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山东大学学报（理学版） 2017年第10期52卷 56-63页

作者：何国庆张量刘海蓉安徽师范大学数学计算机科学学院安徽芜湖241003 南京林业大学理学院江苏南京210037

建立了具有半对称度量联络的广义Sasakian空间形式中关于子流形的Chen-Ricci不等式。这些不等式刻画了子流形关于半对称度量联络的内在不变量(Ricci曲率)、k-Ricci曲率与外在不变量(平均曲率平方‖H‖2)之间的关系。

关键词： Chen-Ricci不等式广义Sasakian空间形式半对称度量联络

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng qing Zhao Mengjie Tao Jijun Du Xingxi Huang Chengjun liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan Long Jiajia liu Yu Wang Haidong guo guohong Cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

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血脑屏障上P-糖蛋白研究进展

神经科学通报 2005年第5期21卷 351-355页

作者：芦颖洪浩刘国卿中国药科大学药理学教研室南京210009

P-糖蛋白是血脑屏障上一种重要的物质外排生物转运体,参与人体多种生理病理过程,并能改变一些药物脑内动力学行为。本文综述了近年来国内外关于血脑屏障上P-糖蛋白研究的新进展,这对于认识某些中枢系统疾病、设计其治疗方案,以及开发新... 详细信息

P-糖蛋白是血脑屏障上一种重要的物质外排生物转运体,参与人体多种生理病理过程,并能改变一些药物脑内动力学行为。本文综述了近年来国内外关于血脑屏障上P-糖蛋白研究的新进展,这对于认识某些中枢系统疾病、设计其治疗方案,以及开发新型P-糖蛋白调节剂都具有重要的指导意义。

关键词： P-糖蛋白血脑屏障转运体多药耐药

考虑椭圆化损伤的大直径薄壁海底管道铺设分析方法研究

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现代化工 2017年第8期37卷 217-221页

作者：韩鹏赵嵩刘远征胡庆国刘黎明中国石油天然气管道局天津设计院天津300457 中国石油管道局工程有限公司河北廊坊065000

为避免张紧器对大直径薄壁海底管道(径厚比D/t≥45)造成椭圆化损伤,须先应用大型有限元软件ABAQUS对张紧器造成的管道椭圆化进行分析,并结合DNV规范确定管道铺设安装期间张紧器的允许最大张紧力。而后应用OFFPIPE软件进行海底管道的安... 详细信息

为避免张紧器对大直径薄壁海底管道(径厚比D/t≥45)造成椭圆化损伤,须先应用大型有限元软件ABAQUS对张紧器造成的管道椭圆化进行分析,并结合DNV规范确定管道铺设安装期间张紧器的允许最大张紧力。而后应用OFFPIPE软件进行海底管道的安装分析,校核管道应力应变。对于大直径薄壁海底管道,是否考虑管道椭圆化损伤将会影响管道铺设方案的确定。

关键词：海底管道铺管夹紧力椭圆化 ABAQUS OFFPIPE

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民族地区的社会主义新农村建设探析

特区经济 2011年第9期 180-182页

作者：朱国庆刘露李兰林三峡大学湖北宜昌443002

建设社会主义新农村,是一项惠及广大农民群众的民心工程、德政工程,对经济社会发展相对落后的少数民族地区来说,建设社会主义新农村,既是考验,又是机遇。本文从民族地区的经济社会发展状况出发,就如何更好地建设民族地区的社会主义新农... 详细信息

建设社会主义新农村,是一项惠及广大农民群众的民心工程、德政工程,对经济社会发展相对落后的少数民族地区来说,建设社会主义新农村,既是考验,又是机遇。本文从民族地区的经济社会发展状况出发,就如何更好地建设民族地区的社会主义新农村提出几点思路,以利于扎实推进民族地区的社会主义新农村建设。

关键词：民族地区社会主义新农村建设

Branched module-modified SN38 prodrug nanoassemblies for improved colorectal cancer therapy:Effectively balance efficacy and safety

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Nano Research 2025年第1期18卷 572-585页

作者： qing Wang Shiyi Zuo Shufang Zheng Cuiyun liu Yaqiao Li Jiayu guo Danping Wang Shuo Wang Wenjing Wang Bowen Zhang Minglong Huang Xianbao Shi Jin Sun Zhonggui He Bingjun Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Joint International Research Laboratory of Intelligent Drug Delivery Systems Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia Department of Pharmacy The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001China

The clinical utility of irinotecan is restricted by individual variability in carboxylesterase *** administration of its active metabolite,7-ethyl-10-hydroxycamptothecin(SN38),presents an appealing alternative due to its potent anti-tumor ***,the undesirable properties of SN38,such as poor water solubility and nontarget toxicity,present significant hurdles to its clinical *** nanoassemblies based on modular design strategy show promise in overcoming these challenges by enhancing drug delivery and selective *** modular design,the modification module plays a crucial role in improving the self-assembly capability of *** current studies mainly focus on using straight aliphatic chains for prodrug design,branched aliphatic chains emerge as superior alternatives warranting further *** this study,we selected 2-heptylundecanol(BAlc18)as modification module to construct an SN38 *** exquisite design,SN38-SS-BAlc18 NPs integrated prominent properties in selfassembly capability,specific activation and biocompatibility,resolving the challenges of irinotecan and SN38,ultimately demonstrating excellent anti-tumor *** exploration enriched the design theory of prodrug nanoassemblies that can effectively balance safety and colorectal anti-tumor efficacy.

关键词： irinotecan SN38 prodrug nanoassemblies disulfide bonds branched aliphatic chains

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农村集体建设用地入市的发展实践与政策变迁

中国土地科学 2016年第10期30卷 3-10页

作者：丁琳琳孟庆国刘文勇中国农业科学院农业经济与发展研究所北京100081 清华大学公共管理学院北京100084

研究目的:剖析中国农村集体建设用地入市政策的形成与演变机制。研究方法:采用公共政策的研究方法和归纳法,从纵向层级和地方多元创新、部门横向协调等方面,对改革开放以来中央和地方出台的相关政策及经济、社会、政治生态背景进行分析... 详细信息

研究目的:剖析中国农村集体建设用地入市政策的形成与演变机制。研究方法:采用公共政策的研究方法和归纳法,从纵向层级和地方多元创新、部门横向协调等方面,对改革开放以来中央和地方出台的相关政策及经济、社会、政治生态背景进行分析。研究结果:(1)农村集体建设用地入市及其政策演变经历了6个阶段,不同时期政策驱动力和政策目标有差别。(2)经济利益和社会矛盾打破了原有封闭性政策的平衡,自下而上的多元主义政策创新促使形成新的政策均衡,自上而下的科层治理扩大新政策的均衡效应,两条路径往复循环促进新的政策体系不断发展完善。政策制定者之间的协调与政策执行效果也深刻影响政策进程。研究结论:农村集体建设用地入市是趋势,该政策体系的形成理性、有序,演变路径科学,在多方主体的多重博弈下,按自身演变的内在逻辑有规律、有节奏地逐步调整,持续推进。

关键词：土地经济政策演变归纳法政策形成路径选择

Amino acid assisted aqueous synthesis of highly stable CsPbBr_(3)nanocrystals for cell imaging

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Nano Research 2025年第1期18卷 675-683页

作者： Xue Li Yanan guo guoying Tan qingyi liu Nan Song Yu Tang State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China

Lead halide perovskite nanocrystals(NCs)exhibit excellent optoelectronic performance and have drawn great interests in the fields of biological imaging and ***,the poor stability of CsPbX_(3)(X=Cl,Br,I)in water is still a challenge to hinder their practical *** this work,a facile strategy has been developed for aqueous synthesis of CsPbX_(3) nanocrystals,in which L-glutamic acid(LGlu)has been used to replace oleic acid in the synthetic *** from the synergic effects of L-Glu and oleylamine(OAm),CsPbBr_(3)nanocrystals(L-Glu/OAm-CsPbBr_(3)NCs)with high water stability have been directly prepared under a mild condition at room temperature in water,facilitated by the process of crystal phase transformation from Cs_(4)PbBr_(6) to CsPbBr_(3).L-Glu/OAm-CsPbBr_(3)NCs exhibit a high quantum yield of 85%and a narrow full width at half maximum of 16 nm,demonstrating their efficient luminescence in ***,L-Glu on the surface have contributed greatly to an acidic environment and passivation of surface defects,improving the water stability and dispersibility of CsPbBr_(3)***,L-Glu/OAm-CsPbBr_(3)NCs exhibit great biocompatibility due to the presence of L-Glu,resulting in their good performance for HeLa cell ***,we propose a facile and effective method to prepare CsPbBr_(3)nanocrystals with excellent water stability by using L-Glu and OAm as cooperated ligands and expand their application in cell imaging.

关键词： aqueous synthesis cell imaging lead halide perovskite nanocrystals L-glutamic acid phase transformation

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie liu qinghua Zeng qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase