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Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

Neural Regeneration Research 2024年第9期19卷 1890-1898页

作者： Qiuqin Han Wenhui Li Peiqing Chen Lijuan Wang Xiwen Bao Renyan Huang guobin liu Xiaorong Chen Department of Scientific Research Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina Department of Traditional Chinese Vascular Surgery Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Physiology Laboratory of Neurodegenerative DiseasesChangzhi Medical CollegeChangzhiShanxi ProvinceChina

Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological diseases.In patients with major depressive disorder,NLRP3 inflammasome levels are significantly elevated.Understanding the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic strategies.In this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 inflammasome.Moreover,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating depression.Additionally,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to depression.Currently,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression treatment.The modulation of NLRP3 inflammasomes in microglia holds promise for the management of depression.Further investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments.

关键词： depression microglia neuroinflammation NLRP3 inflammasome

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Regulating the inner Helmholtz plane structure at the electrolyte-electrode interface for highly reversible aqueous Zn batteries

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Journal of Energy Chemistry 2024年第8期95卷 57-67页

作者： Jianghe liu Sanlue Hu Hexin Guo guobin Zhang Wen liu Jianwei Zhao Shenhua Song Cuiping Han Baohua Li Shenzhen Key Laboratory on Power Battery Safety and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen Key Laboratory of Advanced Materials School of Materials Science and Engineering Harbin Institute of Technology Faculty of Materials Science and Energy Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen HUASUAN Technology Co. Ltd.

The development of aqueous Zn batteries is limited by parasitic water reactions,corrosion,and dendrite growth.To address these challenges,an inner Helmholtz plane（IHP） regulation method is proposed by employing low-cost,non-toxic maltitol as the electrolyte additive.The preferential adsorption behavior of maltitol can expel the water from the inner Helmholtz plane,and thus hinder the immediate contact between Zn metal and H2O.Meanwhile,strong interaction between maltitol and H2O molecules can restrain the activity of H2O.Besides,the "IHP adsorption effect" along with the low LUMO energy level of maltitol-CF3SO3-can promote the in-situ formation of an organic-inorganic complex solid electrolyte interface（SEI） layer.As a result,the hydrogen/oxygen evolution side reaction,corrosion,and dendrites issues are effectively suppressed,thereby leading to highly reversible and dendrite-free Zn plating/stripping.The Zn‖I2battery with hybrid electrolytes also demonstrates high electrochemical performance and ultralong cycling stability,showing a capacity retention of 75% over 20000 charge-discharge cycles at a large current density of 5 A g-1.In addition,the capacity of the device has almost no obvious decay over20000 cycles even at-30℃.This work offers a successful electrolyte regulation strategy via the IHP adsorption effect to design electrolytes for high-performance rechargeable Zn-ion batteries.

关键词： Adsorption effect Dendrite suppression Inner Helmholtz plane SEI layer Zn||I2 battery

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Presence of a long nuclear-localization signal sequence in homeodomain transcription factor Nkx 1.2

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Journal of Oceanology and Limnology 2024年第2期42卷 620-626页

作者： Xinyi LI Lihui CHEN Xinyuan WANG Chen SUN Guangdong JI guobin HU Zhenhui liu College of Marine Life Science and Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdao 266003China Laoshan Laboratory Qingdao 266237China

Homeodomains,a 60-amino acid sequence encoded by 180 nucleotides,are highly conserved DNA-binding motifs that are present in a variety of transcription factors in species ranging from yeast to humans.The NKX proteins belong to the homeodomain(HD)-containing transcription factor family.They play vital roles in the regulation of morphogenesis.NKX1-2 is one member of the NKX subfamily.At present,information about its nuclear localization signal(NLS)sequence is limited.We studied the NLS sequence of zebrafish Nkx1.2 by introducing sequence changes such as deletion,mutation,and truncation,and identified an NLS motif(QNRRTKWKKQ)that is localized at the C-terminus of the homeodomain.Moreover,the deletion of two amino acid residues(RR)in this NLS motif prevents Nkx1.2 from entering the nucleus,indicating that the two amino acids are essential for Nkx1.2 nuclear localization.However,the NLS motif alone is unable to target cytoplasmic protein glutathione S-transferase(GST)to the nucleus.An intact homeodomain is necessary for mediating the complete nuclear transport of cytoplasmic protein.Unlike most nuclear import proteins with short NLS sequences,a long NLS is present in zebrafish Nkx1.2.We also demonstrated that the sequences of homeodomain of NKX1.2 are well conserved among different species.This study is informative to verify the function of the NKX1.2 protein.

关键词： NKX1.2 NKX protein homeodomain nuclear localization signal(NLS) nuclear transport

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M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes

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Science China(Life Sciences) 2024年第3期67卷 579-595页

作者： Yuzhen Hu Li Jiang Guangwen Wang Yangming Song Zhibo Shan Xuyuan Wang Guohua Deng Jianzhong Shi guobin Tian Xianying Zeng Liling liu Hualan Chen Chengjun Li State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China

Influenza A virus(IAV) commandeers numerous host cellular factors for successful replication. However, very few host factors have been revealed to be involved in the fusion of viral envelope and late endosomal membranes. In this study, we identified cation-dependent mannose-6-phosphate receptor(M6PR) as a crucial host factor for the replication of IAV. We found that siRNA knockdown of M6PR expression significantly reduced the growth titers of different subtypes of IAV, and that the inhibitory effect of M6PR siRNA treatment on IAV growth was overcome by the complement of exogenously expressed M6PR. When A549 cells were treated with siRNA targeting M6PR,the nuclear accumulation of viral nucleoprotein(NP) was dramatically inhibited at early timepoints post-infection, indicating that M6PR engages in the early stage of the IAV replication cycle. By investigating the role of M6PR in the individual entry and post-entry steps of IAV replication, we found that the downregulation of M6PR expression had no effect on attachment, internalization, early endosome trafficking,or late endosome acidification. However, we found that M6PR expression was critical for the fusion of viral envelope and late endosomal membranes. Of note, M6PR interacted with the hemagglutinin(HA) protein of IAV, and further studies showed that the lumenal domain of M6PR and the ectodomain of HA2 mediated the interaction and directly promoted the fusion of the viral and late endosomal membranes,thereby facilitating IAV replication. Together, our findings highlight the importance of the M6PR–HA interaction in the fusion of viral and late endosomal membranes during IAV replication.

关键词： influenza A virus M6PR HA membrane fusion late endosome

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Interactions between soil conservation and dryland farming of heterogeneously eroding areas in Loess Hills,China

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International Soil and Water Conservation Research 2022年第4期10卷 574-585页

作者： Boyang Sui Xiaohu Dang Liangxin Fan Bo Guo Wei Bi guobin liu College of Geology and Environment Xi'an University of Science and TechnologyXi'an710054China College of Geomatics and Land Information Engineering Henan Polytechnic UniversityJiaozuo454000China College of Geomatics Xi'an University of Science and TechnologyXi'an710054China Institute of Soil and Water Conservation Chinese Academy of Science and Ministry of Water ResourcesYangling712100China

The unidirectional impacts of soil conservation on dryland farming and local livelihood have been well studied.However,there are gaps in literature regarding the interactions among factors,such as labor force and financial capital,in response to soil conservation,as well as the influence of such interactions on the relationships between environmental projects and agricultural development.By combining the Chinese Soil Loss Equation(CSLE)model and statistical analyses,this study investigated the spatiotemporal characteristics of soil erosion while also identifying the controlling factors that affect crop and livestock farming.The aim was to reveal how these factors interacted to influence agriculture in two case study areas between 2000 and 2017.The results showed that soil erosion substantially declined as a consequence of soil conservation,while the output from crop farming increased,indicating that there was a synergy between soil conservation and dryland farming in both the districts,over time;and factors facilitating crop farming,such as labor force,agricultural machinery,and irrigation,appeared to exert an adverse effect on livestock farming in both areas,implying a tradeoff between livestock and crop farming in the context of programs such as the Grain for Green Program(GGP)in the Loess Hills.Such a tradeoff is a result of the competition for cropland and labor that exists due to grazing prohibition and rural-urban migration.Therefore,policy-related resolutions are required to address the land use conflicts and migration-related rural labor losing due to implementation of the GGP in the Loess Hills.

关键词： Heterogeneous erosion environment Soil conservation Dryland farming Tradeoff/synergy of conservation and agriculture Loess hills

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Inactivated H9N2 vaccines developed with early strains do not protect against recent H9N2 viruses:Call for a change in H9N2 control policy

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Journal of Integrative Agriculture 2024年第6期23卷 2144-2148页

作者： Yanjing liu Qingqing Yu Xiangyu Zhou Wenxin Li Xinwen He Yan Wang Guohua Deng Jianzhong Shi guobin Tian Xianying Zeng Hualan Chen College of Veterinary Medicine Gansu Agricultural UniversityLanzhou 730070China State Key Laboratory for Animal Disease Control and Prevention Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry DiseasesMinistry of Agriculture and Rural Affairs/Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China National Poultry Laboratory Animal Resource Center Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China Harbin Weike Biotechnology Co. Ltd.Harbin 150009China

H9N2 virus has been widely distributed in wild birds and poultry around the world since its first emergence in the United States of America in 1966(Gu et al.2017;Carnaccini and Perez 2020).The virus appeared in chickens in China in the early 1990s,and over the last two decades has gradually become the dominant epidemic subtype(Sun and liu 2015;Bi et al.2020).Although H9N2 virus infection alone cannot cause severe disease or death in poultry,H9N2 virus-infected birds experience a degree of egg production drop and can be easily infected by other pathogens,thus causing economic losses for poultry industry.

关键词： H9N2 poultry policy

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Effects of nitrogen addition on plant-soil-microbe stoichio-metry characteristics of different functional group species in Bothriochloa ischemum community

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Soil Ecology Letters 2022年第4期4卷 362-375页

作者： ZiWen Zhao YanLi Qin Yang Wu WenJing Chen Sha Xue guobin liu State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Institute of Soil and Water ConservationNorthwest A&F UniversityYangling 712100China Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water ResourcesYangling 712100China Key Laboratory of National Forestry and Grassland Administration on Ecological Hydrology and Disaster Prevention in Arid Regions Xi'an University of TechnologyXi'an 710048China

Nitrogen(N)deposition,the source of N input into terrestrial ecosystems,is exhibiting an increasingly serious impact on the biogeochemical cycle and functional stability of ecosystems.Grasslands are an important component of terrestrial ecosystems and play a key role in maintaining terrestrial ecosystem balance.Therefore,it is critical to understand the effects of nitrogen addition on grassland ecosystems.We conducted gradientN addition experiments(0,3,6,and 9 g N m^(-2)2 y^(-1))for threeyears ingrassland communities with similar site conditions.We utilized four typical herbaceous plants,including the dominant species Bothriochloa ischemum(B.ischemum)and companion species Stipa bungeana(S.bungeana),Artemisia gmelinii(A.gmelinii),and Cleistogenes squarrosa(C.squarrosa),to explore how different plant-soil-microbe systems respond to N addition.Stoichiometric homeostasis analysis demonstrated that both plants and microbes were strictly homeostatic.However,the companion species were found to be more susceptible to P dominant species.Furthermore,aggravated overlap in stoichiometric niches between plant species were observed at the N6 and N9 levels.Vector analysis indicated that the vector angle was>45°regardlessof plant species and N levels,suggesting that there was a strong Plimitation in the rhizosphere microbial community.Variation partitioning analysis revealed that the Composite roots exhibited a greater effect(explaining 34.7% of the variation)on the rhizosphere microbes than on the Gramineae,indicating that there may be more intense nutrient competition in its rhizosphere.Ingeneral,the effects of N addition on species were different a cross functional groups,with a significant positive effect on the Gramineae(B.ischemum,S.bungeana,and C.squarrosa)and a significant negative effecton the Compositae(A.gmelinii),which should be fully considered in the future ecological management and restoration.

关键词： N addition Ecological stoichiometry Stoichiometric homeostasis Nutrient limitation Stoichiometric niche Plant-soil-microbe system

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Invasibility and recoverability of a plant community following invasion depend on its successional stages

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Soil Ecology Letters 2022年第2期4卷 171-185页

作者： Hongwei Xu Zemin Ai Qing Qu Minggang Wang guobin liu Sha Xue State Key Laboratory of Soil Erosion and Dryland Farming on Loess Plateau Institute of Soil and Water ConservationChinese Academy of Sciences and Ministry of Water ResourcesYangling 712100China College of Geomatics Xi'an University of Science and TechnologyXi'anShaanxi 710054China Institute of Soil and Water Conservation Northwest A&F UniversityYangling712100China University of Chinese Academy of Sciences Beijing 100049China Research Center of Forest Management Engineering of State Forestry and Grassland Administration Beijing Forestry UniversityBeijing 100083China

Exotic species invasion represent important causes of harming the structure,function,and ecological environment in ecosystems.Yet,knowledge remains limited on the invasibility(invasion advantage of exotic species)and recoverability(recovery ability of native species)of a plant community following invasion depend on its successional stages.We selected three grasses of Setaria viridis,Artemisia gmelinii,and Bothriochloa ischemum representing early(E),middle(M),and late(L)successional species,respectively.Meanwhile,the grasses of Panicum virgatum was selected to represent exotic species(invasion species).Three types of soil were collected to treat the three E,M,and L successional species,and one type of soil was collected to treat the exotic species.We compared the performance of the three native plant species and one exotic species grown in their“own”and“other”soils in a 2-year greenhouse experiment.Our study showed that exotic species performed better in soils of E and M successional species than in the soil of L successional species.After exotic species removed,E and M successional species exhibited poor growth in the soil of exotic species,while that of L successional species performed poor in field exotic species soils,but performed better in soils disturbed by exotic species.Our study demonstrated that the invasibility and recoverability of native plant communities changed with vegetation succession.

关键词： Invasion advantage Recovery advantage Plant growth Exotic species Grass Greenhouse experiment

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Long-term warming does not affect soil ecoenzyme activity and original microbial nutrient limitation on the Qinghai-Tibet Plateau

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Soil Ecology Letters 2022年第4期4卷 383-398页

作者： Yuanze Li Huakun Zhou Wenjing Chen Yang Wu Lei Lei Qiao ZiRan Yan guobin liu Sha Xue State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Institute of Soil and Water ConservationNorthwest A&F UniversityYangling 712100China Qinghai Provincial Key Laboratory of Restoration Ecology in Cold Regions Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810000China State Key Laboratory of Plateau Ecology and Agriculture Qinghai UniversityXining 810000China Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry Water ResourcesYangling 712100China College of Natural Resources and Environment Northwest A&F UniversityYangling 712100China

Microbes play an important role in the carbon cycle and nutrient flow of the soil ecosystem.However,the response of microbial activities to long-term warming over decades is poorly understood.To determine how warming changes ecoenzyme activity and microbial nutrient limitation,we conducted a long-term,21 years,experiment,on the Qinghai–Tibet Plateau.We selected typical grass-and shrub-covered plots,used fiberglass open-top chambers(OTCs)to raise the temperature,conducted soil sampling at different depths,studied the response of nutrient-acquiring enzyme activity and stoichiometry,and conducted vector analysis of stoichiometry.Our results showed that long-term warming did not have a notable effect on the activity of nutrient-acquiring enzymes or enzymatic stoichiometry.However,Spearman correlation analysis indicated a significant and positive correlation between ecoenzyme activity and the available nutrients and microbial biomass in soil.Vector analysis of stoichiometry showed phosphorus limitation for all soil microbes at different depths,regardless of whether the soil experienced warming.These changes in enzymatic stoichiometry and vector analysis suggested that microbial nutrient limitation was not alleviated substantially by long-term warming,and warming did not considerably affect the stratification of microbial nutrient limitation.Our research has also shown that long-term warming does not significantly change soil ecoenzyme activity and original microbial nutrient limitation at different soil depths within the OTUsʼimpact range.These results could help improve understanding of microbial thermal acclimation and response to future long-term global warming.

关键词： Global warming Ecoenzymatic stoichiometry Microbial nutrient limitation Thermal acclimation Qinghai-Tibet Plateau

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数字经济与农业农村信息化协调发展的时空演化及障碍因素解析

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情报科学 2024年第4期42卷 43-54,88页

作者：刘国斌冯博吉林大学生物与农业工程学院吉林长春130012

【目的/意义】数字经济与农业农村信息化协调发展对于加快中国式现代化发展具有重要意义。【方法/过程】在理论分析基础上构建评价指标体系,利用熵值法测度数字经济与农业农村信息化协调发展的水平并进行时空演化特征分析。同时,采用障... 详细信息

【目的/意义】数字经济与农业农村信息化协调发展对于加快中国式现代化发展具有重要意义。【方法/过程】在理论分析基础上构建评价指标体系,利用熵值法测度数字经济与农业农村信息化协调发展的水平并进行时空演化特征分析。同时,采用障碍度模型分析二者协调发展的障碍因素,进而提出相关建议。【结果/结论】研究表明:2012-2021年全国层面和四大区域层面数字经济与农业农村信息化协调发展水平均呈现增长态势;全国数字经济与农业农村信息化协调发展在空间变化上表现出“核心-外围”特征,各地区数字经济与农业农村信息化协调发展水平在空间上表现出“东强西弱”的特征;各地区障碍因素不同。在此基础上,有针对性地提出相关建议。【创新/局限】本文将数字经济与农业农村信息化纳入统一分析框架,并且引入障碍度模型对数字经济与农业农村信息化协调发展的障碍因素进行具体分析,在实证分析方面有所拓展,但忽略了空间计量的系统分析,后续研究仍需深化。

关键词：数字经济农业农村信息化协调发展时空演化障碍度分析

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