检索结果-南通市图书馆

Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011

引用

Chinese Journal of Cancer Research 2019年第5期31卷 825-837页

作者： Jufang Shi guoxiang liu hong Wang Ayan Mao Chengcheng liu Lanwei guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu zhu Jialin Wang Bingbing Song Jinyi zhou Lin zhu Haike Lei Yuqin liu Yunyong liu Lingbin Du Yutong He Kai zhang Ni Li Wanqing Chen Min Dai Jie He Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Health Economics School of Health Management/Public HealthHarbin Medical UniversityHarbin 150081China Office of Public Health Strategic Information Institute of Medical InformationChinese Academy of Medical SciencesBeijing 100020China Department of Cancer Epidemiology Henan Office for Cancer Control and ResearchThe Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhou 450008China Hunan Office for Cancer Control and Research Hunan Provincial Cancer HospitalChangsha 410006China Institute of Epidemiology and Health Statistics Lanzhou UniversityLanzhou 730000China Center for Health Management and Policy Key Lab of Health Economics and PolicyShandong UniversityJinan 250012China Department of Public Health Shandong Cancer Hospital Affiliated to Shandong UniversityJinan 250117China Heilongjiang Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150081China Institute of Chronic Non-communicable Diseases Prevention and Control Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009China Teaching and Research Department Affiliated Cancer Hospital of Xinjiang Medical UniversityUrumqi 830011China Department of Cancer Research and Control Office Chongqing University Cancer HospitalChongqing 400030China Cancer Epidemiology Research Center Gansu Provincial Cancer HospitalLanzhou 730050China Cancer Prevention and Control Office of Liaoning Province Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China Department of Cancer Prevention Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Cancer Institute The Fourth Affiliated Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Thoracic Surg

Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in ***: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 ***: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China.

关键词： Colorectal neoplasms health expenditures diagnosis therapeutics China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cohort profile: design and methods of the Chinese colorectal, breast, lung, liver, and stomach cancer screening trial(C-BLAST)

引用

Cancer Biology & Medicine 2023年第10期20卷 713-720页

作者： Yubei Huang zhangyan Lyu Yu zhang Xiaomin liu Yacong zhang Ya liu Chao Sheng hongyuan Duan Zeyu Fani Chenyang Li Xiao Lin zhuowei Feng Lu Zheng Zhaoxiang Ye hong Lu ying zhu Dejun zhou Xi Wei Li Ren Bin Meng Fangfang Song Fengju Song Kexin Chen Department of Cancer Epidemiology and Biostatistics Key Laboratory of Molecular Cancer Epidemiology(Tianjin)Key Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300060China Department of Radiology Key Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300060China Department of Breast Imaging Diagnosis Key Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300060China Department of Endoscopy Key Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300060China Department of Ultrasound Imaging Diagnosis Key Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300060China Department of Clinical Laboratory Key Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300060China Department of Pathology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300060China

Given the rapid changes in social structure(urbanization),economic structure(industrialization),and demographic structure(population aging)in China,cancer has become a major public health *** evidence has indicated that screening can decrease cancer mortality,particularly among high-risk groups,and several representative national and regional cancer screening programs have been launched in China to cope with the increasing burden of cancer.

关键词： stomach cancer mortality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

KLF4 facilitates chromatin accessibility remodeling in porcine early embryos

引用

Science China(Life Sciences) 2024年第1期67卷 96-112页

作者： Wei zhu guowei Bu Ruifeng Hu Jixiang zhang Lianyong Qiao Kai zhou Tingting Wang Qiao Li Jingjing zhang Linhui Wu Yali Xie Taotao Hu Shichun Yang Jiaqi guan Xiaoyu Chu Juanjuan Shi Xia zhang Falong Lu Xin liu Yi-Liang Miao Institute of Stem Cell and Regenerative Biology College of Animal Science and Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China Key Laboratory of Agricultural Animal Genetics Breeding and Reproduction(Huazhong Agricultural University)Ministry of EducationWuhan 430070China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China Frontiers Science Center for Animal Breeding and Sustainable Production Huazhong Agricultural UniversityWuhan 430070China Hubei hongshan Laboratory Wuhan 430070China

Chromatin accessibility remodeling driven by pioneer factors is critical for the development of early *** studies have illustrated several pioneer factors as being important for agricultural animals,but what are the pioneer factors and how the pioneer factors remodel the chromatin accessibility in porcine early embryos is not *** employing low-input DNase-seq(liDNase-seq),we profiled the landscapes of chromatin accessibility in porcine early embryos and uncovered a unique chromatin accessibility reprogramming pattern during porcine preimplantation *** data revealed that KLF4 played critical roles in remodeling chromatin accessibility in porcine early *** down of KLF4 led to the reduction of chromatin accessibility in early embryos,whereas KLF4 overexpression promoted the chromatin openness in porcine ***,KLF4 deficiency resulted in mitochondrial dysfunction and developmental failure of porcine *** addition,we found that overexpression of KLF4 in blastocysts promoted lipid droplet accumulation,whereas knockdown of KLF4 disrupted this *** together,our study revealed the chromatin accessibility dynamics and identified KLF4 as a key regulator in chromatin accessibility and cellular metabolism during porcine preimplantation embryo development.

关键词： porcine embryos liDNase-seq chromatin accessibility KLF4 mitochondrion lipid droplets

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

引用

World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-ying Meng Lin-zhu Lu Qian-Qian guo Chang-Jun Lv Nian-Hua Tan Zhe Deng Jun-Yi Chen Zi-Shu zhang Bo Zou hong-Ping Long Qing zhou Sha Tian Si Mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transforming growth factor beta-1 upregulates glucose transporter 1 and glycolysis through canonical and noncanonical pathways in hepatic stellate cells

引用

World Journal of Gastroenterology 2021年第40期27卷 6908-6926页

作者： Ming-Yu zhou Ming-Liang Cheng Tao Huang Rui-Han Hu Gao-Liang Zou hong Li Bao-Fang zhang Juan-Juan zhu Yong-Mei liu Yang liu Xue-Ke Zhao Department of Internal Medicine Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina Department of Infectious Diseases Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Clinical Laboratory Center Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

BACKGROUND Hepatic stellate cells(HSCs)are the key effector cells mediating the occurrence and development of liver fibrosis,while aerobic glycolysis is an important metabolic characteristic of HSC *** growth factor-β1(TGF-β1)induces aerobic glycolysis and is a driving factor for metabolic *** occurrence of glycolysis depends on a high glucose uptake *** transporter 1(GLUT1)is the most widely distributed glucose transporter in the body and mainly participates in the regulation of carbohydrate metabolism,thus affecting cell proliferation and ***,little is known about the relationship between TGF-β1 and GLUT1 in the process of liver fibrosis and the molecular mechanism underlying the promotion of aerobic glycolysis in *** To investigate the mechanisms of action of GLUT1,TGF-β1 and aerobic glycolysis in the process of HSC activation during liver *** Immunohistochemical staining and immunofluorescence assays were used to examine GLUT1 expression in fibrotic liver tissue.A Seahorse extracellular flux(XF)analyzer was used to examine changes in aerobic glycolytic flux,lactate production levels and glucose consumption levels in HSCs upon TGF-β1 *** mechanism by which TGF-β1 induces GLUT1 protein expression in HSCs was further explored by inhibiting/promoting the TGF-β1/mothersagainst-decapentaplegic-homolog 2/3(Smad2/3)signaling pathway and inhibiting the p38 and phosphoinositide 3-kinase(PI3K)/AKT signaling *** addition,GLUT1 expression was silenced to observe changes in the growth and proliferation of ***,a GLUT1 inhibitor was used to verify the in vivo effects of GLUT1 on a mouse model of liver *** GLUT1 protein expression was increased in both mouse and human fibrotic liver *** addition,immunofluorescence staining revealed colocalization of GLUT1 and alpha-smooth muscle actin proteins,indicating that GLUT1 expression was related to the development of

关键词： Gene regulation Glycolysis Liver fibrosis Glucose transporter 1 Transforming growth factor-β1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A rare Waxy allele coordinately improves rice eating and cooking quality and grain transparency

引用

Journal of Integrative Plant Biology 2021年第5期63卷 889-901页

作者： Changquan zhang Yong Yang Shengjie Chen Xueju liu Jihui zhu Lihui zhou Yan Lu Qianfeng Li Xiaolei Fan Shuzhu Tang Minghong Gu Qiaoquan liu Key Laboratory of Crop Genomics and Molecular Breeding of Jiangsu Province State Key Laboratory of Hybrid RiceYangzhou UniversityYangzhou 225009China Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genetics and Physiology/Co‐Innovation Center for Modern Production Technology of Grain Crops of Jiangsu Province Yangzhou UniversityYangzhou 225009China State Key Laboratory of Agrobiotechnology School of Life SciencesThe Chinese University of Hong KongHong KongChina

In rice(Oryza sativa), amylose content(AC) is the major factor that determines eating and cooking quality(ECQ). The diversity in AC is largely attributed to natural allelic variation at the Waxy(Wx)locus. Here we identified a rare Wx allele, Wx^(mw) ,which combines a favorable AC, improved ECQ and grain transparency. Based on a phylogenetic analysis of Wx genomic sequences from 370 rice accessions, we speculated that Wx^(mw) may have derived from recombination between two important natural Wx alleles, Wx^(in) and Wx^(b). We validated the effects of Wx^(mw) on rice grain quality using both transgenic lines and near-isogenic lines(NILs). When introgressed into the japonica Nipponbare(NIP) background, Wx^(mw) resulted in a moderate AC that was intermediate between that of NILs carrying the Wx^(b)allele and NILs with the Wx^(mp) allele. Notably, mature grains of NILs fixed for Wx^(mw) had an improved transparent endosperm relative to soft rice. Further, we introduced Wx^(mw) into a high-yielding japonica cultivar via molecular marker-assisted selection: the introgressed lines exhibited clear improvements in ECQ and endosperm transparency. Our results suggest that Wx^(mw) is a promising allele to improve grain quality, especially ECQ and grain transparency of high-yielding japonica cultivars, in rice breeding programs.

关键词： allelic variation amylose content(AC) eating and cooking quality(ECQ) grain appearance Oryza sativa L. Waxy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of slow or controlled release fertilizer types and fertilization modes on yield and quality of rice

引用

Journal of Integrative Agriculture 2018年第10期17卷 2222-2234页

作者： WEI Hai-yan CHEN Zhi-feng XING Zhi-peng zhou Lei liu Qiu-yuan zhang Zhen-zhen JIANG Yan HU Ya-jie zhu Jin-yan CUI Pei-yuan DAI Qi-gen zhang hong-cheng Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Co-Innovation Center for Modem Production Technology of Grain Crops/Agricultural College Yangzhou University Yangzhou 225009 P.R.China

There is limited information about the influence of slow or controlled release fertilizer（S/CRF） on rice yield and quality. In this study, japonica rice cultivar Nanjing 9108 was used to study the effects of three different S/CRFs（polymer-coated urea（PCU）, sulfur-coated urea（SCU）, and urea formaldehyde（UF）） and two fertilization modes（both S/CRF and common urea（CU） as basal fertilizer, S/CRF as basal and CU as tillering fertilizer） on rice yield and quality. CU only was applied separately as control（CK）. Results showed that, rice grain yield, chalky kernel rate, chalky area, overall chalkiness, and the content of gliadin, glutenin, and protein, all showed the trends of UF〉PCU〉SCU within the same fertilization mode, and showed the trends of S/CRF as basal and CU as tillering fertilizer〉both S/CRF and CU as basal fertilizer within the same type of S/CRF. In contrast, the contents of amylose, amylopectin, and starch, as well as taste value, and peak and hot viscosity showed trends of SCU〉PCU〉UF, and the trends of both S/CRF and CU as basal fertilizer〉S/CRF as basal and CU as tillering fertilizer. Among S/CRF treatments and fertilization modes, taste values of cooked rice were positively correlated with amylose, amylopectin, and starch contents, as well as gel consistency, peak viscosity, hot viscosity, and cool viscosity, while negatively correlated with globulin, gliadin, glutenin, and protein contents. The types of S/CRF and fertilization modes are important for improving rice yield and quality. Compared to CK, higher yield and similar quality of rice was achieved with UF as basal and CU as tillering fertilizer, and similar yield with improved appearance and eating and cooking quality of rice was achieved with either both UF and CU as basal fertilizer, or PCU as basal and CU as tillering fertilizer.

关键词： type of slow or controlled release fertilizer fertilization mode yield quality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration

引用

Signal Transduction and Targeted Therapy 2021年第10期6卷 3062-3073页

作者： Ling zhang Li zhou Linlin Bao Jiangning liu Hua zhu Qi Lv Ruixue liu Wei Chen Wei Tong Qiang Wei Yanfeng Xu Wei Deng-hong Gao Jing Xue Zhiqi Song Pin Yu Yunlin Han Yu zhang Xiuping Sun Xuan Yu Chuan Qin NHC Key Laboratory of Human Disease Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina

SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model ***,it remains undear whether and how SARS-CoV-2 crosses the blood-brain barrier(BBB).Herein,SARS-CoV-2 RNA was occasionally detected in the vascular wall and perivascular space,as well as in brain microvascular endothelial cells(BMECs)in the infected K18-hACE2 transgenic ***,the permeability of the infected vessel was in ***,disin tegrity of BBB was discovered in the infected hamsters by administration of Evans ***,the expression of claudin5,ZO-1,occludin and the ultrastructure of tight junctions(TJs)showed unchanged,whereas,the basement membrane was disrupted in the infected *** an in vitro BBB model that comprises primary BMECs with astrocytes,SARS-CoV-2 was found to infect and cross through the *** with in vivo experiments,the expression of MMP9 was increased and collagen IV was decreased while the markers for TJs were not altered in the SARS-CoV-2-infected ***,inflammatory responses including vasculitis,glial activation,and upregulated inflammatory factors occurred after SARS-CoV-2 ***,our results provide evidence supporting that SARS-CoV-2 can cross the BBB in a transcellular pathway accompanied with basement membrane disrupted without obvious alteration of TJs.

关键词： basement alteration barrier

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Paragonimiasis misdiagnosed as liver abscess:A case report

引用

World Journal of Clinical Cases 2024年第21期12卷 4807-4812页

作者： ying-Qi Zheng Gong-Bing guo Mei-Fang Wang He-Zhong zhu Chan zhou Lin-hong Li Lu zhang Yu-Quan liu Department of General Practice Taihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Pulmonary and Critical Care Medicine Taihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUNDParagonimiasis is a typical food-borne zoonotic disease. Hosts acquire Paragonimusinfection through the ingestion of raw or undercooked crayfish and *** clinical manifestations of the disease are varied, and it is often misdiagnosedor missed. The diagnosis of paragonimiasis should be considered *** is the first choice for treatment, and albendazole can beused in combination with repeated courses in severe *** SUMMARYWe report a case of liver paragonimiasis that was misdiagnosed as an abscess. Thepatient presented with fatigue and poor appetite for 2 months, and was diagnosedwith liver abscess in the local hospital. After 6 months, the patient visited ourhospital because of recurrent abdominal pain and was diagnosed with liverparagonimiasis based on epidemiological history, clinical presentations, andlaboratory findings. He was treated with praziquantel (25 mg/kg) three times aday for 3 days;however, the symptoms still presented after treatment. He wastreated with oral praziquantel and albendazole for one further course. Follow-upsuggested that the treatment was effective and the symptoms *** combination of albendazole and praziquantel may improve the therapeuticefficacy of paragonimiasis.

关键词： Liver paragonimiasis Liver abscess Misdiagnosis Albendazole Praziquantel Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thrombus migration in patients with acute ischaemic stroke undergoing endovascular thrombectomy

引用

Stroke & Vascular Neurology 2024年第2期9卷 126-133,I0006-I0395页

作者： ZeFeng Tan Lei zhang Li'an Huang hongyu Qiao Min guan Bing Yang Pengfei Yang Yongwei zhang hongjian Shen Yu zhou Bo hong Huaizhang Shi hongxing Han Xinyi Leng Yi Dong Changlin Lian Wenhuo Chen Anding Xu Jianmin liu Neurology First People's Hospital of FoshanFoshanGuangdongChina Department of Neurology Jinan University First Affiliated HospitalGuangzhouGuangdongChina Neurovascular Center Changhai HospitalNaval Medical UniversityShanghaiChina Department of Neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Neurology Linyi People's HospitalLinyiShandongChina Medicine&Therapeutics The Chinese University of Hong KongHong KongChina Neurology Huashan Hospital Fudan UniversityShanghaiChina Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujianChina Stroke Center Jinan University First Affiliated HospitalGuangzhouGuangdongChina

Objective The impact of thrombus migration(TM)prior to endovascular thrombectomy(EVT)on clinical outcomes and revascularisation rates remains *** aimed to examine whether preinterventional TM modifies the treatment effects of direct EVT versus bridging EVT in acute large vessel occlusion *** All patients undergoing catheter angiography in the Direct Intra-arterial thrombectomy in order to Revascularise acute ischaemic stroke patients with large vessel occlusion Efficiently in Chinese Tertiary hospitals:A Multicentre randomised clinical Trial were *** was determined by radiologists unaware of the study by analysing discrepancies between computed tomographic angiography at baseline and first-run digital subtraction angiography before *** primary outcome was the score on the modified Rankin scale(mRS)assessed at 90 *** Of 627 included patients,the TM rate was 11.3%(71/627).In the multivariable logistic regression model,baseline National Institutes of Health Stroke Scale score(adjusted OR 0.956,95%CI 0.916 to 0.999;p=0.043)and intravenous thrombolysis(adjusted OR 2.614,95%CI 1.514 to 4.514;p<0.001)were independently associated with *** patients with TM were less likely to be completely recanalised than those without TM(21.27%vs 36.23%,p=0.040).The interaction of TM and the EVT treatment effect did not significantly affect mRS shift analysis(p=0.687)or mRS scores of 0 to 1(p=0.436).Conclusion Preinterventional TM does not modify the treatment effects of direct versus bridging EVT on functional outcomes in patients with acute ischaemic stroke with anterior large vessel *** leads to a lower complete recanalisation rate.

关键词： patients throm acute

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：