻醉科浙江富阳311400

目的观察持续和间断静注顺式阿曲库铵对老年患者的肌松效果。方法选取2010年2月～2011年2月于我院在全麻下行上腹部手术的老年患者40例,随机分为两组,间断静注组和持续静注组。术中间断静注组给予间断静注顺式阿曲库铵维持肌松,持续静... 详细信息

目的观察持续和间断静注顺式阿曲库铵对老年患者的肌松效果。方法选取2010年2月～2011年2月于我院在全麻下行上腹部手术的老年患者40例,随机分为两组,间断静注组和持续静注组。术中间断静注组给予间断静注顺式阿曲库铵维持肌松,持续静注组给予微量注射泵持续静注顺式阿曲库铵维持肌松。观察两组患者的顺式阿曲库铵的用药情况、肌松恢复指数及肌松恢复时间。结果持续静注组患者的顺式阿曲库铵的用药总量、期间药量较间断静注组减少(t=2.46,P0.05),而持续静注组的肌松恢复时间较间断静注组明显缩短(t=1.70,P<0.05)。结论持续静注顺式阿曲库铵可减少老年患者手术中阿曲库铵的用药量,可为手术提供稳定而可控的肌肉松弛,是老年患者全身麻醉中较好的一种维持肌松的给药方法。

关键词：顺式阿曲库铵持续静注间断静注肌松效果