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Hepatitis C Virus non-structural 5A abrogates signal transducer and activator of transcription-1 nuclear translocation induced by IFN-α through dephosphorylation

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World Journal of Gastroenterology 2007年第30期13卷 4080-4084页

作者： guo-zhong Gong Jie cao Yong-Fang Jiang Yang Zhou Bo Liu Institute of Hepatology and Department of Infectious Diseases The Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

AIM： To study the effect of Hepatitis C virus nonstructural 5A （HCV NSSA） on IFNα induced signal transducer and activator of transcription-1 （STAT1） phosphorylation and nuclear translocation.METHODS： Expression of STAT1 Tyr701 phosphorylation at different time points was confirmed by Western blot, and the time point when p-STAT1 expressed most, was taken as the IFN induction time for further studies. Immunocytochemistry was used to confirm the successful transient transfection of NS5A expression plasmid. Immunofluorescene was performed to observe if there was any difference in IFNα-induced STAT1 phosphorylation and nuclear translocation between HCV NSSA-expressed and non-HCV NSSA-expressed cells. Western blot was used to compare the phosphorylated STAT1 protein of the cells.RESULTS： Expression of HCV NS5A was found in the cytoplasm of pCNS5A-transfected Huh7 cells, but not in the PRC/ CMV transfected or non-transfected cells, STAT1 Tyr701 phosphorylation was found strongest in 30 min of IFN induction, STAT1 phosphorylation and nuclear import were much less in the presence of HCV NS5A protein in contrast to pRC/CMV-transfected and non-transfected cells under fluorescent microscopy, which was further confirmed by Western blot.CONCLUSION： HCV NSSA expression plasmid is successfully transfected into Huh7 cells and HCV NS5A protein is expressed in the cytoplasm of the cells. IFN-α is able to induce STAT1 phosphrylation and nuclear translocation, and this effect is inhibited by HCV NS5A protein, which might be another possible resistance mechanism to interferon alpha therapy.

关键词： Hepatitis C virus nonstructural protein 5A IFN-α Signal transducer and activator of transcription (STAT1) Phosphorylation Nuclear translocation

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Trivalent Ni oxidation controlled through regulating lithium content to minimize perovskite interfacial recombination

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Rare Metals 2022年第1期41卷 96-105页

作者： Jin-Jin Zhao Xiao Su Zhou Mi Ying Zhang Yan-Jun Hu Hua-Jun guo Yi-Nan Jiao Yu-Xia Zhang Yan Shi Wei-zhong Hao Jing-Wei Wu Yi Wang Cun-Fa Gao guo-zhong cao School of Materials Science and Engineering School of Mechanical EngineeringShijiazhuang Tiedao UniversityShijiazhuang 050043China School of Materials Science and Engineering Hebei Key Laboratory of Material Near Net Forming TechnologyHebei University of Science and TechnologyShijiazhuang 050018China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Materials Science and Engineering University of WashingtonSeattleWA 98195-2120USA

Organic–inorganic hybrid perovskite solar cells,one of the most promising photovoltaic devices,have made great progress in their efficiency and preparation *** this study,uniform,highly conductive Li_(n)NiO_(x)(0≤n... 详细信息

关键词： Lithium ions Ni^(3+) Oxidized defect Photocurrent Perovskite solar cells

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Hydrogen Bonds in Perovskite for Efficient and Stable Photovoltaic

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Chinese Journal of Chemistry 2024年第11期42卷 1284-1306页

作者： Tian-yun Wang Yang-yang Hao Ming-zhe Zhu guo-rui cao zhong-min Zhou College of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyQingdaoShandong266042 China College of Chemical Engineering Qingdao University of Science and TechnologyQingdaoShandong266042 China

Owing to their distinctive optical and physical properties,organic-inorganic hybrid perovskite materials have gained significant attention in the field of electronic devices,especially solar *** achievement of high-performance solar cells hinges upon the utilization of top-notch perovskite thin ***,the fabrication process involving solutions and the polycrystalline nature of perovskite result in the emergence of numerous defects within the perovskite films,consequently exerting a deleterious influence on the overall performance and stability of the *** the performance and stability of perovskite solar cells by additive engineering to suppress/passivate defects is a viable approach,which involves hydrogen bond interactions in these device engineering *** review explores the intrinsic hydrogen bonds in methylammonium and formamidium lead triiodide,while also considering cation rotations,phase transitions,and ***,the review classifies additives into distinct categories,including organic small molecules,polymers,nanodots,classical salts,ionic liquids,and molten *** various forms and characterization techniques of hydrogen bonds are discussed,as well as their potential synergistic effects in conjunction with other chemical ***,this review offers insights into the potential utilization of hydrogen bonds to further enhance the performance and stability of devices.

关键词： Perovskite solar cells Hydrogen bond Additive Performance Stability Charge transfer Inhibition Cooperative effects

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In situ anchoring in carbon matrix of Bi_(2)O_(2)CO_(3) as a high-performance anode material for Li-ion batteries

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Rare Metals 2024年第8期43卷 3634-3646页

作者： Pu-Qiang He Jun guo Hui Huang zhong-Cheng guo Faculty of Metallurgy and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Research Center of Metallurgical Electrode Materials Engineering Technology Kunming 650106China Kunming Hendera Science and Technology Co. Ltd.Kunming 650106China

Bismuth-based anode materials have been regarded as promising Li-ion batteries due to their high theoretical ***,their low conductivity and associated volume expansion inhabited their *** this work,Bi_(2)O_(2)CO_(3)@C composites were successfully synthesized by in situ anchoring of flower-like Bi_(2)O_(2)CO_(3) nanosheets on a carbon-based substrate via *** unique composited structure of Bi_2O_(2)-CO_(3)@C leads to a stable specific capacity of 547 mAh·g^(-1)after 100 cycles at a current density of 0.1 A·g^(-1).Notably,it demonstrates excellent rate capability with a specific capacity of 210 mAh·g^(-1)at 5 A·g^(-1).After 550 cycles at a current density of 0.5 A·g^(-1),a high reversible capacity of nearly 400 mAh·g^(-1)was ***,in situ X-ray diffraction measurements clearly demonstrate the conversion between Bi and Li_(3)Bi during alloying/dealloying,confirming the good electrochemical reversibility of the materials for Li *** reaction kinetics of Bi_(2)O_(2)CO_(3)@C were further investigated using galvanostatic intermittent titration ***,Bi_2O_(2)-CO_(3)@C exhibited excellent long-term stability,maintaining its high reversible capacity for over 200 cycles at a current density of 0.5 A·g^(-1)in a full cell configuration using Li_(1.20)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2) as the cathode *** result further underscores its promising potential for lithium-ion *** work may provide inspiration for the design of alloy-type negative electrode materials for high-performance rechargeable batteries.

关键词： Bi_(2)O_(2)CO_(3) Composite materials Anode materials Full batteries

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Impacts of pancreatic exocrine insufficiency on gut microbiota

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 271-279页

作者： Yulin guo Feng cao Fei LI Department of General Surgery Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Acute Pancreatitis Clinical Center of Capital Medical University Beijing 100053China

Pancreatic exocrine insufficiency(PEI)can be induced by various kinds of diseases,including chronic pancreatitis,acute pancreatitis,and *** main pathogenetic mechanism of PEI involves the decline of trypsin synthesis,disorder of pancreatic fluid flow,and imbalance of secretion *** studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis,with the abundance of Lactobacillus and Bifidobacterium increasing the most,which could be partially reversed by pancreatic enzyme replacement *** studies have also confirmed the association between PEI and the dysbiosis of gut *** exocrine secretions and changes in duodenal p H as well as bile salt malabsorption brought about by PEI may affect and shape the abundance and composition of gut *** turn,the gut microbiota may impact the pancreatic exocrine acinus through potential bidirectional *** forward,more and higher-quality studies are needed that focus on the mechanism underlying the impact of PEI on the gut microbiota.

关键词： Pancreatic exocrine insufficiency Gut microbiota Gut microbiome Pancreatic enzyme replacement therapy

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Influence of bolt dynamic installation on topography characteristics and mechanical behaviors of CFRP interference-fit bolted joints

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Chinese Journal of Aeronautics 2024年第2期37卷 482-500页

作者： Xiaohe WANG Zengqiang cao Yuehaoxuan WANG Yingjiang guo School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China NPU Xuhang Electromagnetic Technology Co. Ltd.Xi’an 710100China

As the controlled research of Dynamic Installation(DI)and Static Installation(SI),a new interference installation method was developed based on electromagnetic loading to enhance the mechanical properties of composite *** different interference-fit sizes were considered,ranging from a net fit to 2.0%.The experiments were conducted to evaluate the installation resistance and the mechanical behavior of the joint under external ***,an FFA model to model the stress distribution and damage behavior of the bolt-hole contact interface was *** load-displacement curve and damage modes of experiments were used to verify the FEA *** results show that the installation resistance during DI process was remarkably lower than that of SI process corresponding to all interference-fit sizes,and the stress amplitudes induced by interference were larger and widely *** damage of the hole wall was positively correlated with interference fit size,but DI can significantly reduce the damage compared to *** performance tests,DI enhanced the static bearing capacity and extended longer fatigue life of the joints than *** methods can be an effective way to achieve highly reliable interference joints in composite structures.

关键词： Carbon Fiber-Reinforced Polymer(CFRP) Bolted joints Interference-fit Electromagnetic installation Finite Element Analysis(FEA) Damage mechanics Bearing behavior

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NeurstrucEnergy:A bi-directional GNN model for energy prediction of neural networks in IoT

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Digital Communications and Networks 2024年第2期10卷 439-449页

作者： Chaopeng guo Zhaojin zhong Zexin Zhang Jie Song Software Campus Northeastern UniversityShenyang110000LiaoningChina

A significant demand rises for energy-efficient deep neural networks to support power-limited embedding devices with successful deep learning applications in IoT and edge computing *** accurate energy prediction approach is critical to provide measurement and lead optimization ***,the current energy prediction approaches lack accuracy and generalization ability due to the lack of research on the neural network structure and the excessive reliance on customized training *** paper presents a novel energy prediction model,*** treats neural networks as directed graphs and applies a bi-directional graph neural network training on a randomly generated dataset to extract structural features for energy *** has advantages over linear approaches because the bi-directional graph neural network collects structural features from each layer's parents and *** results show that NeurstrucEnergy establishes state-of-the-art results with mean absolute percentage error of 2.60%.We also evaluate NeurstrucEnergy in a randomly generated dataset,achieving the mean absolute percentage error of 4.83%over 10 typical convolutional neural networks in recent years and 7 efficient convolutional neural networks created by neural architecture *** code is available at https://***/NEUSoftGreenAI/***.

关键词： Internet of things Neural network energy prediction Graph neural networks Graph structure embedding Multi-head attention

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Numerical study of the influence of the atmospheric pressure on the thermal environment in the passenger cabin

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Building Simulation 2024年第2期17卷 253-265页

作者： Xin Su Yu guo Zhengwei Long Yi cao Tianjin Key Lab.of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin300072China Shanghai Aircraft Design and Research Institute Jinke RoadPudong DistrictShanghai201210China

The cabin air pressure remains lower than the horizontal atmospheric pressure when the airplane is in *** pressure is one of the parameters that must be taken into consideration while studying the thermal environment of an airplane *** are still no reference values for aircraft cabins despite the fact that numerous studies on low pressure heat transfer have demonstrated the connection between convective heat transfer coefficient(CHTC)and air *** this paper,a correction method for CHTC under low pressure conditions was established by using the dummy heat dissipation in the low-pressure cabin *** this basis,a thermal environment simulation model was developed,then was applied to the simulation of a seven-row aircraft cabin containing 42 passengers,and the CHTC and heat loss of dummy surface in the cabin were ***,the results of PMV calculated by using heat dissipation and air parameters at sampling points were *** results show that the modified CHTC can accurately reflect the cabin thermal environment under low pressure conditions,and the correction of CHTC can be realized by adjusting the turbulent Prandtl number,which is nonlinear correlated with the *** simulation results of the thermal environment in the seven-row cabin show that the CHTC changes by about 42%before and after *** air pressure decreases during take-off,which reduces the average CHTC of the crew surface from 5.09 W/(m^(2)·K)to 4.56 W/(m^(2)·K),but the air temperature rises by about 0.2°C as a *** deviation of PMV results calculated by using simulated heat loss data and using air parameters of measuring points in space is up to 0.5,but the latter is representative for calculating the thermal comfort level of the whole cabin.

关键词： low pressure aircraft cabin simulation heat dissipation convective heat transfer coefficient

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Enhanced High-Temperature Cycling Stability of Garnet-Based All Solid-State Lithium Battery Using a Multi-Functional Catholyte Buffer Layer

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Nano-Micro Letters 2024年第7期16卷 59-73页

作者： Leqi Zhao Yijun zhong Chencheng cao Tony Tang Zongping Shao WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerthWA 6102Australia

The pursuit of safer and high-performance lithium-ion batteries(LIBs)has triggered extensive research activities on solid-state batteries,while challenges related to the unstable electrode-electrolyte interface hinder their practical *** has been used extensively to improve the cathode-electrolyte interface in garnet-based all-solid-state LIBs(ASSLBs),while it introduces new concerns about thermal *** this study,we propose the incorporation of a multi-functional flame-retardant triphenyl phos-phate additive into poly(ethylene oxide),acting as a thin buffer layer between LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)cathode and garnet *** electrochemical stability tests,cycling performance evaluations,interfacial thermal stability analysis and flammability tests,improved thermal stability(capacity retention of 98.5%after 100 cycles at 60℃,and 89.6%after 50 cycles at 80℃)and safety characteristics(safe and stable cycling up to 100℃)are *** on various materials characterizations,the mechanism for the improved thermal stability of the interface is *** results highlight the potential of multi-functional flame-retardant additives to address the challenges associated with the electrode-electrolyte interface in ASSLBs at high *** thermal modification in ASSLBs operating at elevated temperatures is also essential for enabling large-scale energy storage with safety being the primary concern.

关键词： Solid-state battery Cathode electrolyte interlayer Flame-retardant additive Cycling stability Interfacial stability

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A Hybrid Air Quality Prediction Model Based on Empirical Mode Decomposition

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Tsinghua Science and Technology 2024年第1期29卷 99-111页

作者： Yuxuan cao Difei Zhang Shaoqi Ding Weiyi zhong Chao Yan School of Computer Science Qufu Normal UniversityRizhao 276826China School of Mathematical Sciences Qufu Normal UniversityQufu 273165China School of Computer Science Qufu Normal UniversityRizhao 270826China College of Economic and Management Shandong University of Science and TechnologyQingdao 250307China

Air pollution is a severe environmental problem in urban *** air quality prediction can help governments and individuals make proper decisions to cope with potential air *** a classic time series forecasting model,the AutoRegressive Integrated Moving Average(ARIMA)has been widely adopted in air quality ***,because of the volatility of air quality and the lack of additional context information,i.e.,the spatial relationships among monitor stations,traditional ARIMA models suffer from unstable prediction *** some deep networks can achieve higher accuracy,a mass of training data,heavy computing,and time cost are *** this paper,we propose a hybrid model to simultaneously predict seven air pollution indicators from multiple monitoring *** proposed model consists of three components:(1)an extended ARIMA to predict matrix series of multiple air quality indicators from several adjacent monitoring stations;(2)the Empirical Mode Decomposition(EMD)to decompose the air quality time series data into multiple smooth sub-series;and(3)the truncated Singular Value Decomposition(SvD)to compress and denoise the expanded *** results on the public dataset show that our proposed model outperforms the state-of-art air quality forecasting models in both accuracy and time cost.

关键词： air quality prediction Empirical Mode Decomposition(EMD) Singular Value Decomposition(SVD) AutoRegressive Integrated Moving Average(ARIMA)

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