检索结果-南通市图书馆

Condylar invasion after postoperative chemotherapy for primary intraosseous squamous cell carcinoma of the mandible: a case report

在线全文

学校读者我要写书评

暂无评论

Oncology and Translational Medicine 2019年第4期5卷 192-194页

作者： Long Cheng Qinyun Li guobo du Daiyuan Ma Bangxian Tan Department of Oncology Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China Department of Nephrology Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant tumor that occurs predominantly in the jaw. Pathological evidence shows that PIOSCC originates from the residual odontogenic epithelium and a preexisting odontogenic cyst or tumor. Here, we report the case of a 63-year-old man with central squamous cell carcinoma of the mandible. On the basis of imaging and histopathology reports, the patient was diagnosed with PIOSCC of the jaw. Subsequently, he was treated with postoperative adjuvant chemotherapy. during a postoperative follow-up visit in the ninth month, mandibular computed tomography (CT) scanning and bone imaging revealed local recurrence and condylar invasion. Therefore, radiation along with chemotherapy was administered. This case study adds to the literature on PIOSCC and widens the understanding of its diagnosis, treatment, and prognosis.

关键词： PIOSCC condyle invasion postoperative chemotherapy

Ewing sarcoma/primitive neuroectodermal tumor of the ureter:A case report and literature review

在线全文

学校读者我要写书评

暂无评论

Oncology and Translational Medicine 2021年第1期7卷 41-44页

作者： Qian Zhou guobo du Jie Tang Yujia Wang Yu Xiao Bangxian Tan North Sichuan Medical College Nanchong 637000China Department of Oncology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000China

Ewing sarcoma/primary neuroectodermal tumors are rare,invasive,and small round blue cell *** are few reports of its occurrence in the urinary ***,we present the first middle-aged female patient whose Ewing sarcoma primary site was in the *** main clinical manifestation was intermittent *** was in good health after complete surgical resection and adjuvant *** date,there has been no recurrence or *** early diagnosis and appropriate treatment can help prolong survival.18F-fluorodeoxyglucose positron emission tomography/computed tomography is expected to be an effective means of evaluating treatment effects and detecting metastasis and *** this article,besides introducing a case of Ewing sarcoma/primitive neuroectodermal tumor of the ureter,we review the literature to discuss the current status of diagnosis and treatment.

关键词： Ewing sarcoma(ES) primitive neuroectodermal tumor(PNET) ureter positron emission tomography/computed tomography(PET/CT)

Three-dimensionally ordered macroporous(3DOM) structure promoted the activity and H_(2)O poisoning resistance of Ce Mn/3DOM-TiO_(2) catalyst in NH_(3)-SCR

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第3期42卷 523-533,I0004页

作者： Yaqin Hu Shipeng Ding Chenchen Tan Peng Wu guobo Li Sheng Wang Hongqiang Yang Yaping Zhang Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing210096China State Power Environmental Protection Research Institute Nanjing210031China

NH_(3)-SCR is an effective mean of NOxremoval in the non-electric industry, however, the high activation temperature and poor H_(2)O resistance of SCR catalysts posed a barrier to its application. In this work, a series of three-dimensionally ordered macroporous(3DOM) catalysts were synthesized via a colloidal crystal template(CCT) method, and various characterizations were carried out to explore the physicochemical property of catalysts. The experiment results reveal that Ce_(0.2)Mn_(0.2)/3DOM-TiO_(2) catalyst presents the excellent low-temperature catalytic activity of nearly 100% at 100℃. Furthermore, the enhanced H_(2)O resistance is achieved, certified by the unaffected NO remove at 150℃ in the participation of 15 vol% H_(2)O. The characterizations results exhibit that the improved dispersion of the active component and enhanced redox ability are conducive to the low-temperature catalytic activity. N_(2) adsorption and desorption experiments indicate that catalyst with 3DOM support possesses a larger pore diameter and specific surface area, which may weaken the condensation of H_(2)O in the microporosity of catalysts and improved the H_(2)O resistance of the catalyst. In situ DRIFTS results manifest that Ce_(0.2)Mn_(0.2)/3DOM-TiO_(2) catalyst could not only absorb more NH_(3) and generate more surface-active sites, but inhibit the competitive adsorption between H_(2)O and SCR reactants.

关键词： 3DOM material NH_(3)-SCR H_(2)O resistance Low-temperature Cerium Rare earths

Nanotechnology’s frontier in combatting infectious and inflammatory diseases:prevention and treatment

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第3期9卷 998-1047页

作者： Yujing Huang Xiaohan Guo Yi Wu Xingyu Chen Lixiang Feng Na Xie guobo Shen Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences and Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases,which continuously pose one of the most serious threats to human health,attributed to factors such as the emergence of new pathogens,increasing drug resistance,changes in living environments and lifestyles,and the aging *** rapid advancements in mechanistic research and drug development for these diseases,current treatments often have limited efficacy and notable side effects,necessitating the development of more effective and targeted anti-inflammatory *** recent years,the rapid development of nanotechnology has provided crucial technological support for the prevention,treatment,and detection of inflammation-associated *** types of nanoparticles(NPs)play significant roles,serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and *** can also directly combat pathogens and *** addition,nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory *** review categorizes and characterizes different types of NPs,summarizes their applications in the prevention,treatment,and detection of infectious and inflammatory *** also discusses the challenges associated with clinical translation in this field and explores the latest developments and *** conclusion,nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

关键词： prevention inflammatory treatment

3D打印口腔支架在头颈部恶性肿瘤放疗中的应用研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华放射肿瘤学杂志 2023年第7期32卷 577-583页

作者：孟雪杜国波吴婷婷谭榜宪川北医学院附属医院肿瘤科南充637000

目的研究3D打印口腔支架在头颈部恶性肿瘤放疗中对靶区、危及器官的剂量影响及减轻放疗相关急性不良反应的效果。方法选取2020年5月1日—2021年11月30日川北医学院附属医院肿瘤科收治的头颈部恶性肿瘤患者58例,采用回顾性队列研究法将... 详细信息

目的研究3D打印口腔支架在头颈部恶性肿瘤放疗中对靶区、危及器官的剂量影响及减轻放疗相关急性不良反应的效果。方法选取2020年5月1日—2021年11月30日川北医学院附属医院肿瘤科收治的头颈部恶性肿瘤患者58例,采用回顾性队列研究法将患者分为试验组(A组)28例(放疗中佩戴3D打印口腔支架)、对照组(B组)30例(放疗中佩戴软木塞口腔支架),比较两组患者放疗期间放射性口腔黏膜炎(RTOM)、口干燥症和口咽黏膜损伤疼痛的发生情况。此外,获得A组中21例患者知情同意,采用自身对照法,每位患者分别佩戴3D打印口腔支架(C组)和软木塞口腔支架(D组)制作两组放疗计划,分析两组计划靶区的均匀性指数(CI)、适形指数(HI)和危及器官(D_(max)、D_(mean))受照剂量的差异。采用SPSS 25.0统计软件进行统计分析。计量资料采用xˉ±s表示,两组间的比较采用配对t检验或重复测量分析;计数资料以率表示,两组间的比较选用卡方检验或Fisher确切概率检验。P0.05);C组上唇、患侧颊黏膜的D_(max)(P=0.014、0.009)、D_(mean)(P<0.001、P=0.033)显著低于D组。结论 3D打印口腔支架在头颈部恶性肿瘤放疗中获得了较好的均匀性与适形度,显著降低口腔周围危及器官的受照剂量,并有效减轻放疗相关急性RTOM、口干燥症和口咽黏膜损伤疼痛的发生和严重程度。

关键词：头颈部肿瘤,恶性口腔支架放射性黏膜炎口干燥症

在线全文

学校读者我要写书评

暂无评论

长链非编码RNA与宫颈癌预后关系研究进展

医学综述 2020年第2期26卷 274-279页

作者：张科杜国波谭榜宪川北医学院临床医学系四川南充637000 川北医学院附属医院肿瘤科四川南充637000

宫颈癌是妇科最常见的恶性肿瘤之一,严重威胁着女性健康。虽然近年来其治疗取得了一定进展,但仍有部分患者在治疗后的2年内发生转移,且预后不良。而长链非编码RNA(lncRNA)在多种恶性肿瘤中异常表达,且与肿瘤的预后密切相关。因此,研究ln... 详细信息

宫颈癌是妇科最常见的恶性肿瘤之一,严重威胁着女性健康。虽然近年来其治疗取得了一定进展,但仍有部分患者在治疗后的2年内发生转移,且预后不良。而长链非编码RNA(lncRNA)在多种恶性肿瘤中异常表达,且与肿瘤的预后密切相关。因此,研究lncRNA在宫颈癌中的表达情况及其与宫颈癌预后的关系对宫颈癌的早期诊断、治疗及预后评价具有重要意义。目前关于宫颈癌lncRNA的研究较多,但大多数为lncRNA在宫颈癌中的表达、lncRNA与临床病理特征及预后关系的研究,其具体机制尚不清楚未来需进一步探索。

关键词：宫颈癌长链非编码RNA 预后异常表达

良性阵发性位置性眩晕与骨质疏松及骨量低下的关系研究

在线全文

学校读者我要写书评

暂无评论

现代医药卫生 2017年第9期33卷 1307-1309页

作者：周晶刘新杜国波川北医学院附属医院神经内科四川南充637000

目的探讨原发性良性阵发性位置性眩晕(BPPV)和骨质疏松及骨量低下之间的关系。方法选择2014年8月至2016年3月收治的原发性BPPV患者102例作为BPPV组,同时选择同期无BPPV发作病史或无现症发作的体检人员150例作为对照组。通过双能X射线吸... 详细信息

目的探讨原发性良性阵发性位置性眩晕(BPPV)和骨质疏松及骨量低下之间的关系。方法选择2014年8月至2016年3月收治的原发性BPPV患者102例作为BPPV组,同时选择同期无BPPV发作病史或无现症发作的体检人员150例作为对照组。通过双能X射线吸收法对两组患者腰椎进行骨密度(BMD)测定诊断骨质疏松、骨量低下,BMD测量结果采用T值表示。采用logistic回归分析BPPV的危险因素。结果 BPPV组患者骨质疏松、骨量低下发生率[55.9%(57/102)]较对照组[25.3%(38/150)]明显升高,差异有统计学意义(P0.05),而大于或等于49岁女性患者T值明显低于对照组,差异有统计学意义(P<0.05)。单因素分析显示,性别与BPPV有相关性;logistic回归分析显示,骨量减少、骨质疏松为BPPV的危险因素(OR=2.8,95%CI 1.32~7.25,P=0.031)。结论原发性BPPV与骨量减少、骨质疏松存在明显相关性,差异主要来源于大于或等于49岁女性患者。

关键词：眩晕骨质疏松年龄因素良性阵发性位置性眩晕骨量低下

头部额叶间变型孤立性纤维性肿瘤/血管外皮细胞瘤1例报道

在线全文

学校读者我要写书评

暂无评论

现代肿瘤医学 2019年第16期27卷 2943-2946页

作者：彭鸥杜国波谭榜宪川北医学院附属医院

神经系统肿瘤分类(WHO-2016)将脑膜孤立性纤维性肿瘤(solitary fibrous tumor,SFT)及血管外皮细胞瘤(hemangiopericytomas,HPC)重新界定为一类疾病[1],为来源于脑膜间叶组织的颅内脑外肿瘤,属于纤维母细胞/肌纤维母细胞来源肿瘤的中间... 详细信息

神经系统肿瘤分类(WHO-2016)将脑膜孤立性纤维性肿瘤(solitary fibrous tumor,SFT)及血管外皮细胞瘤(hemangiopericytomas,HPC)重新界定为一类疾病[1],为来源于脑膜间叶组织的颅内脑外肿瘤,属于纤维母细胞/肌纤维母细胞来源肿瘤的中间性肿瘤,罕见。该肿瘤在中枢神经系统原发性肿瘤中<1%[2,3],多为良性,恶性及间变性极为罕见。现报道收治的1例脑间变SFT,并复习相关文献,讨论该肿瘤的临床病理特征、影像特征、诊断、治疗和预后。

关键词：孤立性纤维性肿瘤/血管外皮细胞瘤诊断 STAT-6 放疗

下调微小RNA-425-5p靶向第10号染色体同源缺失性磷酸酶-张力蛋白调控宫颈癌细胞侵袭和迁移的分子机制

在线全文

学校读者我要写书评

暂无评论

安徽医药 2022年第3期26卷 523-527,F0003页

作者：李敏赵妍丽杜国波川北医学院附属医院肿瘤科四川南充637000

目的研究下调微小RNA(miR)-425-5p靶向第10号染色体同源缺失性磷酸酶-张力蛋白(PTEN)调控宫颈癌Caski细胞侵袭和迁移的分子机制。方法本研究起止时间为2018年12月至2019年11月。以宫颈癌Caski细胞为探讨对象,转染miR-425-5p抑制剂(inhib... 详细信息

目的研究下调微小RNA(miR)-425-5p靶向第10号染色体同源缺失性磷酸酶-张力蛋白(PTEN)调控宫颈癌Caski细胞侵袭和迁移的分子机制。方法本研究起止时间为2018年12月至2019年11月。以宫颈癌Caski细胞为探讨对象,转染miR-425-5p抑制剂(inhibitor),PTENsiRNA和miR-425-5p inhibitor共转染到宫颈癌Caski细胞;MTT法测定细胞增殖,Transwell小室测定细胞侵袭和迁移;在线靶基因预测软件发现PTEN与miR-425-5p可能互为靶向关系,荧光素酶报告系统鉴定靶向关系;蛋白质印迹法(Westernblotting)测定上皮钙黏素(E-cadherin)、神经钙黏素(N-cadherin)蛋白表达。结果转染miR-425-5p inhibitor后的宫颈癌Caski细胞miR-425-5p表达量降低[(0.96±0.15)比(0.32±0.04)],增殖[(0.47±0.05)比(0.23±0.04)]、侵袭[(95.32±7.86)比(63.17±5.22)]及迁移[(140.88±13.94)比(89.64±9.57)]能力降低,E-cadherin表达上调[(0.29±0.05)比(0.65±0.07)],N-cadherin表达下调[(0.59±0.04)比(0.30±0.04)]。miR-425-5p靶向负调控PTEN表达。PTENsiRNA可以逆转下调miR-425-5p对宫颈癌Caski细胞增殖、侵袭和迁移的抑制作用。结论下调miR-425-5p靶向PTEN抑制宫颈癌Caski细胞侵袭和迁移。

关键词：子宫肿瘤 CaSki细胞钙黏着糖蛋白类微小RNA-425-5p 第10号染色体同源缺失性磷酸酶-张力蛋白转移侵袭