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Body size induced changes in metabolic carbon of soil nematodes under N deposition and precipitation regime change in a temperate grassland

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Ecological Processes 2024年第1期13卷 120-131页

作者： Shuyan Cui Xiaomei mo guo Zheng College of Life Science Shenyang Normal University

Background Global climate change has resulted in precipitation regimes exhibiting an increasing trend in rainfall intensity but a reduction in its frequency. Nitrogen(N) deposition is a crucial component of the global N cycling. Nematode body size is a trait that responds to climate change and is used as a standard trait-based indicator in soil community analysis. Variations in body size influence metabolic carbon(C). We examined the ways by which body size and metabolic C of nematodes respond to changing precipitation regimes and how N deposition regulates these responses by an 8-year manipulative *** Nematode body size was indicated by the community-weighted mean(CWM) mass. We quantified C metabolism components of soil nematodes including production C, respiration C, and corresponding C use efficiency(CUE) under different precipitation intensities and N addition in a semi-arid steppe on the mongolian Plateau. The Mantel test was used to determine the correlations between CWM, CUE and environmental factors. The partial least squares path modeling(PLS-PM) was conducted to quantify direct or indirect contributions among latent *** We found that heavy precipitation intensity increased the CWM mass of total nematodes and omnivorespredators without N addition. N addition decreased CWM mass of bacterivores across all the precipitation intensity treatments. Stronger precipitation intensities might be favorable for nematode production and respiration C. Variations in the nematode CWM mass drove the CUE to change with N *** Our findings provide new insights into the mechanisms underlying nematode body size and C metabolism, and highlight that explorative studies, such as manipulative experiments, are needed to identify traits underlying size-related effects and to investigate how they affect CUE of nematodes. These efforts may increase our understanding of how changes in precipitation regimes and N deposition may alter soil nema

关键词： Community-weighted mean Metabolic footprint Nitrogen addition Precipitation intensity

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To explore the pathogenesis of anterior resection syndrome by magnetic resonance imaging rectal defecography

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 529-538页

作者： Ling-Hou Meng Xian-Wei mo Bing-Yu Yang Hai-Quan Qin Qing-Zhou Song xin-xin He Qiang Li Zheng Wang Chang-Lin mo guo-Hai Yang Department of Gastrointestinal Surgery Guangxi Clinical Research Center for Colorectal CancerGuangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal and Anal Surgery Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiology Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina First Department of Chemotherapy Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Over 90%of rectal cancer patients develop low anterior resection syndrome(LARS)after sphincter-preserving *** current globally recognized evaluation method has many drawbacks and its subjectivity is too strong,which hinders the research and treatment of *** To evaluate the anorectal function after colorectal cancer surgery by quantifying the index of magnetic resonance imaging(MRI)defecography,and pathogenesis of *** We evaluated 34 patients using the standard LARS score,and a new LARS evaluation index was established using the dynamic images of MRI defecography to verify the LARS *** In the LARS score model,there were 10(29.41%)mild and 24(70.58%)severe cases of *** comparison of defecation rate between the two groups was 29.36±14.17%versus 46.83±18.62%(P=0.004);and MRI-rectal compliance(MRI-RC)score was 3.63±1.96 versus 7.0±3.21(P=0.001).Severe and mild LARS had significant differences using the two evaluation *** was a significant negative correlation between LARS and MRI-RC score(P<0.001),and they had a negative correlation with defecation rate(P=0.028).CONCLUSION MRI defecography and standard LARS score can both be used as an evaluation index to study the pathogenesis of LARS.

关键词： Anterior resection syndrome Colorectal cancer Diagnostic evaluation system Magnetic resonance imaging defecography Pathogenesis

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Editorial: Welcome Message from Editor-in-Chief, Xuming mo

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Congenital Heart Disease 2024年第1期19卷 1-3页

作者： Xuming mo Department of Cardiothoracic Surgery Children’s Hospital of Nanjing Medical UniversityNanjing210008China

1 Introduction The release of the most recent volume of Congenital Heart Disease(CHD)(Issue 19,Volume 1,2024)coincides with my assumption of the role of Co-Editor-In-Chief for CHD.I would like to express my appreciation to CHD for providing me with the opportunity to use the Editorial page.I took on this responsibility on November 18,2023.I would like to take this opportunity to share reflections and convey my *** in 2006,CHD stands as the pioneering professional periodical exclusively dedicated to the exploration and treatment of congenital cardiac abnormalities across all age *** paramount goal is to elevate the scholarly and educational dimension of CHD,driven by an unwavering commitment to provide optimal,holistic cardiac care to patients spanning infancy to *** commitment remains steadfast,with a focus on community service,research,and education quality,regardless of the patient’s financial situation.

关键词： cardiac education release

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Confined cobalt single-atom catalysts with strong electronic metal-support interactions based on a biomimetic self-assembly strategy

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Carbon Energy 2024年第9期6卷 156-171页

作者： Bowen guo Zekun Wang Lei Zheng Guang mo Hongjun Zhou Dan Luo State Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Biogas Upgrading UtilizationCollege of New Energy and MaterialsChina University of Petroleum(Beijing)BeijingChina Beijing Key Laboratory of Micro-Nano Energy and Sensor CAS Center for Excellence in NanoscienceBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijingChina School of Chemical Engineering Shandong Institute of Petroleum and Chemical TechnologyDongyingShandongChina School of Chemistry Beijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijingChina Institute of High Energy Physics Chinese Academy of SciencesBeijingChina

Designing high-performance and low-cost electrocatalysts for oxygen evolu-tion reaction(OER)is critical for the conversion and storage of sustainable energy *** by the biomineralization process,we utilized the phosphorylation sites of collagen molecules to combine with cobalt-based mononuclear precursors at the molecular level and built a three-dimensional(3D)porous hierarchical material through a bottom-up biomimetic self-assembly strategy to obtain single-atom catalysts confined on carbonized biomimetic self-assembled carriers(Co SACs/cBSC)after subsequent high-temperature *** this strategy,the biomolecule improved the anchoring efficiency of the metal precursor through precise functional groups;meanwhile,the binding-then-assembling strategy also effectively suppressed the nonspecific adsorption of metal ions,ultimately preventing atomic agglomeration and achieving strong electronic metal-support interactions(EMSIs).Experimental characterizations confirm that binding forms between cobalt metal and carbonized self-assembled substrate(Co–O_(4)–P).Theoretical calculations disclose that the local environment changes significantly tailored the Co d-band center,and optimized the binding energy of oxygenated intermediates and the energy barrier of oxygen *** a result,the obtained Co SACs/cBSC catalyst can achieve remarkable OER activity and 24 h durability in 1 M KOH(η10 at 288 mV;Tafel slope of 44 mV dec-1),better than other transition metal-based catalysts and commercial IrO_(2).Overall,we presented a self-assembly strategy to prepare transition metal SACs with strong EMSIs,providing a new avenue for the preparation of efficient catalysts with fine atomic structures.

关键词： biomimetic self-assembly support electronic metal-support interactions oxygen evolution reaction single atoms catalysts

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Effect of Low-temperature Imidization on Properties and Aggregation Structures of Polyimide Films with Different Rigidity

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Chinese Journal of Polymer Science 2024年第8期42卷 1134-1146页

作者： Yan Jia Lei Zhai Song mo Yi Liu Li-xin Liu xin-Yu Du Min-Hui He Lin Fan Key Laboratory of Science and Technology on High-tech Polymer Materials Institute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

The traditional high-temperature preparation process of polyimide can cause many problems and limits the wider application in extreme *** important challenge to be solved urgently is the reduction of imidization *** this work,twelve kinds of polyimide films with different chain rigidity were prepared at low temperature of 200℃,in the absence or presence of imidazole used as the *** molecular rigidity and free volume were theoretically calculated,and relationship between structure and properties were systematically *** results show that imidization reaction under low temperatures is significantly affected by the rigidity of molecula r *** rigid structure of polyimide is not conducive to the low-temperature imidization,but this adverse effect can be eliminated by adding catalyst,resulting the notably increased imidization *** optical and thermal properties can be improved to a certain extent for the chemically catalyzed system,resulting in relatively higher heat resistance and thermal *** the mechanical performance could be determined by com plicating factors,greatly different from polyimide films prepa red by high temperature *** investigate aggregation structures of film s,the effect of chain rigidity and catalyst on the stacking or orientation of molecular chains was further *** wo rk can contribute to the understanding of chemically catalyzed imidization that is rarely reported in the existing research,and will provide guidance for the low-temperature preparation of high-performance polyimides.

关键词： Polyimide Imidization Catalyst Structure and properties Aggregation structures

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Efficient hydrogen production from high-concentration aqueous formic acid over bio-basedγ-mo_(2)N catalysts

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Carbon Resources Conversion 2024年第3期7卷 8-16页

作者： Zeyu Liu Song Yang Yanyan Yang Wenyao guo Jianfei Wang Bixi Wang xin Gao Ting Wang Shoujun Liu Zhongliang Yu College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemistry and Environmental Science Shangrao Normal UniversityShangrao 334001China Engineering Center of Civil Clean Fuel Taiyuan 030024China College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China School of Chemistry and Chemical Engineering Kunming UniversityKunming 650214China

Formic acid is regarded to be one of the most prospective hydrogen *** screening of the fitting non-noble-metal-based heterogeneous catalysts to substitute the expensive noble-metal-based ones for FA dehydrogenation is considered as a key to the commercial application for hydrogen ***,dehydrogenation of liquid neat FA achieved a gas production value of 1753.5 mL/gcat./h at 94℃by using a biomass-derivedγ-mo_(2)N based catalyst synthesized from the earth-abundant molybdenum and soybean with a facile pyrolysis *** effect of material ratio,pyrolysis temperature on the catalytic performance of FA dehydrogenation were studied in *** particular,the catalyst obtained at a pyrolysis temperature of 700℃,weight ratios of ammonium molybdate to soybean of 0.2/1 exhibited the highest *** addition,the catalytic activity increased with the increase of FA concentration,but conversely,the dehydrogenation selectivity decreased with the increasing FA ***,it was found that the Bio-mo_(2)N catalyst was rather stable over the 40 h continuous reaction period.

关键词： Formic acid Non-noble-metal catalyst Dehydrogenation Hydrogen molybdenum nitride

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World Journal of Gastroenterology 2024年第26期30卷 3206-3209页

作者： mo-Wei Kong xin-Rui Li Yu Gao Ting-Fang Yang Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina Department of Endocrinology The Affiliated Hospital of Chengde Medical CollegeChengde 067000Hebei ProvinceChina Department of Oncology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

In this editorial,we review the work of Razali et al published in World J Gas-troenterology,with a particular focus on the effect of rs10889677 variation in the phosphatidylinositol 3-kinase(PI3K)pathway and buparlisib on colitis-associated *** role of PI3K in promoting cancer progression has been widely recognized,as it is involved in regulating the survival,differentiation,and prolif-eration of cancer *** complement Clq/TNF-related protein 6(CTRP6)is a newer tumor-associated *** studies have revealed the pro-tumor effect of CTRP6 in gastric cancer,hepatocellular carcinoma,colorectal cancer,and other gastrointestinal tumors through the PI3K *** article attempts to reveal the mechanism through which the CTRP6 affects the development of digestive system tumors through the PI3K pathway by summarizing recent research.

关键词： Phosphatidylinositol 3-kinase Complement Clq/TNF-related protein 6 Gastric cancer Colorectal cancer Tumor-related factor

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Present situation and prospect of immunotherapy for unresectable locally advanced esophageal cancer during peri-radiotherapy

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 1-7页

作者： Feng-Mei Wang Peng mo Xue Yan xin-Yue Lin Zhi-Chao Fu Department of Obstetrics and Gynecology Fuzong Clinical Medical College(900th Hospital)Fujian Medical UniversityFuzhou 350025Fujian ProvinceChina Department of Obstetrics and Gynecology Dongfang HospitalXiamen UniversityFuzhou 350025Fujian ProvinceChina Department of Radiotherapy Fuzong Clinical Medical College(900th Hospital)Fujian Medical UniversityFuzhou 350025Fujian ProvinceChina Department of Radiotherapy Dongfang HospitalXiamen UniversityFuzhou 350025Fujian ProvinceChina

Four major studies(Checkmate577,Keynote-590,Checkmate649 and Attraction-4)of locally advanced esophageal cancer published in 2020 have established the importance of immunotherapy,represented by anti-programmed death protein(PD)-1 in postoperative adjuvant treatment and advanced first-line treatment of locally advanced or advanced esophageal cancer and esophagogastric junction cancer,from the aspects of proof of concept,long-term survival,overall survival rate and progression-free *** unresectable or inoperable nonmetastatic esophageal cancer,concurrent radiotherapy and chemotherapy is the standard treatment recommended by various *** its curative effect is still not ideal,it is necessary to explore radical radiotherapy and chemotherapy in the future,and it is considered to be promising to combine them with immunotherapeutic drugs such as *** paper mainly discusses how to combine radical concurrent radiotherapy and chemotherapy with immunotherapy for unresectable local advanced esophageal cancer.

关键词： Esophageal carcinoma Locally advanced Radiotherapy Immunotherapy

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Manipulating the Macroscopic and Microscopic morphology of Large-Area Gravure-Printed ZnO Films for High-Performance Flexible Organic Solar Cells

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Energy & Environmental Materials 2024年第2期7卷 229-239页

作者： Zhenguo Wang Jingbo guo Yaqin Pan Jin Fang Chao Gong Lixin mo Qun Luo Jian Lin Changqi Ma School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China i-Lab&Printable Electronics Research Center Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of Sciences(CAS)Suzhou 215123China Beijing Engineering Research Center of Printed Electronics Beijing Institute of Graphic CommunicationBeijing 102600China Jiangxi Institute of Nanotechnology Chinese Academy of Sciences(CAS)Nanchang 330200China

Gravure printing is a promising large-scale fabrication method for flexible organic solar cells(FOSCs)because it is compatible with two-dimension patternable roll-to-roll ***,the unsuitable rheological property of ZnO nanoinks resulted in unevenness and looseness of the gravure-printed ZnO interfacial *** we propose a strategy to manipulate the macroscopic and microscopic of the gravure-printed ZnO films through using mixed solvent and poly(vinylpyrrolidone)(PVP)*** regulation of drying speed effectively manipulates the droplets fusion and leveling process and eliminates the printing ribbing structure in the macroscopic *** additive of PVP effectively regulates the rheological property and improves the microscopic compactness of the *** this method,large-area ZnO∶PVP films(28×9 cm^(2))with excellent uniformity,compactness,conductivity,and bending durability were *** power conversion efficiencies of FOSCs with gravure-printed AgNWs and ZnO∶PVP films reached 14.34%and 17.07%for the 1 cm^(2)PM6:Y6 and PM6∶L8-BO flexible *** efficiency of 17.07%is the highest value to date for the 1 cm^(2)*** use of mixed solvent and PVP addition also significantly enlarged the printing window of ZnO ink,ensuring high-quality printed thin films with thicknesses varying from 30 to 100 nm.

关键词： flexible organic solar cell gravure printing large-area flexible interfacial layer rheology properties zinc oxide

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N-glycosylation of Wnt3 regulates the progression of hepatocellular carcinoma by affecting Wnt/β-catenin signal pathway

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2769-2780页

作者： xin-Zhan Zhang Xiao-Chuan mo Zhu-Ting Wang Rong Sun Da-Quan Sun Department of Biochemistry and molecular Biology&Research Center for Basic Medical Sciences Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina

BACKGROUND Wnt/FZD-mediated signaling pathways are activated in more than 90%of hepatocellular carcinoma(HCC)cell *** a well-known secretory glycoprotein,Wnt3 can interact with FZD receptors on the cell surface,thereby activating the Wnt/β-catenin signaling ***,the N-glycosylation modification site of Wnt3 and the effect of this modification on the biological function of the protein are still *** To investigate the effect of Wnt3 N-glycosylation on the biological function of HCC *** Site-directed mutagenesis was used to verify the Wnt3 N-glycosylation sites,actinomycin D treatment was used to detect the stability of Wnt3 after site-directed mutation,the binding of the N-glycosylation site-directed mutant Wnt3 to FZD7 was observed by laser confocal microscopy,and the effects of the N-glycosylation site-directed mutation of Wnt3 on the Wnt/β-catenin signaling pathway and the progression of HCC cells were detected by western blot and cell function *** Wnt3 has two N-glycosylation-modified sites(Asn90 and Asn301);when a single site at amino acid 301 is mutated,the stability of Wnt3 is weakened;the binding ability of Wnt3 to FZD7 decreases when both sites are mutated simultaneously;and the level of proteins related to the Wnt/β-catenin signaling pathway is *** proliferation,migration and invasion are also weakened in the case of single 301 site and double-site *** These results indicate that by inhibiting the N-glycosylation of Wnt3,the proliferation,migration,invasion and colony formation abilities of liver cancer cells can be weakened,which might provide new therapeutic strategies for clinical liver cancer in the future.

关键词： Wnt3 N-glycosylation Hepatocellular carcinoma Liver cancer Wnt/β-catenin FZD7

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