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Grape seed proanthocyanidin protects liver against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress

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World Journal of Gastroenterology 2015年第24期21卷 7468-7477页

作者： Zhen-Chao Xu Jie Yin Bo Zhou Yu-Ting liu Yue Yu guo-qiang li liver Transplantation Center First Affiliated Hospital of Nanjing Medical University Department of Respiratory Medicine Jinling Hospital

AIM: To explore the effect of grape seed proanthocyanidin(GSP) in liver ischemia/reperfusion(IR) injury and alleviation of endoplasmic reticulum ***: Male Sprague-Dawley rats(220-250 g) were divided into three groups, namely, sham, IR, and GSP groups(n = 8 each). A liver IR(70%) model was established and reperfused for 6 h. Prior to reperfusion, the GSP group was administered with GSP(100 mg/kg) for 15 d, and liver histology was then investigated. Serum aminotransferase and inflammatory mediators coupled with superoxide dismutase and methane dicarboxylic aldehyde were detected. Western blot was conducted to analyze the expression of glucoseregulated protein 78, CCAAT/enhancer-binding protein homologous protein, activating transcription factor-4, inositol-requiring enzyme-1, procaspase-12, and nuclear factor-κb. Apoptotic cells were detected by TUNEL ***: The serum aminotransferase, apoptotic cells, and Suzuki scores decreased in the GSP group compared with the IR group(P s lic aldehyde level was decreased in the GSP group, but the superoxide dismutase level was reversed(P s lieving endoplasmic reticulum stress through regulation of related signaling pathways to protect the liver against IR injury.

关键词： Anti-apoptosis Endoplasmic reticulumstress Grape seed proanthocyanidin Inflammation Ischemia/reperfusion injury

基于多标签共享子空间学习和内核脊回归的空谱分类算法

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光子学报 2020年第5期49卷 115-127页

作者：郭利强孟庆超洛阳师范学院教育科学学院河南洛阳471000 洛阳师范学院信息技术学院河南洛阳471000

针对高光谱图像维度高、地物间非线性可分造成的分类精度低等问题,提出一种基于多标签共享子空间和内核脊回归的空谱分类算法.该算法利用内核脊回归将地物相近像素在线性空间的不可分特征映射到高维空间中,实现分类特性在高维空间下的... 详细信息

针对高光谱图像维度高、地物间非线性可分造成的分类精度低等问题,提出一种基于多标签共享子空间和内核脊回归的空谱分类算法.该算法利用内核脊回归将地物相近像素在线性空间的不可分特征映射到高维空间中,实现分类特性在高维空间下的有效分离,以提高地物相近特性的区分精度;同时将高维样本数据映射到低维共享子空间中,在低维环境下以多类标为指导,引入低秩矩阵建立类别标签与共享空间的预测关系,挖掘多标签间的共同特性,提高融合利用多类别间的共同属性提高高光谱图像的分类精度;最后利用奇异值分解迭代法求解目标函数,一定程度上加速参数求解.在Indian Pines和Pavia University两组高光谱数据集上进行仿真实验,实验结果表明,与其他同类算法相比,在低样本比例下,本文算法在总体分类精度、平均分类精度和Kappa系数等评价指标上至少提高4.76%、4.24%和5.19%,与非内核化的算法相比,本文算法在基本不增加运行时间的情况下总体分类精度、平均分类精度和Kappa系数至少提高2.92%、2.8%和3.48%.

关键词：高光谱图像分类内核脊回归多标签共享子空间学习奇异值分解

Effects of Heavy Ion Irradiation on Cell Survival and Cell Cycle Delays in Synchronous SMMC-7721 Hepatoma Cells

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2005年第1期 73-74页

作者： Wei Wei, li Wenjian, Xia Jinguang, Jin Xiaodong, guo Chuanling, li qiang and Su Xu

Ionizing radiation produces various kinds of damage, for example, DNA double- or single-strand break, and base damage. Cellular responses after ionizing radiation exposure can be considered to protect the cells from the radiation-induced damage. The purpose of this study is to investigate and compare cell survival and cell cycle progression in human hepatoma cells (SMMC-7721) synchronized at G0/C1,G1/S and G2/M phases, respectively.

关键词：细胞存活电离辐射肝癌细胞周期时滞同步重离子单链断裂辐射照射

Eunicellin-Based Diterpenoids and Seroids from the South China Sea Gorgonian Muricella sibogae

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Eunicellin-Based Diterpenoids and Seroids from the South Chi...

2014年中国药学大会暨中国药师周

作者： Xing-Wang Zhang Xu-li Tang Ping-lin li guo-qiang li Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of China College of Chemistry and Chemical Engineering Ocean University of China

A present continuous study of the gorgonian Muricella sibogae collected from the South China Sea showed a new understanding of its chemical ***-four compounds were obtained,including two new eunicellin-based diterpenoids sibogins C and D,a new 9,10-secosteroid sibogol D,and two new1,4-dien-3-one-steroids sibogols E and F,together with eight known eunicellin-based diterpenoids and twenty-one known *** structures were elucidated by extensive spectroscopic analyses（1D-and 2D-NMR,IR and MS）and by careful comparisons with data in *** the bioassay in vitro,three eunicellin-based diterpenoids showed moderate cytotoxicities against selected tumor cell lines,while two steroids displayed significant cytotoxicities against HL-60 cell lines with IC50values of 1.27mM and 5.26mM respectively;and one of them also showed potent cytotoxicity against HCT116 cell lines with an IC50 value of ***,an interesting structure-activity relationship among the three types of biogenetically related 9,10-seco-,1,4-dien-3-one-and 4-en-3-one-steroids was discovered for the first time.

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Three new non-brominated pyrrole alkaloids from the South China Sea sponge Agelas nakamurai

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Three new non-brominated pyrrole alkaloids from the South Ch...

2016年中国药学大会暨第十六届中国药师周

作者： Mei-Jun Chu Xu-li Tang Ping-lin li guo-qiang li Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of China College of Chemistry and Chemical Engineering Ocean University of China

Marine sponges of the genus Agelas（class Demospongiae, order Agelasida, family Agelasidae） are important source of bioactive natural products with major representatives of pyrrole alkaloids, diterpene alkaloids, glycolipids, and so on. The natural-occurring pyrrole alkaloids are a unique family structurally featured by a bromopyrrole-2-carboxamide core and diverse linear side chains, fused rings, and dimmer structure patterns. Since 1971, more than 130 pyrrole alkaloids have been isolated from Agelas sponges with only 10 non-brominated pyrrole-2-carboxamide metabolites found. Many of these pyrrole alkaloids showed promising biological activities represented by the matrix metalloproteinase inhibitor ageladine A, antihistaminic taurodispacamide A, and antimicrobial nagelamide J. In our continuing search for novel secondary metabolites with potential bioactivity from Agelas sponges collected off Xisha Islands（Paracel Islands）, an investigation on another species of A. nakamurai afforded three new non-brominated pyrrole-2-carboxamide alkaloids, nakamurines A–C（1–3）. Their structures were elucidated on the basis of spectroscopic data. It was noticed that the sponge of the genus Agelas derived linear pyrrole-2-carboxamide metabolites containing an ester group at the end of the side chain were only found in the South China Sea. In the bioassay, compound 2 showed weak antimicrobial activity against Candida albicans with MIC of 60 μg/ml.

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Management of life-threatening celiac-hepatic arterial hemorrhage after pancreaticoduodenectomy： usefulness of temporary balloon occlusion

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Chinese Medical Journal 2011年第23期124卷 4115-4118页

作者： WANG Mao-qiang guo li-ping liN Han-ying DUAN Feng liU Feng-yong WANG Zhi-jun Department of Interventional Radiology Chinese People＇s Liberation Army General Hospital Beijing 100853 China

When a large visceral artery is ruptured, uncontrolled bleeding may lead to hemodynamic collapse. Use of endovascular occlusion balloon catheter may provide rapid control of hemorrhage and facilitate definitive therapy. We reported two patients with massive hemorrhage from ruptured celiac-hepatic artery after pancreaticoduodenectomy, who were initially treated percutaneously by temporary selective balloon occlusion. They became critically hemodynamic unstable during the angiographic procedure. Through an 8Fr sheath, a 6Fr compliant latex occlusion balloon was placed proximal to the celiac trunk and inflated, and upon patient stabilization surgical revision and stent-graft placement were successfully performed in the two patients, respectively. Temporary selective balloon occlusion provides fast and effective bleeding control for patient with critically uncontrollable visceral arterial hemorrhage, permitting subsequent use of conventional techniques for management of the arterial bleeding source.

关键词： postoperative bleeding shock, hemorrhagic balloon occlusion pancreaticoduodenectomy radiology, interventional

Prediction of outcome after paraquat poisoning by arterial lactate concentration-time data

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Prediction of outcome after paraquat poisoning by arterial l...

第七次全国中毒与危重症救治学术年会、第二届宝安急危重症高峰论坛、国家级继续项目“心肺复苏与急危重症学习班”

作者： liang Sun guo-qiang li Lu-Qing Wei. Department of Respiratory and Critical Care Medicine Pingjin Hospital Affiliated Hospital of Armed Police Logistics College

A retrospective analysis of 170 patients with a diagnosis of paraquat poisoning is to clarify whether the arterial lactate-time(arterial lactate concentrationx time between ingestion and arterial lactate were measured)is a good predictor of mortality in patients with acute paraquat *** study showed that there has a positive correlation between the arterial lactate-time and PQ concentrations-time(R=0.485).The arterial lactate-time date had a similar discriminative power to the plasma paraquat concentration-time data(z=0.712,P=0.864).For the ROC curve analysis,the lactate-time date had an area of 0.782 and the cut off was 11.95mmol/L.h(sensitivity64.52%,specificity 84.42%).To calculate a predicted probability of survival for any specified time and initial arterial lactate concentration,a formula was derived based on the logistic regression coefficients:logit(p)=3.066-0.139×(Time lag after PQ ingestion)-0.177×(initial arterial lactate).Probability of survivors=1/1+e-logit(p).It could be concluded that the arterial lactate-time data had a good predictive power in evaluating the prognosis of patients with acute paraquat poisoning.

关键词： arterial lactate paraquat poisoning prognosis

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei Xiao Zhiyong Kan Jing guo qiang li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

Comparison of the prognostic value of arterial lactate concentration,plasma organophosphate concentration and APACHE Ⅱ score in organophosphate poisoning patients

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Comparison of the prognostic value of arterial lactate conce...

2016中国中毒救治首都论坛——暨第八届全国中毒及危重症救治学术会议

作者： liang Sun guo-qiang li Peng-bo Yan Xin Yu guo-feng li Lu-qing Wei Department of Intensive Care Medicine and Respiratory Affiliated Hospital of Logistic University of Chinese People’s Armed Police Force

Objective:Initial arterial lactate has been used as a prognostic marker in patients with acute paraquat ***,prognostic value of initial arterial lactate in organophosphate poisoned patients is *** aim of this study was to assess the usefulness of initial arterial lactate,initial plasma organophosphate concentration and APACHE Ⅱ score,for predicting death with identified organophosphate ***:117 patients with proven organophosphate self-poisoning were retrospective *** arterial lactate concentration,initial plasma organophosphorus concentration and APACHE Ⅱ score of the patients were compared for predicting death by analyzing receiver operating characteristic(ROC) ***:Our resultes shown that there was no statistically difference between APACHE Ⅱ score,arterial lactate and plasma organophosphate concentration in terms of area under ROC Curve in predicting *** prediction,the best cut off point was 17 for APACHE Ⅱ,3.40mmol/L for arterial lactate,and 1.20 mmol/L for plasma organophosphate *** correlation was observed between arterial lactate and APACHE Ⅱ score(p=0.457),as well as between arterial lactate and the length of hospitalization in survivors(p=0.406).Conclusion:These data demonstrate that initial arterial lactate can provide useful information in predicting prognosis in organophosphate ***,whether it can be used as a prognostic marker still need to be confirmed by large sample data.

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