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Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a ***,multicenter,cross-sectional survey

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Chinese Journal of Cancer 2017年第8期36卷 352-366页

作者： Hui-Yao huang Ju-Fang Shi Lan-wei guo Ya-Na Bai Xian-zhen Liao guo-iangLiu A-Yan Mao jian-Song Ren xiao-jie Sun Xin-Yu Zhu Le wang Bing-Bing Song ling-Bin Du lin Zhu ji-Yong gong Qi zhou Yu-Qin Liu Rong cao ling Mai Li Lan xiao-hua Sun ying Ren jin-Yi zhou Yuan-zheng wang xiao Qi Pei-An Lou Dian Shi Ni Li Kai zhang jie He Min Dai Program Office for Cancer Screening in Urban China National Cancer Center/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical College17 South Panjiayuan LaneChaoyang DistrictBeijing 100021P.R.China Department of Cancer Epidemiology Henan Cancer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenan 450008P.R.China Institute of Epidemiology and Health Statistics Lanzhou UniversityLanzhouGansu 730000P.R.China Hunan Office for Cancer Control and Research Hunan Provincial Cancer HospitalChangshaHunan 410006P.R.China Department of Health Economics School of Health ManagementHarbin Medical UniversityHarbinHeilongjiang 150081P.R.China Public Health Information Research Office Institute of Medical InformationChinese Academy of Medical SciencesBeijing 100020P.R.China Center for Health Management and Policy Key Lab of Health Economics and PolicyShandong UniversityJinanShandong 250012P.R.China Heilongjiang Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical UniversityHarbinHeilongjiang 150081P.R.China Zhejiang Office for Cancer Control and Research Zhejiang Cancer HospitalHangzhouZhejiang 310022P.R.China Teaching and Research Department Affiliated Cancer Hospital of Xinjiang Medical UniversityürümqiXinjiang 830011P.R.China Science and Education Department of Public Health Division Shandong Tumor HospitalJinanShandong 250117P.R.China Chongqing Office for Cancer Control and Research Chongqing Cancer HospitalChongqing 400030P.R.China Cancer Epidemiology Research Center Gansu Provincial Cancer HospitalLanzhouGansu 730050P.R.China Department of Health Policy and Economic Research Guangdong Provincial Institute of Public HealthGuangzhouGuangdong 511430P.R.China Department of Institute of Tumor Research Henan Cancer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenan 450008P.R.China Institute of Chronic Disease Prevention and Control Harbin Center for Disease Control and PreventionHarbinHei

Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in ***: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall ***: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 *** overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagno

关键词： Colorectal neoplasms Direct expenditure Financial burden China

Medical expenditure for esophageal cancer in China:a 10-year multicenter retrospective survey(2002-2011)

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Chinese Journal of Cancer 2017年第11期36卷 548-559页

作者： Lan-wei guo Hui-Yao huang Ju-Fang Shi Li-Hong Lv Ya-Na Bai A-Yan Mao Xian-zhen Liao guo-Xiang Liu jian-Song Ren xiao-jie Sun Xin-Yu Zhu jin-Yi zhou ji-Yong gong Qi zhou lin Zhu Yu-Qin Liu Bing-Bing Song ling-Bin Du xiao-jing Xing Pei-An Lou xiao-hua Sun xiao Qi Shou-ling Wu Rong cao Li Lan ying Ren Kai zhang jie He jian.gong zhang Min Dai Department of Cancer Epidemiology Henan Office for Cancer Control and Research The Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital No. 127 Dongming Road Zhengzhou 450008 Henan P. R China Program Office for Cancer Screening in Urban China Cancer Hospital Chinese Academy of Medical Sciences (CAMS) Peking Union Medical College National Cancer Center of China No. 17 Panjiayuannanli Chaoyang District Beijing 100021 P. R. China Department of Human Resources The Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital Zhengzhou 450008 Henan P. R. China Institute of Epidemiology and Health Statistics Lanzhou University Lanzhou 730000 Gansu P. R. China Public Health Information Research Office Institute of Medical Information Chinese Academy of Medical Sciences (CAMS) Beijing 100020 P. R. China Hunan Office for Cancer Control and Research Hunan Provincial Cancer Hospital Changsha 410006 Hunan P. R. China Department of Health Economics School of Health Management Harbin Medical University Harbin 150081 Heilongjiang P. R. China Center for Health Management and Policy Key Lab of Health Economics and Policy Shandong University Jinan 250012 Shandong P. R. China Institute of Chronic Non.Communicable Diseases Prevention and Control Jiangsu Provincial Center for Disease Control and Prevention Nanjing 210009 Jiangsu P. R. China Science and Education Department Public Health Division Shandong Tumor Hospital Jinan 250117 Shandong P. R. China Chongqing Office for Cancer Control and Research Chongqing Cancer Hospital Chongqing 400030 P. R. China Teaching and Research Department Affiliated Cancer Hospital of Xinjiang Medical University ürümqi 830011 Xinjiang P. R. China Cancer Epidemiology Research Center Gansu Provincial Cancer Hospital Lanzhou 730050 Gansu P. R. China Heilongjiang Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University Harbin 150081 Heilongjiang P R. China Zhejiang Office for Cancer

Background: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the diagnosis and treatment of esophageal cancer in China has not been fully quantified. This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated ***: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 37 hospitals in 13 provinces/municipalities across China as a part of the Cancer Screening Program of Urban China. For each esophageal cancer patient diagnosed between 2002 and 2011, clinical information and expense data were extracted by using structured questionnaires. All expense data were reported in Chinese Yuan(CNY; 1 CNY = 0.155 USD) based on the2011 value and inflated using the year-specific health care consumer price index for ***: A total of 14,967 esophageal cancer patients were included in the analysis. It was estimated that the overall average expenditure per patient was 38,666 CNY, and an average annual increase of 6.27% was observed from 2002(25,111 CNY) to 2011(46,124 CNY). The average expenditures were 34,460 CNY for stage Ⅰ,39,302 CNY for stage Ⅱ,40,353 CNY for stage Ⅲ, and 37,432 CNY for stage IV diseases(P < 0.01). The expenditure also differed by the therapy type, which was 38,492 CNY for surgery, 27,933 CNY for radiotherapy, and 27,805 CNY for chemotherapy(P < 0.05).Drugs contributed to 45.02% of the overall ***: These conservative estimates suggested that medical expenditures for esophageal cancer in China substantially increased in the last 10 years, treatment for early-stage esophageal cancer costs less than that for advanced cases, and spending on drugs continued to account for a considerable proportion of the overall expenditure.

关键词： Esophageal neoplasms Medical expenditure Diagnosis and treatment China

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑jiao wang jing‑Yu Tang Xiang‑Biao qiu zhen Chen Mao‑Yuan Zhao chang‑Jun Ning Kai Pan wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan chang‑qing Feng Rong zhang xiao‑Yang Sun Qi An Hao‑Fan Bai jiang‑Bo Bai jie Bao Ping cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑zhen Feng Min‑Hao Gu chang‑Cai Han Zi‑jie Han guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑wei Hu Han‑Xiong huang wei jiang Zhi‑jie jiang zheng‑Yao jin ling Kang Bo Li gong Li xiao Li Yang Li jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu guang‑Yuan Luan jie Ren Zhi‑zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang jin‑Cheng wang Peng‑Cheng wang Zhao‑Hui wang Zhong‑wei Wen xiao‑guang Wu Xuan Wu Cong Xia Yong‑ji Yu guo‑Hui zhang Hang‑chang zhang lin‑Hao zhang Qi‑wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang Zhi‑Yong zhang Zhi‑Hao zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑jiao wang Xiang‑Biao qiu jing‑Wen Li wei Xu Tao Li Ze‑Bin lin chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun jing‑Yu Tang Rong zhang Han‑Tao jing Bo Mei Qi An Hao‑Fan Bai jiang‑Bo Bai jie Bao Ping cao Qi‑Ping Chen zhen Chen Zeng‑Qi Cui An‑Chuan Fan chang‑qing Feng Fan‑zhen Feng Ke‑qing Gao Min‑Hao Gu chang‑Cai Han Zi‑jie Han guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑wei Hu Han‑Xiong huang wei‑hua jia Hao‑Yu jiang wei jiang Zhi‑jie jiang zheng‑Yao jin ling Kang Bo Li Chao Li gong Li jia‑Wen Li xiao Li Yang Li jie Liu Rong Liu Shu‑Bin Liu guang‑Yuan Luan Bin‑Bin Qi jie Ren Zhi‑zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng wang Zhao‑Hui wang Zhong‑wei Wen xiao‑guang Wu Xuan Wu Li‑Kun Xie Yi‑wei Yang Han Yi Yong‑ji Yu guo‑Hui zhang lin‑Hao zhang Mo‑Han zhang Qi‑wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang Zhi‑Yong zhang Mao‑Yuan Zhao Lu‑Ping zhou Zhi‑Hao zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen jing-Yu Tang Rui-Rui Fan Qiang Li gong Li Dong Liu zheng-Yao jin Xing-Zhu Cui Tian-Xiang Chen Yi-wei Yang Rong Liu Han Yi Yang Li zhen Yang Qi An Hao-Fan Bai jiang-Bo Bai jie Bao Ping cao Qi-Ping Chen zhen Chen Zeng-Qi Cui An-Chuan Fan chang-qing Feng Fan-zhen Feng Ke-qing Gao Min-Hao Gu chang-Cai Han Zi-jie Han guo-Zhu He Yong-Cheng He Yang Hong Yi-wei Hu Han-Xiong huang wei-hua jia Hao-yu jiang wei jiang Zhi-jie jiang ling Kang Bo Li Chao Li jia-Wen Li xiao Li jie Liu Shu-Bin Liu guang-Yuan Luan chang-Jun Ning Bin-Bin Qi jie Ren Zhi-zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-jiao wang Peng-Cheng wang Zhao-Hui wang Zhong-wei Wen xiao-guang Wu Xuan Wu Li-Kun Xie Yong-ji Yu guo-Hui zhang lin-Hao zhang Mo-Han zhang Qi-wei zhang Xian-Peng zhang Yu-Liang zhang Yue zhang Zhi-Yong zhang Mao-Yuan Zhao Lu-Ping zhou Zhi-Hao zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI jiang Feng CHEN Hong CHEN Li ying FENG Qiao guo Tuan Mao HOU Yong HU Gui Fen HU xiao Mei HU Yun Hong huaNG jin huaNG qiu hua huaNG Shao zhen ji Liang jiN Hai Hao LEI xiao LI Chun Yan LI Min qing LI Qun Tang LI Xian Yong LIU Hong De LIU jin Ping LIU zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui wang jing wei SONG Fang Li SUN Sheng wang Dong Ting wang Ming Xuan wang xiao Yan wang Yin zhen wang Yu Dong WU wei WU Lan Ping xiao Yan hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li zhang gong Qi zhang jin Bo zhang lin Song ZHAO Shu Sen ZHAO Wan ying zheng Kai zhou ying Chun ZHU Jun Teng ZHU Tian qing zhang hua Min wang Yan Ping wang Yong Yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-zhou Ren Yi-wei Yang Yong-Hao Chen Rong Liu Bang-jiao Ye jie Wen Hai-Rui guo Zi-jie Han Qi-Ping Chen Zhong-wei Wen wei-Li Sun Han Yi Xing-Yan Liu Tao Ye jiang-Bo Bai Qi An jie Bao Yu Bao Ping cao Hao-Lei Chen zhen Chen Zeng-Qi Cui Rui-Rui Fan chang-qing Feng Ke-qing Gao xiao-Long Gao Min-Hao Gu chang-Cai Han guo-Zhu He Yong-Cheng He Yang Hong Yi-wei Hu Han-Xiong huang Xi-Ru huang Hao-Yu jiang wei jiang Zhi-jie jiang Han-Tao jing ling Kang Bo Li Chao Li jia-Wen Li Qiang Li xiao Li Yang Li jie Liu Shu-Bin Liu Ze Long guang-Yuan Luan chang-Jun Ning Meng-Chen Niu Bin-Bin Qi jie Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-jia Sun Zhi-Xin Tan jing-Yu Tang Xin-Yi Tang Bin-Bin Tian Li-jiao wang Peng-Cheng wang Zhao-Hui wang xiao-guang Wu Xuan Wu Li-Kun Xie xiao-Yun Yang Li Yu Tao Yu Yong-ji Yu guo-Hui zhang lin-Hao zhang Qi-wei zhang Xian-Peng zhang Yu-Liang zhang Zhi-Yong zhang Lu-Ping zhou Zhi-Hao zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

D型产气荚膜梭菌ε毒素基因表达及其免疫保护作用的初步研究

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中国畜牧兽医 2012年第3期39卷 36-41页

作者：王光华蔺国珍郑福英曹小安宫晓炜周继章邱昌庆中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室农业部兽医公共卫生重点开放实验室甘肃兰州730046

利用PCR技术,从D型产气荚膜梭菌标准株(C60-2)染色体DNA中扩增出ε毒素基因。该基因产物大小为906bp,序列分析结果表明,与GenBank报道的产气荚膜梭菌参考菌株ε毒素基因序列同源性大于99%。将扩增的ε毒素基因定向克隆到原核表达载体pET... 详细信息

利用PCR技术,从D型产气荚膜梭菌标准株(C60-2)染色体DNA中扩增出ε毒素基因。该基因产物大小为906bp,序列分析结果表明,与GenBank报道的产气荚膜梭菌参考菌株ε毒素基因序列同源性大于99%。将扩增的ε毒素基因定向克隆到原核表达载体pET32a中,得到重组质粒pET32a-ETX,将重组质粒转化大肠杆菌BL21(DE3)plys中,经IPTG诱导后,SDS-PAGE分析可见大小为54ku的特异条带;经Western blotting和ELISA检测结果表明,表达的ε毒素能与抗天然ε毒素抗体发生特异性反应,说明ε毒素蛋白具有较好的反应原性。将表达的ε毒素蛋白用0.4%的甲醛溶液制成类毒素疫苗,免疫小鼠后,具有一定的保护力,这表明该重组菌株有望成为产气荚膜梭菌基因工程类毒素疫苗的候选菌株。

关键词： D型产气荚膜梭菌 ε毒素类毒素免疫保护

PandaX: a liquid xenon dark matter experiment at CJPL

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Science China(Physics,Mechanics & Astronomy) 2014年第8期57卷 1476-1494页

作者： cao Xiguang CHEN Xun CHEN Yunhua CUI XiangYi FANG Deqing fu changBo GIBONI Karl L. gong Haowei guo guoDong HE Ming HU jie huaNG XingTao ji XiangDong JU Yonglin LI ShaoLi lin qing LIU huaXuan LIU jiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI Yujie STEPHENSON Scott TAN AnDi TARLé Greg wang Hongwei wang jiMing wang Meng wang XuMing wang zhou wei Yuehuan WU ShiYong xiao Mengjiao xiao Xiang XIE Pengwei YE Tao YOU yingHui ZEN XiongHui zhang hua zhang Tao ZHAO Haiying ZHAO Li zhou xiaoPeng ZHU Zhonghua Shanghai Institute of Applied Physics The Institute of Nuclear and Particle Physics Astronomy and Cosmology (INPAC) and Department of Physics and AstronomyShanghai Jiao Tong University Yalong River Hydropower Development Company Ltd. School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE) Shandong University School of Physics Peking University Department of Physics University of Maryland College Park MD 20742 USA School of Mechanical Engineering Shanghai Jiao Tong University Department of Physics University of Michigan Ann Arbor MI 48109 USA

PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay *** central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton *** experiment is located in the jinping Deep-Underground Laboratory in Sichuan,*** detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional *** this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented.

关键词： dark matter liquid xenon detector underground experiment time projection chamber