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Prostate Cancer Detection with Multiparametric Magnetic Resonance Imaging： Prostate Imaging Reporting and Data System Version 1 versus Version 2

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Chinese Medical Journal 2016年第20期129卷 2451-2459页

作者： Zhao-Yan Feng Liang wang Xiang-De Min Shao-Gang wang guo-ping wang Jie Cai Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Background：Prostate Imaging Reporting and Data System （PI-RADS） is a globally acceptable standardization for multiparametric magnetic resonance imaging （mp-MRI） in prostate cancer （PCa） *** American College of Radiology revised the PI-RADS to address the limitations of version 1 in December *** study aimed to determine whether the PI-RADS version 2 （PI-RADS v2） scoring system improves the diagnostic accuracy of mp-MRI of the prostate compared with PI-RADS ***：This retrospective study was approved by the institutional review board.A total of 401 consecutive patients,with clinically suspicious Pca undergoing 3.0 T mp-MRI （T2-weighted imaging ＋ diffusion-weighted imaging ＋ DCE） before transrectal ultrasound-guided biopsy between June 2013 and July 2015,were included in the *** patients were scored using the 5-point PI-RADS scoring system based on either PI-RADS v1 or *** operating characteristics were calculated for statistical ***,specificity,and diagnostic accuracy were compared using McNemar＇s ***：Pca was present in 150 of 401 （37.41%） *** we pooled data from both peripheral zone （PZ） and transition zone （TZ）,the areas under the curve were 0.889 for PI-RADS v1 and 0.942 for v2 （P =0.0001）.Maximal accuracy was achieved with a score threshold of *** this threshold,in the PZ,similar sensitivity,specificity,and accuracy were achieved with v 1 and v2 （all P 〉 0.05）.In the TZ,sensitivity was higher for v2 than for v1 （96.36% vs.76.36%,P =0.003）,specificity was similar for v2 and v1 （90.24% vs.84.15%,P =0.227）,and accuracy was higher for v2 than for v1 （92.70% vs.81.02%,P =0.002）.Conclusions：Both v1 and v2 showed good diagnostic performance for the detection of ***,in the TZ,the performance was better with v2 than with v1.

关键词： Multiparametric Magnetic Resonance Imaging Prostate Prostate Imaging Reporting and Data System Version 1 Prostate Imaging Reporting and Data System Version 2

Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients

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Current Medical Science 2020年第4期40卷 618-624页

作者： Ya-qi DUAN Ming-hui XIA Liang REN Yan-fang ZHANG Qi-lin AO San-peng XU Dong KUANG Qian LIU Bing YAN Yi-wu ZHOU Qian CHU Liang LIU Xiang-ping YANG guo-ping wang Institute of Pathology Tongjii HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Immunology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Forensic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega ScienceChinese Academy of SciencesWuhan 430071China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Summary:The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ *** the dysregulated human immune responses in the fatal subjects is critical for management of COVID-19 patients and the *** this study,we examined the immune cell compositions in the lung tissues and hilar lymph nodes using immunohistochemistry on 6 deceased COVID-19 patients and 4 focal organizing pneumonia(FOP)patients who underwent lung surgery and served as *** found a dominant presence of macrophages and a general deficiency of T cells and B cells in the lung tissues from deceased COVID-19 *** contrast to the FOP patients,Tfh cells and germinal center formation were largely absent in the draining hilar lymph nodes in the deceased COVID-19 *** was correlated with reduced IgM and IgG levels compared to convalescent COVID-19 *** summary,our data highlight a defect of germinal center structure in deceased COVID-19 patients leading to an impaired humoral *** the mechanisms of this deficiency will be one of the key points for the management of this epidemic.

关键词： COVID-19 immune responses germinal center T follicular helper cells

Metastasis and micrometastasis in ultra-low rectal cancer

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The Chinese-German Journal of Clinical Oncology 2010年第9期9卷 524-527页

作者： Xuefeng guo ping Lan Lei wang Hui Peng Jianping wang Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655China

Objective:The aim of our study was to investigate the lymph node metastasis of mesorectum and ischiorectal foss in ultra-low rectal cancer and its influence on the surgical procedure ***:Large slices and tissue microarray technology were used to detect metastasis lymph nodes from 23 dissected specimens of ultra-low rectal ***:415 lymph nodes were detected in the 23 specimens.169 and 59 lymph nodes were metastasis and micrometastasis, *** specimens were diagnosed with lymph node metastasis, while other 4 specimens were with lymph node *** were 29.0% (49/169) and 17.2% (29/169) metastatic lymph nodes located in the outer and anterior region of *** were 2 cases with ischiorectal fossa lymph node metastasis and 1 case with *** 3 metastatic cases were only 13% (13/23) of all the 23 ***:There is regional lymph node metastasis existing in ultra-low rectal *** metastatic incidences in distal mesorectum and ischiorectal fossa are relatively *** Miles operation as the standard surgical procedure for ultra-low rectal cancer should be evaluated renewedly.

关键词： rectal neoplasm lymph nodes neoplasm metastasis

Mid-infrared waveguiding in three-dimensional microstructured optical waveguides fabricated by femtosecond-laser writing and phosphoric acid etching

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Photonics Research 2020年第3期8卷 257-262页

作者： JINMAN LV BINBIN HONG YANG TAN FENG CHEN JAVIER RODRíGUEZ VáZQUEZ DE ALDANA guo ping wang Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen 518052China School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Departamento Fisica Aplicada Facultad CienciasUniversidad de SalamancaSalamanca 37008Spain

We fabricated a three-dimensional microstructured optical waveguide(MOW)in a single-crystal using femtosecond-laser writing and phosphoric acid etching techniques,and observed excellent midinfrared waveguiding performance with low loss of^0.5 d B∕*** with a periodic arrangement were written inside the yttrium aluminum garnet(YAG)crystal via femtosecond laser inscription,and then etched by the phosphoric acid(H3 PO4)to form hollow *** evolution of the microstructure of tracks was investigated in *** function of the MOW was analyzed by different numerical methods,indicating the proposed MOW can effectively operate in quasi-single-mode pattern in the midinfrared wavelength range,which agrees well with our experiment results.

关键词： microstructure laser wave

Anomaly Detection of Controllable Electric Vehicles through Node Equation against Aggregation Attack

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Computers, Materials & Continua 2025年第1期82卷 427-442页

作者： Jing guo Ziying wang Yajuan guo Haitao Jiang State Grid Jiangsu Electric Power Co. Ltd.Research InstituteState Grid Corporation of ChinaNanjing211100China

The rapid proliferation of electric vehicle(EV)charging infrastructure introduces critical cybersecurity vulnerabilities to power grids *** study presents an innovative anomaly detection framework for EV charging stations,addressing the unique challenges posed by third-party aggregation *** approach integrates node equations-based on the parameter identification with a novel deep learning model,xDeepCIN,to detect abnormal data reporting indicative of aggregation *** employ a graph-theoretic approach to model EV charging networks and utilize Markov Chain Monte Carlo techniques for accurate parameter *** xDeepCIN model,incorporating a Compressed Interaction Network,has the ability to capture complex feature interactions in sparse,high-dimensional charging *** results on both proprietary and public datasets demonstrate significant improvements in anomaly detection performance,with F1-scores increasing by up to 32.3%for specific anomaly types compared to traditional methods,such as wide&deep and DeepFM(Factorization-Machine).Our framework exhibits robust scalability,effectively handling networks ranging from 8 to 85 charging ***,we achieve real-time monitoring capabilities,with parameter identification completing within seconds for networks up to 1000 *** research contributes to enhancing the security and reliability of renewable energy systems against evolving cyber threats,offering a comprehensive solution for safeguarding the rapidly expanding EV charging infrastructure.

关键词： Anomaly detection electric vehicle aggregation attack deep cross-network

Remote sensing image classification based on BP neural network model

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中国有色金属学会会刊：英文版 2005年第S1期15卷 240-243页

作者： ZHENG Yong-guo, wang ping, MA Jing, ZHANG Hong-bo (Shandong University of Science and Technology, Tai’an 271019, China)

Aiming at the characteristics of remote sensing image classification, the mixed pixel problem is one of the main factors that affect the improvement of classifying precision in remote sensing classification. A BP neural network was established to solve mixed pixel classifying problems. The aim of our work is to improve the BP network algorithm and set the intensity of training, which changes with training process, because the BP algorithm converyging speed of learning algorithm is rather slow, it is possible to fall into the local minimum, and because the algorithm makes the learning result poor, the global minimum value can’t be reached. The results show that this method effectively solves mixed pixel classifying problem, improves learning speed and classification accuracy of BP network classifier,so it is one kind of effective remote sensing imagery classifying method.

关键词： remote sensing image classification neural network training intensity

Effect of Nb-V microalloying on the hot deformation behavior of medium Mn steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 360-368页

作者： Yumeng wang Qinyi guo Bin Hu Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression *** establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow *** concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.

关键词： medium manganese steel niobium-vanadium microalloying flow behavior dynamic recrystallization hot workability

Perovskite LiBaH3 for photo-assisted dinitrogen fixation

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Science China Chemistry 2025年

作者： Kaixun Cui Yeqin Guan Yongli Cai Runze wang Qianru wang Wenbo Gao Jianping guo ping Chen Department of Chemical Physics University of Science and Technology of China Dalian Institute of Chemical Physics Chinese Academy of Sciences Center of Materials and Optoelectronics Engineering University of Chinese Academy of Sciences

Establishing supply chains for future ammonia energy systems requires the development of efficient materials and processes for ammonia production under mild conditions. Recent researches disclose unique functionalities of binary alkali and alkaline earth metal hydrides in mediating ammonia synthesis. Thanks to the rich compositional and structural properties of the metalhydrogen system, we herein report that LiBaH3, as a narrow band gap perovskite hydride, exhibits a strong response to visible light illumination. Specifically, hydridic hydrogen undergoes reductive elimination of producing H2and creates an electron-rich surface. Such an environment favors dinitrogen fixation to form N–H bonds. Based on this chemical property, a chemical looping ammonia synthesis process mediated by LiBaH3and driven by both photo and thermal energies was proposed and *** work demonstrates that hydride perovskites are promising candidates for mediating photo-assisted nitrogen fixation reactions.

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A New Approach to Prepare 2-Acetyl-Mono(5,6,7,8)-Nitro-l,2,3,4-Tetrahydroisoquinolincs

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Chinese Chemical Letters 2000年第10期11卷 857-860页

作者： Chong Zhao RAN, Tat Zhi WU, guo ping wang, Met Hua XIE (Department of Medicinal Chemistry, Shanghai institute of Pharmaceutical industry, Shanghai 200437)

N-Acetyl-P. m or o-nitro-phenylethylamines and (HCHO). were treated in 60% H,SO./HOAc. via α -amidoalkylation to give 2-acetyl-mono(5, 6, 7 or 8)-nitro-l .2,3.4- tetrahydroisoquinolines. Additionally. solme interesting phenomena were observed when the comparison between 2-acetyl-5, 6. 7 or 8-nitro-l,2.3.4-tetrahydroisoqui and 2-alkylsulfonyl-5. 6 or 7nitro-l,2.3,4-tetrahydroisoquinolines was made.

关键词： α-Amidoalkylation 2-acetyl-mono (5 6. 7. 8)-nitro-l.2,3.4-tetrahydroisoqu nitro- I .2.3.4-tetrahydroisoquinolines.