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Genes & Diseases 2023年第3期10卷 915-930页

作者： Hong-Yang luo jie-Ying Zhu Min Chen Wang-Jing Mu Liang guo Shanghai Frontiers Science Research Base of Exercise and Metabolic Health Shanghai University of SportShanghai 200438China School of Kinesiology Shanghai University of SportShanghai 200438China

Krüppel-like factor 10 (KLF10), also known as TGFβ-inducible early gene-1 (TIEG1), was first found in human osteoblasts. Early studies show that KLF10 plays an important role in osteogenic differentiation. Through decades of research, KLF10 has been found to have complex functions in many different cell types, and its expression and function is regulated in multiple ways. As a downstream factor of transforming growth factor β (TGFβ)/SMAD signaling, KLF10 is involved in various biological functions, including glucose and lipid metabolism in liver and adipose tissue, the maintenance of mitochondrial structure and function of the skeletal muscle, cell proliferation and apoptosis, and plays roles in multiple disease processes, such as nonalcoholic steatohepatitis (NASH) and tumor. Besides, KLF10 shows gender-dependent difference of regulation and function in many aspects. In this review, the biological functions of KLF10 and its roles in disease states is updated and discussed, which would provide new insights into the functional roles of KLF10 and a clearer view of potential therapeutic strategies by targeting KLF10.

关键词： Adipose tissue Estrogen signaling Glucose and lipid metabolism NASH Obesity Skeletal muscle TGFβ/SMAD signaling Tumor

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui Niu Xiaodong He Wenqi luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

Effect of Electrodeposition Methods of Cuprous Oxide on Antibacterial Properties of Concrete

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Journal of Wuhan University of Technology(Materials Science) 2023年第4期38卷 823-833页

作者：徐怡 XU Ning guo Mingzhi luo jie LI Yi 储洪强 ZENG Youxu JIANG Linhua College of Mechanics and Materials Hohai UniversityNanjing211100China Materials&Structural Engineering Department Nanjing Hydraulic Research InstituteNanjing210024China School of Civil Engineering Shaoxing UniversityShaoxing312000China

Three types of electrodeposition,DC electrodeposition,low-frequency pulsed electrodeposition and high-frequency pulsed electrodeposition,were used to deposit cuprous oxide on the concrete surface to improve the antibacterial properties of *** effects of pulse deposition frequency on the antibacterial property of concrete were studied using sulfate-reducing bacteria(SRB)and Escherichia coli(***)as model *** bacterial concentration and the antibacterial rate were measured to evaluate the antibacterial performance of *** effects of different deposition methods on the elemental content of copper and the amount of copper ions exuded were *** and SEM were used to analyze the microstructure of the deposited *** experimental results show that the concrete treated by electrodeposition exhibited good antibacterial properties against SRB and *** antibacterial effect of cuprous oxide deposited on concrete by pulse method was better than that by direct current(DC)*** antibacterial rate of concrete was positively correlated with the exudation rate of copper *** the pulse frequency increased,the deposits content on the surface was increased with an accompanying improvement in the antibacterial ***,the pulsed current had an indiscernible effect on the composition of the sediments,which were all mainly composed of Cu_(2)O,but the morphology of the Cu_(2)O differed *** octahedral cuprous oxide had better antibacterial properties with the highest copper ion leaching rate compared with cubic and spherical cuprous oxide.

关键词： cuprous oxide electrodeposition mode microbial corrosion antibacterial properties

Structural phase transition, precursory electronic anomaly, and strong-coupling superconductivity in quasi-skutterudite (Sr1-xCax)3Ir4Sn13 and Ca3Rh4Sn13

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Chinese Physics B 2018年第7期27卷 163-170页

作者： Jun luo jie Yang S Maeda Zheng Li guo-Qing Zheng Institute of Physics Chinese Academy of Sciences and Beijing National Laboratory for Condensed Matter Physics Beijing 100190 China School of Physical Sciences University of Chinese Academy of Sciences Beijing 100049 China Department of Physics Okayama University Okayama 700-8530 Japan

The interplay between superconductivity and structural phase transition has attracted enormous interest in recent years. For example, in Fe-pnictide high temperature superconductors, quantum fluctuations in association with structural phase transition have been proposed to lead to many novel physical properties and even the superconductivity itself. Here we report a finding that the quasi-skutterudite superconductors （Sr1-xCax）3Ir4Sn13 （x = 0, 0.5, 1） and Ca3Rh4Snl3 show some unusual properties similar to the Fe-pnictides, through 119Sn nuclear magnetic resonance （NMR） measurements. In （Sr1-xCax）3Ir4Sn13, the NMR linewidth increases below a temperature T＊ that is higher than the structural phase transition temperature Ts. The spin-lattice relaxation rate （1/T1 ） divided by temperature （T）, 1/TI T and the Knight shift K increase with decreasing T down to T＊, but start to decrease below T＊, and followed by more distinct changes at Ts. In contrast, none of the anomalies is observed in Ca3Rh4Sn13 that does not undergo a structural phase transition. The precursory phenomenon above the structural phase transition resembles that occurring in Fe-pnictides. In the superconducting state of Ca3Ir4Sn13, 1/T1 decays as exp（-△/kBT） with a large gap △ = 2.21kBTc, yet without a Hebel-Slichter coherence peak, which indicates strong-coupling superconductivity. Our results provide new insight into the relationship between superconductivity and the electronic-structure change associated with structural phase transition.

关键词： nuclear magnetic resonance antiferromagnetic fluctuation structural phase transition phase diagram

Psychoactive Substance Use and the Impact on the AIDS Epidemic Among the MSM Population:a Meta-Analysis—Worldwide,2014-2023

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China CDC weekly 2024年第42期6卷 1086-1092,I0001-I0006页

作者： Donghang luo jie Xu Wei luo National Center for AIDS/STD Control&Prevention Chinese Center for Diseases Control and PreventionBeijingChina

What is already known about this topic?There is a correlation between psychoactive substance use and heightened human immunodeficiency virus(HIV)susceptibility in men who have sex with men(MSM)populations,although the precise impact on transmission risk remains *** is added by this report?In MSM populations,rush poppers and amphetamines are widely used,with rates of 10.91%and 9.97%.In China,rush poppers usage is notably higher at 47.26%.For other regions and coutries,amphetamines(12.86%),rush poppers(3.62%),and GHB(3.34%)are most ***,17%of MSM use psychoactive substances,with higher HIV risk from amphetamines[Odds ratio(OR)3.06]compared to rush poppers(OR 1.51)and general substances(OR 1.76).What are the implications for public health practice?This study supports the idea that targeting specific regions and types of psychoactive substances for reduction among MSM populations can help decrease HIV transmission as well as promote prevention strategies.

关键词： prevention precise Impact

Early detection of multiple endocrine neoplasia type 1: A case report

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World Journal of Gastroenterology 2024年第26期30卷 3247-3252页

作者： jie-Hao Yuan Su luo Ding-guo Zhang Li-Sheng Wang Department of Gastroenterology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan University)Shenzhen 518020Guangdong ProvinceChina

BACKGROUND Multiple endocrine neoplasias(MENs)are a group of hereditary diseases invol-ving multiple endocrine glands,and their prevalence is *** type 1(MEN1)has diverse clinical manifestations,mainly involving the parathyroid glands,gastrointestinal tract,pancreas and pituitary gland,making it easy to miss the clinical *** SUMMARY We present the case of a patient in whom MEN1 was detected early.A middle-aged male with recurrent abdominal pain and diarrhea was admitted to the *** tests at admission revealed hypercalcemia and hypophosphatemia,and emission computed tomography of the parathyroid glands revealed a hy-perfunctioning parathyroid *** findings suggested a duodenal bulge and *** endoscopy revealed a hypoechoic lesion in the duodenal *** blood tests revealed elevated levels of serum *** was performed,and pathological analysis of the surgical specimens revealed a parathyroid adenoma after parathyroidectomy and a neuroendocrine tumor after duodenal *** time from onset to the definitive diagnosis of MEN1 was only approximately 1 *** For patients who present with gastrointestinal symptoms accompanied by hyper-calcemia and hypophosphatemia,clinicians need to be alert to the possibility of MEN1.

关键词： Multiple endocrine neoplasia type 1 Gastrointestinal symptoms Hypercal-cemia Early detection Case report

A pseudo transient nonequilibrium method for rigorous simulation of multicomponent separation columns

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Chinese Journal of Chemical Engineering 2023年第10期62卷 57-64页

作者： jie Wu Yiqing luo Xigang Yuan School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China Chemical Engineering Research Center Tianjin UniversityTianjin 300350China State Key Laboratory of Chemical Engineering Tianjin UniversityTianjin 300350China

Nonequilibrium stage model is a significant improvement in multicomponent separation process simulation,but more equations are involved and the solution of the model equations,which relies on an adequate initial guess for convergence of the Newton method,is *** this work,based on the concept of pseudo-transient continuation approach,we proposed a new pseudo-transient(PT)nonequilibrium *** proposed method decouples the strongly coupled model equations by introducing dynamic equations for material and energy conservation,as well as transition ***,the steady-state solution of the nonequilibrium stage model can be obtained through a robust and fast integration process,and the initial guess issue in Newton method can be effectively *** simulation cases were used to demonstrate the advantages and applicability of the proposed PT nonequilibrium method.

关键词： Nonequilibrium stage model Pseudo-transient continuation Distillation Numerical simulation Systems engineering

L_1 adaptive control with sliding-mode based adaptive law

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Control Theory and Technology 2015年第3期13卷 221-229页

作者： jie luo Chengyu CAO Department of Mechanical Engineering University of Connecticut

This paper presents an adaptive control scheme with an integration of sliding mode control into the L1 adaptive control architecture, which provides good tracking performance as well as robustness against matched uncertainties. Sliding mode control is used as an adaptive law in the L1 adaptive control architecture, which is considered as a virtual control of error dynamics between estimated states and real states. Low-pass filtering mechanism in the control law design prevents a discontinuous signal in the adaptive law from appearing in actual control signal while maintaining control accuracy. By using sliding mode control as a virtual control of error dynamics and introducing the low-pass filtered control signal, the chattering effect is eliminated. The performance bounds between the close-loop adaptive system and the closed-loop reference system are characterized in this paper. Numerical simulation is provided to demonstrate the performance of the presented adaptive control scheme.

关键词： L1 adaptive control sliding-mode control matched uncertainties

Epsilon-near-zero or mu-near-zero materials composed of dielectric photonic crystals

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Science China(Information Sciences) 2013年第12期56卷 148-157页

作者： luo jie LAI Yun Wave-Functional Materials Lab Department of Physics Soochow University

We theoretically demonstrate that at certain frequencies two-dimensional dielectric photonic crystals(PCs)may be regarded as either epsilon-near-zero or mu-near-zero *** show that the transmission through a slab of such materials upon normal incidence is normally non-unity and decays with slab ***,when the incident angle increases slightly,the transmittance experiences a dramatic increase due to the Brewster *** combination of the tunneling and resonance efects makes such materials good candidates for almost perfect bending waveguides and cloaking in *** zero index also enables applications of focusing and directive *** last,the distinction between the single-zero and double-zero media is *** all of the above results,the numerical simulations perfectly match with theoretical predictions from the efective medium analysis.

关键词： photonic crystal epsilon-near-zero material mu-near-zero material efective medium transmission properties Brewster efect