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Isotopic evidence for soil water sources and reciprocal movement in a semi-arid degraded wetland:Implications for wetland restoration

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fundamental Research 2023年第6期3卷 861-867页

作者： Yuanchun Zou Sijian Zhang Xiaofei Yu guobin fu Xianguo Lu Heilongjiang Xingkai Lake Wetland Ecosystem National Observation and Research Station&Key Laboratory of Wetland Ecology and Environment&Jilin Provincial Joint Key Laboratory of Changbai Mountain Wetland and Ecology Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China State Environmental Protection Key Laboratory for Wetland Conservation and Vegetation Restoration&Jilin Provincial Key Laboratory of Ecological Restoration and Ecosystem Management&Key Laboratory of Vegetation Ecology of Ministry of Education School of EnvironmentNortheast Normal UniversityChangchun 130117China CSIRO Land and Water Private Bag 5WembleyWA 6913Australia

Understanding water dynamics is a prerequisite for the restoration of degraded ecosystems in arid and semiarid regions.In this study,we carried out δD and δ^(18)O analyses of precipitation,unsaturated soil water,overland flow,surface runoff,and groundwater samples from a seasonally flooded wetland in the Momoge National Nature Reserve of the Songnen Plain,Northeast China,to identify the water sources and understand the mechanisms of unsaturated soil water movement.Unsaturated soil water content(W/W%)at every 20 cm along with a soil profile(0–100 cm)was collected during the growing season,and the HYDRUS-1D model was used to simulate temporal-spatial variations.The results showed that the local meteoric water line(δD=5.90δ18O-7.34,R2=0.95)had a smaller slope and intercept than the global meteoric water line because of strong evaporation at our study site under semi-arid climate.The groundwater was partly recharged by local precipitation via overland flow and unsaturated soil water infiltration.Unsaturated soil water was sourced from both precipitation and groundwater with variations at different depths.The upper soil layer at 0–15 cm was mainly sourced from limited precipitation,while the groundwater could move up to a 25 cm layer during the dry period.The unsaturated soil water content increased with soil depth in the top 40 cm,decreased at depths of 40 to 80 cm,and increased again at depths of 80 to 100 cm.The HYDRUS-1D model could simulate the unsaturated soil water dynamics well in the upper(0–40 cm)and lower(80–100 cm)sections,but poorly for depths of 40–80 cm due to the upward and downward flow.The bidirectional unsaturated soil water movement highlights the importance of capillary groundwater for wetland plants with similar climatic or hydrogeological conditions.

关键词： Water stable isotopes Unsaturated soil water sourcing HYDRUS-1D Degraded wetland restoration Songnen Plain

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Opportunities and challenges of immune checkpoint inhibitors for extensive-stage small-cell lung cancer

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Cancer Innovation 2022年第2期1卷 183-193页

作者： Jing Zhao Xiaoli Zhuo Lei Liu Zhe Yang guobin fu The Department of Oncology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanChina The Department of Oncology The College of Clinical MedicineShandong First Medical University(Shandong Academy of Medical Sciences)JinanChina The Department of Oncology Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinanChina

Small-cell lung cancer(SCLC)accounts for 15%–20%of primary lung cancers,and it is characterized by low differentiation,rapid proliferation,and early metastasis.At least two-thirds of SCLC patients present with the extensive stage(ES)at the time of initial clinical diagnosis.Over the last 2 decades,platinum-based combination chemotherapy has remained the standard first-line treatment for SCLC.With the introduction of the immunotherapy era,immunotherapy plus chemotherapy has replaced conventional chemotherapy as the first-line treatment option for ES-SCLC and is recommended by National Comprehensive Cancer Network clinical guidelines.Therefore,in this review,we present the latest research advances in SCLC treatment,predictive biomarkers,and other topics of high interest to provide options for patients with SCLC.

关键词： small-cell lung cancer immune checkpoint inhibitors molecular typing targeted therapy

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Vegetation dynamics induced by groundwater fluctuations in the lower Heihe River Basin,northwestern China

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Journal of Plant Ecology 2011年第1期4卷 77-90页

作者： Ping Wang Yichi Zhang Jingjie Yu guobin fu Fei Ao Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences11ADatun RoadChaoyang DistrictBeijing 100101China Graduate University of the Chinese Academy of Sciences 19AYuquan RoadBeijing 100049China

Aims Since 2000,the environmental flow controls project has been implemented in the lower Heihe River Basin,a typical arid inland river basin in northwest China,to restore the deteriorated ecological environment in this region.The aim of this study was to explore the impacts of groundwater fluctuations on vegetation dynamics.Our results can be used as a reference for water resources planning and management to maintain proper environmental flows in arid areas.Methods The location(by Global Positioning System)and depth of the monitoring wells,as well as groundwater table depth and salinity were measured in situ at each site from July to August 2009.Based on the measurements of the groundwater table depth and salinity following the implementation of environmental flow controls project(EFCP)in the lower Heihe River Basin,the groundwater fluctuations during the period from 2001 to 2009 were analyzed.Descriptive statistics and Pearson’s correlation were used to analyze the relationship between vegetation changes and groundwater table fluctuations.Additionally,the spatial distributions of the groundwater table depth and salinity were interpolated using the simple kriging method.Trend analysis was applied to the time series of integrated Moderate Resolution Imaging Spectroradiometer normalized difference vegetation index data to identify interannual vegetation dynamics.The relationship between vegetation status and groundwater environment was investigated at different spatial scales by analyzing and comparing the time series and trends.Important Findings(i)The groundwater table and salinity increased significantly in most of the study area with spatial heterogeneity.On average,the groundwater table rose;0.5 and 1.5 m in the upper and lower Ejina Basin,respectively,and the groundwater salinity increased across the study area by 0–4%.(ii)A notable correlation between the vegetation status and the groundwater table was revealed when the groundwater table depth fluctuated between 1.8 and 3.5 m,whereas the vegetation did not

关键词： seasonal average NDVI groundwater table salinity Mann-Kendall method arid area

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Operational Reliability Model of Hybrid MMC Considering Multiple Time Scales and Multi-state Submodule

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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 648-656页

作者： Fei Feng Juan Yu Wei Dai Zhifang Yang Xingpan Zhao Salah Kamel guobin fu State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqing 400044China Chuxiong Power Supply Bureau of Yunnan Power Grid Chuxiong 67500China Electric Power Research Institute State Grid Qinghai Electric Power CompanyXining 810008China

Environmental and electrical factors such as wind speed,air temperature and switching frequency have significant influences on the operational reliability of hybrid modular multilevel converter(MMC),which is commonly used for the wind power transmission.However,the existing reliability model of hybrid MMC based on statistics cannot accurately reflect the impact of these factors.In this paper,a new operational reliability model of hybrid MMC is presented.The reliability index of the hybrid MMC is coupled with its operation characteristics by calculating multi-term thermal cycling.In addition,an operation strategy of hybrid MMC is proposed to improve its reliability.The multi-state submodule(SM)is developed,which is capable of bypassing specific faulty power modules instead of the whole SM.Case studies show that the proposed operational reliability model could describe the impact of environmental and electrical factors.Also,the proposed operation strategy can improve the reliability of hybrid IMMC by extending the operation time of SMs.

关键词： Modular multilevel converter(MMC) multiple time scales submodule(SM) operational reliability thermal cycling

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Recent Changes in Precipitation Extremes in the Heihe River Basin,Northwest China

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Advances in Atmospheric Sciences 2015年第10期32卷 1391-1406页

作者： CHENG Aifang FENG Qi guobin fu ZHANG Jiankai LI Zongxing HU Meng WANG Gang Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences University of Chinese Academy of Sciences CSIRO Land and Water Flagship School of Atmospheric Sciences Lanzhou University Guangzhou Meteorological Satellite Ground Station

Changes in rainfall extremes pose a serious and additional threat to water resources planning and management, natural and artificial oasis stability, and sustainable development in the fragile ecosystems of arid inland river basins. In this study, the trend and temporal variation of extreme precipitation are analyzed using daily precipitation datasets at 11 stations over the arid inland Heihe River basin in Northwest China from 1960 to 2011. Eight indices of extreme precipitation are studied. The results show statistically significant and large-magnitude increasing and decreasing trends for most indices, primarily in the Qilian Mountains and eastern Hexi Corridor. More frequent and intense rainfall extremes have occurred in the southern part of the desert area than in the northern portion. In general, the temporal variation in precipitation extremes has changed throughout the basin. Wet day precipitation and heavy precipitation days show statistically significant linear increasing trends and step changes in the Qilian Mountains and Hexi Corridor. Consecutive dry days have decreased obviously in the region in most years after approximately the late 1980s, but meanwhile very long dry spells have increased, especially in the Hexi Corridor. The probability density function indicates that very long wet spells have increased in the Qilian Mountains. The East Asian summer monsoon index and western Pacific subtropical high intensity index possess strong and significant negative and positive correlations with rainfall extremes, respectively. Changes in land surface characteristics and the increase in water vapor in the wet season have also contributed to the changes in precipitation extremes over the river basin.

关键词： precipitation extremes atmospheric circulation Heihe River basin Northwest China

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Siglec-15与肿瘤免疫关系的研究进展

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中华肿瘤防治杂志 2024年第10期31卷 632-636页

作者：刘子文李涛于源滋付国斌胡锦华山东第一医科大学附属省立医院消化内科山东第一医科大学附属省立医院肿瘤科

目的总结唾液酸结合免疫球蛋白样凝集素-15(Siglec-15)在肿瘤免疫领域的研究进展，以期为肿瘤免疫治疗提供新的理论依据。方法以“Siglec-15、肿瘤、免疫调节、信号通路、免疫治疗”为中文关键词，以“Siglec-15、tumor、immunoregula... 详细信息

目的总结唾液酸结合免疫球蛋白样凝集素-15(Siglec-15)在肿瘤免疫领域的研究进展，以期为肿瘤免疫治疗提供新的理论依据。方法以“Siglec-15、肿瘤、免疫调节、信号通路、免疫治疗”为中文关键词，以“Siglec-15、tumor、immunoregulation、signal pathway、immunotherapy”为英文关键词，系统检索中国知网和PubMed数据库2013-01-01-2023-12-31发表的相关文献。纳入标准：(1)Siglec-15的发现及分子特征；(2)Siglec-15在肿瘤免疫调节中的作用机制及相关信号通路；(3)Siglec-15的免疫治疗前景。排除标准：低质量以及数据陈旧的文献。最终纳入51篇文献进行分析。结果现有研究表明，Siglec-15在多种肿瘤细胞以及肿瘤相关巨噬细胞(TAM)中均高表达。其通过抑制T细胞的活化和增殖来诱导肿瘤的免疫逃逸。此外，Siglec-15还可通过介导特定的分子信号通路调节肿瘤微环境。目前，多种具有抗肿瘤活性的Siglec-15相关药物正在积极开发中，这为肿瘤免疫治疗提供了新的思路。结论近年来，随着程序性死亡受体1(PD-1)及其配体(PD-L1)抗体耐药性问题的出现，Siglec-15可被认为是替代或协同抗PD-1/PD-L1治疗的新兴靶点，有望发挥重要作用。

关键词： Siglec-15 肿瘤免疫调节信号通路免疫治疗

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某型辅助动力装置集油总管检查装置设计研究

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机械管理开发 2024年第5期39卷 189-191,194页

作者：付国斌王振河计鑫中国航发南方工业有限公司湖南株洲412002

集油总管各喷嘴流量分布不均、喷嘴积碳堵塞等原因是导致某型辅助动力装置起动不成功的主要原因之一,现场仅能作目视定性检查,一般需将集油总管返厂检查。参考厂内检查设备工作原理,设计制作一套可用于用户现场检查的检查装置,便于开展... 详细信息

集油总管各喷嘴流量分布不均、喷嘴积碳堵塞等原因是导致某型辅助动力装置起动不成功的主要原因之一,现场仅能作目视定性检查,一般需将集油总管返厂检查。参考厂内检查设备工作原理,设计制作一套可用于用户现场检查的检查装置,便于开展定量检查,准确定位故障并开展现场排故,减少返厂数量,降低对客户的使用影响。另外,该检查装置对解决具有类似结构的辅助动力装置起动困难问题具有一定的参考价值。

关键词：辅助动力装置集油总管检查装置

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某型发动机引射管喷油雾故障研究

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机械管理开发 2024年第4期39卷 262-264,298页

作者：付国斌计鑫王振河中国航发南方工业有限公司湖南株洲412002

针对某型发动机工作过程中引射管喷油雾故障,依据发动机滑油系统结构、工作原理、滑油系统附件工作原理,对故障进行机理分析,制定了故障树和故障排查流程.在实际工作中,应用制定的排查流程进行检查,能快速定位故障点,提高排除故障效率,... 详细信息

针对某型发动机工作过程中引射管喷油雾故障,依据发动机滑油系统结构、工作原理、滑油系统附件工作原理,对故障进行机理分析,制定了故障树和故障排查流程.在实际工作中,应用制定的排查流程进行检查,能快速定位故障点,提高排除故障效率,该流程对排除同类故障具有一定的参考意义.

关键词：发动机滑油系统离心通风器空气-滑油混合液引射管故障树

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准噶尔盆地东部双井子地区上石炭统泥岩地球化学特征及其地质意义

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地质论评 2024年第4期70卷 1512-1532页

作者：邓敏程锦翔唐勇付国斌王正和冯伟明李嵘中国地质调查局成都地质调查中心(西南地质科技创新中心) 成都610213 自然资源部沉积盆地与油气资源重点实验室成都610213 中国石油新疆油田分公司新疆克拉玛依834000 中国石油吐哈油田分公司新疆哈密839000

准噶尔盆地东部石钱滩凹陷石炭系巴塔玛依内山组火山岩之后发育一套连续稳定的碎屑岩沉积。笔者等通过XRD、主微量元素分析等手段针对其中的细粒沉积岩开展元素地球化学研究,其结果对恢复准东地区晚石炭世源区风化特征、古气候、判断其... 详细信息

准噶尔盆地东部石钱滩凹陷石炭系巴塔玛依内山组火山岩之后发育一套连续稳定的碎屑岩沉积。笔者等通过XRD、主微量元素分析等手段针对其中的细粒沉积岩开展元素地球化学研究,其结果对恢复准东地区晚石炭世源区风化特征、古气候、判断其源岩性质及源区构造背景具有重要意义。研究表明,巴山组—石钱滩组泥岩具有低石英含量特点,其中巴山组泥岩黏土含量稍高,而石钱滩组泥岩中长石含量高,两者黏土成份均为蒙脱石(>99%),反映了干燥、寒冷的气候特征且沉积介质长期为碱性;CIA结果显示巴山组—石钱滩组时期经历了中等—弱化学风化作用,并具有干湿交替气候变化特征;主微量元素及相关判别图解显示巴山组—石钱滩组泥岩的源岩多以偏中性的长英质火山岩为主,少量中基性及少量偏酸性的火山岩物源,并且多数为未分异的弧;泥岩的地球化学特征反映了沉积物源区构造背景主要为大陆岛弧背景,结合石钱滩组碎屑锆石峰值年龄及主要物源区分析认为,野马泉地体与其南部的准噶尔地体东北缘于335 Ma左右开始由俯冲转变为碰撞造山。

关键词：准噶尔盆地东部石炭系源岩性质古气候构造背景地球化学特征

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非小细胞肺癌驱动基因突变的中医辨证分型研究进展

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辽宁中医杂志 2024年第5期51卷 201-205页

作者：蒋凤仙禚孝丽赖靖江王景亮刘寨东付国斌山东第一医科大学附属省立医院肿瘤中心山东济南250021 山东中医药大学第二临床医学院山东济南250002 山东第一医科大学(山东省医学科学院)临床医学院山东济南250117 山东中医药大学附属医院肿瘤科山东济南250014 山东大学附属省立医院肿瘤中心山东济南250021

随着基因组学的不断发展,研究者们对非小细胞肺癌的致病机制有了更深层次的认识。相应地,非小细胞肺癌驱动基因与中医证型之间是否存在相关性亦引起了中西医学者密切关注。通过检索万方数据、中国知网、重庆维普、考克兰图书馆(Cochranc... 详细信息

随着基因组学的不断发展,研究者们对非小细胞肺癌的致病机制有了更深层次的认识。相应地,非小细胞肺癌驱动基因与中医证型之间是否存在相关性亦引起了中西医学者密切关注。通过检索万方数据、中国知网、重庆维普、考克兰图书馆(Cochrance Library)、美国生物技术信息中心下属的医学图书检索系统(PubMed)、荷兰医学文摘数据库(Embase)6个数据库尚未发现有非小细胞肺癌驱动基因与中医证型相关性研究进展综述,故该文系统梳理了肺癌主要驱动基因突变的中医证型研究,发现EGFR基因突变的肺癌患者中医证型主要以气阴两虚证和脾虚痰湿证最为常见;EML4-ALK融合基因、KRAS基因突变的肺癌患者中医证型研究较少且未达成共识;对于突变率小于5%的驱动基因BRAF、ROS1、HER2、RET、NTRK、MET阳性肺癌患者的中医证型尚未有研究报道。同时,期望该文能为非小细胞肺癌驱动基因突变的中医辨证分型研究提供线索和在精准靶向时代拓展中西医结合诊断治疗新思路。

关键词：非小细胞肺癌驱动基因中医证型

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