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Sedimentary and Heavy Mineral Records for the Oligocene-Miocene Exhumation of the Easternmost Tianshan

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Journal of Earth Science 2024年第2期35卷 449-461页

作者： Yan Ding Tianyi Shen guocan Wang Junliang Ji School of Earth Sciences Center for Global TectonicsChina University of GeosciencesWuhan430074China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan430078China Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan430074China

The topography of the Harlik Mountain has a strong impact on the formation of current arid climate in the Turpan-Hami ***,it is still controversial if Harlik Mountain experienced significant exhumation during the Middle to Late Cenozoic according to the previous thermochronology *** features of the Oligocene to Miocene sediments in the foreland basin could provide productive information for resolving the *** peak ages of detrital apatite fission track analysis of the Oligocene–Miocene sandstone in the Turpan-Hami Basin are well comparable with the cooling age records of the Harlik Mountain rocks,indicating that the Oligocene–Miocene Taoshuyuanzi Formation in the basin was mostly derived from the Harlik *** stratigraphic sequence exhibits coarsening upward,reflecting that the source area was in a tectonically active period during the deposition *** mineral assemblages also suggest that the unstable minerals in the sediment increased significantly at the end of the ***,the proportion of apatite increased up-section,while the garnet content decreased significantly,indicating that the Carboniferous metamorphic rocks have been gradually eroded out and more intrusive rocks have been exposed to the *** observations suggest that the Harlik Mountain experienced exhumation during the Oligocene to Miocene,and the denudation depth afterward was probably less than 2.5 km according to the previously apatite(U-Th)/He *** Oligocene–Miocene exhumation probably acted as one of the triggers for the heavy drought of the Turpan-Hami Basin during the Middle–Late Neogene.

关键词： Turpan-Hami Basin Harlik Mountain Taoshuyuanzi Formation Oligocene–Miocene uplift sedimentology structural geology

Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy

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Chinese Chemical Letters 2024年第10期35卷 205-212页

作者： Ying Gao Rong Zhou Qiwen Wang Shaolong Qi Yuanyuan Lv Shuang Liu Jie Shen guocan Yu Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhou 310015 China Department of Cardiology The First Afiliated HospitalZhejiang University School of MedicineHangzhou 310003China MEKey Laboratoryof Bioorganic Phosphorus Chemistry Chemical Bology epartmentof ChemtryTsinghua UniversityBeijing04Chin Emergency Department State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

Photodynamic therapy(PDT)has garnered significant attention as a promising approach to cancer therapy,harnessing the combined benefits of localized light treatment and the accompanying host immune *** this study,we engineered an immuno-enhanced PDT nanoplatform,denoted as HM@p-MOF(hybrid membrane@porphyrin-metal organic framework).The core porphyrin-MOF was cloaked with a hybrid membrane derived from B16F10 cancer cells and NK cells,resulting in enhanced *** both in vitro and in vivo experiments,our finding demonstrated that the hybrid membrane conferred dual targeting capabilities to the nanoplatform,leveraging the unique properties of the B16F10 membrane and NK membrane to augment immunogenic cell death(ICD)induced by photodynamic ***,in conjunction with the immunomodulatory functions of the NK cell membrane,we observed an expansion of in situ immune infiltration leading to a systemic immune *** HM@p-MOF nanoplatform exhibited the capacity to not only inhibit the growth of mouse melanoma but also suppress *** innovative HM@p-MOF nanoplatform present a viable strategy to enhance phototherapeutic efficacy for both localized and metastatic *** provides a direction for the fabrication of biomimetic nanomedicines possessing immuno-modulatory function.

关键词： Biomimetic Cell membrane Metal-organic framework Phototherapy Tumor targeting

Clinical distribution and drug resistance of Acinetobacter baumannii in a Chinese university affiliated hospital

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Clinical distribution and drug resistance of Acinetobacter b...

持续质量改进在降低生化室不合格标本率中的应用

2014年浙江省检验医学学术年会

作者： Qi Liu guocan yang Xuejun Dong Yaner Qian Zongxin Wang 绍兴市人民医院

Objective Acinetobacter baumannii is characterized by its innate and acquired resistance to multiple antimicrobial *** aim of this study is to suyvey the clinical distribution and drug resistance of Acinetobacter baumannii isolated from 2006 to 2012 in our *** The inclusion criteria were used for the selection of carbapenem-resistant Acinetobacter baumannii *** were identified by an automatic *** the Kirby-Bauer disc diffusion method,the isolates were tested for antimicrobial *** A total of 1997 clinical strains of Acinetobacter baumannii are isolated from 2006 to 2012 in our ***,Tobramycin and Polymyxin B have a good antibacterial effect against Acinctobacter *** Monitoring the drug resistance in Acinetobacter baumannii,and mastering its epidemiological data can provide guidance for clinical treatment.

关键词： Acinetobacter baumannii multi-drug resistant antimicrobial sensitivity drug resistance

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中国医院 2012年第8期16卷 41-43页

作者：包国祥杨国灿浙江省绍兴市人民医院

分析了生化室出现不合格标本原因:患者配合程度不够、开单医师告知欠详、护士采集标本不规范、标本运送护工培训不够、生化室操作程序不够标准。针对上述情况成立持续质量改进管理小组:加强对患者的宣教、提高开单医师的告知意识、规范... 详细信息

分析了生化室出现不合格标本原因:患者配合程度不够、开单医师告知欠详、护士采集标本不规范、标本运送护工培训不够、生化室操作程序不够标准。针对上述情况成立持续质量改进管理小组:加强对患者的宣教、提高开单医师的告知意识、规范护士采集标本、加强对运送护工的培训、建立生化室标准操作程序。实施持续质量改进以后,比较2011年1月至6月的不合格标本率(实施持续质量改进以前)和2011年7月至12月的不合格标本率(实施持续质量改进以后),不合格率明显降低,差异具有统计学意义(P<0.01)。

关键词：持续质量改进不合格标本率生化检验

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大跨度悬挑混凝土结构支撑体系设计与施工

施工技术 2013年第14期42卷 90-93页

作者：丰艳琴张凯华马纯权肖现永杨国灿吴江中建三局建设工程股份有限公司广东深圳518000

深圳市福田区石厦旧村改造工程A塔20层为大跨度悬挑混凝土结构,由于其施工高度高、悬挑面积大,采用型钢悬挑支架支模方法施工。架体搭设前,需要对悬挑桁架及以上部分的各受力体系、主要连接节点、构件等进行强度、稳定性、挠度等方面的... 详细信息

深圳市福田区石厦旧村改造工程A塔20层为大跨度悬挑混凝土结构,由于其施工高度高、悬挑面积大,采用型钢悬挑支架支模方法施工。架体搭设前,需要对悬挑桁架及以上部分的各受力体系、主要连接节点、构件等进行强度、稳定性、挠度等方面的验算,证明其满足安全要求,同时需对桁架进行预压试验。重点介绍了支撑体系搭设与拆除等施工工艺。

关键词：混凝土悬挑支撑设计施工

Accelerated Exhumation During the Cenozoic in the Dabie Mountains: Evidence from Fission-Track Ages

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Acta Geologica Sinica(English Edition) 1998年第4期72卷 409-419页

作者： WANG guocan yang Weiran Faculty of Earth Science China University of Geosciences Wuhan Hubei 430074

Abstract: Zircon and apatite fission-track dating indicates that the exhumation of the Dabie Mountains tended to be accelerated in the Cenozoic and that the exhumation of the eastern Dabie Mountains was more and more intense from south to north, which is in accordance with the more and more intense dissection from south to north, as is reflected by the modern geomorphologic features of the Dabie Mountains. The accelerated exhumation during the Cenozoic was related to the high elevation of the Dabie Mountains resulting from Late Cretaceous-Palaeogene detachment faulting and subsequent fault-block uplift and subsidence. The average elevation at that time was at least about 660 m higher than that at the present. The intense exhumation lagged behind intense uplift.

关键词： Dabie Mountains accelerated exhumation Cenozoic fission-track age

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斜钢管柱内混凝土浇筑技术

施工技术 2014年第14期43卷 162-164页

作者：丰艳琴刘家甫马纯权肖现永刘华杨国灿付锦中建三局建设工程股份有限公司广东深圳518000

钢管混凝土结构作为一种新型组合结构,由于其能够更有效地发挥钢材和混凝土两种材料的优点,近年来越来越广泛地应用于超高层结构中。以斜钢管柱混凝土浇筑技术为切入点,分别从材料措施和工艺措施两个方面探讨钢管柱内的混凝土浇筑技术... 详细信息

钢管混凝土结构作为一种新型组合结构,由于其能够更有效地发挥钢材和混凝土两种材料的优点,近年来越来越广泛地应用于超高层结构中。以斜钢管柱混凝土浇筑技术为切入点,分别从材料措施和工艺措施两个方面探讨钢管柱内的混凝土浇筑技术。通过现场实践检验,发现通过外加剂及自密实混凝土的选用、钢管柱和内环板上开设排气孔等方法可以改善斜钢管柱内混凝土浇筑质量。

关键词：高层建筑混凝土钢管柱浇筑施工技术

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地形场景的地理空间认知与内容表达

地球信息科学学报 2024年第4期26卷 790-798页

作者：朱红春张怡宁徐月雪朱国灿宋词山东科技大学测绘与空间信息学院青岛266590

地球表面空间承载着诸多地理实体,随着时空大数据时代的到来,以还原论为基础、以独立分层建模为特征的传统信息描述方式越发难以描述地形及其关联环境要素所具有的海量信息、产生的复杂相互作用和呈现的时空变化规律,相关研究亟需以系... 详细信息

地球表面空间承载着诸多地理实体,随着时空大数据时代的到来,以还原论为基础、以独立分层建模为特征的传统信息描述方式越发难以描述地形及其关联环境要素所具有的海量信息、产生的复杂相互作用和呈现的时空变化规律,相关研究亟需以系统和整体的角度考察研究对象。针对这一问题,本文从场景学的视角对地形本体及关联环境要素的内容和相互作用开展系统的地理空间认知,提出了地形场景的概念,用于整体性地描述地形场景中的实体、联系与时空变化过程;分析了地形场景的要素构成和逻辑结构,使用时间、地点(空间)、事物、事件、现象为核心的更加整体化、语义化和逻辑化的要素对地形场景进行描述;对地形场景对象及其信息的内容构成进行解析和整理,创建了以“要素-对象-信息”为核心的结构描述框架,并对地形场景未来的发展与可能的技术应用进行了展望。地形场景的提出是场景学概念从整体表达朝向整体研究的一次探索,为进一步进行地形问题的场景化求解和表达奠定基础。

关键词：地形地形场景地理场景场景学地理信息地理空间认知内容表达地理规律

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α-烯醇化酶的研究进展

中华临床实验室管理电子杂志 2016年第2期4卷 91-94页

作者：张丽红王宏斌杨国灿董学君浙江省绍兴市人民医院临床检验中心 312000

α-烯醇化酶(alpha-enolase,ENO1)在很长一段时间内被认为是一种古老的、功能单一的糖酵解酶。近年发现ENO1除了在糖酵解中发挥作用外,还具有多种生物学功能。目前研究主要集中在ENO1的免疫原性、纤溶酶原受体、肿瘤生长调控作用等方向... 详细信息

α-烯醇化酶(alpha-enolase,ENO1)在很长一段时间内被认为是一种古老的、功能单一的糖酵解酶。近年发现ENO1除了在糖酵解中发挥作用外,还具有多种生物学功能。目前研究主要集中在ENO1的免疫原性、纤溶酶原受体、肿瘤生长调控作用等方向,而与恶性肿瘤发生、发展的关系研究则备受关注。

关键词： α-烯醇化酶肿瘤免疫原性纤溶酶原受体