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High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

Science China(life Sciences) 2024年第2期67卷 286-300页

作者： Bi-Ang Kang Hua-ming li Ya-Ting Chen Meng-Jie Deng Yan li Yue-ming Peng Jian-Jun Gao Zhi-Wei Mo Jia-guo Zhou Zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

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Presentation of the Berry-Tabor conjecture in Levy plates

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Chinese Physics B 2024年第10期33卷 240-247页

作者： Chao li guo-lin Hou School of Mathematical Sciences Inner Mongolia UniversityHohhot 010021China

The Berry-Tabor(BT)conjecture is a famous statistical inference in quantum chaos,which not only establishes the spectral fluctuations of quantum systems whose classical counterparts are integrable but can also be used to describe other wave *** this paper,the BT conjecture has been extended to Lévy *** predicted by the BT conjecture,level clustering is present in the spectra of Lévy *** consequence of level clustering is studied by introducing the distribution of nearest neighbor frequency level spacing ratios P(r),which is calculated through the analytical solution obtained by the Hamiltonian *** work investigates the impact of varying foundation parameters,rotary inertia,and boundary conditions on the frequency spectra,and we find that P(r)conforms to a Poisson distribution in all *** reason for the occurrence of the Poisson distribution in the Lévy plates is the independence between modal frequencies,which can be understood through mode functions.

关键词： Berry-Tabor conjecture frequency spectra Hamiltonian approach Lévy plates

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Flexible printed three dimensional(3D) integrated carbon nanotube complementary metal oxide semiconductor(CMOS) thin film transistors and circuits

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Science China(Information Sciences) 2024年第9期67卷 280-293页

作者： Zhaofeng CHEN Jiaqi li Min li Hongxuan guo Jianwen ZHAO SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of Education Southeast University Printable Electronics Research Center Division of Nanodevices and Related NanomaterialsSuzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences School of Nano Technology and Nano Bionics University of Science and Technology of China

The threshold voltage modulation of carbon nanotube thin-film transistors（TFTs） and flexible three-dimensional（3D） integration circuits has become hot research topics for carbon-based electronics. In this paper, a doping-free gate electrode technology is introduced to significantly modulate the threshold voltage of polymer-sorted semiconducting single-walled carbon nanotube（sc-SWCNT） TFTs in combination with the highly effective gate-controlling ability of solid-state electrolyte thin films as the dielectrics. A systematic investigation was conducted on the impact of printed silver, evaporated silver, and evaporated aluminum（Al） gate electrodes on the threshold voltage of flexible printed bottom-gate and top-gate SWCNT TFTs. The results indicate that the SWCNT TFTs with Al gate electrodes exhibit enhancement-mode characteristics with excellent electrical properties, such as the negative threshold voltages（-0.6 V）, high Ion/Ioff（up to 10～6）, low subthreshold swing(61.4 mV · dec-1), and small hysteresis. It is attributed to either the formation of lower work function thin films（Al2O3） at the electrode/dielectric layer interfaces through the natural oxidation of the Al bottom-gate electrodes or the dipole reaction of the Al top-gate electrodes from X-ray photoelectron spectroscopy（XPS） and ultraviolet photoelectron spectroscopy（UPS） data. In addition, 3D complementary metal-oxide-semiconductor（CMOS） inverters with common gate electrodes were constructed using the resulting enhancement-mode P-type SWCNT TFTs and matched N-type SWCNT TFTs, which shows high voltage gain（34）, rail-to-rail output and high noise margins(80.04%, VDD=-1 V)as well good mechanical flexibility at low operation voltages. It demonstrates that SWCNT TFTs have great advantages for building large-scale 3D flexible integrated circuits.

关键词： three-dimensional CMOS circuits printing technology polymer-sorted semiconducting carbon nanotubes enhancement-mode thin-filmtransistors threshold voltage modulation

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Design of weak current measurement system and research on temperature impact

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Nuclear Science and Techniques 2024年第4期35卷 46-56页

作者： Chu-Xiang Zhao San-Gang li Rong-Rong Su li Yang ming-Zhe liu Qing-Yue Xue Shan liao Zhi Zhou Qing-Shan Tan Xian-guo Tuo Yi Cheng College of Nuclear Technology and Automation Engineering Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China University of Science and Technology of China Hefei 230026China School of Physics and Electronic Engineering Sichuan University of Science and EngineeringZigong 643000China

A dedicated weak current measurement system was designed to measure the weak currents generated by the neutron ionization *** system incorporates a second-order low-pass filter circuit and the Kalman filtering algorithm to effectively filter out noise and minimize interference in the measurement *** conducted under normal temperature conditions has demonstrated the system's high precision ***,it was observed that temperature variations can affect the measurement *** were collected across temperatures ranging from -20 to 70℃,and a temperature correction model was established through linear regression fitting to address this *** feasibility of the temperature correction model was confirmed at temperatures of -5 and 40℃,where relative errors remained below 0.1% after applying the temperature *** research indicates that the designed measurement system exhibits excellent temperature adaptability and high precision,making it particularly suitable for measuring weak currents.

关键词： Weak current measurement system Neutron ionization chamber Kalman filter algorithm Temperature correction model

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Fullerenes and derivatives as electrocatalysts: Promises and challenges

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Green Energy & Environment 2024年第1期9卷 7-27页

作者： Kun guo Ning li lipiao Bao Xing Lu State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China

Carbon-based metal-free nanomaterials are promising alternatives to precious metals as electrocatalysts of key energy storage and conversion *** paramount signiﬁcance are the establishment of design principles by understanding the catalytic mechanisms and identifying the active *** from sp2-conjugated graphene and carbon nanotube,fullerene possesses unique characteristics that are growingly being discovered and exploited by the electrocatalysis *** instance,the well-deﬁned atomic and molecular structures,the good electron afﬁnity to tune the electronic structures of other substances,the intermolecular self-assembly into superlattices,and the on-demand chemical modiﬁcation have endowed fullerene with incomparable advantages as electrocatalysts that are otherwise not applicable to other carbon *** increasing studies are being reported on this intriguing topic,it is necessary to provide a state-of-the-art overview of the recent *** review takes such an initiative by summarizing the promises and challenges in the electrocatalytic applications of fullerene and its *** content is structured according to the composition and structure of fullerene,including intact fullerene(e.g.,fullerene composite and superlattices)and fullerene derivatives(e.g.,doped,endohedral,and disintegrated fullerene).The synthesis,characterization,catalytic mechanisms,and deﬁciencies of these fullerene-based materials are explicitly *** conclude it by sharing our perspectives on the key aspects that future efforts shall consider.

关键词： Fullerene Fullerene derivative Metal-free catalyst Structural defect Electrocatalyst

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Petroleum Science 2024年第4期21卷 2383-2392页

作者： li-ming Zhao Cai-Ping Lu Yang liu Chao-Chao li School of Mines China University of Mining and Technology Henan Institute of Geophysical Space Information

The similarities and differences in inherent mechanism and characteristic frequency between the onedimensional(1D) poroelastic model and the layered White model were investigated. This investigation was conducted under the assumption that the rock was homogenous and isotropic at the mesoscopic scale. For the inherent mechanism, both models resulted from quasi-static flow in a slow P-wave diffusion mode, and the differences between them originated from saturated fluids and boundary conditions. On the other hand, for the characteristic frequencies of the models, the characteristic frequency of the 1D poroelastic model was first modified because the elastic constant and formula for calculating it were misused and then compared to that of the layered White model. Both of them moved towards higher frequencies with increasing permeability and decreasing viscosity and diffusion length. The differences between them were due to the diffusion length. The diffusion length for the 1D poroelastic model was determined by the sample length, whereas that for the layered White model was determined by the length of the representative elementary volume(REV). Subsequently, a numerical example was presented to demonstrate the similarities and differences between the models. Finally, published experimental data were interpreted using the 1D poroelastic model combined with the Cole-Cole *** prediction of the combined model was in good agreement with the experimental data, thereby validating the effectiveness of the 1D poroelastic model. Furthermore, the modified characteristic frequency in our study was much closer to the experimental data than the previous prediction, validating the effectiveness of our modification of the characteristic frequency of the 1D poroelastic model. The investigation provided insight into the internal relationship between wave-induced fluid flow(WIFF)models at macroscopic and mesoscopic scales and can aid in a better understanding of the elastic modulus d

关键词： 1D poroelastic model Layered White model Quasi-static flow Slow P-wave diffusion Characteristic frequency Diffusion length

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Meibomian glands segmentation in infrared images with limited annotation

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 401-407页

作者： Jia-Wen lin ling-Jie lin Feng Lu Tai-Chen Lai Jing Zou lin-ling guo Zhi-ming lin li li College of Computer and Data Science Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Shengli Clinical Medical College of Fujian Medical University Fuzhou 350001Fujian ProvinceChina Department of Ophthalmology Fujian Provincial Hospital South BranchFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

●AIM:To investigate a pioneering framework for the segmentation of meibomian glands(MGs),using limited annotations to reduce the workload on ophthalmologists and enhance the efficiency of clinical diagnosis.●METHODS:Totally 203 infrared meibomian images from 138 patients with dry eye disease,accompanied by corresponding annotations,were gathered for the study.A rectified scribble-supervised gland segmentation(RSSGS)model,incorporating temporal ensemble prediction,uncertainty estimation,and a transformation equivariance constraint,was introduced to address constraints imposed by limited supervision information inherent in scribble *** viability and efficacy of the proposed model were assessed based on accuracy,intersection over union(IoU),and dice coefficient.●RESULTS:Using manual labels as the gold standard,RSSGS demonstrated outcomes with an accuracy of 93.54%,a dice coefficient of 78.02%,and an IoU of 64.18%.Notably,these performance metrics exceed the current weakly supervised state-of-the-art methods by 0.76%,2.06%,and 2.69%,***,despite achieving a substantial 80%reduction in annotation costs,it only lags behind fully annotated methods by 0.72%,1.51%,and 2.04%.●CONCLUSION:An innovative automatic segmentation model is developed for MGs in infrared eyelid images,using scribble annotation for *** model maintains an exceptionally high level of segmentation accuracy while substantially reducing training *** holds substantial utility for calculating clinical parameters,thereby greatly enhancing the diagnostic efficiency of ophthalmologists in evaluating meibomian gland dysfunction.

关键词： infrared meibomian glands images meibomian gland dysfunction meibomian glands segmentation weak supervision scribbled annotation

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Attention-Based CNN Fusion Model for Emotion Recognition During Walking Using Discrete Wavelet Transform on EEG and Inertial Signals

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Big Data Mining and Analytics 2024年第1期7卷 188-204页

作者： Yan Zhao ming guo Xiangyong Chen Jianqiang Sun Jianlong Qiu School of Communication Engineering Hangzhou Dianzi UniversityHangzhou 310018China School of Automation and Electrical Engineering Linyi UniversityLinyi 276000China

Walking as a unique biometric tool conveys important information for emotion *** in different emotional states exhibit distinct walking *** this purpose,this paper proposes a novel approach to recognizing emotion during walking using electroencephalogram(EEG)and inertial *** recognition of emotion is achieved by training in an end-to-end deep learning fashion and taking into account multi-modal *** wear virtual reality head-mounted display(VR-HMD)equipment to immerse in strong emotions during *** environment shows excellent imitation and experience ability,which plays an important role in awakening and changing *** addition,the multi-modal signals acquired from EEG and inertial sensors are separately represented as virtual emotion images by discrete wavelet transform(DWT).These serve as input to the attention-based convolutional neural network(CNN)fusion *** designed network structure is simple and lightweight while integrating the channel attention mechanism to extract and enhance *** effectively improve the performance of the recognition system,the proposed decision fusion algorithm combines Critic method and majority voting strategy to determine the weight values that affect the final decision *** investigation is made on the effect of diverse mother wavelet types and wavelet decomposition levels on model performance which indicates that the 2.2-order reverse biorthogonal(rbio2.2)wavelet with two-level decomposition has the best recognition *** experiment results show that the proposed method outperforms other existing state-of-the-art works with an accuracy of 98.73%.

关键词： walking multi-modal fusion virtual reality emotion recognition discrete wavelet transform attention mechanism

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Single Ti atoms coupled with Ti-O clusters enable low temperature hydrogen cycling by sodium alanate

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Rare Metals 2024年第6期43卷 2671-2681页

作者： Zhuang-He Ren Xin Zhang Wen-Xuan Zhang Zhen-guo Huang li-Mei Yang Ya-Xiong Yang Zheng-Long li Juan li Wen-Ping Sun ming-Xia Gao Hong-Ge Pan Yong-Feng liu State Key Laboratory of Silicon and Advanced Semiconductor Materials Zhejiang UniversityHangzhou 310027China School of Materials Science and Engineering Zhejiang UniversityHangzhou 310058China School of Civil&Environmental Engineering.University of Technology Sydney Sydney2007 NSWAustralia Institute of Science and Technology for New Energy Xi'an Technological UniversityXi'an 710021China College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014China

Ti-based catalysts are known to improve the hydrogen storage performance of NaAlH4by facilitating the dissociation/recombination of H-H and Al-H *** catalytic activity of metallic Ti species strongly depends on its particle size and *** clusters and even single atoms are therefore highly desirable,but their controllable fabrication has been highly *** rein,we demonstrate a novel facile sonochemical synthesis of a Ti-O clusters featuring single Ti atom catalyst at room *** reducing TiCl_(4)by MgBu_(2)with ultrasound instead of heating as driving force,numerous single Ti atoms coupled with Ti-O clusters with Ti loading on graphene(Ti_(1)/Ti-O@G)up to 22.6 wt%have been successfully *** prepared Ti_(1)/Ti-O@G contributes high reactivity and superior catalytic activity,therefore enabling full dehydrogenation of NaAlH_(4)at 80℃in thermogravimetric mode and re-hydrogenation at 30℃and 10 MPa with 4.9 wt% H_(2).This fact indicates for the first time that single Ti atom catalyst with high loading is highly effective in catalyzing hydrogen cycling of NaAlH4at remarkably reduced temperatures.

关键词： Hydrogen storage Nanocatalysis Transition metals Single Ti atoms NaAlH_(4)

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Plasma-exfoliated g-C_(3)N_(4) with oxygen doping: tailoring photocatalytic properties

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Frontiers of Chemical Science and Engineering 2024年第2期18卷 27-39页

作者： Yuxin li Junxin guo Rui Han Zhao Wang National Engineering Research Centre of Industry Crystallization Technology School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Heteroatom doping and defect engineering have been proposed as effective ways to modulate the energy band structure and improve the photocatalytic activity of g-C_(3)N_(4). In this work, ultrathin defective g-C_(3)N_(4) was successfully prepared using cold plasma. Plasma exfoliation reduces the thickness of g-C_(3)N_(4) from 10 nm to 3 nm, while simultaneously introducing a large number of nitrogen defects and oxygen atoms into g-C_(3)N_(4). The amount of doped O was regulated by varying the time and power of the plasma treatment. Due to N vacancies, O atoms formed strong bonds with C atoms, resulting in O doping in g-C_(3)N_(4). The mechanism of plasma treatment involves oxygen etching and gas expansion. Photocatalytic experiments demonstrated that appropriate amount of O doping improved the photocatalytic degradation of rhodamine B compared with pure g-C_(3)N_(4). The introduction of O optimized the energy band structure and photoelectric properties of g-C_(3)N_(4). Active species trapping experiments revealed ·O_(2)^(–) as the main active species during the degradation.

关键词： graphitic carbon nitride cold plasma oxygen doping nitrogen defect visible-light photocatalysis

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