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Intricate roles of estrogen and estrogen receptors in digestive system cancers:a systematic review

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Cancer Biology & Medicine 2024年第10期21卷 898-915页

作者： Xiaoning Gan Guanqi Dai Yonghao Li Lin Xu guolong liu Department of Medical Oncology The Second Affiliated HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China Department of Physiology Michigan State UniversityEast Lansing 48824USA Department of Radiation Oncology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China

Gender disparities are evident across different types of digestive system cancers,which are typically characterized by a lower incidence and mortality rate in females compared to *** finding suggests a potential protective role of female steroid hormones,particularly estrogen,in the development of these *** is a well-known sex hormone that not only regulates the reproductive system but also exerts diverse effects on non-reproductive organs mediated through interactions with estrogen receptors(ERs),including the classic(ERαand ERβ)and non-traditional ERs[G protein-coupled estrogen receptor(GPER)].Recent advances have contributed to our comprehension of the mechanisms underlying ERs in digestive system *** this comprehensive review we summarize the current understanding of the intricate roles played by estrogen and ERs in the major types of digestive system cancers,including hepatocellular,pancreatic,esophageal,gastric,and colorectal ***,we discuss the potential molecular mechanisms underlying ERα,ERβ,and GPER effects,and propose perspectives on innovative therapies and preventive measures targeting the pathways regulated by estrogen and *** roles of estrogen and ERs in digestive system cancers are complicated and depend on the cell type and tissue ***,deciphering the intricate roles of estrogen,ERs,and the associated signaling pathways may guide the discovery of novel and tailored therapeutic and preventive strategies for digestive system cancers,eventually improving the care and clinical outcomes for the substantial number of individuals worldwide affected by these malignancies.

关键词： Estrogen estrogen receptor cancer digestive system cancers gender disparity

Effect of cold rolling process on microstructure and mechanical properties of high strength β titanium alloy thin sheets

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Progress in Natural Science:Materials International 2018年第6期28卷 711-717页

作者： Yan Ma Zhaoxin Du Xiaoming Cui Jun Cheng guolong liu Tianhao Gong Huimin liu Xiaopeng Wang Yuyong Chen School of Materials Science and Engineering Inner Mongolia University of Technology Northwest Institute for Nonferrous Metal Research National Key Laboratory for Precision Hot Forming of Metals Harbin Institute of Technology

The microstructure and mechanical properties of Ti-3.5Al-5Mo-6V-3Cr-2Sn-0.5Fe high strength titanium alloy sheets prepared by unidirectional cold rolling and two-step cross cold rolling were investigated. Results showed that the β phase grains were refined significantly by cold rolling followed by solution treatment for a short *** to unidirectional cold rolling, the short time solution treatment after two-step cross rolling could significantly reduce the non-uniformity of the microstructure of the alloy sheets. After aging treatment at 550 ℃,the anisotropy of the mechanical properties still existed in the unidirectional rolled sheets, and the tensile strength was highest along the rolling direction. After solution and aging treatment, the anisotropy of the mechanical properties of the two-step cross rolling process sheet was not obvious than unidirectional cold rolling,and alloy had good strength and plasticity matching.

关键词： Cold rolling process High strength β titanium alloy Microstructure Mechanical properties

Gonadal mosaicism mediated female-biased gender control in mice

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Protein & Cell 2022年第11期13卷 863-868页

作者： Meizhu Bai Dan Liang Yan Cheng guolong liu Qiudao Wang Jinsong Li Yuxuan Wu State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032China

Dear Editor, In nature or during artificial breeding,evolutionary interven-tion or desirable trait selection could be achieved by means of gender control in an *** reported approaches including sex-sorted semen and genetic manipulation of a certain gene(Holden and Butler,2018;Yosef et al.,2019).In mice,a recent study demonstrated a genetic system for biasing sex ratio through crossing two genetically engineered mouse lines(Yosef et al.,2019).The maternal line encodes functional Cas9 protein on an auto-somal chromosome,whereas the paternal encodes guide RNAs on Y chromosome targeting vital *** fertil-ization,males carrying both Cas9 and guide RNAs were self-destructed,resulting in a female biased sex ***,the litter size is proximate half of normal size since half of the progeny are ***,a reproductive reservoir of males and females must be maintained for ***,we established a mouse line carrying Hspa2 promoted Cas9 and constitutively expressed sgRNA targeting repetitive sequences on Y *** those mice,spermatogenic cells carrying Y chromosome were eliminated during sper-matogenesis,resulting in female biased sex ratio in proge-nies whereas the total number was unaffected.

关键词： female eliminated reservoir

微波辅助萃取油松松针精油的工艺优化及抗氧化活性研究

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食品工业科技 2025年第2期46卷 184-191页

作者：吕素媛商冰清孙璐颜刘国龙赵发梁秀清吴秋耿越山东师范大学食品营养和安全重点实验室山东省动物抗性生物学重点实验室山东师范大学生命科学学院山东省食品药品检验研究院

目的：优化油松松针精油的最佳萃取工艺，并对油松松针精油进行成分分析、抗氧化研究。方法：以响应面法优化微波辅助萃取（Microwave-assisted extraction,MAE）提取油松松针精油的工艺，利用气相色谱-质谱联用仪（Gaschromatography-m... 详细信息

目的：优化油松松针精油的最佳萃取工艺，并对油松松针精油进行成分分析、抗氧化研究。方法：以响应面法优化微波辅助萃取（Microwave-assisted extraction,MAE）提取油松松针精油的工艺，利用气相色谱-质谱联用仪（Gaschromatography-mass spectrometry,GC-MS）对萃取的松针精油进行成分检测，并以DPPH、ABTS+自由基清除能力为指标探究其抗氧化活性。结果：最佳萃取工艺为：萃取时间55 min、微波功率550 W、液料比10:1 mL/g，得率预测值0.245%，优化工艺验证结果为0.238%。从精油中得到的候选化合物共104种，其主要成分有桑贝醇（3.938%）、[1R-（1R*, 3E,7E,11R*,12R*）]-4,8,12,15,15-五甲基[9.3.1]十五碳-3,7-二烯-12-醇（3.597%）等。抗氧化实验中以L-抗坏血酸为对照，测定其DPPH和ABTS+自由基清除能力，其半抑制浓度(Half maximal inhibitory concentration,IC50)分别为101.74和12.39 mg/mL。松针精油浓度为128.00 mg/mL时，DPPH自由基清除率可达64.92%,ABTS+自由基清除率可达84.11%。结论：通过优化微波辅助萃取油松松针精油的工艺，并测定该方法获得的松针精油的主要挥发性成分，证实其抗氧化活性，为开发松针精油绿色高效提取方法及进一步利用松针精油资源提供了理论支持。

关键词：油松松针精油微波辅助萃取响应面分析抗氧化

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Establishment of an astronomical time scale for the Shizigou Formation in the Qaidam Basin,Inner Asia and orbital forced evolution of lakes during The Pliocene

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Research in Cold and Arid Regions 2023年第5期15卷 239-252页

作者： DunZhu JiaoBa MingZhen Zhang guolong liu JianGuo Hui ShaoHua Lin AiJing Li Jing Zhang Jing Peng YiQiao Fu Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhouGansu 730000China University of Chinese Academy of Science Beijing 100049China Key Laboratory of Petroleum Resources Gansu ProvinceLanzhouGansu 730000China Key Laboratory of Mineral Resources in Western China(Gansu Province) Lanzhou UniversityLanzhouGansu 730000China

The Qaidam Basin,as the largest inland basin within the Tibetan Plateau,has accumulated more than 10,000 m of Cenozoic continental *** serves as a crucial research area for documenting Cenozoic climate changes and plateau uplift processes in the Asian ***,the basin holds vast reserves of oil and gas resources,making high-resolution drilling data invaluable for studying *** this study,the longsequence lacustrine deposits of JS1 drill core across the Shizigou Formation in the Yiliping Depression at the western center of the basin were studied,aiming to establish an astronomical timescale for the Shizigou Formation and investigate the characteristics of paleoclimatic changes during the late Miocene to the Pliocene for the Asian *** analysis was carried out using high-resolution natural gamma ray(GR)data sequences,employing techniques such as spectral analysis,filtering,and wavelet analysis in *** results indicated the presence of a stable Milankovitch orbital signal was perfectly recorded in the Shizigou Formation,primarily influenced by eccentricity cycles,with weaker obliquity and precession *** the stable and continuous 405 ka eccentricity cycle in astronomical tuning,a"floating"astronomical timescale with a duration of 6.1 Ma for the Yiliping depression's Shizigou Formation has been *** reference to previously established stratigraphic age anchor points,an absolute astronomical timescale(2.5–8.6 Ma)has been ultimately provided for the Shizigou ***,a clear 100 ka short eccentricity cycle record has been identified during the Pliocene(5.3–2.5 Ma),which corresponds in time with the aridification within the basin during this Pliocene *** addition,a comparison of the Pliocene natural gamma ray curve of the Qaidam Basin with global ice volume variations indicated that the basin's aridification was influenced by global cooling,with eccentricity-modulated prec

关键词： Qaidam basin Shizigou Formation Astronomical time scale Astronomical tuning~100 ka orbital eccentricity

Super Resolution Perception for Improving Data Completeness in Smart Grid State Estimation

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Engineering 2020年第7期6卷 789-800页

作者： Gaoqi Liang guolong liu Junhua Zhao Yanli liu Jinjin Gu Guangzhong Sun Zhaoyang Dong School of Science and Engineering Chinese University of Hong KongShenzhenShenzhen 518172China School of Computer Science and Technology University of Science and Technology of ChinaHefei 230027China Shenzhen Institute of Artificial Intelligence and Robotics for Society Shenzhen 518172China School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China School of Electrical Engineering and Telecommunications University of New South WalesSydneyNSW 2052Australia

The smart grid is an evolving critical infrastructure,which combines renewable energy and the most advanced information and communication technologies to provide more economic and secure power supply *** cope with the intermittency of ever-increasing renewable energy and ensure the security of the smart grid,state estimation,which serves as a basic tool for understanding the true states of a smart grid,should be performed with high *** complete system state data are needed to support high-frequency state *** data completeness problem for smart grid state estimation is therefore studied in this *** problem of improving data completeness by recovering highfrequency data from low-frequency data is formulated as a super resolution perception(SRP)problem in this paper.A novel machine-learning-based SRP approach is thereafter *** proposed method,namely the Super Resolution Perception Net for State Estimation(SRPNSE),consists of three steps:feature extraction,information completion,and data *** studies have demonstrated the effectiveness and value of the proposed SRPNSE approach in recovering high-frequency data from low-frequency data for the state estimation.

关键词： State estimation Low-frequency data High-frequency data Super resolution perception Data completeness

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高速垂向运动声源声场干涉特性及其可观测性

声学学报 2023年第6期48卷 1081-1097页

作者：赵春鹏梁国龙邱龙皓付进柳国龙哈尔滨工程大学水声技术全国重点实验室哈尔滨150001 工业和信息化部海洋信息获取与安全工信部重点实验室(哈尔滨工程大学) 哈尔滨150001 哈尔滨工程大学水声工程学院哈尔滨150001

以高速垂向运动声源宽带连续谱噪声为研究对象,基于射线理论分析了声场干涉现象的产生机理,推导了干涉条纹的轨迹方程,讨论了影响干涉结构特性的因素,揭示了声场干涉结构的特性和规律。理论和仿真结果表明:干涉周期与多途信号时延差成... 详细信息

以高速垂向运动声源宽带连续谱噪声为研究对象,基于射线理论分析了声场干涉现象的产生机理,推导了干涉条纹的轨迹方程,讨论了影响干涉结构特性的因素,揭示了声场干涉结构的特性和规律。理论和仿真结果表明:干涉周期与多途信号时延差成反比关系;减小接收深度或增大接收距离可以提高干涉条纹的可观测性;较大的海面起伏易使干涉条纹形成断点,可观测性降低。湖试数据分析结果表明,干涉条纹主要由直达声-海面反射声干涉条纹构成,干涉条纹宽度和干涉周期随水平距离的增大而增大。该结果可为高速垂向运动声源运动状态分析、环境参数反演等提供参考。

关键词：声场干涉特性干涉条纹水下动目标观测浅海波导随机海面起伏

Effects of High Pressure Treatment on Microstructure and Electrical Conductivity of CuCrAI Alloy

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材料科学与工程（中英文A版） 2012年第5期2卷 454-457页

作者： Xuemei Yang Jingrui Cai guolong Li Jianhua liu Ruijun Zhang State Key Laboratory of Metastable Materials Science and Technology Yan Shan University Qinhuangdao 066004 China

改性凹凸棒土-氧化石墨烯/环氧树脂复合材料的力学性能和热电性能

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复合材料学报 2020年第5期37卷 1056-1062页

作者：孙琦周宏张航刘国隆哈尔滨理工大学材料科学与工程学院哈尔滨150040 哈尔滨理工大学工程电介质及其应用教育部重点实验室哈尔滨150080

分别用硅烷偶联剂KH560改性凹凸棒土(Attapulgite,ATP)和氧化石墨烯(Graphene oxide,GO),并将其复合制备ATP-GO复合物。以环氧树脂(Epoxy,EP)为基体,采用原位聚合法制备ATP-GO/EP复合材料。采用SEM和FTIR对ATP-GO复合物的形貌和化学结... 详细信息

分别用硅烷偶联剂KH560改性凹凸棒土(Attapulgite,ATP)和氧化石墨烯(Graphene oxide,GO),并将其复合制备ATP-GO复合物。以环氧树脂(Epoxy,EP)为基体,采用原位聚合法制备ATP-GO/EP复合材料。采用SEM和FTIR对ATP-GO复合物的形貌和化学结构进行表征。结果表明:ATP与GO成功键合并附着在GO表面;ATP-GO的加入,提高了EP的冲击强度、弯曲强度和热稳定性,降低了其介电常数和介电损耗。3wt%ATP-0.5wt%GO/EP复合材料的弯曲强度和冲击强度分别为138.58 MPa和20.80 kJ/m^2,比纯EP分别提高了75.5%和351.6%,而其介电常数和介电损耗分别低至3.36和0.0118,比纯EP降低了7.7%和27.3%。

关键词：环氧树脂凹凸棒土氧化石墨烯复合材料力学性能